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All Journal Jurnal Bios Logos Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Keperawatan dan Fisioterapi (JKF) Jurnal Kesmas dan Gizi (JKG) JURNAL FARMASIMED (JFM) Jurnal Dunia Farmasi Science Midwifery Jurnal Penelitian Farmasi dan Herbal Jurnal Antara Abdimas Keperawatan Jurnal Pengmas Kestra (JPK) Jurnal Pengabdian Masyarakat Ilmu Kesehatan
Romaulianna Theresia Marbun
Institut Kesehatan Medistra Lubuk Pakam
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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A EFEKTIVITAS FORMULASI SEDIAAN SABUN MANDI PADAT EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa Bilimbi) SEBAGAI PELEMBAB KULIT Situmorang, Novidawati Boru; Monica Marpaung, Dorima; Aminah, Aminah; Marbun, Romauli Anna Teresia
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.360

Abstract

Daun belimbing wuluh dapat diformulasikan menjadi sediaan sabun mandi padat karena berdasarkan penelitian sebelumnya daun belimbing wuluh mengandung antioksidan tinggi diwakili dengan kandungan senyawa flavonoid dan saponin. Tujuan penelitian ini adalah untuk mengetahui daun belimbing wuluh dapat diformulasikan kedalam sediaan sabun mandi padat dan sediaan sabut mandi padat dari ekstrak etanol daun belimbing dapat melembabkan kulit. Penelitian ini menggunakan metode eksperimental dimana daun belimbing wuluh diekstraksi dengan metode maserasi. Pemeriksaan sediaan sabun mandi padat yang dilakukan penelitian ini adalah uji skrining fitokimia, uji iritasi dan uji kelembapan kulit dengan dibuat dengan 5 kelompok uji yaitu konsentrasi 2,5%, 3,5% dan 4,5%, control negative dan control positif ( sediaan X yang beredar dipasaran). Hasil pemeriksaan menggunakan skin analyzer sediaan dengan konsentrasi 4,5% paling tinggi melembabkan kulit yaitu 52,56% dan tidak mengiritasi kulit namun terjadi perubahan fisik setelah beberapa hari sedangkan dengan konsentrasi 3,55 melembabkan kulit 45,53% hamper setara dengan kontrol positif yang beredar dipasaran. Kesimpulan ekstrak etanol daun belimbing wuluh dapat diformulasikan menjadi sediaan sabun mandi padat dan dapat digunakan untuk melembabkan kulit.
FORMULASI SEDIAAN MASKER WAJAH MENGGUNAKAN EKSTRAK ETANOL BUNGA KECOMBRANG (ETLINGERA ELATIOR) TERHADAP KELEMBABAN KULIT WAJAH Pranata, Chandra; Boru Situmorang, Novidawati; Marbun, Romauli Anna Teresia
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.364

Abstract

ABSTRACT Skin is an essential and vital organ and a reflection of health. Natural antioxidants such as flavonoids, polyphenols and Sapponin are believed to increase moisture on the skin. This ability is the main reason for using Torch Ginger flower extract which is formulated into a form of facial mask in the form of clay facial mask. Objective: To formulate facial moisturizing mask preparations using the extract of Torch Ginger(Etlingera elatior). This study used the Torch Ginger Flower extract facial moisturizing mask formulation method with a concentration of 0 (Blank), 5% and 10%. Evaluation of mask preparations included homogeneity, stability of dosage at temperatures of 80C and 250C, Organoleptic test and pH of preparations. Measurements of skin moisture activity were measured using alar Skin Analyzer which was tested on the face surface 3cm wide. The results showed that the preparation was stable in terms of odor, color and was at a pH of 4.2-6.3 using observations of litmus discoloration. Effectiveness of facial skin moisture with 10% Torch Ginger extract concentration is more effective to produce results at a concentration of 5% and blank. Conclusion: Torch Ginger flower extract can be formulated into preparations of face masks with various concentrations and has the effect of moisturizing the skin and brightening the complexion. Keywords: Torch Ginger Flower Extract, Facial Mask, Clay Facial Mask, Facial Skin Moisture
EFEKTIVITAS KERASIONALAN PEMBERIAN ANTIDIABETIK PENGOBATAN ORAL PASIEN DIABETES MELLITUS PADA USIA 30-50 TAHUN TIPE 2 DI RAWAT INAP PENYAKIT DALAM RSUD DELI SERDANG LUBUK PAKAM TAHUN 2020 Sebayang, Loraetta Brety; Anna Teresia Marbun, Romauli; Kartika, Dewi
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.582

