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Bagus Komang Satriyasa
Bagian Farmakologi Fakultas Kedokteran Universitas Udayana
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Uji efektivitas ekstrak air daun ubi jalar ungu (Ipomoea batatas) terhadap profil lipid tikus putih jantan galur wistar yang diinduksi pakan dislipidemia I Pande Putu Deny Heriwijaya; I Made Jawi; Bagus Komang Satriyasa
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1365.719 KB) | DOI: 10.15562/ism.v11i2.584

Abstract

Background: The conventional drugs for dyslipidemia theraphy needed to be concerned in the usage because of the side effect of the drugs. The Anthocyanin was one of the flavonoid compound that can be used as an alternative theraphy for dyslipidemia. The leaf of the purple sweet potato have been proved containing anthocyanin.Aim: The study aims to know the effectivity of the sweet potato leaf on lipid profile of male wistar rats induced by dyslipidemia feed extract.Method: The study design was pre and post-test control group design. Thirty white male rats were divided into five groups. All of the groups were given high-cholesterol diet for three months. Negative control groups of rats were given only high-cholesterol diet alone, positive control groups were given dyslipidemia drugs and the treatment groups were given sweet potato leaf water extract with the doses of each group were 3cc, 6cc and 9cc. Before and after treatment, lipid profile levels were measured.Results: There was a decrease in total cholesterol, triglyseride and LDL in treatmen group with 6cc and 9cc dose significantly (p<0,05) compared with the negative control group.Conclusion: The sweet potato leaf extract can improve the lipid profile of the dyslipidemia rats. Latar Belakang: Obat konvensional yang biasa dipakai untuk terapi dari dislipidemia masih harus diperhatikan dalam pemakaiannya karena masih adanya efek samping yang tidak diinginkan. Senyawa antosianin merupakan salah satu senyawa flavonoid yang dapat berpotensi sebagai terapi alternatif untuk dislipidemia. Pada daun ubi jalar ungu terbukti terdapat senyawa antosianin yang dapat digunakan sebagi terapi alternatif dislipidemia. Tujuan: untuk mengetahui efektivitas dari ekstrak daun ubi jalar ungu (Ipomoea batatas) terhadap profil lipid tikus putih jantan galur wistar yang diinduksi pakan dislipidemia. Metode: Rancangan penelitian adalah pre and post-test control group design. Penelitian dilakukan pada 30 ekor tikus putih jantan yang dibagi menjadi lima kelompok. Kelima kelompok tikus diberi makanan tinggi kolesterol selama tiga bulan. Pada kelompok tikus kontrol negatif hanya diberi pakan kolesterol, kontrol positif diberikan juga obat dislipidemia dan tiga kelompok perlakuan diberikan ekstrak air daun ubi ungu dengan dosis masing-masing kelompok 3cc, 6cc dan 9cc. Sebelum dan setelah mendapat perlakuan dilakukan pengukuran profil lipid. Hasil: Terdapat penurunan pada kolesterol total, trigliserida dan LDL pada kelompok perlakuan dengan dosis 6cc dan 9cc secara signifikan (p<0,05) dibandingkan dengan kontrol negatif. Kesimpulan: Pemberian ekstrak air daun ubi jalar ungu dapat memperbaiki profil lipid tikus dislipidemia.
The characteristic of anxiety and depression among medical students at the Faculty of Medicine, Universitas Udayana, Bali in 2016 Tharsani Devi Srinivasagam; Bagus Komang Satriyasa
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.227 KB) | DOI: 10.15562/ism.v11i2.600

Abstract

Background: Anxiety and depression are some of the most prevalent mental health problems, especially among medical students. This study aims to evaluate the severity of anxiety and depression and also the prevalence of anxiety and depression faced by the students of the Medical Faculty, Universitas Udayana, Bali, IndonesiaMethods: A retrospective cross-sectional study was conducted among 95 medical students from the Faculty of Medicine, Universitas Udayana, Bali, Indonesia, during January-December 2016. The variables assessed in this study were gender, nationality, the severity of anxiety and depression, frequency, causes, symptoms, and medication usage in this study. Data were analyzed using SPSS version 20 for Windows.Results: The characteristic of anxiety and depression among medical students was predominant in female (55.8%), Indonesian students (57.9%), mild severity (89.5%), once in two weeks of frequency (52.6%), and exam as the primary causes (91.6%). Besides, most symptoms of anxiety and depression were headache (100.0%) following by paracetamol usage (94.7%) as medication.Conclusion: Several characteristics of anxiety and depression found among medical students were primarily related to the female Gender, Indonesian students, exam as the primary causes, headache symptoms, and paracetamol as the main medication uses to relieve the symptoms.
Pemberian Ekstrak Etanol Biji Klabet (Trigonella foenum-graecum L.) Menurunkan Kualitas Spermatozoa Mencit (Mus musculus) Dewasa Muda Putu Susilawati; Bagus Komang Satriyasa; I Gusti Ayu Widianti
Metamorfosa: Journal of Biological Sciences Vol 9 No 2 (2022)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2022.v09.i02.p11

