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All Journal JURNAL PENELITIAN SAINTIKA Jurnal Pendidikan Biologi Indonesia Biology, Medicine, & Natural Product Chemistry Jurnal Florea Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Perspektif Jurnal Pembelajaran dan Biologi Nukleus Best Journal (Biology Education, Sains and Technology) IJOEP : International Journal of Ecophysiology JURNAL BIOSHELL Bioscientist : Jurnal Ilmiah Biologi Continuous Education : Journal of Science and Research INVENTION: Journal Research and Education Studies Journal of Learning Improvement and Lesson Study Biocaster : Jurnal Kajian Biologi Jurnal Kedokteran Hewan Journal of Pharmaceutical and Sciences. BIO-CONS: Jurnal Biologi dan Konservasi Biodik: Jurnal Ilmiah Pendidikan Biologi AR-RUMMAN: Journal of Education and Learning Evaluation
Melva Silitonga
Department of Biology, State University of Medan
Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Uji Aktivitas Antibakteri Ekstrak Etanol Daun Sirih Cina (Peperomia pellucida) terhadap Bakteri Penyebab Jerawat (Propionibacterium acnes) Sihotang, Wahyu Frans; Restuati, Martina; Silitonga, Melva
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 4 (2025): October
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i4.684

Abstract

This study aims to determine the mechanism of action, antibacterial activity, and effect of ethanol concentration of Chinese betel leaf extract (Peperomia pellucida) on the growth of Propionibacterium acnes. The method used was disc diffusion with 96% ethanol solvent as well as determination of the number of test bacteria through the cup counting method, with the absorbance value adjusted to the McFarland standard of 0.5. The concentration of the extracts tested was 10%, 20%, 30%, 40%, and 50%. The data was analyzed using the One Way ANOVA test with the help of SPSS. The results showed that the ethanol extract of betel leaves of china had antibacterial activity against Propionibacterium acnes, characterized by the formation of an inhibition zone. At 10% of the activity is moderate, while at the concentration of 20%, 30%, 40%, and 50% of the activity is moderate. Standard conformity tests show that McFarland Kit's standard solution (Himedia) has an absorbance value of approximately 0.08–0.1 at a wavelength of 625 nm. The suspension of the test bacteria that was diluted to the absorbance value resulted in a number of Propionibacterium acnes cells of 1.2 × 10^7 CFU/mL. This shows that the number of test bacterial cells used is not entirely the same as McFarland's standard solution of 0.5. Thus, the ethanol extract of betel leaves has the potential to be an antibacterial agent against Propionibacterium acnes.
Kemampuan Literasi Digital pada Materi Inovasi Teknologi Biologi Siswa Arda, Gladys Mutia; Hasruddin, Hasruddin; Silitonga, Melva; Daulae, Abdul Hakim
Continuous Education: Journal of Science and Research Vol. 6 No. 2 (2025)
Publisher : Pusdikra Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/ce.v6i2.2739

Abstract

Penelitian ini bertujuan untuk menganalisis kemampuan literasi digital pada aspek pencarian di internet, pandu arah hypertext, evaluasi konten, dan penyusunan pengetahuan siswa SMA pada mata pelajaran biologi khususnya materi inovasi teknologi biologi. Penelitian ini menggunakan metode deskriptif kuantitatif, dengan populasi penelitian yaitu seluruh siswa kelas X SMAN 1 Medan yang terdiri dari 12 kelas. Pengambilan sampel dilakukan dengan menggunakan teknik random sampling yaitu teknik undian sehingga ditetapkan 2 kelas sebagai sampel penelitian ini yaitu siswa kelas X8 dan X10 SMAN 1 Medan yang berjumlah 72 orang. Instrumen pengumpulan data adalah tes uraian untuk mendapatkan data literasi digital siswa pada aspek pencarian di internet dan pandu arah hypertext serta angket untuk mendapatkan data literasi digital siswa pada aspek evaluasi konten dan penyusunan pengetahuan. Data yang diperoleh dianalisis menggunakan analisis deskriptif dengan membuat persentase yang selanjutnya diinterpretasikan berdasarkan kategori persentase skor literasi digital siswa. Hasil penelitian ini menunjukkan bahwa kemampuan literasi digital siswa pada aspek pencarian di internet (internet searching) termasuk dalam kategori sedang (64,93%), aspek pandu arah hypertext (hypertextual navigation) termasuk dalam kategori sedang (62,78%), aspek evaluasi konten (content evaluation) termasuk dalam kategori tinggi (75,02%), aspek penyusunan pengetahuan (knowledge assembly) termasuk dalam kategori tinggi (77,22%).
Respon Mahasiswa Terhadap Modul Sistem Peredaran Darah Pada Manusia Berbasis Flipbook: (Student Responses to the Flipbook-Based Human Circulatory System Module) Frisillia, Unikhe; Sianturi, Stephanie Agustin; Tarigan, Cania Yekholia; Witin, Theresia Adhellia; Afdhannisa, Daffa; Rosmanta Aritonang, Frince Winda; Silitonga, Melva
BIODIK Vol. 10 No. 4 (2024): Desember 2024
Publisher : Program Studi Pendidikan Biologi FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/biodik.v10i4.38714