Abstract

Background: Diabetes Mellitus is a chronic condition, which occurs because the body cannot produce insulin, normally or insulin cannot work effectively. Objective: To determine the effectiveness of the rational administration of antidiabetic, oral treatment of diabetes mellitus patients at the age of 30-50 years type 2 in Deli Serdang Hospital, lubuk pakam in 2020. Method: This study is a non-experimental type of research using descriptive methods. Results: Shows that from 72 samples of Type II Diabetes Mellitus patients at Deli Serdang General Hospital, April-July Period 2020. With the number (52.8%) of male sex patients and the number (47.2%) of type patients female genitalia and antidiabetic drugs most widely used by patients, in the period of April-July 2020, namely (20.8%) glycionion + metformin and (20.8%) insulin drugs. the use of DM drugs with the right rational indication (65.3%), Rational with the right medicine (100%), rational with the right dosage (100%), the right rational patient (100%) and the rational way of administration (100:%). Conclusion: Evaluation of drug use is a structured quality assurance process that is carried out continuously to ensure that the drugs used are appropriate, safe, and efficient.
EVALUASI PENGGUNAAN OBAT ASAM URAT DAN POLA PERESEPANNYA PADA PASIEN GOUT ARTRITIS DI INSTALASI RAWAT INAP DI RSUD DELI SERDANG LUBUK PAKAM TAHUN 2020 Rahayu, Asvia; Anna Teresia Marbun, Romauli; Nopita Sari Manalu, Dian; Siregar, Sa’adah; Ade Rizky, Vincentia; Krisdianilo, Visensius
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.681

Abstract

Uric acid is a disease that arises due to excess purine in the body caused by uric crystals in the joint tissue that attacks the fingers, elbows, knees, toes, toes and heels. Gouty arthritis is a progressive disease caused by deposition of monosodium urate crystals (MSU) found in the joints, kidneys, and other connective tissue due to chronic hyperuricemia. The incidence of gouty arthritis is common in men as many as 25 patients (65.8%) and women as many as 13 patients (34.2%). The incidence of gouty arthritis continues to increase with age, at the age of 21-35 years (7.9%), ages 36-55 years (36.7%), age 56-65 years (28.9%), and at the age of 66 -75 years (26.3%). The purpose of this study was to examine the use of uric acid and its prescription patterns in arthritis patients in Deli Serdang Lubuk Pakam Hospital in 2020 in terms of the right parameters according to the indications, the right patients, the right drugs, and the right dosages. This research is a non-experimental study, data retrospective retrieval was done by looking at the medical record data of arthritis gout patients and analyzed descriptively. Sampling as many as 38 patients with puposive sampling method. Inclusion criteria in this study were patients who were diagnosed with gout and given arthritis medication with complete medical record data. The results of the study evaluated the use of gout and its prescribing patterns in 38 patients at Deli Serdang Lubuk Pakam Regional Hospital in 2020, which were 100% correct, 100% right, 100% right, and 96% right.
ANTIBACTERIAL ACTIVITY OF KERSEN LEAF EXTRACT (MUNTINGIA CALABURA L) AGAINST STAPHYLOCOCCUS AUREUS Kartika, Dewi; Marbun, Romauli Anna Teresia; Dewi, Ayu Puspita
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1012

