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IMMUNOPATHOGENESIS OF DENGUE SHOCK SYNDROME Karta Sawenda; I Wayan Putu Sutirta Yasa; DAP Rasmika Dewi; Bagus Komang Satriyasa
Bali Journal of Medical and Health Sciences vol 1no1 2013
Publisher : Faculty of Medicine, Udayana University

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Abstract

Dengue is the most important emerging tropical viral disease of humans in the world today. It is estimated that there are between 50 and 100 million cases of dengue fever (DF) and about 500.000 cases of dengue haemorrhagic fever (DHF) each year which require hospitalization. Persons of all ages can be infected and develop dengue fever. However, children younger than 15 years typically present with only a nonspecific self-limited febrile illness. Untreated dengue hemorrhagic fever mostly likely progresses to dengue shock syndrome which is defined as dengue fever with signs of circulatory failure. The prognosis depends on prevention or early recognition and treatment with case fatality rate is as high as 12% to 14% once shock has set in. Management of dengue fever requires rest, oral fluids to compensate for losses via diarrhoea or vomiting, antipyretics and analgesics. Patients who present with shock may require central venous pressure monitoring. An arterial line may be required in unstable patients for the assessment of blood gases, electrolytes, and coagulation profile to help identify patients needing ventilatory support.
MULTI-INFARCT DEMENTIA Ayu Diandra Sari; Nyoman Ratep; Bagus Komang Satriyasa
Bali Journal of Medical and Health Sciences vol 1no1 2013
Publisher : Faculty of Medicine, Udayana University

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Abstract

Dementia is a cognitive functional deficits that causes memory impairment with symptoms such as: aphasia, agnosia, apraxia or a disturbance in executive functioning (the ability to plan, sequence, and organize) that interferes with social, occupational, or interpersonal skills. Most of dementia among older people in Asia, especially Indonesia is Vascular dementia. Most of vascular dementia among older people in Indonesia is multi-infarct dementia (MID). Multi-infarct dementia (MID) is a disorder involving deterioration in mental function caused by changes or damage to the brain tissues from lack of oxygen as a result of multiple blood clots throughout the brain. Risk factor for MID include a history of: Hardening of arteries (arthrosclerosis), high blood pressure (hypertension), smoking, and stroke. In MID, disruption of blood flow leads to damaged brain tissue. For diagnose the patient with MID, the most important thing we must do is anamnesis. From anamnesis, we can get history of sufficient exposure, Onset of symptoms, checking sign and doing tests, and also ask whether the patient has risks factors about MID or not. There is no known definitive treatment for MID. Treatment is based on control of symptoms. Other treatments may be advised based on the individual condition.
THE CORRELATION OF TRANSAMINASES AND LIVER DISEASES Bastianus Alfian Juatmadja; I Wayan Putu Sutirta Yasa; DAP Rasmika dewi; Bagus Komang Satriyasa
Bali Journal of Medical and Health Sciences vol 1no1 2013
Publisher : Faculty of Medicine, Udayana University

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Abstract

The symptoms of liver diseases are very diverging, from the mild one till the severe one. Sometimes we may find that severe heart disorders but the symptoms are too less. We need some tools to make a good diagnosis. We can not only use a good anamnesis, but also have to use good physical examination and the other support test. Transaminase also called aminotransferase. This aminotransferase catalyzes the transfer of the amino group (?NH2) of an amino acid to a carbonyl compound. The liver contains specific transaminases for the transfer of an amino group from glutamic acid to ?-keto acids that correspond to most of the other amino acids. Other transaminases catalyze reactions in which an amino group is transferred from glutamic acid to other compounds. Transamination is one of the principal mechanisms for the formation of necessary amino acids in the metabolism of proteins. Transaminase as a sign to cell damage may divided into Serum Glutamic Oxalocetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), and Lactic Dehydrogenase (LDH). Gamma GT and alkali fosfatase correlate with cholestasis. Cholinestrase correlate with liver synthesis capacity.
Comparison of Antibacterial Activity of Sambiloto (Andrographis paniculata) Ethanol and Water Stem Extract Against Methicillin-Resistant Staphylococcus aureus (MRSA) ATCC 3351 In Vitro Ni Wayan Sinta Devi Arini; Bagus Komang Satriyasa; I Made Jawi; Agung Wiwiek Indrayani
Jurnal Epidemiologi Kesehatan Komunitas Vol 5, No 2: Agustus 2020
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v5i2.6908

