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Nunuk Hariani Soekamto
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Hasanuddin University, Perintis Kemerdekaan Street KM 10, Tamalanrea Makasssar, Indonesia.
Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Antibacterial Activities of Novel Xestospongienol Compounds: Potential Natural Agents Against Vibrio sp. Latifah, Lulu Adilla; Soekamto, Nunuk Hariani; Tahir, Akbar
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.101132

Abstract

The marine sponges, especially Xestospongia, belonging to the class Demospongiae, order Haplosclerida, family Petrosiidae, produce diverse bioactive secondary metabolites, which can be the source of potentially valuable marine natural products. These secondary metabolites could be used as alternative antibiotics to inhibit pathogenic bacteria Vibrio sp. This study aimed to isolate and characterize active compounds from Xestospongia testudinaria collected from Badi Island, South Sulawesi, Indonesia, and to evaluate their antibacterial potential. Research methods were evaporation, fractionation, purification, identification, and characterization of compounds using 1D and 2D NMR. Pure compounds were determined for their antibacterial activities using agar diffusion method against Vibrio harveyi M-120, Vibrio parahaemolyticus T-170, and Vibrio alginolyticus B-425. The fractionation and elucidation results presented two new compounds: xestospongienol, one of the types of brominated polyunsaturated acetylenic fatty acids (BPUFAs). The inhibition zone value of new compounds is 6.33–7.97 mm, where compound 2 showed higher activity than compound 1 against V. harveyi (7.97 mm). This study was the first report on the antibacterial activity of xestospongienol compounds against Vibrio sp., suggesting their potential as natural antibacterial agents.
Antihistamine Potential of Red Alga Acanthophora spicifera Through Combination In Vivo, In Vitro, and In Silico Study Wahyuni, Ilmi; Soekamto, Nunuk Hariani; Rasyid, Herlina; Annisa, Nurul; Adriana, Risda; Putri, Alifiah Alfaniah Alfattah; Basir, Djabal Nur; Ahmad, Ahyar; Fauziah, St.; Irfandi, Rizal
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.109199

Abstract

Red alga Acanthophora spicifera is a marine species with potential as a source of natural antihistamines. This study evaluated the bioactivity of its secondary metabolites through in vivo, in vitro, and in silico approaches. Extracts were obtained by successive maceration using n-hexane, ethyl acetate, and methanol. In vivo testing on BALB/c mice showed that extract administration did not cause significant weight loss. However, its effect on allergic symptoms was significant (p < 0.05), with the methanol extract identified as the most effective by the Mann–Whitney test. In vitro assays revealed a significant reduction in histamine levels (p < 0.05) during sensitization, treatment, and post-challenge phases, particularly in the methanol extract group. In silico docking demonstrated that two compounds from the methanol extract exhibited strong binding affinity to the H1 receptor (PDB ID: 3RZE), with binding energies of −6.27 and −5.06 kcal/mol. These findings suggest that A. spicifera, particularly its methanol extract, is a promising source of natural antihistamines with potential applications in the development of safer allergy treatments.
Co-Authors . Asmirah A.A. Ketut Agung Cahyawan W Abdul Karim Abdul Wahid Wahab Adriana, Risda Ahyar Ahmad Ahyar Ahmad Ajuk Sapar Akbar Tahir, Akbar Alfian Noor Alfian Noor Alfian Noor Alfian Noor Alfian Noor Alfian Noor Amalia, Hilda Ayu Melvi Arfah, Rugaiyah A. Artania Adnin Tri Suma Ayun Dwi Astuti Badrawati, Kadek Susi Bahrun Bahrun Beddu Jawahir Djabal Nur Basir Erwin Erwin Erwin Erwin Erwin Erwin Felycitae Ekalaya Appa Firdaus Firdaus Firdaus Firdaus Firdaus Firdaus, Firdaus Fitriyanti Jumaetri Sami Fredryk Welliam Mandey Hanapi Usman Harningsih Karim Hasnah Natsir Hasnah Natsir Ihsanul Arief Imran Imran Irfandi, Rizal Irmawan, Muhammad Jalifah Latip Kalalinggi, Septaria Yolan Kasturiasih, Ni Putu Khairunnur, Siti Kolo, La La Kalamu, La Yusran La Kolo Labanni, Arniati Lulu Adilla Latifah, Lulu Adilla Maming Maming Marry Garson Muh. Bachri Amran Muhammad Zakir Muhammad Zakir Muhammad Zakir Musa, Bulkis Musrifah Tahar Nasriadi Dali Nursiah La Nafie NURUL ANNISA Nurwijayanti Paulina Taba Payapo Irfa Apriliyanti Putri, Alifiah Alfaniah Alfattah Rasyid, Herlina Rosmawaty Rosmawaty S Siswanto Sahidin . Samriani Samriani Selfi Wullur Seniwati Dali Sernita, Sernita St. Fauziah St. Fauziah Suriani Nur Syadza Firdausiah Syadza Firdausiah Syahrir, Nur Hilal A. Syarifuddin, Syamsidar Haji Tjodi Harlim Tjodi Harlim Tjodi Harlim Tri Aryono Hadi Tri Aryono Hadi USMAN - Wahyuni, Ilmi Yana Maolana Syah Yusafir Hala Yusuf, Mohammad Taufik Zakaria Zakaria Zakaria