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KADAR FENOLIK DAN FLAVONOID TOTAL SERTA AKTIVITAS ANTIOKSIDAN DARI EKSTRAK METANOL AKAR, DAUN DAN BUNGA SIMPUR AIR (Dillenia suffroticosa Griff. Ex Hook) Rahayu Utami Utami; Ginta Rio Maranti; Mustika Furi; Melzi Octaviani; Septi Muharni; Fina Aryani; Husnawati; Wira Noviana Suhery; Musyirna Rahmah Nst; Haiyul Fadhli; Emma Susanti; Emrizal
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1418

Abstract

Simpur air is one of plant that has been using as traditional medicine for treating several diseases. Some studies on its chemical constituents and biological activities of this species have been published. However, chemical constituents and antioxidant activity of this plant which is Riau origin has not been reported before. This study aims to determine the total of phenolic and flavonoid content as well as its antioxidant activity of methanol extracts of roots, leaves and flowers of simpur air. Determination of total of phenolic and flavonoid content was performed by spectrophotometric method using Folin Ciocalteu and AlCl3 as reagents, respectively. Whereas, its antioxidant activity was evaluated using DPPH method. The results showed that methanol extracts of its roots afforded the highest total of phenolic and flavonoid content and also its antioxidant activity. The total of phenolic content of methanol extracts of its roots of 428.131 GAE/mg extract; its total of flavonoid content of 766.164 QE/mg extract; as for its antioxidant activity gave IC50 value of 3.852 µg/ml.
Microemulsion Formulation of Combination of Virgin Coconut Oil and Rice Bran Oil for Hair Growth Wira Noviana Suhery; Mira Febrina; Ivone Permatasari
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (330.606 KB) | DOI: 10.22146/mot.29213

Abstract

Research on micro emulsion formulation of combination of virgin coconut oil (VCO) and rice bran oil (RBO) as a hair growth promoter has been done. The purpose of this study was to formulate and produce the best formula that is physically stable and optimally promoting the hair growth by varying the content of VCO and RBO in the form of micro emulsions. These dosage formulations were prepared in three formulas using 45% tween 80 as surfactants and 20% glycerin as co surfactant i.e.: F,I containing a combination of VCO and RBO 1:1; FII (1:2) and FIII (2:1). Physical evaluation of the preparation was carried out for 8 weeks of storage which included organoleptic examination, pH, homogeneity, density, globule particle size, phase freeze thaw, and rabbit hair growth activity test for 18 days. Based on the results of the evaluation, it was found that the FI, FII and FIII micro emulsion formulations were physically stable for 8 weeks of storage with a pH ranging from 6.7 to 7.0, density of 1.085-1.088 g/mL, average globul particle size of FI (34.6 nm ), FII (54 nm) and FIII (68.8 nm). The best formulas is FIII for hair growth length of 1.26 cm for 18 days.
Pembuatan Dan Evaluasi Pati Talas (Colocasia esculenta Schoot) Termodifikasi dengan Bakteri Asam Laktat (Lactobacillus sp) Wira Noviana Suhery; Deni Anggraini; Novtafia Endri
Jurnal Sains Farmasi & Klinis Vol 1, No 2 (2015): J Sains Farm Klin 1(2), Mei 2015
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.149 KB) | DOI: 10.29208/jsfk.2015.1.2.36

Abstract

Production and evaluation of modified taro (Colocasia esculenta Schott) starch by lactic acid bacteria (Lactobacillus sp) has been done. The purpose of this study was to observe the effect of lactic acid bacteria to the yield of taro starch and to evaluate physicochemical of starch. The evaluation which includes organoleptic, moisture content, pH, angle of repose, swelling power, gelatination temperature, amylose content, and examination of the surface shape of starch granules using SEM (Scanning Electron Microscope). The result showed that modified taro starch yield higher (19,12%) than native taro starch (11,79%). Modified taro starch of organoleptic examination showed better results where the smell was slighly reduced and the colour was white. Meanwhile, from the results of the evaluation of swelling power, gelatination temperature, and amylose content showed an increase. In addition, the modified taro starch granule were rougher due to some holes presented distinctively.
Perbandingan Metode Granulasi Basah dan Kempa Langsung Terhadap Sifat Fisik dan Waktu Hancur Orally Disintegrating Tablets (ODTs) Piroksikam Wira Noviana Suhery; Armon Fernando; Buddy Giovanni
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.701 KB) | DOI: 10.29208/jsfk.2016.2.2.65

