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Bagian Farmakologi Fakultas Kedokteran Universitas Udayana
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Gambaran umum status anemia dan prestasi belajar anak usia sekolah dasar di SD Negeri 4 Abiansemal Ida Ayu Mas Suryani; Bagus Komang Satriyasa
E-Jurnal Medika Udayana Vol 7 No 4 (2018): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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Abstract

Anemia is a condition of concentration of red blood cells that carries oxygen in the blood (Hb) is not sufficient for the physiological body needs. Anemia resulting decreases immune tend to get infections, impaired school performance because of having difficulty concentrating. The purpose of this study to describe the incidence of anemia and learning achievement of children in SD Negeri 4 Abiansemal, Badung, Bali conducted from August to November 2015. This study used cross sectional design include 44 respondents. Respondents filled out a questionnaire symptoms of anemia, the data retrieved grades, and hemoglobin levels were measured using HemoSmart Gold. Symptoms of anemia, the data grades, and hemoglobin levels were analyzed using a Chi Square test and Simple Linear Regression test. Results of study there are differences in learning achievement of children who are anemic and not anemic. The prevalence of anemia in SD Negeri 4 Abiansemal is 34.1%. Most of the subjects were female (52.3%), mean age 10 years (45.5%), father education is high school education (79.5%), the mother education is high school education (72.7%), father’s occupation not labor/farmers/traders (59.1%), working mothers (77.3%), suspected symptoms of worm infection (2.3%), underweight (63.6%), good learning achievement (54.5%). Keywords: anemia, elementary school students, learning achievement
EFEKTIFITAS EKSTRAK ETANOL BIJI BESERTA ARIL BUAH DELIMA (Punica granatum l.) MENGHAMBAT PERTUMBUHAN BAKTERI Staphylococcus epidermidis SECARA IN VITRO Ida Bagus Budha Dharma Kusuma; Ida Bagus Ngurah; , Bagus Komang Satriyasa
E-Jurnal Medika Udayana Vol 9 No 6 (2020): Vol 9 No 06(2020): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (232.818 KB) | DOI: 10.24843/MU.2020.V09.i6.P09

Abstract

ABSTRAKInfeksi nosokomial telah mengalami peningkatan seiring waktu dan bakteri Staphylococcus epidermidis merupakan salah satu bakteri yang sering menyebabkan infeksi nosokomial tersebut.Tanaman delima dipercaya memiliki aktivitas antimikroba dan di Bali tanaman ini merupakantanaman hias di pekarangan. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak etanol bijibeserta aril buah delima (Punica granatum L.) menghambat pertumbuhan bakteri Staphylococcusepidermidis secara in vitro. Penelitian ini merupakan penelitian eksperimental murni denganrancangan post test only control group design. Sampel dibagi menjadi 2 kelompok yakni kontrol danperlakuan yang dibagi atas empat kelompok berdasarkan konsentrasi. Sampel bakteri Staphylococcusepidermidis didapat dari Lab. Mikrobiologi FK UNUD. Penelitian ini menunjukkan bahwa ekstraketanol biji beserta aril buah delima memiliki potensi sebagai penghambat pertumbuhan bakteri S.epidermidis dengan konsentrasi hambat minimum adalah konsentrasi 25% dan zona hambat terbesardihasilkan pada konsentrasi ekstrak 100%. Kata Kunci: Antimikroba, Zona Hambat, Staphylococcus epidermidis, buah delima
KARAKTERISTIK PENDERITA AIDS DAN INFEKSI OPORTUNISTIK DI RUMAH SAKIT UMUM PUSAT SANGLAH DENPASAR PERIODE JULI 2013 SAMPAI JUNI 2014 Putri Uli Saktina; Bagus Komang Satriyasa
E-Jurnal Medika Udayana Vol 6 No 3 (2017): E-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

AIDS is a set of symptomps due to the decreased of immune system caused by HIV. Opportunistic infections are infections caused by the decrease in the immune system. This study aims to know the description of individual characteristic and opportunistic infections in people with AIDS at Sanglah Hospital Denpasa period July 2013 – June 2014. This study is observational descriptive. The sampel in this study were all patients with AIDS who are hospitalized in Sanglah Hospital period July 2013 – June 2014 that has a complete data. One hundred and seventy nine AIDS patients consist of 121 males (67.6%), mostly between 30-39 years old (39.7%), majority were private employes (43%), Hinduism (74.3%), married (73.7%), and lived in Bali (98.3%). The highest OI type is Candidiasis (28.3%). It is hoped this study ca be useful for management of HIV/AIDS in the future.  
GAMBARAN POLA PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI DI INSTALASI RAWAT INAP RSUP SANGLAH DENPASAR TAHUN 2016 Luh Sonya Astana Putri; Bagus Komang Satriyasa
E-Jurnal Medika Udayana Vol 8 No 6 (2019): Vol 8 No 6 (2019): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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Abstract

