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All Journal JURNAL PENELITIAN SAINTIKA Jurnal Pendidikan Biologi Indonesia Jurnal Florea Jurnal Pembelajaran dan Biologi Nukleus Best Journal (Biology Education, Sains and Technology) IJOEP : International Journal of Ecophysiology JURNAL BIOSHELL Bioscientist : Jurnal Ilmiah Biologi Continuous Education : Journal of Science and Research INVENTION: Journal Research and Education Studies Journal of Learning Improvement and Lesson Study Jurnal Kedokteran Hewan BIO-CONS: Jurnal Biologi dan Konservasi Biodik: Jurnal Ilmiah Pendidikan Biologi AR-RUMMAN: Journal of Education and Learning Evaluation
Melva Silitonga
Department of Biology, State University of Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Energy Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Development of Human Excretory System Module Based on Problem Based Learning to Improve Student Learning Outcomes in Class XI Science Sumbayak, Mika Canthika Amelia; Silitonga, Melva; Sitohang, Odelia Nova Maria Br.; Wulandari, Ayu; Sembiring, Gres Anjelia; Rajagukguk, Nia Anggelina; Sitohang, Mohonia Sabarito
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 2 (2025): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i2.15515

Abstract

This research aims to develop and test the feasibility and effectiveness of the module of human excretory system based on Problem Based Learning (PBL). The research method use is Research and Development (R&D) with the 4-D model, namely the defining stage, the design stage, the development stage, and the dissemination stage. Validation was conducted by module design experts with an average score of 93.32, material experts 92.32, learning experts 90.86, and one biology teacher of class XI 94.68, all categorized as “very feasible.” The module appeal trial shows high results with assessment categories 85.01 - 100 (highly appealing), 70.01 - 85 (appealing), 50.01-70 (less appealing), and 01.00-50 (not appealing). The results of the individual trial were 3 students at 100 (highly appealing), a small group of 10 students at 82.14 (appealing), and a limited group of 20 students at 98.75 (highly appealing). The effectiveness of the module tested through student learning outcomes using independent t test. In the cognitive aspect, the average value of the experimental class reached 96.15 (very good) with t count 2.170 > t table 1.666 and supported by a significant value of 0.033 <0.05. Affective aspects obtained a value of 94.30 (very good) with t count 2.296 > t table 1.666 supported by a significant value of 0.025 < 0.05, and psychomotor aspects reached 97.13 (very good) with t count 7.619 > t table 1.666 supported by a significant value of 0.000 < 0.05. The results of this study indicate that the developed module can be useful as an effective alternative learning media to improve students' learning outcomes.
The Spectrum of Sensory Disorders in Humans: A Review of the Literature Siregar, Suci Asda Mutia; Manalu, Mentari; Sidabutar, Efimah; Pasaribu, Tania Valentina; Silitonga, Melva
Invention: Journal Research and Education Studies Volume 6 Nomor 1 Maret 2025
Publisher : CV. PUSDIKRA MITRA JAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/invention.v6i1.2484

Abstract

This literature review aims to explore the spectrum of visual sensory disorders in humans, focusing on major disorders such as cataracts, glaucoma, and anisometropia. This condition is one of the leading causes of vision impairment and blindness globally, especially in developing countries. The study synthesizes findings from recent national and international scientific publications to identify the causes of preventable and unpreventable visual dysfunction. Cataracts, often associated with aging and systemic diseases, remain the most common cause of blindness but can be treated through surgical interventions such as phacoemulsification. Glaucoma, known for its asymptomatic progression, causes irreversible damage to the optic nerve and requires early detection and ongoing treatment. Anisometropia, a refractive disorder that results in different visual inputs between the eyes, poses a risk of amblyopia if not treated early. In addition, the study highlights the increasing incidence of visual impairment due to excessive use of digital devices, especially among children, emphasizing the importance of precautions such as regulated screen time and regular eye check-ups. These findings emphasize the important role of early intervention, public awareness, and access to quality eye care in reducing the burden of visual impairment. The review also underscores the need for policy and research support to improve treatment strategies and maintain visual health in the digital age.
Mekanisme Detoksifikasi: Cara Sistem Ekskresi Melindungi Tubuh dari Racun Batubara, Astrida J.A; Situmorang, Imelda; Nasution, Irma Riavael; Matanari, Ninta Dumaria; Hasanah, Niswatun; Silitonga, Melva
Invention: Journal Research and Education Studies Volume 6 Nomor 1 Maret 2025
Publisher : CV. PUSDIKRA MITRA JAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/invention.v6i1.2490