Abstract

This study aimed to determine the activity of the ethanol extract of Fenugreek Seed (Trigonella foenum-graecum Linn.) to reduce the sperm quality of young adult mice (Mus musculus) as a natural male contraceptive. This research is an experimental study using a post-test only control group design. The sample of this study consisted of 36 male Swiss Webster (Mus musculus) mice aged 2-3 months with a body weight of 20-30 grams which were divided into two groups randomly. The control group (P0) was given 0.5 ml of CMC Na 0.3% and the treatment group (P1) was given the ethanol extract of Fenugreek Seed (Trigonella foenum-graecum Linn.) 0.4 mg/gram BW as much as 0.5 ml for 36 day orally. The results showed that the administration of ethanol extract of Fenugreek Seed (Trigonella foenum-graecum Linn.) could reduce the quality (concentration, motility, viability, and morphology) of spermatozoa (P?0.05), so that Fenugreek Seed (Trigonella foenum-graecum Linn.) has potential as a natural male contraceptive.
Uji Aktivitas Peningkatan Fibrogenesis Salep Ekstrak Daun Binahong (Anredera Scandens (L.) Moq.) 10% Dalam Penyembuhan Luka Diabetes Pada Tikus Galur Sprague dawley I Putu Riska Ardinata; Bagus Komang Satriyasa; I Wayan Sumardika
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 4, No 1 (2023): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v4i1.11376

Abstract

Desain penelitian ini adalah eksperimen labrotatorik post test only. Penelitian menggunakan tikus jantan Galur Sprague dawley yang sudah diiduksi dengan STZ (Streptozotocin) dengan dosis 40mg/kgBB. Tikus dibagi ke dalam 4 kelompok yaitu normal yang tidak dberikan perlakuan apapun, negatif yang hanya diberikan perlukaan, positif diberikan salep gentamisin, dan kelompok uji ekstrak yang diberikan salep 10%. Dilakukan uji untuk melihat peningkatan aktivitas fibrogenesis berupa pembentukan jaringan ikat dengan melihat sel fibroblast dengan histopatologi.Hasil penelitian menunjukkan bahwa kelompok uji yang diberi salep ekstrak 10% daun Anredera scandens (L.) Moq. skoring histopatologi fibrogenesis pada kelompok esktrak 10% daun Anredera scandens (L.) Moq. Menunjukkan rata-rata nilai skor sebesar 3,5 yang signifikan (P=0,032) dibandingkan kelompok negatif dengan nilai rata-rata sebesar 2,75 pada hari ke-14. Namun jika dibandingkan dengan skoring kelompok positif sebesar 3,5 kelompok esktrak daun Anredera scandens (L.) Moq. menunjukkan nilai skor tidak signifikan (P=1,000) atau memiliki kemampuan yang setara dalam pembentukan jaringan ikat.Berdasarkan penelitian didapatkan hasil ekstrak daun Anredera scandens (L.) Moq. memiliki kemampuan dalam meningkatkan aktivitas fibrogenesis secara histopatologi mampu mempercepat pembentukan jaringan ikat pada hari ke-14 yang setara dengan kontrol positif.
PELATIHAN PEMBUATAN SABUN PADAT DAN CAIR BERBAHAN EKSTRAK RIMPANG TEMULAWAK DAN SAMBILOTO PADA IBU-IBU PKK DESA MAMBANG, SELEMADEG TIMUR, TABANAN I.G.A. Artini; A.W. Indrayani; N.W.S. Dewi; I.W. Sumardika; I.G.M.G.S.C. Trapika; I.M. Jawi; B.K. Satriyasa; I.G.M. Aman; A.N. Mahendra; I.A.A. Widhiartini; D.K. Ernawati; N.W. Tianing; N.L. Suriani; I.G. Wiranatha
Buletin Udayana Mengabdi Vol 22 No 2 (2023): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/BUM.2023.v22.i02.p03