Abstract

This study aims to determine how students respond to the use of flipbook modules in Human Anatomy and Physiology courses on the material of the human circulatory system. Flipbook-based modules use animation, sound, and images to communicate information dynamically that increases student engagement and understanding. This study involved 50 Biology Department students from the 2022 batch. A 4-point Likert-based questionnaire was used to collect data, and the questionnaire contained questions about the clarity of the module's objectives, understanding of the content, attractiveness, and learning independence. The results showed that 79% of students found the module material easy to understand, and 76% found it interesting and interactive. Although this module is effective overall, there are several things that need to be considered, including the way the content is delivered and elements that encourage students to learn independently. Therefore, the flipbook module has proven to be practical for use in education, although it still needs improvement to get better results. Absrtak. Penelitian ini bertujuan untuk mengetahui bagaimana respon mahasiswa terhadap penggunaan modul flipbook dalam mata kuliah Anatomi dan Fisiologi Manusia pada materi sistem peredaran  darah  pada  manusia.  Modul  berbasis  flipbook menggunakan   animasi,   suara,   dan   gambar   untuk mengomunikasikan informasi secara dinamis yang meningkatkan keterlibatan dan pemahaman mahasiswa. Penelitian ini melibatkan 50 mahasiswa Jurusan Biologi dari stambuk 2022. Kuesioner berbasis Likert 4 poin digunakan untuk mengumpulkan data, dan kuesioner tersebut berisi pertanyaan tentang kejelasan tujuan modul, pemahaman konten, daya tarik, dan kemandirian belajar. Hasil penelitian menunjukkan bahwa 79% mahasiswa menganggap materi modul mudah dipahami, dan 76% menganggapnya menarik dan interaktif. Meskipun modul ini secara keseluruhan efektif, ada beberapa hal yang perlu diperhatikan, termasuk cara penyampaian konten dan elemen yang mendorong siswa untuk belajar secara mandiri. Oleh karena itu, modul flipbook terbukti praktis untuk digunakan dalam pendidikan,  meskipun  masih  perlu  penyempurnaan  untuk mendapatkan hasil yang lebih baik.
Development of Human Excretory System Module Based on Problem Based Learning to Improve Student Learning Outcomes in Class XI Science Sumbayak, Mika Canthika Amelia; Silitonga, Melva; Sitohang, Odelia Nova Maria Br.; Wulandari, Ayu; Sembiring, Gres Anjelia; Rajagukguk, Nia Anggelina; Sitohang, Mohonia Sabarito
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 2 (2025): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i2.15515

