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All Journal Medicina E-Jurnal Medika Udayana Jurnal Veteriner e-CliniC Medical Journal of Indonesia The Indonesian Biomedical Journal JBN (Jurnal Bedah Nasional) ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Patologi Indonesia Jurnal Respirasi (JR) Neurologico Spinale Medico Chirurgico Jurnal Kedokteran Universitas Palangka Raya Indonesian Journal of Cancer Journal of Global Pharma Technology
Ni Putu Sriwidyani
Departemen Patologi Anatomi Fakultas Kedokteran Universitas Udayana
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Giant Cell Lung Carcinoma: A Case Report of a Rare Histology Type of Non-Small Cell Lung Cancer Putri, Kadek Sri Adi; Kusumawardani, Ida Ayu Jasminarti Dwi; Sriwidyani, Ni Putu; Komalasari, Ni Luh Gede Yoni
Jurnal Respirasi Vol. 10 No. 2 (2024): May 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.2.2024.143-148

Abstract

Introduction: Giant cell carcinoma (GCC) of the lung is a subtype of lung cancer, undifferentiated non-small cell carcinoma, in which there are no features of small cell carcinoma, adenocarcinoma, or squamous cell carcinoma. Due to its aggressive clinical manifestations and peculiar pathological features, GCC of the lung is a highly anaplastic variant of bronchogenic carcinoma. Case: A 45-year-old woman was clinically suspected of having a lung malignancy, and a biopsy of the right lower lobe pleura and parietal pleura was performed. The histopathology showed hypercellular tumor cell clusters, forming a syncytia-like sheet pattern. Tumor cells were pleomorphic and contained many giant cells that confirmed the diagnosis of GCC. The patient was diagnosed with GCC of the lung, stage IVB, Karnofsky scores 50-60% with malignant pleural effusion, peritoneal metastases, bone metastases, and grade 3 malignant ascites with bacterial peritonitis. The patient passed away due to septic shock caused by bacterial peritonitis. GCC of the lung is one of the aggressive types of lung cancer. GCC has an unusual tendency to metastasize to the gastrointestinal tract. In this case, the patient had an enlarged abdomen since it was known that she had a malignancy that had continued to grow. From the ascitic fluid analysis, a carcinoma was found to be seeding. Conclusion: The prognosis of GCC of the lung is generally poor. Our case was diagnosed with GCC of the lung that had already spread to the bone, peritoneal, and had grade ascites. The patient's survival rate was generally poor, and she passed away due to bacterial peritonitis without having received any therapy for her cancer.
Co-Authors Anak Agung Ayu Ngurah Susraini Angelia Ongko Prabowo annie minerva datui Astuti, Ida Ayu Jelantik Bintang Dwi Oktaviani Cahyani, Kadek Cindy Dwi Citra, Dandy Damayanti, Ni Kadek Ayu Maya Desak Made Cittarasmi Saraswati Seputra Dewi, Ida Ayu Krisna Cantika Dewi, Ida Ayu Meilasari Dewi, Ni Putu Wulan Tantri Diahningrum, Sylvi Handoko, Jovi Carina Henky, . Herlina Eka Shinta Herman Saputra Herman Saputra Herman Saputra Herman Saputra Herman Saputra Herman Saputra Herman Saputra I Dewa Ayu Inten Primayanti I Gde Raka Widiana I Gede Indradika Pratama Putra I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Sri Mahendra Dewi I Gusti Kamasan I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Kade Mahardika I Gusti Ngurah Made Cesar Vajrashrava Sunantara I Gusti Ngurah Mayun I Gusti Ngurah Pratama Yuda Atmaja I Gusti Nyoman Sri Wiryawan I Kadek Yana Parastuta I Ketut Bawantika Adi Putra I Made Gotra I Made Jawi I Made Muliarta I MADE MULIARTA . I W. Sudarsa I Wayan Juli Sumadi I Wayan Niryana I Wayan Putu Sutirta Yasa I Wayan Sugiritama Ida Ayu Jasminarti Dwi Kusumawardani Ida Ayu, Priandini Iin Indrayani Maker, Luh Putu Ivana Juliarty Sitanggang Kadek Dwi Pradnyawati Kandy Rosa Ismalia Katrin Rotua Simbolon Ketut Mulyadi Komang Chandra Surya Dika Limantoro, Joshua Lisanthoni, Johnathan Luh Ayu Widayanti Luh Ayu Widayanti Luh Komang Ayu Widhiaty Karang Luh Putu Iin Indrayani Maker Luh Yeni Laksmini M. Arif Perdana Ariyansyah Made Agus Cahya Nugraha Koriawan Maker, Luh Putu Iin Indrayani Manuaba, Ida Bagus Tjakra Wibawa Moestikaningsih . Nariswari, Ida Ayu Ista Nathaniela, Jocelin Ni Gusti Ayu Agung Manik Yuniawaty Wetan Ni Kadek Ayu Maya Damayanti Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Ni Made Adi Tarini Ni Made Mahastuti Ni Putu Ekawati Ni Wayan Candrawati Ni Wayan Winarti Nornazirah Binti Azizan Popi Imelda Margareth Sitompul Pramitasuri, Tjokorda Istri Putra, Putu Krishna B. S. Putri, Kadek Sri Adi Putu Ayu Widya Pramesti Putu Erika Paskarani Putu Febry Krisna Pertiwi Putu Julia Chandra Devi Raka-Sudewi A. A. Sang Ayu Putu Yuliantini Setiawan, I Gede Budhi Silvia Nuhyil Indriani Sinaga, Naomi Juliana Sri Mahendra Dewi, I Gusti Ayu Suastini, Kadek Denik Sumadi, I Wayan J. Suryawisesa, Ida Bagus Made Susilawathi, Ni Made tanaka, Tanaka Tjandra Kristiana Volman Tampubolon Wetan, Ni Gusti Ayu Agung Manik Yuniawaty Wilananda, Ida Bagus Ardya Kurnia Wimpie I Pangkahila Winari, Ni Wayan Yasa, I Nyoman Wawan Tirtha