Abstract

Temulawak is one of medicinal plants which possess antibacterial activity against two major causes of infection in acne namely Staphylococcus epidermidis and Propionibacterium acnes. The active compounds of temulawak are curcumin and xanthorrhizol essential oil, which possess antibacterial activity as antiseptic and antibiotic. Sambiloto (known as Andrographis paniculate), contains active compound andrographolide, which is also assumed to possess antibacterial activity. This community program was the implementation of our research for community wellbeing, which aimed to raise the knowledge and skill of PKK women at Mambang village, Selemadeg Timur, Tabanan especially in producing liquid and solid soap from natural substances (temulawak and sambiloto extract). The program was conducted by visiting our partner company PT Bali Tangi and training for liquid and solid soap production from temulawak and sambiloto (as one form of temulawak and sambiloto utilization for skin health especially for acne management). We assess participant knowledge improvement by using questionaire before and after conducting the activity. There was an improvement in participant knowledge regarding the production of soap from natural substances (temulawak and sambiloto). In conclusion, this program had increase the knowledge and skill of PKK women at Mambang village regarding liquid and solid soap production from natural substances. Keywords: antiacne, liquid soap, sambiloto, solid soap, temulawak
Young Papaya Seeds Ethanol Extract (Carica Papaya Seed) Inhibit Testosterone Hormone and Leydig Cells of Male Mice (Mus Musculus) Bagus Komang Satriyasa
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Currently, the effort to invent ideal natural male contraceptives still faces many obstacles, especially due to the fact that ideal contraceptives should meet certain requirements such as: be able to cause total azoospermia; easily used; cause no untoward or toxic effects; not disturbing libido or sexual behavior; and be reversible. As male contraceptives are very limited in types, efforts to develop ideal male contraceptive drugs is crucial; particularly the effort to find alternative effective substances derived from natural resources. The purpose of this study is to investigate whether of young papaya seeds extract has a to inhibit the testosterone. The study used 30 male mice strain Balb-C which were allocated by simple random sampling into two groups: Control Group (P0) consisted of 17 male mice and Treatment Group 1 (P1) consisted of 17 male mice. After 36 days of treatment, control group and treatment group were taken for their blood. The blood was taken for testosterone hormone test using Radioimmunoassay (RIA) technique and the scrotum was taken for obtaining the Leydig cells. The result of t-test analysis showed that the level of testosterone in control group was 104,27 ± 25,79 ng/dl and Leydig cells 129,41±30,92, in treatment group 91,76 ± 30,45 ng/dl and Leydig cells 122,94±20,85.  The difference between control group and treatment group was the decrease of testosterone and Leydig cells. Young papaya seeds extract reduces testosterone and Leydig cells insignificantly.Keywords: Papaya seeds extract, Testosterone hormone, Leydig cel, Male Mice balb/C
The Addition of Caffeine in EBSS Media by Sperm Swim-up Washing Method Increased the Human Sperm Motility and Acrosomal Reaction Bagus Komang Satriyasa; J. Alex Pangkahila
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Caffeine, a methylxanthine derivate, had a role as a phosphodiesterase inhibitor, thereby inhibiting the break down of cAMP and increasing its concentration inside the cell. Aim: This study aimed to assess the effect of caffeine in EBSS and evaluated the increase in motility and the acrosomal reaction of spermatozoa using the swim-up method. Method: This was an experimental study using a pre-post test control group design. This study was carried out at the Sexology and Andrology Clinic, Sanglah Hospital in Denpasar Bali. The samples were sperm specimens of eighteen infertile male or volunteers aged 20-40 years. They were divided into two groups: treatment group (caffeine + EBSS) and control group (EBSS). The data were analyzed statistically by normality test (Kolmogorov – Smirnov Goodness of Fit Test), homogeneity test and paired student’s t test. Result: The caffeine addition in EBSS medium increased the sperm motility significantly from 71.94% to 80.28% (p<0.05) and the acrosomal reaction from 83.33% to 88.89% (p<0.05). Conclusion: The addition of caffeine in EBSS medium increased the motility and the acrosomal reaction of the human sperm.Keywords: Caffeine, EBSS, Sperm motility, Acrosomal reaction, Spermatozoa.
WATER EXCTRACT OF PURPLE SWEET POTATO INCREASE SUPEROXIDE DISMUTASE, CATALASE GENES AND DECREASE MDA LEVEL IN MULTIPLE ORGANS OF DIABETIC WISTAR RATS Bagus Komang Satriyasa; I Made Jawi
Journal of Global Pharma Technology Volume 09 Issue 05
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Objective: The purpose of this study was to prove the water extract of purple sweet potatoes can increase superoxide dismutase (SOD) gene expression and catalase (CAT) and decrease malondialdehyde (MDA) in vital organs of diabetic rats. Method: This study was randomized experimental design with posttest only control group design. Sample divided into 2 groups: control and treatment groups, respectively 18 diabetic Wistar rats. The control group will be given streptozotocin. The treatment group was given streptozotocin and water extract of purple sweet potato 4 cc/day. This treatment is carried out for 2 months. Result: Water extract of purple sweet potato was proven significantly increased mRNA expression of aorta and kidney SOD but decreased SOD mRNA expression in the liver (p <0.05). This water extract also increases SOD mRNA expression in cardiac but not statistically significant (p> 0.05). Water extract of purple sweet potatoes also found significantly increased renal and cardiac expression of CAT mRNA (P <0.05), but not statistically significant (p> 0.05). Conclusion: Purple sweet potatoes extract to decrease the expression of liver CAT mRNA non-significantly, and decrease MDA in liver and kidney of diabetic Wistar rats significantly (P <0.05).
PEMANFAATAN JAMU HERBAL UNTUK MENINGKATKAN IMUNITAS TUBUH DI ERA PANDEMI COVID-19 I.G.A. Artini; I.G.M.G.S.C. Trapika; N.W.S. Dewi; A.W. Indrayani; I.W. Sumardika; I.M. Jawi; B.K. Satriyasa; I.G.M. Aman; A.N. Mahendra; I.A.A. Widhiartini; D.K. Ernawati
Buletin Udayana Mengabdi Vol 22 No 4 (2023): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/BUM.2023.v22.i04.p02