Tingginya angka kejadian hipertensi berdampak terhadap meningkatnya morbiditas dan mortalitas masyarakat. Diperlukan manajemen yang tepat untuk mengontrol hipertensi, salah satunya dengan pemberian terapi farmakologis antihipertensi. Penelitian ini bertujuan untuk mengetahui gambaran pola penggunaan obat antihipertensi di Instalasi Rawat Inap RSUP Sanglah Denpasar tahun 2016. Penelitian ini dirancang dengan metode deskriptif cross-sectional. Subyek penelitian dipilih menggunakan teknik consecutive sampling dari populasi terjangkau yang memenuhi kriteria inklusi periode April-Desember 2016. Data bersumber dari rekam medis pasien dan dianalisis secara statistik deskriptif. Hasil penelitian menunjukkan bahwa dari 56 subyek penelitian sebanyak 60,7% mendapat politerapi dan 39,3% mendapat monoterapi. Golongan obat yang paling banyak digunakan untuk monoterapi adalah ACE-I dan untuk politerapi yaitu golongan ACE-I dan CCB. Berdasarkan derajat hipertensi, sebagian besar monoterapi diberikan pada pasien dengan hipertensi stadium 1 dan politerapi pada pasien dengan hipertensi stadium 2. Pada penelitian ini disimpulkan bahwa penatalaksanaan farmakologis antihipertensi sebagian besar dalam bentuk politerapi. Penelitian ini diharapkan dapat menjadi acuan dalam pemberian terapi farmakologis antihipertensi pada pasien hipertensi. Kata Kunci : Hipertensi, pola penggunaan, obat antihipertensi, rawat inap.
PENGARUH EKSTRAK BIJI PEPAYA MUDA (Carica papaya L.) TERHADAP KOPULASI DAN JUMLAH ANAKAN MENCIT (Mus musculus L.) Ni Wayan Saka Rahayu; Bagus Komang Satriyasa; Made Jawi; Ni Wayan Sucindra Dewi
E-Jurnal Medika Udayana Vol 10 No 8 (2021): Vol 10 No 08(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i8.P12