Abstract

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is penicillin and cephalosporine resistant Staphylococcus aureus which is a major cause of nosocomial infection. Various studies have been conducted for resistant cases, especially herbs which have antibacterial activity. Sambiloto (Andrographis paniculata) is an example of herb which has antibacterial activity due to the presence of andrographolide. Andrographolide soluble in ethanol and poorly in water, while extraction with alcohol causes andrographolide’s degradation. This study aimed to investigate the antimicrobial activity of ethanol and water stem extract and compare them against MRSA ATCC 3351 in vitro.Methods: This is an experimental study with a post-test only control group design and conducted by disc diffusion technique to obtain an inhibition zone against MRSA.Result: The result of this study showed the mean inhibitory zone of ethanol stem extract was 5,87mm, 6,77mm, 7,87mm respectively for 25%, 50%, and 100% concentrations, while 1% concentration did not show antibacterial activity. Water stem extract at 1%, 25%, 50%, and 100% concentrations showed mean inhibitory zone was at 4,57mm, 7,17mm, 8,67mm, and 9,67mm respectively.Conclusion: Ethanol and water stem extract showed antibacterial activity against MRSA. The independent sample t-test didn’t show a difference between ethanol and water stem extract of Andrographis paniculata toward MRSA (p>0,05).
PEMBERIAN EKSTRAK ETANOL KUBIS UNGU (Brassica oleraceae L.) MENURUNKAN KADAR MALONDIALDEHID DAN JUMLAH MAKROFAG JARINGAN PARU TIKUS YANG TERPAPAR ASAP ROKOK I Gde Haryo Ganesha; Ni Made Linawati; Bagus Komang Satriyasa
Jurnal Ilmiah Medicamento Vol 6 No 1 (2020): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v6i1.714

Abstract

Asap rokok merupakan polutan bagi manusia dan lingkungan. Asap rokok mengandung senyawa radikal bebas yang akan menyebabkan stres oksidatif. Pada kondisi stres oksidatif, radikal bebas menyebabkan peroksidasi lipid membran sel dan merusak organisasi membran sel ditandai dengan peningkatan kadar MDA dan peningkatan jumlah makrofag pada paru. Penggunaan antioksidan dari tumbuhan seperti kubis ungu yang mengandung senyawa flavonoid menjadi salah satu alternative untuk menetralisir terjadinya peningkatan malondialdehyde (MDA) dan peningkatan jumlah makrofag pada paru. Penelitian ini adalah penelitian eksperimental dengan menggunakan post-test control group design yang menggunakan 36 ekor tikus putih (Rattus norvegicus) jantan, berumur 2-3 bulan, dengan berat badan 200 gram. Hasil penelitian menunjukan bahwa rerata jumlah rerata kadar malondialdehyde (MDA) pada kelompok (P0) adalah 4,575±2,034 dan pada kelompok (P1) adalah 2,451±1,036 (p < 0,001). Sedangkan untuk rerata jumlah makrofag pada kelompok (P0) adalah 4,294±0,619, dan kelompok (P1) adalah 1,839±0,624, (p < 0,000). Hasil ini menunjukan secara bermakna bahwa pemberian ekstrak kubis ungu (Brassica oleraceavar. capitata L.) pada tikus galur wistar (Rattus norvegicus) jantan dapat menurunkan kadar malondialdehyde (MDA) dan dapat menurunkan jumlah makrofag pada paru. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa pemberian ekstrak etanol kubis ungu pada tikus galur wistar jantan dapat menurunkan kadar malondialdehyde (MDA) dan dapat menurunkan jumlah makrofag pada paru. tikus galur wistar jantan yang dipaparkan asap rokok sebanyak 3 batang selama 14 hari.
PELATIHAN DAYA TAHAN OTOT BERBEBAN ½ KG 20 REPETISI 3 SET MENINGKATKAN FREKUENSI PUKULAN PENDETA TANGAN KIRI DAN KANAN PADA ANGGOTA PENCAK SILAT PERISAI DIRI RANTING SESETAN IKW. Suryawan; J.A. Pangkahila; B.K. Satriyasa; LMIS. Handari Adiputra; IP. Adiartha Griadi; IMA. Wirawan
Jurnal Pendidikan Kesehatan Rekreasi Vol. 5 No. 2 (2019): Juni 2019
Publisher : Program Studi Pendidikan Jasmani Kesehatan dan Rekreasi FKIP Universitas PGRI Mahadewa Indonesia bekerjasama dengan Asosiasi Prodi Olahraga Perguruan Tinggi PGRI (APOPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (103.338 KB) | DOI: 10.5281/zenodo.3338702