Abstract

To date, COVID-19 infection still become an important health problem in Indonesia, including Bali. We may concern about this situation since there has been no specific drug or vaccine available against COVID-19 infection. In this new normal era, we should maintain our immunity to prevent the infection. Some herbs potentially possess great effect on maintaining immunity to protect ourselves from COVID-19 infection, such as kunyit, temulawak, jahe, kencur, pegagan and kelor. To date, herbs utilization for health in Banjar Sambahan remains very limited. This is related to the limited skill in processing herbal drink (jamu). This activity aimed to raise participant (PKK women at Banjar Sambahan) knowledge, as well as skills, on producing herbal drinks (jamu/loloh) that potentially increase the immunity during COVID-19 pandemic era. This programme was performed by socialization about herbs utilization for health (especially for immunity), accompanied by training (by video) on producing herbal drink and survey for herbal medicine utilization in community. The results of this programme were video, publication on national journal (SINTA indexed) and presentation on national scientific meeting. It can be concluded that this activity supply knowledge and skill for PKK women at Banjar Sambahan in processing herbal drink for maintaining the immunity against COVID-19 infection. Keywords: covid-19, immune, herbal drink, community service
Phytochemical Screening of Secondary Metabolites of 96% Ethanol Extract of Coriander Seeds (Coriandrum Sativum L.) Ni Putu Oka Mahayani*; Bagus Komang Satriyasa; I Wayan Sumardika
Riwayat: Educational Journal of History and Humanities Vol 6, No 3 (2023): Social, Political, and Economic History
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jr.v6i3.33934