Abstract

Latar Belakang: Upaya pemerintah untuk mengatur kepadatan jumlah penduduk adalah dengan menggunakan kontrasepsi. Menurut data BKKBN, penggunaan kontrasepsi pada pria lebih sedikit dibandingkan perempuan. Rendahnya partisipasi pria dalam Keluarga Berencana dikarenakan ketersediaan kontrasepsi pria yang minimal. Kontrasepsi pria bisa didapat dari bahanaalam seperti biji pepaya muda (Carica papaya L.) memiliki kandungan bersifat anti fertilitas. Hasil dan Pembahasan: Penelitian ini menggunakan metode True Experimental Post Test Only Control Group Design. Sampel dibagi dalam 3 kelompok yakni kelompok kontrol (P0), kelompok perlakuan 1 (P1) dan kelompok perlakuan 2 (P2) dengan masing-masing jumlah sampel 10 ekor mencit (Mus Musculus L.) setiap kelompok. Data dianalisis menggunakan SPSS. Ekstrak biji pepaya muda (Carica papaya L.) tidak berpengaruh terhadap kopulasi mencit, didapatkan nilai p 0,342 (p>0,05). Ekstrak biji pepaya muda (Carica papaya L.) berpengaruh signifikan terhadap jumlah anakan mencit (Mus Musculus L.) didapatkan nilai p <0,001. Ekstrak biji papaya muda (Carica papaya L.) berpengaruh signifikan terhadap kategori kehamilan mencit (Mus Musculus L.) didapatkan nilai p <0,001. Ekstrak biji papaya muda (Carica papaya L.) tidak berpengaruh terhadap kopulasi mencit disebabkan oleh regulasi umpan balik negatif sistem hipotalamus-hipofisis, sehingga hormon testosteron masih dalam kadar normal. Ekstrak biji pepaya muda (Carica papaya L.) berpengaruh terhadap jumlah anakan mencit disebabkan oleh kandungan ekstrak biji pepaya muda (Carica papaya L.) yang bersifat anti fertilitas. Kesimpulan : Ekstrak biji pepaya muda (Carica papaya L.) tidak berpengaruh terhadap kopulasi mencit (Mus Musculus L.) , sedangkan berpengaruh terhadap jumlah anakan mencit (Mus Musculus L.) Kata kunci : Ekstrak biji pepaya muda, kopulasi mencit, jumlah anakan mencit
KARAKTERISTIK PENDERITA HIPERTENSI YANG DIRAWAT INAP DI RUMAH SAKIT UMUM PUSAT SANGLAH TAHUN 2013 I Gede Restu Mahendra Sugiarta; Bagus Komang Satriyasa
E-Jurnal Medika Udayana vol 4 no 11(2015):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Hipertensi merupakan penyakit yang sering disebut sebagai the silent killer karena pada awalnya tidak menunjukkan gejala. Berdasarkan Survei Pendahuluan di Rumah Sakit Umum Pusat (RSUP) Sanglah tahun 2014, tercatat 44 pasien menderita hipertensi di ruang Instalasi Rawat Inap (IRNA) B, C, dan D RSUP Sanglah pada tahun 2013. Penelitian ini bertujuan untuk mengetahui karakteristik penderita hipertensi yang meliputi proporsi penderita hipertensi (berdasarkan umur, jenis kelamin, keluhan utama, derajat hipertensi, komplikasi, dan keadaan keluar) dan lama rawatan rerata penderita hipertensi. Penelitian ini merupakan penelitian deskriptif dengan metode studi survei observasional. Penelitian ini dilaksanakan di Instalasi Rekam Medis RSUP Sanglah pada bulan April 2014 hingga bulan Juli 2014 dengan data yang digunakan adalah data sekunder yang diperoleh dari catatan rekam medis pasien di RSUP Sanglah. Sampel penelitian berjumlah 44 orang dari bagian IRNA B, C, dan D di RSUP Sanglah dengan menggunakan time-series data serta dari total sampling pada survei pendahuluan di RSUP Sanglah tahun 2014. Distribusi proporsi penderita hipertensi tertinggi terdapat pada umur 45 s/d 64 tahun (63,6%), berdasarkan jenis kelamin terdapat pada lelaki (56,8%), berdasarkan keluhan utama terdapat pada sakit kepala (34,1%), berdasarkan derajat hipertensi terdapat pada Hipertensi Stadium 3 (63,6%), berdasarkan status komplikasi terdapat pada Tanpa Komplikasi (52,3%), serta berdasarkan keadaan keluar terdapat pada Membaik (100%). Lama rawatan rerata penderita hipertensi adalah 7,52 hari.        
NEBIVOLOL: A THIRD GENERATION BETA BLOCKER AS ANTIHYPERTENSION AGENT Ni Putu Wirantari; I Made Jawi; Bagus Komang Satriyasa
E-Jurnal Medika Udayana vol 2 no 7 (2013):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Hypertension is a silent killer because it causes complications in vital organs unwitting patients. Beta blockers are generally a choice of safe and effective drugs for initial treatment of hypertension. However, the current hypertension treatment guidelines said beta blockers were not suitable use as first-line therapy because of complications caused. On the use of atenolol found an increased incidence of cardiovascular death of 24%, 14% and cardiac complications 23% cerebrovascular complications. Nebivolol is a third-generation beta-blocker that is highly selective for ?1-adrenergic receptors and has the ability as a direct vasodilator was able to stimulate the activity of endothelial L-arginin/nitric oxide synthase, is expected nebivolol can reduce blood pressure so can achieve blood pressure that expected.
TINGKAT KEBERHASILAN NIFEDIPIN SEBAGAI TOKOLITIK PADA PASIEN PARTUS PREMATURUS IMMINENS DI RUMAH SAKIT UMUM PUSAT SANGLAH DENPASAR I Putu Eka Kusuma Yasa; I Gusti Made Aman; Bagus Komang Satriyasa
E-Jurnal Medika Udayana Vol 8 No 5 (2019): Vol 8 No 5 (2019): Vol 8 No 5 (2019): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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Abstract

