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Journal : AKSONA

Refractory Hyponatremia due to Systemic Infection: A Systematic Review Inayah, Dinda Rifdayani; Priyanto, Bambang; Rohadi, Rohadi; Januarman, Januarman
AKSONA Vol. 4 No. 2 (2024): JULY 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v4i2.51685

Abstract

Highlight: Hyponatremia is a potentially life-threatening condition. Refracter hyponatremia can be seen in patients with systemic infection who have undergone therapy.   ABSTRACT Introduction: Hyponatremia is a condition in which the sodium serum level is below the normal range. This condition is most common in hospitalized patients receiving systemic infection therapy and can lead to worse outcomes, potentially life-threatening.Objective: This study aimed to summarize the incidence of refractory hyponatremia due to systemic infection therapy. Methods: This was a systematic literature search conducted in October 2023 on the online database PubMed regarding refractory hyponatremia due to systemic. The analysis excluded narrative reviews, non-English studies, and studies that only discussed transient hyponatremia or local infections. Results: A total of 10 case reports of 11 patients were included in the final analysis. The mean age of patients was 46.63 years (SD = 20.79 years), and 63.64% were male. Strongloides stercoralis hyperinfection was the most common cause of systemic infection (54%). It was followed by disseminated Varicella-zoster virus infection (28%), tuberculosis (9%), and systemic nocardiosis (9%). The most common cause of immune compromise is stem cell transplant recipients (28%), followed by miliary tuberculosis (18%). Up to 91% of cases are caused  by the syndrome of inappropriate antidiuretic hormone (SIADH), which is the pathophysiology of hyponatremia. Conclusion: Most patients with systemic infections and refractory hyponatremia have conditions that encourage immune compromise. The treatment of systemic infections is a priority since they contribute to hyponatremia.
Co-Authors A., Bq. Dina Ayuni Abdul Wahid Abdul Wahid Afriza, Afriza Agustiar agustiar Agustin, Della Arditha Wira Ahmad Taufik Aldi, Muhammad Warid Amanda, Wira Risky Amelia Pratiwi Anshori, Maz Isa Antonia Nani Cahyanti Anwar, Nik Syahrim Nik Ardiansyah, Randy Arifathiyah, Meylia Azkia, Mita Nurul Bambang Kunarto Bambang Priyanto, Bambang Bambang Tutuko Bungawan, Ahmad Muhammad D., Arya Wiradana M. Decky Aditya Zulkarnaen Dirja, Bayu Tirta Edi Suhaedi Ellya Roza Farhan, Najwa A’yuni Firmanto, Adit Arief fitriana, ika Hadlin, Muhammad Wahyu Janwar Haikal, Zikrul Hardiani, Febrika Heliany, Ina Hunaida, Patlial Husni Teja Sukmana I., Johan Trinanda Hermawan Inayah, Dinda Rifdayani Januarman, Januarman Joni Wahyuhadi, Joni Juniyantika, Vina Dwi Kadriyan, Hamsu Kafrawi, Achmad Evin Kibtiah, Kamariatul Kusyandi, Andi Madaniyah, Madaniyah Mudasir Mudasir Mudjiastuti Handajani Muhammad Syaifuddin Mulyadi Mulyadi Nandana, Pandu Ishaq Nunu Mahnun Nurwijayanti Parenrengi M. A Phami Tomas Pramucitra, Sinta Pramucitra Pratiwi, MM. Shinta Prihatina, Lale Maulin Purnaning, Dyah Putri, Listia Rachma, Anisa Rafiq, Azhar RAHAYU, WIDYA Rayi Pradono Iswara RR. Ella Evrita Hestiandari Safira, Mas Ayu Saniwati, Saniwati Saputri, Dinda Rahmayanti Sarip Sarip Satria Pinandita Sigit Kusdaryono Siqhny, Zulhaq Dahri Siradz, Bayu Fidaus Siti Sumartini, Siti Sohiron, Sohiron Sri Budi Wahjuningsih, Sri Budi Sri Kusriyah Sumartini, Siti Sumartini Sunanto Sunanto Tassya, Thania Olang Tatas Transinata Taufik, Ahmad Utari, Febiani Dwi Zuhan, Arif