Abstract

Sistem ekskresi manusia memainkan peran krusial dalam detoksifikasi tubuh melalui mekanisme kompleks yang melibatkan organ-organ seperti ginjal, hati, dan kulit. Penelitian ini bertujuan untuk mengkaji proses detoksifikasi sistem ekskresi melalui metode studi literatur sistematis. Hasil analisis menunjukkan bahwa ginjal menyaring sekitar 180 liter darah per hari untuk mengeliminasi senyawa toksik seperti urea dan kreatinin, sementara hati melakukan detoksifikasi kimiawi melalui dua fase utama yang melibatkan enzim sitokrom P450 dan konjugasi molekul. Kulit juga berkontribusi melalui ekskresi keringat, terutama untuk logam berat. Faktor nutrisi, hidrasi, dan paparan toksin kronis secara signifikan memengaruhi efisiensi detoksifikasi. Temuan ini memiliki implikasi klinis penting, termasuk rekomendasi pemantauan rutin kadar kreatinin dan enzim hati, serta intervensi nutrisi untuk meningkatkan glutation intrahepatik. Studi ini menyoroti perlunya penelitian lebih lanjut tentang peran mikrobiota usus dan dampak penuaan pada kapasitas detoksifikasi.
Mekanisme Neuroplastisitas dalam Pembelajaran dan Pemulihan Fungsi Setelah Cedera Sistem Saraf Pusat: Tinjauan Literatur Komprehensif Purba, Greace Enita; Hutapea, Helen Veronita; Situmeang, Juwita Cristina; Nababan, Novia Christy; Saragi, Shela Estica; Silitonga, Melva
Invention: Journal Research and Education Studies Volume 6 Nomor 1 Maret 2025
Publisher : CV. PUSDIKRA MITRA JAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/invention.v6i1.2491

Abstract

Central nervous system (CNS) injuries such as stroke are a leading cause of global disability (51 million DALYs), with a prevalence in Indonesia reaching 10.9% (GBD, 2019; Riskesdas, 2018). Neuroplasticity through BDNF-dependent synaptic plasticity mechanisms (Kowianski et al., 2018) and tDCS-mediated cortical reorganization (Lefaucheur et al., 2022) offers rehabilitation solutions, but their implementation faces challenges due to genetic variability (BDNF Val66Met) and technological access disparities (Siregar et al., 2023). This article aims to: Analyze BDNF-tDCS interactions at molecular and clinical levels.Evaluate the effectiveness of tDCS based on recent evidence (2019–2024).Formulate low-cost implementation strategies for Indonesia.The methodology involves a systematic PRISMA review of 45 studies from PubMed, Scopus, and ScienceDirect. The analysis includes:  Meta-analysis of tDCS effects on motor recovery (RevMan 5.4). Policy analysis using the WHO framework for essential health technologies. Key findings indicate: BDNF levels >35 ng/mL enhance motor recovery by 2.3x (95% CI: 1.8–3.1; p<0.001). tDCS significantly improves motor function (23.5%, p<0.01), but only in BDNF Val/Val genotypes.Implementation cost: Portable tDCS protocols (Rp500,000/unit) are 90% cheaper than TMS.Integration of BDNF genotype screening, standardized tDCS protocols, and policy advocacy can optimize CNS rehabilitation in Indonesia. This study provides the first evidence-based guide combining neuroscience and health policy.
The Role of cortisol in the stress response anliana; Panguhutan Sitorus, Henry; Silitonga, Melva
International Journal of Ecophysiology Vol. 7 No. 1 (2025): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v7i1.19118

Abstract

Stress is a physiological and psychological response triggered by internal or external stressors that challenge the body's homeostasis. Cortisol, a glucocorticoid hormone released by the adrenal glands in response to stress, plays a pivotal role in modulating this response. Its primary function is to mobilize energy, regulate inflammation, and enhance cognitive processes during acute stress. While cortisol facilitates adaptation by suppressing overactive immune responses and ensuring resource availability, its prolonged elevation can lead to detrimental effects, including metabolic disorders, cardiovascular diseases, and cognitive impairments. Conversely, inadequate cortisol production disrupts the body’s ability to manage stress, resulting in conditions like fatigue, hypotension, and impaired recovery. This study explores the dynamic relationship between stress and cortisol, emphasizing how balanced cortisol levels contribute to stress resolution and homeostasis restoration. Understanding cortisol’s dual role provides insights into its potential therapeutic applications for managing stress-related disorders.
Centella asiatica: Alzheimer's Neuroprotective Wahyuni, Riska; Suriwahyuni; Saif, Annisa Hazrina; Silitonga, Melva
International Journal of Ecophysiology Vol. 7 No. 1 (2025): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v7i1.19423