Abstract

Pencak silat adalah seni beladiri yang membutuhkan konsentrasi tinggi. Komponen biomotorik yang terpenting dikembangkan adalah kekuatan, daya tahan otot, kecepatan waktu reaksi dan koordinasi. Dalam penelitian ini peneliti menerapkan pelatihan daya tahan otot untuk meningkatkan frekuensi pukulan pendeta dengan dua tipe pelatihan yaitu, Kelompok 1 melakukan pelatihan daya tahan otot dengan beban dumbbell seberat ½ kg sebanyak 20 repetisi 3 set dan Kelompok 2 melakukan pelatihan daya tahan otot berbeban ½ sebanyak 15 repetisi 4 set. Secara keseluruhan penelitian ini bertujuan untuk meningkatkan frekuensi pukulan pendeta. Perbedaan rerata frekuensi pendeta sebelum pelatihan pada Kelompok 1 26,22 ± 1,21 x/30 detik dan sesudah pelatihan 32,28 ± 1,03 x/30 detik menunjukkan adanya perbedaan bermakna p = 0,000 (p<0,05). Rerata frekuensi pukulan pendetasebelum pelatihan pada Kelompok 2 adalah sebesar 26,22 ± 1,56x/30 detik dan sesudah pelatihan 29,56 ± 1,23x/30 detik (p<0,05). Perbedaan frekuensi pukulan sesudah pelatihan antara kedua kelompok juga menunjukkan perbedaan yang bermakna p = 0,000 (p<0,05). Disimpulkan bahwa pelatihan daya tahan otot berbeban ½ kg 20 repetisi 3 set lebih meningkatkan dibandingkan pelatihan daya tahan otot berbeban ½ kg 15 repetisi 4 set.
EFEK PEMBERIAN EKSTRAK BIJI PEPAYA (Carica papaya Linn.) TERHADAP GAMBARAN HISTOPATOLOGI TESTIS PADA MENCIT (Mus musculus) JANTAN Anak Agung Gede Fandhiananta Widyanjaya; Agung Bagus Sista Satyarsa; Ni Luh Gede Ayu Candranita Dharmadi; Maura Marda Mayang Sari; Xena Laveda; Bagus Komang Satriyasa
Essence of Scientific Medical Journal Vol 18 No 2 (2020): Volume 18 No. 2 (Juli - Desember 2020) Essential: Essence of Scientific Medical
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2020.v18.i02.p07