Abstract

Coriander seeds are spices that are generally used by Indonesian people not only as a food ingredient, but also as a medicinal ingredient. The purpose of this study was to determine the content of secondary metabolites in coriander seeds ( Coriandrum sativum L.). This study used the maceration extraction method with 96% ethanol as a solvent and then continued with phytochemical screening. From the results of the phytochemical screening of 96% ethanol extract of coriander seeds ( Coriandrum Sativum L.), it was found that the extract contained phenolic compounds, flavonoids, tannins, saponins, triterpenoids and steroids, and did not contain alkaloids .
Co-Authors A.N. Mahendra A.W. Indrayani Adiputra, LMIS. Handari Agung Bagus S. Satyarsa Agung Nova Mahendra Agung Wiwiek Indrayani Ali Imron Amaral, Meriana Barreto Anak Agung Gede Eka Septian Utama Anak Agung Gede Fandhiananta Widyanjaya Artini , I Gusti Ayu Ayu Diandra Sari Bastianus Alfian Juatmadja Desak Ketut Ernawati Desak Made Wihandani Dewa Ayu Putu Rasmika Dewi Dewa Putu Gede Purwa Samatra Dita Permatasari Edelweishia, Melissa Efraldo Yudistira Fendy Nugroho Griadi, IP. Adiartha I Dewa Ayu Inten Dwi Primayanti I Dewa Made Sukrama I Dewa Putu Sutjana I Gde Haryo Ganesha I Gede Krisna Putra Yasa I Gede Restu Mahendra Sugiarta I Gede Widhiantara I Gusti Ayu Widianti I Gusti Made Aman I Kadek Arya Gangga Permana I Made Ady Wirawan I Made Jawi I Made Krisna Dinata I MADE MULIARTA . I Made Sudarmaja I Nengah Sandi I Nyoman Adi Putra I Nyoman Mangku Karmaya I Pande Putu Deny Heriwijaya I Putu Adiartha Griadhi I Putu Agus Budi Sudarsana I Putu Eka Kusuma Yasa I Putu Gede Adiatmika I Putu Riska Ardinata I Wayan Putu Sutirta Yasa I Wayan Rosiana I Wayan Sumardika I Wayan Sumardika I Wayan Weta I.A.A. Widhiartini I.G. Wiranatha I.G.A. Artini I.G.M. Aman I.G.M.G.S.C. Trapika IB Putra Manuaba, IB Putra Ida Ayu Mas Suryani Ida Bagus Budha Dharma Kusuma Ida Bagus Ngurah Ida Bagus Putra Manuaba IKW. Suryawan Imakulata Magi Loda Iman Santoso IP. Adiartha Griadi Irawan, Angeline Aprilia Ivana, Jocelyn J. A. Pangkahila Joppi Huwae Karta Sawenda Ketut Agus Adrianta Ketut Tirtayasa Klaudius H. M. Meti Kristanto, Andre Kurniawan, Yukhi Listya Triandari LMIS. Handari Adiputra Lorena Samanta Adelina Luh Made Indah Sri Handari Adiputra Luh Sonya Astana Putri M Widnyana M. Ali Imron Made Indra Prasetya Permana Maura Marda Mayang Sari Muh. Ali Imron Muh. Ali Imron Muh. Irfan Muhammad Irfan Muthiah Munawaroh N. Adiputra N. Adiputra N.W. Tianing N.W.S. Dewi Nabasa, Gayus Erino Ni Luh Gede Ayu Candranita Dharmadi Ni Luh Suriani Ni Made Intansari Tri Buana Ni Made Linawati Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Budiani, Ni Nyoman Ni Putu Oka Mahayani* Ni Putu Widya Astuti Ni Putu Wirantari Ni Wayan Arni Sardi Ni Wayan Saka Rahayu Ni Wayan Sinta Devi Arini Ni Wayan Sucindra Dewi Ni Wayan Sucindra Dewi Nyoman Ratep Nyoman Suarjana Ocktaviana Saputri, Legis Ode Mahesa Putra Oktovianus Fufu Oktovianus Fufu Oktovianus Fufu Permatasari, Anak Agung Ayu Putri Putri Uli Saktina Putu Ananda Sutiksna Mulya Putu Angga Wiradana Putu Astawa Putu Susilawati Putu Wandari Pranitha S.Indra Lesmana Selviani, Iit Sugijanto - Sugijanto - Sugijanto - Sugijanto - Suryawan, IKW. Susy Purnawati Syahmirza Indra Lesmana Tharsani Devi Srinivasagam Tjokorda Gde Bagus Mahadewa Tri Wahyu Wulandari Wahyuddin, Wahyuddin Widianti, I Gusti Ayu Widiyanti, I Gusti Ayu Wijaya Surya, I Gede Ngurah Harry Wimpie I Pangkahila Wirawan, IMA. Xena Laveda Yogie Wiswadewa Yuniarti N