Abstract

Centella asiatica (CA) in Indonesia is known as gotu kola plant which is known to have many compounds contained in it, such as Asiatic acid, madecassic acid (6-hydroxyacetic acid), asiaticoside, madecassoside, betulinic acid, thankunic acid, and isothankunic acid. This study is to determine the benefits of CA triterpenoid bioactive content and the mechanism of CA as a neuropretective against alzheimer's disease. This research used the literature study method by searching online data on various types of article publications and selected according to the PRISMA method. From the literature collected, it was found that CA has the ability as a neoroprotective against Alzheimer's disease. This is because triterpenoid compounds with the bioactive content of asiaticoside, madecid acid, and asiatic acid play a role in inhibiting the enzyme acetylcholinesterase which can act as a neuroprotective in the brain by reducing ROS production which can then restore mitochondrial dysfunction and can improve nerve function in Alzheimer's disease.
Respons Fisiologis Manusia terhadap Penurunan Suhu Inti pada Kejadian Hipotermia: Suatu Studi Literatur Ujung, Siti Nuraisah A; Azhari, Muhammad; Tambunan, Diana Putri K; Amanda, Putri; Pribadi, Koko; Apriliani, Indah Rizka; Silitonga, Melva
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 2 (2025): September 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i2.13219

Abstract

Hipotermia merupakan kondisi penurunan suhu inti tubuh yang dapat menimbulkan risiko fisiologis serius. Pemahaman tentang respons fisiologis manusia terhadap hipotermia penting untuk pencegahan dan manajemen klinis. Artikel ini bertujuan untuk meninjau literatur mengenai mekanisme fisiologis yang terjadi pada tubuh manusia akibat penurunan suhu inti. Penelitian ini menggunakan metode, dengan meninjau publikasi ilmiah terbaru terkait respons fisiologis terhadap hipotermia, termasuk mekanisme termoregulasi, metabolisme energi, habituasi terhadap dingin, dan adaptasi jaringan adiposa. Berdasarkan studi literatur, tubuh manusia merespons penurunan suhu inti melalui mekanisme vasokonstriksi perifer, menggigil, peningkatan kapasitas non-shivering thermogenesis melalui adiposit cokelat dan beige, serta habituasi terhadap paparan dingin berulang. Mekanisme ini membantu mempertahankan homeostasis internal dan melindungi organ vital. Namun, paparan dingin yang ekstrem atau tidak terkontrol dapat memicu respons maladaptif, termasuk gangguan koagulasi, infeksi luka, dan inflamasi berlebihan setelah pemanasan ulang.literatur menunjukkan bahwa respons fisiologis manusia terhadap hipotermia bersifat kompleks dan melibatkan berbagai mekanisme adaptif. Pemahaman mendalam terhadap mekanisme ini penting untuk strategi pencegahan dan manajemen klinis pada individu yang mengalami hipotermia.
Co-Authors Abdila, Alya Nur Afdhannisa, Daffa Amanda, Putri anliana Apriliani, Indah Rizka Arda, Gladys Mutia Ayu Putri Ningsih Ayu Wulandari Azhari, Nabilah Syahirah Batubara, Astrida J.A Binari Manurung, Binari Br Barus, Sari Apriani Daulae, Abdul Hakim Fauziyah Harahap Frisillia, Unikhe Ginting, Aminata Gultom, Febry Yeni Gultom, Novayanti Hariyadi, Itra Hasruddin Hutapea, Helen Veronita Karinanta Sembiring, Surya Kurniawan, Rizal Eko Limbong, Forentina Manalu, Mentari Matanari, Ninta Dumaria Muhammad Azhari Nababan, Novia Christy Nainggolan, Junister Nasution, Irma Riavael Nasution, Marina Azzahra Naura Kamila, Aryediutami Niswatun Hasanah Nora, Putri Panguhutan Sitorus, Henry Pardede, Lastiar H Pasar Maulim Silitonga Pasaribu, Tania Valentina Patresia, Indri Pranoto, Hendro Pribadi, Koko Purba, Greace Enita Rajagukguk, Nia Anggelina RISKA WAHYUNI Rosmanta Aritonang, Frince Winda Rumapea, Lusiana Ruth Susanty, Revi Saif, Annisa Hazrina Saragi, Shela Estica Selvia Dewi Pohan Sembiring, Gres Anjelia Sianturi, Stephanie Agustin Sidabutar, Efimah Sihite, Judika Adventist Maleakhi Sinaga, Erlintan Sinaga, Odor Debora Pita Uli Siregar, Suci Asda Mutia Sitohang, Mohonia Sabarito Sitohang, Odelia Nova Maria Br. Situmeang, Juwita Cristina Situmorang, Berri Situmorang, Elisa Rauli Situmorang, Imelda Situmorang, Rany Solin, Naomi Putri Chelsea Sumbayak, Mika Canthika Amelia Suriwahyuni Suryani, Cicik Syahmi Edi Tambunan, Diana Putri K Tarigan, Cania Yekholia Ujung, Siti Nuraisah A Windah, Putri Witin, Theresia Adhellia