Tenaga medis melakukan usaha preventif Preterm Labor selama pasien masih didiagnosis Ancaman Persalinan Prematur (Partus Prematurus Imminens), salah satunyayaitu pemberian nifedipin sebagai agen tokolitik. Penelitian ini dilakukan untukmengetahui tingkat keberhasilan terapi nifedipin sebagai tokolitik pada pasien PartusPrematurus Imminens di Rumah Sakit Umum Pusat Sanglah Denpasar tahun 2014-2016.Penelitian ini menggunakan metode penelitian deskriptif cross-sectional. Penelitiandilakukan di Intalasi Rawat Inap Cempaka Obstetri RSUP Sanglah Denpasar.Keseluruhan proses penelitian membutuhkan waktu selama 5 bulan. Populasi terjangkaudalam penelitian ini adalah pasien terdiagnosis Partus Prematurus Imminens yangmenjalani rawat inap dan memperoleh terapi nifedipin di Intalasi Rawat Inap RSUPSanglah Denpasar selama periode Januari 2014 – Desember 2016. Dapat disimpulkanbahwa tingkat keberhasilan nifedipin dalam mencegah terjadinya Preterm Labor selama 2x 24 jam yaitu sebesar 47,05%. Hasil penelitian ini diharapkan mampu dimanfaatkansebagai data suplemen dalam membuat kebijakan.Kata kunci: Nifedipin, tokolitik, Partus Prematurus Imminens
Fraksi Heksan dan Fraksi Metanol Ekstrak Biji Pepaya Muda Menghambat Spermatogonia Mencit (Mus Musculus) Jantan Bagus Komang Satriyasa; Wimpie I Pangkahila2
Jurnal Veteriner Vol 11 No 1 (2010)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

To avoid population booming, family planning program should be maintained in which menand woman have the same rights and obligations. However in execution of family planning the roleof men is still low. Studies about contraception in men are limited. Male contraception that isknown in society are condom and vasectomy. In the recent few years in particular, researcheshave been refocused on investigating traditional plants as anti fertility. In use researches manyplants have been studied, including papaya seed. Some researches on herbal anti fertility propertiesof papaya seed have been carried out including those on the active compounds of anti fertility, onapprolaki-lakite dosage of extract of carica papaya seed by animal experiments. Hexane fraction ofunripe papaya seed extract contains glycosides, alkaloid and triterpenoids, which is assumed hasan antifertility effect, so it can be used as a male contraceptive, although the mechanism of actionis not yet clear. Research is conducted at Animal Laboratory Unit Department of PharmacologyFaculty of Medicine University of Udayana, and Laboratorium Patologi Balai Penyidikan danPengujian Veterian (BPPV) Wilayah VI Denpasar Direktorat Jenderal Peternakan, DepartmentPertanian. This study used the pre-test and post-test control group design, using 30 male mice ofbalb C strain, aged 12 weeks, weight 20-22 gram, subsequently grouped by random into 3 groupseach consisting of 10 male mice. One control group (P0 = control group) was given double distilledwater, and two treatment groups (P1 = treatment group) was given fraction of the hexane extractof young Carica papaya seed 20 mg/20gram Body wieght/day, (P2 = treatment group) was givenfraction of the methanol extract of young Carica papaya seed 20 mg/20 gram/day). After 36 days oftreatment, evaluation of the testis, of the male mice was conducted. Data were analysed by normalitytest of Shapiro-will, homogeneity test, and Anova test. This study showed that cells of spermatogoniaA decreased significantly (p < 0,01). It is concluded that hexan fraction and methanol fraction ofunripe carica papaya seeds extract can decrease spermatogonia A cell of male mice (mus musculus).
The Antioxidant Capacity of Peristrophe Bivalvis (L.) Merr. as Natural-Based Nephroprotection Ketut Agus Adrianta; Bagus Komang Satriyasa; Desak Made Wihandani; I Made Jawi
Majalah Obat Tradisional Vol 26, No 1 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.53861