Abstract

This research aims to develop and test the feasibility and effectiveness of the module of human excretory system based on Problem Based Learning (PBL). The research method use is Research and Development (R&D) with the 4-D model, namely the defining stage, the design stage, the development stage, and the dissemination stage. Validation was conducted by module design experts with an average score of 93.32, material experts 92.32, learning experts 90.86, and one biology teacher of class XI 94.68, all categorized as “very feasible.” The module appeal trial shows high results with assessment categories 85.01 - 100 (highly appealing), 70.01 - 85 (appealing), 50.01-70 (less appealing), and 01.00-50 (not appealing). The results of the individual trial were 3 students at 100 (highly appealing), a small group of 10 students at 82.14 (appealing), and a limited group of 20 students at 98.75 (highly appealing). The effectiveness of the module tested through student learning outcomes using independent t test. In the cognitive aspect, the average value of the experimental class reached 96.15 (very good) with t count 2.170 > t table 1.666 and supported by a significant value of 0.033 <0.05. Affective aspects obtained a value of 94.30 (very good) with t count 2.296 > t table 1.666 supported by a significant value of 0.025 < 0.05, and psychomotor aspects reached 97.13 (very good) with t count 7.619 > t table 1.666 supported by a significant value of 0.000 < 0.05. The results of this study indicate that the developed module can be useful as an effective alternative learning media to improve students' learning outcomes.
The Spectrum of Sensory Disorders in Humans: A Review of the Literature Siregar, Suci Asda Mutia; Manalu, Mentari; Sidabutar, Efimah; Pasaribu, Tania Valentina; Silitonga, Melva
Invention: Journal Research and Education Studies Volume 6 Nomor 1 Maret 2025
Publisher : CV. PUSDIKRA MITRA JAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/invention.v6i1.2484

Abstract

This literature review aims to explore the spectrum of visual sensory disorders in humans, focusing on major disorders such as cataracts, glaucoma, and anisometropia. This condition is one of the leading causes of vision impairment and blindness globally, especially in developing countries. The study synthesizes findings from recent national and international scientific publications to identify the causes of preventable and unpreventable visual dysfunction. Cataracts, often associated with aging and systemic diseases, remain the most common cause of blindness but can be treated through surgical interventions such as phacoemulsification. Glaucoma, known for its asymptomatic progression, causes irreversible damage to the optic nerve and requires early detection and ongoing treatment. Anisometropia, a refractive disorder that results in different visual inputs between the eyes, poses a risk of amblyopia if not treated early. In addition, the study highlights the increasing incidence of visual impairment due to excessive use of digital devices, especially among children, emphasizing the importance of precautions such as regulated screen time and regular eye check-ups. These findings emphasize the important role of early intervention, public awareness, and access to quality eye care in reducing the burden of visual impairment. The review also underscores the need for policy and research support to improve treatment strategies and maintain visual health in the digital age.
Mekanisme Detoksifikasi: Cara Sistem Ekskresi Melindungi Tubuh dari Racun Batubara, Astrida J.A; Situmorang, Imelda; Nasution, Irma Riavael; Matanari, Ninta Dumaria; Hasanah, Niswatun; Silitonga, Melva
Invention: Journal Research and Education Studies Volume 6 Nomor 1 Maret 2025
Publisher : CV. PUSDIKRA MITRA JAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/invention.v6i1.2490

Abstract

Sistem ekskresi manusia memainkan peran krusial dalam detoksifikasi tubuh melalui mekanisme kompleks yang melibatkan organ-organ seperti ginjal, hati, dan kulit. Penelitian ini bertujuan untuk mengkaji proses detoksifikasi sistem ekskresi melalui metode studi literatur sistematis. Hasil analisis menunjukkan bahwa ginjal menyaring sekitar 180 liter darah per hari untuk mengeliminasi senyawa toksik seperti urea dan kreatinin, sementara hati melakukan detoksifikasi kimiawi melalui dua fase utama yang melibatkan enzim sitokrom P450 dan konjugasi molekul. Kulit juga berkontribusi melalui ekskresi keringat, terutama untuk logam berat. Faktor nutrisi, hidrasi, dan paparan toksin kronis secara signifikan memengaruhi efisiensi detoksifikasi. Temuan ini memiliki implikasi klinis penting, termasuk rekomendasi pemantauan rutin kadar kreatinin dan enzim hati, serta intervensi nutrisi untuk meningkatkan glutation intrahepatik. Studi ini menyoroti perlunya penelitian lebih lanjut tentang peran mikrobiota usus dan dampak penuaan pada kapasitas detoksifikasi.
Mekanisme Neuroplastisitas dalam Pembelajaran dan Pemulihan Fungsi Setelah Cedera Sistem Saraf Pusat: Tinjauan Literatur Komprehensif Purba, Greace Enita; Hutapea, Helen Veronita; Situmeang, Juwita Cristina; Nababan, Novia Christy; Saragi, Shela Estica; Silitonga, Melva
Invention: Journal Research and Education Studies Volume 6 Nomor 1 Maret 2025
Publisher : CV. PUSDIKRA MITRA JAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/invention.v6i1.2491