Abstract

Kersen (Muntingia calabura) is a shady plant that is usually used as a shade. Cherry leaves contain several secondary metabolites such as flavonoid, tannin and terpenoid. Flavonoid can inhibit bacterial growth by denaturing proteins and damaging cell membranes and dissolving fats contained in cell walls. According to the World Health Organization as many as 25 million deaths worldwide in 2011, one third were caused by infectious diseases. One of the most common infectious diseases caused by the bacterium Staphyloccus aureus. The purpose of this study was to see whether the 96% ethanol extract of cherry leaves had antibacterial activity against Staphylococcus aureus. The concentration of the extract used was 15%, 30%, 45% and 60%. From the test results, it can be concluded that the largest inhibition zone diameter is at a concentration of 60% with an inhibition zone diameter of 6.78 mm and the smallest at a concentration of 30%, which is 0.42 mm. Concentration of 45% has (weak) activity inhibiting bacterial growth with an inhibition zone of 2.13 mm, while at a concentration of 15% it has no activity in the inhibition zone of bacterial growth.
The EVALUATION OF THE USE OF ANTI-INFLAMMATORY DRUGSIN PATIENTS RHEUMATOID ARTHRITIS OUTPATIENT AT GRANDMED HOSPITAL LUBUK PAKAM Sihombing, Yanna Rotua; Marbun, Romauli Anna Teresia; Zebua, Kristian Cahayani; Lestari, Dayana
Jurnal FARMASIMED (JFM) Vol 5 No 1 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i1.1315

Abstract

Rheumatoid arthritis is an autoimmune disease characterized by inflammation of the joints that can become chronic. Rational use of drugs aims to ensure that patients get safe and effective treatment in the right time frame and at an affordable price according to their needs In the outpatient facility of Lubuk Pakam Hospital, patients experience symptoms such as pain, inflammation, morning joint stiffness and difficulty moving at appropriate doses. This study aims to aim to obtain an objective picture or picture of the situation. Data collection was carried out retrospectively, namely by observing the medical records of rheumatoid arthritis patients at Grandmed Lubuk Pakam Hospital in 2021. A total of 13 (56.5%) female patients and 10 (56.5%) (43.5%) male patients, according to the number of rheumatoid arthritis patients at the outpatient facility of GrandMed Lubuk Pakam Hospital in 2021. This makes the inclusion criteria for all anti-inflammatory agents incomplete in rheumatoid arthritis and the exclusion criteria for all medical records in rheumatoid arthritis patients. Analysis of data based on age, gender, rationality of the drug, correct indications, correct patient, correct drug, correct dosage. The Outpatient Study of GrandMed Lubuk Pakam Hospital 2021 is: Correct Indications (100%), Correct Patients (100%), Correct Drugs (100%), Correct Dosage (91.3%). The treatment of patients with rheumatoid arthritis at GrandMed Lubuk Pakam Hospital can still be said to be fully good
TEST OF EFFECT KEDONDONG LEAF ETHANOL EXTRACT (SPONDIAS DULCIS) ON STAPHYLOCOCCUS AUREUS BACTERIA Situmorang, Novidawati Boru; Fatima, Nurdilla; Teresia Marbun, Romauli Anna; Sihombing, Yanna Rotua
Jurnal FARMASIMED (JFM) Vol 5 No 2 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i2.1541