Abstract

The kidneys as one of the important body organs have a very important role in maintaining a healthy body. The kidneys function to regulate fluid balance in the body the concentration of salt in the blood, acid-base balance in the blood, and excretion of waste materials such as urea and other nitrogenous waste in the blood. Magenta plants (Peristrophe bivalvis (L.) Merr.) contain secondary metabolites, namely alkaloids, saponins, triterpenoids, tannins, and flavonoids as antioxidants. The abundance of antioxidants sourced from natural sources for various diseases is often used as a complementary therapy and is one of the current therapeutic choices. However, the development of natural sources must also consider kidney function during an intervention. The incidence of kidney failure can be caused either by the occurrence of oxidative stress or exposure to drugs and other chemical compounds must also consider the physiological functions of important organs in the body such as the liver and kidneys. This study was conducted to determine the protective role of magenta leaves extract (Peristrophe bivalvis (L.) Merr.) on the kidneys after being given an acetaminophen hepatotoxic dose. In this study, the effectiveness of magenta leaves antioxidants and the safety of use was analyzed by looking at the kidney function in the experimental model of Wistar strain male white rats, using a Randomized Post Test Only Control Group Design. Four treatment groups showed that magenta leaves extract (Peristrophe bivalvis (L.) Merr.) at 125 and 250 mg/kg BW can protect the kidneys with average creatinine levels of 0.63 and 0.75 and with a normal range (0.7 - 1.2). It means that these two groups could protect the kidney function although in the histopathology test only the group administering extracts of 250 mg/Kg BW showed good results. It can be concluded that administration of the magenta leaves extracts at 250 mg/kg BW can protect renal function as seen from serum creatinine levels. Besides, histopathological features can provide a protective effect on the kidneys with the incidence of necrosis in the kidneys of less than 60% of the toxic dose of acetaminophen.
Co-Authors A.N. Mahendra A.W. Indrayani Adiputra, LMIS. Handari Agung Bagus S. Satyarsa Agung Nova Mahendra Agung Wiwiek Indrayani Ali Imron Amaral, Meriana Barreto Anak Agung Gede Eka Septian Utama Anak Agung Gede Fandhiananta Widyanjaya Artini , I Gusti Ayu Ayu Diandra Sari Bastianus Alfian Juatmadja Desak Ketut Ernawati Desak Made Wihandani Dewa Ayu Putu Rasmika Dewi Dewa Putu Gede Purwa Samatra Dita Permatasari Edelweishia, Melissa Efraldo Yudistira Fendy Nugroho Griadi, IP. Adiartha I Dewa Ayu Inten Dwi Primayanti I Dewa Made Sukrama I Dewa Putu Sutjana I Gde Haryo Ganesha I Gede Krisna Putra Yasa I Gede Restu Mahendra Sugiarta I Gede Widhiantara I Gusti Ayu Widianti I Gusti Made Aman I Kadek Arya Gangga Permana I Made Ady Wirawan I Made Jawi I Made Krisna Dinata I MADE MULIARTA . I Made Sudarmaja I Nengah Sandi I Nyoman Adi Putra I Nyoman Mangku Karmaya I Pande Putu Deny Heriwijaya I Putu Adiartha Griadhi I Putu Agus Budi Sudarsana I Putu Eka Kusuma Yasa I Putu Gede Adiatmika I Putu Riska Ardinata I Wayan Putu Sutirta Yasa I Wayan Rosiana I Wayan Sumardika I Wayan Sumardika I Wayan Weta I.A.A. Widhiartini I.G. Wiranatha I.G.A. Artini I.G.M. Aman I.G.M.G.S.C. Trapika IB Putra Manuaba, IB Putra Ida Ayu Mas Suryani Ida Bagus Budha Dharma Kusuma Ida Bagus Ngurah Ida Bagus Putra Manuaba IKW. Suryawan Imakulata Magi Loda Iman Santoso IP. Adiartha Griadi Irawan, Angeline Aprilia Ivana, Jocelyn J. A. Pangkahila Joppi Huwae Karta Sawenda Ketut Agus Adrianta Ketut Tirtayasa Klaudius H. M. Meti Kristanto, Andre Kurniawan, Yukhi Listya Triandari LMIS. Handari Adiputra Lorena Samanta Adelina Luh Made Indah Sri Handari Adiputra Luh Sonya Astana Putri M Widnyana M. Ali Imron Made Indra Prasetya Permana Maura Marda Mayang Sari Muh. Ali Imron Muh. Ali Imron Muh. Irfan Muhammad Irfan Muthiah Munawaroh N. Adiputra N. Adiputra N.W. Tianing N.W.S. Dewi Nabasa, Gayus Erino Ni Luh Gede Ayu Candranita Dharmadi Ni Luh Suriani Ni Made Intansari Tri Buana Ni Made Linawati Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Budiani, Ni Nyoman Ni Putu Oka Mahayani* Ni Putu Widya Astuti Ni Putu Wirantari Ni Wayan Arni Sardi Ni Wayan Saka Rahayu Ni Wayan Sinta Devi Arini Ni Wayan Sucindra Dewi Ni Wayan Sucindra Dewi Nyoman Ratep Nyoman Suarjana Ocktaviana Saputri, Legis Ode Mahesa Putra Oktovianus Fufu Oktovianus Fufu Oktovianus Fufu Permatasari, Anak Agung Ayu Putri Putri Uli Saktina Putu Ananda Sutiksna Mulya Putu Angga Wiradana Putu Astawa Putu Susilawati Putu Wandari Pranitha S.Indra Lesmana Selviani, Iit Sugijanto - Sugijanto - Sugijanto - Sugijanto - Suryawan, IKW. Susy Purnawati Syahmirza Indra Lesmana Tharsani Devi Srinivasagam Tjokorda Gde Bagus Mahadewa Tri Wahyu Wulandari Wahyuddin, Wahyuddin Widianti, I Gusti Ayu Widiyanti, I Gusti Ayu Wijaya Surya, I Gede Ngurah Harry Wimpie I Pangkahila Wirawan, IMA. Xena Laveda Yogie Wiswadewa Yuniarti N