Abstract

Study on comparison of wet granulation and direct compression method of physical properties and disintegration time of orally disintegrating tablets piroxicam has been done. This study aims to comparison which method gives better results of physical properties and disintegration time between wet granulation and direct compression method. Both methods are made with the same composition formula of each tablets is Piroxicam 20 mg, Primellose® 5%, 1% PVP K30, magnesium stearate 1%, Mannitol 10%, and Comprecel® up to 175 mg. ODTs then evaluated physical properties which include weight variation, thickness, hardness, friability and friksibility, disintegration time, ratio of water absorption, wetting time, drug content and dissolution test. The results showed that both methods produce the physical properties of a good tablets. However, the method of direct compression provides a disintegrating faster 55.51 seconds compared with the wet granulation method. Statistical test using independent sample T test showed that there were significant differences in the disintegration time (P <0.05) between the formula with the method of direct compression and wet granulation.
FORMULASI DAN PENENTUAN NILAI SUN PROTECTION FACTOR (SPF) SEDIAAN KRIM TABIR SURYA EKSTRAK ETANOL BEKATUL PADI BERAS MERAH (Oryza sativa L) Wira Noviana Suhery; Novita Dewi; Rahayu Utami; Mustika Furi; Melzi Octaviani
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 1 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i1.1408

Abstract

Study of formulation of sunscreen cream with ethanolic extract of red rice bran (Oryza sativa L) and determining the SPF value in vitro using a UV spectrophotometer has been carried out. Ethanol extract of red rice bran has been shown antioxidant activity. Determining the SPF value due to determine the ability of the red rice bran ethanol extract to protect the skin from UV radiation. Ethanol extract of red rice bran was formulated in the form of a cream type o/w of F1 and F2 containing extract concentrations of 5% and 10%, respectively. Based on the research conducted, it was found that F2 had a higher SPF value of 13,098 than F1 of 11,861. Based on the SPF value generated from the formula, this study showed that the sunscreen cream preparation of red rice bran extract can protect the skin from UV radiation maximally for 110-130 minutes.
Uji Aktivitas Antioksidan Dari Ekstrak Bekatul Padi Ketan Merah Dan Hitam (Oryza Sativa L. Var. Glutinosa) Dan Formulasinya Dalam Sediaan Krim Wira Noviana Suhery; Armon Fernando; Netralis Has
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 13 No. 01 Juli 2016
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRAK Bekatul merupakan hasil samping proses penggilingan padi yang mengandung senyawa bioaktif seperti tokoferol, tokotrienol, dan oryzanol. Penelitian ini bertujuan untuk menguji aktivitas antioksidan dari ekstrak bekatul padi ketan (Oryza sativa L. var. glutinosa) merah dan hitam kemudian memformulasikannya dalam bentuk sediaan krim. Pengujian aktivitas antioksidan dilakukan dengan metode DPPH (2,2-difenil-1-pikrihidrazil). Hasil uji aktivitas antioksidan dari ekstrak bekatul padi ketan merah dan hitam, diperoleh nilai IC50 berturut-turut sebesar 31,7525 dan 434,7525 ppm. Selanjutnya ekstrak bekatul padi ketan merah dan hitam diformulasikan dalam bentuk sediaan krim tipe M/A dengan konsentrasi ekstrak bekatul padi ketan merah (FI) dan hitam (FII) masing-masing 2,5%. Hasil evaluasi fisik sediaan krim yang meliputi organoleptis, homogenitas, pH, stabilitas terhadap perubahan suhu, uji daya menyebar, uji daya tercuci dan uji iritasi menunjukkan bahwa sediaan krim ekstrak bekatul padi ketan merah (FI) dan hitam (FII) memenuhi persyaratan dan tidak mengiritasi selama 8 minggu penyimpanan. Hasil uji aktivitas antioksidan sediaan krim menunjukkan persen inhibisi untuk FI dan FII masing-masing sebesar 95,0974 dan 92,3569% pada minggu pertama, dan 89,9576 dan 86,9537% pada minggu kedelapan. Kata kunci: ekstrak bekatul, padi ketan merah, padi ketan hitam, antioksidan, krim. ABSTRACT Rice bran is a by-product of rice milling process that contain bioactive compounds such as tocopherol, tocotrienol, and oryzanol. This study aimed to test the antioxidant activity of the extract of red and black glutinous rice bran (Oryza sativa L. var. glutinosa) and then formulatethem into cream. Testing of antioxidant activity using DPPH (2,2-diphenyl-1-pikrihidrazil). The IC50 of the extract of red and black glutinous rice bran are 31.7525 and 434.7525 ppm, respectively. Subsequently, extract of red and black glutinous rice bran is formulated into type o/w cream with concentration of 2.5%. The results of evaluation of physical cream consist of organoleptic, homogeneity, pH, stability to temperature changes, power test spread, test of power washed and test of irritation. The results showed that the cream of both red (FI) and black (FII) glutinous rice bran extract meet the physical properties requirements and do not irritate during the 8 weeks of storage. The result of antioxidant activity test showed that inhibition percentage of FI and FII are 95.0974 and 92.3569% in the first week, and 89.9576 and 86.9537% in the eighth week, respectively. Key words: extract of rice bran, glutinous rice bran red, glutinous rice bran black, antioxidant, cream.
Potential of Modified Cassava Starch as a Tablet Binder in Direct Compression Method Wira Noviana Suhery; Anita Lukman; Afriyanti Afriyanti
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 2 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i2.25212