Abstract

Central nervous system (CNS) injuries such as stroke are a leading cause of global disability (51 million DALYs), with a prevalence in Indonesia reaching 10.9% (GBD, 2019; Riskesdas, 2018). Neuroplasticity through BDNF-dependent synaptic plasticity mechanisms (Kowianski et al., 2018) and tDCS-mediated cortical reorganization (Lefaucheur et al., 2022) offers rehabilitation solutions, but their implementation faces challenges due to genetic variability (BDNF Val66Met) and technological access disparities (Siregar et al., 2023). This article aims to: Analyze BDNF-tDCS interactions at molecular and clinical levels.Evaluate the effectiveness of tDCS based on recent evidence (2019–2024).Formulate low-cost implementation strategies for Indonesia.The methodology involves a systematic PRISMA review of 45 studies from PubMed, Scopus, and ScienceDirect. The analysis includes:  Meta-analysis of tDCS effects on motor recovery (RevMan 5.4). Policy analysis using the WHO framework for essential health technologies. Key findings indicate: BDNF levels >35 ng/mL enhance motor recovery by 2.3x (95% CI: 1.8–3.1; p<0.001). tDCS significantly improves motor function (23.5%, p<0.01), but only in BDNF Val/Val genotypes.Implementation cost: Portable tDCS protocols (Rp500,000/unit) are 90% cheaper than TMS.Integration of BDNF genotype screening, standardized tDCS protocols, and policy advocacy can optimize CNS rehabilitation in Indonesia. This study provides the first evidence-based guide combining neuroscience and health policy.
The Role of cortisol in the stress response anliana; Panguhutan Sitorus, Henry; Silitonga, Melva
International Journal of Ecophysiology Vol. 7 No. 1 (2025): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v7i1.19118

Abstract

Stress is a physiological and psychological response triggered by internal or external stressors that challenge the body's homeostasis. Cortisol, a glucocorticoid hormone released by the adrenal glands in response to stress, plays a pivotal role in modulating this response. Its primary function is to mobilize energy, regulate inflammation, and enhance cognitive processes during acute stress. While cortisol facilitates adaptation by suppressing overactive immune responses and ensuring resource availability, its prolonged elevation can lead to detrimental effects, including metabolic disorders, cardiovascular diseases, and cognitive impairments. Conversely, inadequate cortisol production disrupts the body’s ability to manage stress, resulting in conditions like fatigue, hypotension, and impaired recovery. This study explores the dynamic relationship between stress and cortisol, emphasizing how balanced cortisol levels contribute to stress resolution and homeostasis restoration. Understanding cortisol’s dual role provides insights into its potential therapeutic applications for managing stress-related disorders.
Centella asiatica: Alzheimer's Neuroprotective Wahyuni, Riska; Suriwahyuni; Saif, Annisa Hazrina; Silitonga, Melva
International Journal of Ecophysiology Vol. 7 No. 1 (2025): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v7i1.19423

Abstract

Centella asiatica (CA) in Indonesia is known as gotu kola plant which is known to have many compounds contained in it, such as Asiatic acid, madecassic acid (6-hydroxyacetic acid), asiaticoside, madecassoside, betulinic acid, thankunic acid, and isothankunic acid. This study is to determine the benefits of CA triterpenoid bioactive content and the mechanism of CA as a neuropretective against alzheimer's disease. This research used the literature study method by searching online data on various types of article publications and selected according to the PRISMA method. From the literature collected, it was found that CA has the ability as a neoroprotective against Alzheimer's disease. This is because triterpenoid compounds with the bioactive content of asiaticoside, madecid acid, and asiatic acid play a role in inhibiting the enzyme acetylcholinesterase which can act as a neuroprotective in the brain by reducing ROS production which can then restore mitochondrial dysfunction and can improve nerve function in Alzheimer's disease.
Factors Affecting The Interest Of Women Of Reproductive Age Regarding Visual Inspection Of Acetic Acid (IVA) Pardosi, Maida; Silitonga, Melva
Jurnal Penelitian Pendidikan IPA Vol 10 No 6 (2024): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i6.5326

