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Journal : eJournal Kedokteran Indonesia

The Expression of LFA-1, MMP-9, and Dicer1 in The Histological Grading of Colorectal Cancer Wahyuniari, Ida Ayu Ika; Sumadi, I Wayan Juli; Darwinata, Agus Eka; Linawati, Ni Made; Ratnayanti, I Gusti Ayu Dewi; Sugiritama, I Wayan; Wiryawan, I Gusti Nyoman Sri; Komalasari, Ni Luh Gede Yoni; Arijana, I Gusti Kamasan Nyoman; Ganesha, I Gde Haryo
eJournal Kedokteran Indonesia Vol. 13 No. 2 (2025): Vol 13, No. 2 - Agustus 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1076.1

Abstract

Colorectal cancer (CRC) remains one of the most common cancers in many Asian countries, alongside lung and breast cancer. Tumor dissemination to the organs, particularly the liver, contributed to the mortality of this disease. The β2 subunit of lymphocyte function-associated antigen-1 (LFA-1) was revealed to cause impairments in liver endothelial activation, cytokines release, and tumor cell retention in the liver of CRC in the in vivo study. Epigenetic and matrix metalloproteinase (MMP)-9 are essential for CRC progression and poor prognosis. Tumor differentiation grade correlates with TNM staging, prognostic factors, patient survival, and lymph node metastasis. This study aimed to investigate the expression of the β2 subunit of LFA-1, MMP-9, and Dicer1 in the histological grading of CRC. A total of 38 formalin-fixed paraffin-embedded (FFPE) CRC samples were classified into low-grade, high-grade, and histology variants. Tissue samples were processed for qRT-PCR to examine the β2 subunit of LFA-1 expression and immunohistological staining to evaluate Dicer1 and MMP-9 expression. The results show that the expression of LFA-1 was significantly higher in high-grade compared to low-grade (p<0.05), except for mucinous type adenocarcinoma. In contrast, no significant difference was found in Dicer1 and MMP-9 expressions of all grades of CRC (p>0.05). In addition, no significant correlation (p>0.05) was found between Dicer1 expression and LFA-1 and MMP-9. In conclusion, the expression of LFA-1 is upregulated in high-grade tumors; however, Dicer1 and MMP-9 expressions are not correlated with the histological grade.
Co-Authors Agus Eka Darwinata Alifia Dwi Lestari Anak Agung Gede Eka Septian Utama Arcana N Ari Wibawa Ari Wibawa Aria Wibawa Arijana, I G Kamasan Nyoman Arijana, I Gusti Nyoman Kamasan Arijana, IGK Nyoman Bella Aulya Safitri Desak Ketut Ernawati Desak Putu Citra Udiyani Dewa Ayu Agus Sri Laksmi Dewi, Anak Ayu Nyoman Trisna Narta Dewi, Ni Made Gita Kusuma Dyta Putri Aryo Eswariy Chandramogan Etik Nurhidayati Eugenia Meidy Fedik Abdul Ratam Ferbian M. Siswanto, Ferbian M. Fitrotul Imaniyah Gabrielle, Gabrielle Gayathiri Mohana Krishnan Gede Parta Kinandana Gede Wirata Gusti Ngurah Mayun Hernowo, Elliana Freya I Dewa Ayu Eka Widiari Putri I Dewa Ayu Inten Primayanti I Dewa Gede Angga Triadi Nata I Gde Haryo Ganesha I Gusti Ayu Dewi Ratnayanthi I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Dwita Wahyu Laksmi I Gusti Kamasan I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Mayun I Gusti Nyoman Sri Wiryawan I Gusti Nyoman Sri Wiryawan I Made Jawi I Made Krisna Dinata I MADE MULIARTA . I Made Niko Winaya I Made Sudarmaja I Nyoman Adi Putra I Nyoman Gede Wardana I Nyoman Wande I Putu Adi Merta I Putu Adiartha Griadhi I Putu Bayu Mayura, I Putu Bayu I Putu Dema Prasetya I Wayan Juli Sumadi I. G. A. D. Ratnayanthi Ida Ayu Dewi Wiryanthini Ida Ayu Ika Wahyuniari IGN Iswarabhuwana WP Indira Vidiari Juhanna Intan Syahirah Bt Abdul Rauap Jessica Yuwono Joshua Ezra Ronaldo Bayak Kadek Ady Antara Kenjiro, Eduardo Komang Dhyanayuda P. Komang Jegek Triangga Apsari Linawati N.M Linawati, Ni M. Linawati, NM Luh Putu Ratna Sundari M Widnyana Made Dwi Indah Permatahati Gita Made Hendra Satria Nugraha Made Tami Budirejeki Mahen Isaac Pannir Chelvam Masnathasari, NM Ayu Maulidya, Maulidya Mayun G.N Melita Soares Cristovao N. M. Linawati Negara, Anak Agung Gede Angga Puspa Ni Kadek Mira Wirayani Ni Komang Tristiana Dewi Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Ni Luh Nopi Andayani Ni Luh Nopi Andayani, Ni Luh Nopi Ni Made Deni Purnama Ni Made Linawati Ni Made Mertaniasih Ni Made Rininta Adi Putri Ni Nyoman Mekar Sari Ni Nyoman Sri Budayanti Ni Putu Candra Paramita Ni Putu Junika Putri Ni Putu Sriwidyani Nila Wahyuni Norshazreen Nazri Nuril Hidayah Pangkahila, Elionardo Putra, I Putu Yudi Pramana Putri Miucin Raditya Pradipta Rahcmanita, Dhila Cahya Rastika, I Gede Agus Ratnayanthi, I Gusti Ayu Dewi Ratnayanti, Gusti Ayu Dewi Regina, Ni Kadek Pramesti Ruthirar Kalaichelvam Santoso, Natania Faustine Saraswati, Ni Luh Putu Gita Karunia Saraswati, Putu Ayu Sita Susilo, Yunike Trisna Damayanti Vania Lannisa Haestidyatami Widianti, I Gusti Ayu Widianti, IGA Wona, Yohana Virani Wong, Ferdinand Yogarani V.C Rajappan Zahra, Fahdia Fitrianti