Abstract

Research on the potential of modified cassava starch as a binder for the direct compression method has been carried out. The use of modified cassava starch as a binder using six formulas with the drug model ibuprofen. Variations in the concentration of modified cassava starch were modified cassava starch 48 and modified cassava starch 72 were 15%, 17.5%, and 20%, respectively. The formula with a modified starch 72 concentration (15%) is the best formula that produced optimal tablets. The value of hardness was 5.3 kg/cm2, friability of 0.90%, and disintegration time of 2.06 minutes which are the main parameters of the binder
FORMULASI MINYAK ANGIN AROMATERAPI MINYAK JERUK KASTURI (Citrofortunella microcarpa) Wira Noviana Suhery; Dinda Wijayaningsih; Ratna Fitry Yenny
Jurnal Penelitian Farmasi Indonesia Vol. 11 No. 1 (2022): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v11i1.1744

Abstract

Inovasi terhadap bentuk sediaan dan aroma minyak angin dilakukan agar dapat memperluas pasar minyak angin, termasuk kalangan remaja dan anak muda. Inovasi minyak angin yang lebih modern, baik terhadap aroma khasnya serta kemasannya tanpa mengurangi efektivitas farmakologi. Penelitian ini bertujuan untuk memformulasikan minyak angin aromaterapi dengan minyak jeruk kasturi sebagai pengaroma dan menevaluasi sifat fisik minyak angin, dan menguji tingkat kesukaan terhadap minyak angin yang dibuat. Penelitian ini merupakan penelitian eksperimental yang memformulasi minyak angin menggunakan 3 konsentrasi minyak jeruk kasturi (4%, 6%, dan 10%) sebagai aromaterapi. Uji tingkat kesukaan terhadap produk dilakukan pada 100 panelis dengan parameter organoleptis sediaan terhadap warna, bau, dan sensasi di kulit. Hasil menunjukkan bahwa F3 (10%) memiliki sifat fisik baik dan memiliki tingkat kesukaan yang tinggi diantara 100 panelis.
FORMULASI DAN EVALUASI FISIK MASKER GEL PEEL OFF EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus Polyrhizus) Nofriyanti - Nofriyanti; wira noviana suhery; nesa agistia; wildan khairi muhtadi
Jurnal Penelitian Farmasi Indonesia Vol. 11 No. 2 (2022): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v11i2.1741

Abstract

Kulit adalah organ penting dari tubuh kita, umumnya wanita menginginkan kulit yang bersih dan cerah terutama pada kulit wajah, salah satu sediaan kosmetik untuk menjaga kebersihan dan perawatan kulit wajah adalah masker wajah. Jenis masker wajah yang praktis digunakan yaitu masker gel yang setelah kering dapat langsung dikelupas atau biasa dikenal dengan sebutan masker gel peel off. Masker gel peel off merupakan masker gel yang mudah dalam penggunaannya, setelah kering masker dapat langsung dilepas dan menghilangkan sisa-sisa kotoran yang menempel pada permukaan kulit wajah. Penelitian ini bertujuan untuk memformulasi sediaan masker gel peel off dengan variasi konsentrasi F1 (3%), F2 (5%) dan F3 (7%), yang memiliki stabilitas fisik yang baik dari ekstrak kulit buah naga merah, serta menegetahui variasi konsentrasi zat aktif manakah yang lebih baik. Dari hasil yang didapatkan selama empat minggu penyimpanan didapatkan F1, F2, dan F3 homogen pada minggu pertama dan kedua penyimpanan, namun pada minggu ketiga sampai keempat penyimpanan sediaan tidak homogen lagi karena membentuk dua bagian yaitu air dan basis, pemeriksaan pH pada sediaan menunjukan bahwa pH masker gel selama empat minggu penyimpanan menunjukan penurunan pH yaitu basis dengan rentang 6,48-5,38, F1 dengan rentang 5,22-4,71, F2 dengan rentang 5,19-4,91, dan F3 dengan rentang 5,06-4,79 tetapi masih dalam range pH kulit yaitu 4,5-6,5. Untuk daya sebar dan waktu mengering tidak masuk dalam syarat masing-masing evaluasi karena sediaan tidak homogen selama penyimpanan empat minggu.
Formulation and Antioxidant Activity Test of Rice Bran Extract Cream from Two Varieties of White Rice Wira Noviana Suhery; Hayu Lestari; Armon Fernando; Fina Aryani; Gressy Novita
Majalah Obat Tradisional Vol 28, No 2 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.84715

Abstract

Rice bran extract contains high antioxidant compounds. Formulation and antioxidant activity testing of cream preparations containing rice bran extract has been carried out. This study aims to formulate and evaluate cream preparations containing bran extract from two varieties of white rice and their antioxidant activity. The white rice varieties used were the Kalpatali variety (FI) and the Rice 64 (FII) variety. There were three cream formulas, namely the basic formula (F0) and the formula containing rice bran extract with a concentration of 3.1% each (FI and FII). Evaluation of cream preparations included organoleptic test, homogeneity, pH, washability, stability, irritation test, and antioxidant activity test. This study showed that FI has an antioxidant activity of 87.23% and FII has an antioxidant activity of 64.08%. Different varieties of rice show differences in antioxidant activity in cream preparations containing bran extract. The best formula is FI which has good physical properties and higher antioxidant activity compared to FII.Â