Abstract

Pepaya (Carica papaya L.) merupakan tanaman yang hampir semua bagiannya dapat digunakan untuk keperluan manusia. Salah satunya adalah biji pepaya yang telah diuji memiliki efek antifertilitas. Kriteria kontrasepsi yang baik yakni mudah digunakan, efektif, efisien, tidak ada efek samping dan bersifat refersibel yang dapat digunakan dalam jangka waktu panjang. Penelitian ini dilakukan untuk mengetahui efek ekstrak biji pepaya terhadap gambaran histologi testis. Penelitian eksperimental ini menggunakan sebanyak dua puluh tujuh ekor mencit jantan fertil. Kelompok kontrol (P0) diberikan akuabides per oral sebanyak 0,5 ml selama 36 hari. Kelompok perlakuan 1 (P1) diberikan ekstrak biji pepaya muda per oral dengan dosis 20 mg/mencit/hari sebanyak 0,5 ml selama 36 hari. Kelompok perlakuan 2 (P2) diberikan ekstrak biji pepaya muda per oral dengan dosis 50 mg/mencit/hari sebanyak 0,5 ml selama 36 hari. Berdasarkan hasil penelitian dapat disimpulkan bahwa pemberian ekstrak biji pepaya pada dosis 20 mg dan 50 mg selama 36 hari pada mencit jantan berpengaruh terhadap kerusakan struktur histologi testis. Maka dari itu, biji pepaya dapat menyebabkan infertilitas sehingga dapat dikembangan sebagai bahan kontrasepsi alami pada pria.
PENINGKATAN SEL OSTEOBLAST MANDIBULA TIKUS WISTAR JANTAN SETELAH PEMBERIAN FERMENTASI TEH KOMBUCHA Ni Wayan Arni Sardi; I Dewa Made Sukrama; Bagus Komang Satriyasa
Interdental: Jurnal Kedokteran Gigi Vol. 14 No. 2 (2018): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Faculty of Dentistry, Mahasaraswati Denpasar University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v14i2.376

Abstract

Osteoblasts are bone-forming cells to grow and play a role in regulation of bone metabolism, including alveolar bone. Imbalance of osteoblasts number in bone formation may lead loss of bone mass, which is causes osteoporosis. Reactive Oxygen Species (ROS) is an oxidant that take important roles in osteoclast activation, osteoclastogenesis and activation of osteoblasts inhibition. Kombucha tea has antioxidant effects. This study was conducted to determine Kombucha tea fermented on 14 days make the osteoblasts in the mandibular bone of male wistar rat more numerous.This research was a purely experimental method with Randomized Post Test Control Group Design. Subjects consisted of ten of three – month male wistar rats were divided into 2 groups. Control group received aquadest for 30 days, on the other hand the treatment group were treated by 8 ml of Kombucha tea for 30 days. On the 31st day, rats were euthanized for tissue sampling and histological preparation of mandibular bone and subjected for HE staining. The test results based on comparison between the control group and treatment group with independent t-test showed that there were significant differences in osteoblasts number in mandibular bone of wistar rats (p<0.05). Kombucha tea contain epicatechin gallate (ECG) that stimulate osteoblasts differentiation and inhibit induction of Receptor Activator Of Nuclear Factor-κB Ligand (RANKL). Further more, Epigallocatechin gallate (EGCG) and theaflavin (TF) detoxify molecules of ROS and enhance osteoblastogenesis. This study concluded that administration of Kombucha tea fermented on 14 days make osteoblasts in the mandibular bone of wistar rat more numerous.
Uji efektivitas ekstrak etanol air kelopak bunga Hibiscus sabdariffa linn terhadap profil lipid tikus hiperlipidemia Ode Mahesa Putra; I Made Jawi; Bagus Komang Satriyasa
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.449 KB) | DOI: 10.15562/ism.v10i2.189