Abstract

Bacteria that cause infection and disease are commonly found in our environment, one of which is Staphylococcus aureus bacteria. Several infectious diseases are also caused by Staphylococcus aureus, including cellulitis, acne (acne), and infection with Staphylococcal Scalded Skin Syndrome (SSSS). To determine whether the ethanol extract of kedondong leaves (EEDK) has antibacterial activity against Staphylococcus aureus bacteria. This study used a laboratory experimental method with several stages such as sample collection, identification of plants for making simplicia, phytochemical screening, extract preparation and preparation of kedondong leaf extract test solutions with various concentrations of 15%, 25%, 35% and positive control (Chloramphenicol), negative control (DMSO), and antibacterial activity testing using the paper disc method. The results of phytochemical screening of kedondong leaf simplicia (Spondias dulcis) found that kedondong leaves contain secondary metabolites such as alkaloids, flavonoids, tannins and saponins that have the potential to inhibit bacterial growth. % of 9.4 mm, 25% concentration of 13.5 mm and the greatest inhibition was at a concentration of 35% of 19.5 mm. Kedondong leaf extract has antibacterial activity against the growth of Staphylococcus aureus bacteria, with moderate to strong categories. inhibit the activity of Staphylococcus aureus bacteria is a concentration of 35%. Based on the description above, it was found that the EED with a concentration of 35% had the greatest antibacterial effect compared to the concentration of 15% and 25%. and it can be concluded that the higher the concentration of the extract used, the higher the antibacterial effect.
EVALUATION OF THE USE OF THE DRUG IN PATIENTS ACUTE RESPIRATORY TRACT INFECTION (ARI) NON PNEUMONIA AT PUSKESMAS SIGUMPAR Sihombing, Yanna Rotua; Romauli Anna teresia Marbun; Friska Novita Pasaribu; Novidawati Br Situmorang
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1630

Abstract

Acute Respiratory Infection (ARI) is one of the main causes of patient visits to health centers (40%-60%) and hospitals (15%-30%). In Indonesia the level of use of antibiotics is still quite high. The unwise use of antibiotics and the incorrect application of standard precautions in health care facilities an lead to the occurrence of resistane. This study aims to determine the evaluation of drug use in non-pneumonia Aucute Respiratory Infection (ARI) patients at the Sigumpar Health Center. This Type of research is an observational study with a descriptive design and data taken retrospectively. The total sample of 101 medical records was taken by purposive sampling technique. The patients who often suffer from non-pneumonia acute respiratory infections at the Sigumpar Health Center occur in the age group of 6-11 years, namely children by 20,79%. Based on the results of this study, the most widely used drugs were analgesic-antipyretic (69.30%), antihistamine (65.34%), vitamins (62.37%), mucolytics (48.51%), expectorants (32.67%), antibiotics (27.72%) and corticosteroids (23.76%). The use antibiotics for non-pneumonia ARI patients at the Sigumpar Health Center was 27,72% so that it was categorized as not in accordance with the provisions of the Inonesian Ministry of Health in 2017 that the use of antibiotics in non-pneumonia ARI patients was ? 20%.
Comparison Of Naso Faring And Oro Pharynx Swab Samples On Positivity Rate For Covid – 19 With The Reverse Transcription Method Pcr (Rt–Pcr) In The Lab. Rsud Pcr. City Padang Sidempuan Sihombing, Yanna Rotua; Romauli Anna Teresia Marbun; Lenni Rismayanti; Ratih Anggraeni; Octavian Ashido Nababan; Kristian Cahayani Zebua
Jurnal FARMASIMED (JFM) Vol 6 No 2 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i2.2021

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) could be a coronavirus that causes COVID-19 infection. SARS-CoV-2 is classified as an RNA infection that can cause gentle to severe respiratory diseases. Viral contaminations proceed to extend quickly, so it is critical to prevent the spread of the infection through nasopharyngeal and/or oropharyngeal swabs within the community. The point of this consider was to decide the exactness of nasopharyngeal or pharyngeal spread testing and the inspiration rate in RSUD patients. Padang Sidempuan City This think about was performed by collecting 20 nasopharyngeal swabs and 20 pharyngeal swabs from RSUD patients. City of Padang Sidempuan Infection testing was performed within the research facility by turn around transcriptase polymerase chain response (RT-PCR). Information were analyzed employing a chi-square test with p < 0.05. Judging from the nasopharynx and oropharynx positive rate comes about, the nasopharynx positive rate esteem is higher than the nasopharynx positive rate esteem, indeed in case it is the same persistent. The conclusion of this ponder is that the discovery of SARS-CoV-2 by nasopharyngeal swab will be more precise.
Effect of guazuma ulmifolia lamk. extract on interleukin-1 and interleukin-2 levels as immunomodulatory agent candidates Sihombing, Yanna Rotua; Marbun, Romauli Anna Teresia; S, Aminah.; Siska, Fitri
Science Midwifery Vol 12 No 4 (2024): October: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i4.1714