Abstract

Reproductive health is a multidimensional state of physical, mental, and social well-being, covering all aspects of the reproductive system, functions, and processes. Cervical cancer is abnormal cell growth and development, which can lead to abnormal function of the reproductive organs and generally affects women of reproductive age, so the impact on the family is very significant. This study aims to determine the factors between the level of knowledge, access to information, and husband/family support with low Acetic Acid Visual Inspection (IVA) visits. This type of research is survey research with an analytical approach cross-sectional. The samples taken were 67 respondents obtained by the technique of purposive Sampling. The instrument used is a questionnaire. The data obtained is processed using a test Chi Square with a degree of significance (α) = 0.05. The results showed that there was a significant influence between the factors associated with the low number of IVA visits, namely the level of knowledge, access to information, and husband/family support. In the statistical test, the p-value is 0.000. The conclusions of WUS researchers who are married should always pay attention to their reproductive health, one of which is the IVA examination.
Co-Authors Abdila, Alya Nur Afdhannisa, Daffa Amanda, Putri anliana Apriliani, Indah Rizka Arda, Gladys Mutia Ashar Hasairin Ayu Putri Ningsih Ayu Wulandari Azhari, Nabilah Syahirah Batubara, Astrida J.A Binari Manurung, Binari Br Barus, Sari Apriani Daulae, Abdul Hakim Fauziyah Harahap Fitriyani, Dina Frisillia, Unikhe Ginting, Aminata Gultom, Febry Yeni Gultom, Novayanti Hariyadi, Itra Hasibuan, Hasni Periadi Hasruddin Hutapea, Helen Veronita Karinanta Sembiring, Surya Kurniawan, Rizal Eko Limbong, Forentina Lumbangaol, Adriana Yulinda Dumaria Maida Pardosi Manalu, Mentari Marpaung, Mieky Grasiaella Martina Restuati Masdiana Sinambela Matanari, Ninta Dumaria Mufti Sudibyo, Mufti Muhammad Azhari Nababan, Novia Christy Nainggolan, Junister Nasution, Irma Riavael Nasution, Marina Azzahra Naura Kamila, Aryediutami Niswatun Hasanah Nora, Putri Panguhutan Sitorus, Henry Pardede, Lastiar H Pasar Maulim Silitonga Pasaribu, Tania Valentina Patresia, Indri Pehulisa, Rensiva Ray Pranoto, Hendro Pribadi, Koko Purba, Greace Enita Rajagukguk, Nia Anggelina RISKA WAHYUNI Rosmanta Aritonang, Frince Winda Rumapea, Lusiana Ruth Susanty, Revi Saif, Annisa Hazrina Saragi, Shela Estica Selvia Dewi Pohan Selvia Selvia Sembiring, Gres Anjelia Sianturi, Stephanie Agustin Sidabutar, Efimah Sihite, Judika Adventist Maleakhi Sihotang, Wahyu Frans Sinaga, Erlintan Sinaga, Odor Debora Pita Uli Sipahutar, Feimmy Ruth Pratiwi Siregar, Suci Asda Mutia Sitohang, Mohonia Sabarito Sitohang, Odelia Nova Maria Br. Situmeang, Juwita Cristina Situmorang, Berri Situmorang, Elisa Rauli Situmorang, Imelda Situmorang, Rany Solin, Naomi Putri Chelsea Sumbayak, Mika Canthika Amelia Suriwahyuni Suryani, Cicik Syahmi Edi Tambunan, Diana Putri K Tambunan, Diana Putri Kamila Tarigan, Cania Yekholia Ujung, Siti Nuraisah A Ujung, Siti Nuraisah Asma Windah, Putri Witin, Theresia Adhellia