Abstract

Introduction: Cardiovascular disease is still the biggest cause of death in the world. Many factors that play a role in the development of this disease, one of them is Hiperlipidemia. The situation can be handled using conventional medicines, but there are concerns about the side effects of conventional medicines. Hibiscus Sabdariffa L. (roselle) is rich in polyphenols, anthocyanins, flavonoids which can be used as drugs for the prevention of cardiovascular diseases that have biological activities such as antihypertensive, antimutagenic, chemopreventive, antioxidant, anticonvulsant, anxiogenic, CNS-depressant, serotoninergic activity, reducing damage from oxidative liver, anti-inflammatory and hypoglycemic activity. This study aims to evaluate the effects of roselle ethanol extract as a hypolipidemic agent.Method: This study used an experimental design, using wistar mouse divided into five groups: C1 received aquadest intervention, C2 (simvastatin 0.2g / kg / day), I1 (100mg / kg / day roselle extract), I2 (200 mg / kg / day roselle extract), and I3 (300 mg / kg / day roselle extract) mice was given hypercholesterol oil feed for two weeks preceeding drugs intervention, then intervention was given for eight weeks and analyzed on mouse lipid profile component.Result: There were significant differences in total cholesterol, triglyceride, LDL, and HDL values among the intervention groups (p = 0.000). The lowest total cholesterol belonging to the C2 group (117.83 ± 6.36) was followed by I3 (143.66 ± 11.75), the lowest triglyceride belonging to the C2 group (284.83 ± 7.46) was followed by I3 (306.84 ± 8.61), the lowest LDL was owned by the group C2 (104.50 ± 4.37), followed by I3 (120.50 ± 2.42), the highest HDL belonging to the C2 group (44.80 ± 3.16 followed by I3 group (38.02 ± 3.40).Conclusion: The ethanol extract at 300mg / kg / day gave better improvement of lipid profile rather than roselle ethanol extract 100mg / kg / day, 200 mg / kg / day, and aquadest control, but still not able to provide better improvement than simvastatin.
The effect of young pepaya leaf ethanol extract (Carica papaya L.) with concentration variants on the growth of pathogenic Streptococcus pyogenes bacteria causing pharyngitis through in vitro testing I Gede Krisna Putra Yasa; Agung Nova Mahendra; Bagus Komang Satriyasa
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.783 KB) | DOI: 10.15562/ism.v10i2.402

