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All Journal Jurnal Sains dan Seni ITS Jurnal Kedokteran Brawijaya Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Reproduksi The Indonesian Biomedical Journal Universa Medicina Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Kesehatan Reproduksi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Andalas obstetrics and gynecology journal Jurnal Mnemonic Narra J Physical Therapy Journal of Indonesia Jurnal Kesehatan Masyarakat Folia Medica Indonesiana International Journal of Computing Science and Applied Mathematics-IJCSAM
Soetrisno Soetrisno
Institut Teknologi Sepuluh Nopember
Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : the indonesian biomedical journal

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Mahkota Dewa (Phaleria macrocarpa) Fruit Extract Decrease Malondialdehyde, Tumor Necrosis Factor-α, and Caspase 3 Levels May Improve Infertility in Endometriosis Mice Brahmana, Ivanna Beru; Soetrisno, Soetrisno; Purwanto, Bambang; Pamungkasari, Eti Poncorini; Wasita, Brian; Budihastuti, Uki Retno; Pangestu, Mulyoto; Cempaka, Rita; Lestariningsih, Sri; Wulandari, Eka Tri; Maesaroh, Siti
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.2736

Abstract

BACKGROUND: Endometriosis, which often causes infertility, is characterized by a complex interplay between oxidative stress, inflammatory response, and apoptosis. Currently, the most effective therapy used for endometriosis is hormonal treatments, however it has many common side effects. Therefore, it is necessary to explore alternative treatments for endometriosis, including herbal ingredients. Phaleria macrocarpa fruit contains flavonoids with strong antioxidant and anti-inflammatory properties which have potency to improve fertility in endometriosis cases. However, assessments of whether P. macrocarpa might have any effect on oxidative stress, inflammatory response, and apoptosis in relation to endometriosis are still limited. This study was conducted to identify the effect of P. macrocarpa fruit ethanol extract (PMFEE) in improving infertility by assessing oxidative stress, inflammatory response, and apoptosis parameters in endometriosis mice model.METHODS: Female Balb/C mice were endometriosis-induced, and treated either with 6.5 µg/day Letrozole, 7.5 mg/kgBW/day PMFEE, or 15 mg/kgBW/day PMFEE for 14 days. Heatlhy mice were also included as control. Mice were necropsied, then the uterus and fat tissue around the uterus was collected. Malondialdehyde (MDA) as oxidative stress marker, tumor necrosis factor (TNF)-α as inflammatory marker, and Caspase-3 as apoptosis marker were assessed using enzyme-linked immunosorbent assay (ELISA).RESULTS: In uterus, MDA and TNF-α levels were significantly different among all groups (p<0.05). PMFEE both at 7.5 and 15 mg/kgBW/day lowered MDA and TNF-α compared to the healthy mice and mice receiving Letrozol. Meanwhile, Caspase-3 levels were quite indifferent among groups, showing that PMFEE was able to maintain the Caspase-3 levels in the endometriosis-induced mice.CONCLUSION: PMFEE reduces the MDA and TNF-α, also maintains Caspase-3 levels in the uterus of endometriosis-induced mice, suggesting it might have potential to improve fertility in endometriosis mice.KEYWORDS: Phaleria macrocarpa, endometriosis, infertility, MDA, TNF-α, Caspase-3
Co-Authors Abd. Rasyid Syamsuri Adang Bachtiar Adang Muhammad Gugun, Adang Muhammad Agus Kristiyanto Ambar Mudigdo Anwar Sandi Wibowo, Anwar Sandi Asrial, An A. Bambang Eko Wiyono, Bambang Eko Bambang Purwanto Brahmana, Ivanna Beru Brian Wasita Budi, Erindra Cahyanto, Erindra Budi Didon Muhammad Trimulya Donny Irawan, Donny Dono Indarto Dwi Ratna Sulistyaningrum Eddy Tiro Eka Tri Wulandari, Eka Tri Eric Edwin Yuliantara Eti Poncorini Pamungkasari Fadhlan Septianto Eka Putra Faris, Abdul Ferry, Ferdinal Fitriana Fitriana Hari Wujoso Harsono Salimo Ida Nurwati Imam Mukhlash Isharyadi, Isharyadi Isi Bifawa’idati John Arianto Sondakh, John Arianto Kurniawan, Hendro Laqif, Abdurahman Laqif, Abdurrahman Laras Binarwati Manuel, Christian Todo Mappaware, Nasrudin Andi Mohammad Hakimi Mohammad Isa Irawan Muchsin Doewes MULYOTO PANGESTU Nasrudin, Muhamad Nizar Hero K, Nizar Hero Nugroho, Anung N. Nugroho, Muhammad Anggit Nur Shani Meida Nurinasari, Hafi Ova Emilia Pamungkasari, Eti P. Pudjiastuti, Anggit Rabrageri, Alberthzon Kris Silo Rahmah Rahmah Reviono Reviono Rifdy Fachry Risanto Siswosudarmo Risya Cilmiaty, Risya Rita Cempaka Rizanda Machmud Senyum Indrakila Setianto, Budi Y. Shahab, Muhammad Luthfi Siti Maesaroh Soerjo Hadijono Sri Lestariningsih Sri Mulyani Sri Sulistyowati Sulistyawati, Sri Sulistyawati, Sri Supriyadi H Respati Supriyadi Hari Respati Suryoningrat, Dewanto Syamsiar, Syamsiar Syetiawinanda, Amriansyah Titin J. Ambarwati Tjiang, Rubin Enhui Tonang Dwi Ardyanto Trimulya, Didon M Uki Retno Budihastuti Umar Malinta Vitri Widyaningsih Wulandari, Eka T. Yarso, Kristanto Y. Yusup Subagio Zaidah, Lailatuz Zulfa Afiq Fikriya