Abstract

The incidence of infections that attack the body's immunity is a major problem in various Country. In 2019, Indonesia was shocked by the occurrence of Coronavirus infection that requires an immediate therapeutic approach. The infection attacks the body's immunity in biological and physiologically there are defense mechanisms that can protect body. Indonesia has abundant biodiversity and become an opportunity in the exploration of natural medicinal ingredients. Guazuma ulmifolia Lamk. is a type of plant and a parasite that is widely found in the highlands and is widely found in Janji Maria Village, North Tapanuli Regency Traditionally, it used for overweight, cholesterol, cancer therapy by boiling and drink it. This study purpose to analyze the activity of extract on IL-1 and IL-2 levels using male rats as test animals by the enzyme-linked immunosorbent assay. The method used is experimentally by measuring IL-1 and IL-2 levels in serum isolated from blood rats that have been given Guazuma ulmifolia Lamk. extract. Guazuma ulmifolia Lamk. extract at doses of 50, 100, 200, and 400 mg/kgBW and quercetin as a marker agent. The levels of IL-1 and IL-2 also increased following treatment with Guazuma ulmifolia Lamk. Extract and quercetin in both groups as compared to the negative control group. The extract at dose of 400 mg/kg BW and quercetin showed higher immunostimulatory activity than levamisole as a positive control. It was concluded that Guazuma ulmifolia Lamk. exhibit immunomodulatory activity, acting as immunostimulatory agent and has potential to be developed as a therapeutic agent.
Co-Authors *, Yanna Rotua Sihombing Aminah Aminah Aminah Syarifudin Aritonang, Barita AROFATUL HIDAYAH Br Situmorang, Novidawati Cahya, Cucu Arum Dwi Dalimunthe, Juliana Dewi Kartika Dewi Kartika Dewi, Ayu Puspita Dicky Yuswardi Wiratma Elliya Siswanti Fatima, Nurdilla Friska Novita Pasaribu Harahap, Hasni Yaturramadhan Imelda Oktaviani Br Sihombing Juniaro Virgilius Dakhi Karmayanti Karokaro, Tati Murni Klara Jeina Br Tarigan Koto, Rahmadona Krisdianilo, Visensius Kristian Cahayani Zebua Kristian Cahayani Zebua Lenni Rismayanti Lestari, Dayana Loraetta Brety Sebayang Lubis, Amelia Hasana Lubis, Basyariah Lulu Atikah Maharani, Anisa Mega Silalahi Meirizal Jefrinaldi Meirizal Jefrinaldi Monica Marpaung, Dorima Montysory Silalahi Munthe, Novita Br Ginting Nainggolan, Hotdoriska Naro Ida Sari G. Manihuruk Nopita Sari Manalu, Dian Novidawati Boru Situmorang Novidawati Br Situmorang Novidawati Br Situmorang Novidawati Situmorang Novita Ginting Munthe Novitasari Sihaloho Octavian Ashido Nababan Octora, Debi Dinha Parinduri, Anggi Isnani Pranata, Chandra Purba, Novandi Putri, Puji Audina Radika Bella Fista Ginting Rahayu, Asvia Ratih Anggraeni Ratih anggraeni Ratih Anggraeni Ratih Anggraeni S, Aminah. SAADAH SIREGAR Sebayang, Loraetta Brety Siagian, Hartika Samgryce Sihombing, Yanna Sihombing, Yanna Rotua Sinaga, Falentina Sinurat, Jhon Patar Siregar, Sa’adah Siska, Fitri Siti Wahyuni Situmorang, Novidawati Br Sri Wahyuni Syarifuddin, Aminah Nur Syarifuddin, Shofian Vincentia Ade Rizky Yanna Rotua Sihombing Zantrie, Rezky Zebua, Kristian Cahayani