Abstract

Background: Pharyngitis infection issues by Streptococcus pyogenes bacteria have been increasing worldwide, and antibiotic resistance to the bacterium treatment also continues to escalate. Young papaya leaves (Carica papaya L.) have a bactericidal and bacterostatic effect (include papain, flavonoids, alkaloids (karpain alkaloids), saponins, glycosides, phenols (tacophenol), and tannins) that can be an option for treatment of pharyngitis infections other than drugs. This study aims to determine the effectiveness of ethanol extract of young papaya leaves (Carica papaya L.) in inhibiting the growth of Streptococcus pyogenes bacteria through in vitro testing.Methods: This study was a true-post experimental study using control group design. The sample was divided into 2 groups: positive and negative control groups as well as treatment groups with concentration variants of 25%, 50%, 75%, and 100%. Data were analyzed using SPSS version 17 software for windows.Results: The result obtained from this study showed that papaya leaf extract (Carica papaya L.) was proven to significantly inhibit the growth of Streptococcus pyogenes bacteria at concentrations of 25% to 100% with an average diameter of the inhibition zone of 6.4 mm to 7.4 mm (P<0.05).Conclusion: This evidences that the ethanol extract of young papaya leaves (Carica papaya L.) with various concentrations does exhibit an influence on the growth of Streptococcus pyogenes bacteria.
Co-Authors A.N. Mahendra A.W. Indrayani Adiputra, LMIS. Handari Agung Bagus S. Satyarsa Agung Nova Mahendra Agung Wiwiek Indrayani Ali Imron Amaral, Meriana Barreto Anak Agung Gede Eka Septian Utama Anak Agung Gede Fandhiananta Widyanjaya Artini , I Gusti Ayu Ayu Diandra Sari Bastianus Alfian Juatmadja Desak Ketut Ernawati Desak Made Wihandani Dewa Ayu Putu Rasmika Dewi Dewa Putu Gede Purwa Samatra Dita Permatasari Edelweishia, Melissa Efraldo Yudistira Fendy Nugroho Griadi, IP. Adiartha I Dewa Ayu Inten Dwi Primayanti I Dewa Made Sukrama I Dewa Putu Sutjana I Gde Haryo Ganesha I Gede Krisna Putra Yasa I Gede Restu Mahendra Sugiarta I Gede Widhiantara I Gusti Ayu Widianti I Gusti Made Aman I Kadek Arya Gangga Permana I Made Ady Wirawan I Made Jawi I Made Krisna Dinata I MADE MULIARTA . I Made Sudarmaja I Nengah Sandi I Nyoman Adi Putra I Nyoman Mangku Karmaya I Pande Putu Deny Heriwijaya I Putu Adiartha Griadhi I Putu Agus Budi Sudarsana I Putu Eka Kusuma Yasa I Putu Gede Adiatmika I Putu Riska Ardinata I Wayan Putu Sutirta Yasa I Wayan Rosiana I Wayan Sumardika I Wayan Sumardika I Wayan Weta I.A.A. Widhiartini I.G. Wiranatha I.G.A. Artini I.G.M. Aman I.G.M.G.S.C. Trapika IB Putra Manuaba, IB Putra Ida Ayu Mas Suryani Ida Bagus Budha Dharma Kusuma Ida Bagus Ngurah Ida Bagus Putra Manuaba IKW. Suryawan Imakulata Magi Loda Iman Santoso IP. Adiartha Griadi Irawan, Angeline Aprilia Ivana, Jocelyn J. A. Pangkahila Joppi Huwae Karta Sawenda Ketut Agus Adrianta Ketut Tirtayasa Klaudius H. M. Meti Kristanto, Andre Kurniawan, Yukhi Listya Triandari LMIS. Handari Adiputra Lorena Samanta Adelina Luh Made Indah Sri Handari Adiputra Luh Sonya Astana Putri M Widnyana M. Ali Imron Made Indra Prasetya Permana Maura Marda Mayang Sari Muh. Ali Imron Muh. Ali Imron Muh. Irfan Muhammad Irfan Muthiah Munawaroh N. Adiputra N. Adiputra N.W. Tianing N.W.S. Dewi Nabasa, Gayus Erino Ni Luh Gede Ayu Candranita Dharmadi Ni Luh Suriani Ni Made Intansari Tri Buana Ni Made Linawati Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Budiani, Ni Nyoman Ni Putu Oka Mahayani* Ni Putu Widya Astuti Ni Putu Wirantari Ni Wayan Arni Sardi Ni Wayan Saka Rahayu Ni Wayan Sinta Devi Arini Ni Wayan Sucindra Dewi Ni Wayan Sucindra Dewi Nyoman Ratep Nyoman Suarjana Ocktaviana Saputri, Legis Ode Mahesa Putra Oktovianus Fufu Oktovianus Fufu Oktovianus Fufu Permatasari, Anak Agung Ayu Putri Putri Uli Saktina Putu Ananda Sutiksna Mulya Putu Angga Wiradana Putu Astawa Putu Susilawati Putu Wandari Pranitha S.Indra Lesmana Selviani, Iit Sugijanto - Sugijanto - Sugijanto - Sugijanto - Suryawan, IKW. Susy Purnawati Syahmirza Indra Lesmana Tharsani Devi Srinivasagam Tjokorda Gde Bagus Mahadewa Tri Wahyu Wulandari Wahyuddin, Wahyuddin Widianti, I Gusti Ayu Widiyanti, I Gusti Ayu Wijaya Surya, I Gede Ngurah Harry Wimpie I Pangkahila Wirawan, IMA. Xena Laveda Yogie Wiswadewa Yuniarti N