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All Journal Jurnal Hukum Khaira Ummah Cakrawala Pendidikan Jurnal Kependidikan: Penelitian Inovasi Pembelajaran Jurnal Penelitian dan Evaluasi Pendidikan Pedagogi: Jurnal Ilmu Pendidikan J-Simbol: Jurnal Magister Pendidikan Bahasa dan Sastra Indonesia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Kesehatan Information Management For Educators And Professionals (IMBI) Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Lentera: Jurnal Ilmiah Kependidikan KEUDA : JURNAL KAJIAN EKONOMI DAN KEUANGAN DAERAH Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan JURNAL PANGAN Agritech: Jurnal Fakultas Pertanian Universitas Muhammadiyah Purwokerto Faktor Jurnal Ilmiah Kependidikan Jurnal Doktor Manajemen (JDM) BioEksakta : Jurnal Ilmiah Biologi Unsoed Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Triton Borobudur EKONOMIKA45 Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal An-Nufus VIGOR: JURNAL ILMU PERTANIAN TROPIKA DAN SUBTROPIKA Journal of Social Empowerment Widyaparwa Scholarly Journal of Elementary School CKI On Spot Jurnal Teknologi Industri Jurnal Pedagogi Matematika JIIS Journal of Fundamental Management (JFM) International Journal of Education, Vocational and Social Science Jurnal Penelitian Pendidikan

Sugiyono Sugiyono

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Author-ID : 388997

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Peluang Aplikasi Mikroenkapsulat Vitamin A Dan Zat Besi Sebagai Fortifikan (The Chance of Aplication Microencapsulat Vitamin A and Iron as Fortificants) Sugiyono Sugiyono; Windi Asterini; Endang Prangdimurti
JURNAL PANGAN Vol. 25 No. 1 (2016): PANGAN
Publisher : Perum BULOG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33964/jp.v25i1.306

Vitamin A dan zat besi termasuk salah satu zat gizi mikro yang dibutuhkan oleh tubuh. Kekurangan asupan dan absorbsi zat gizi mikro dapat mengakibatkan gangguan pada kesehatan, pertumbuhan, dan fungsi lainnya di dalam tubuh. Program fortifikasi merupakan salah satu cara yang dilakukan oleh pemerintah untuk mengatasi masalah defisiensi vitamin A dan zat besi. Kedua mikronutrien ini sering digunakan menjadi fortifikan akan tetapi masing-masing senyawa ini memiliki reaksi negatif di dalam bahan pangan. Vitamin A merupakan senyawa yang rentan terhadap suhu tinggi, cahaya dan udara (oksigen), sedangkan zat besi dapat menghasilkan efek negatif pada sensori (bau dan warna) pangan fortifikasi. Perlindungan fortifikan dari pengaruh lingkungan sangat diperlukan untuk mendukung keberhasilan program fortifikasi. Salah satu caranya ialah dengan menggunakan teknologi enkapsulasi. Berbagai penelitian menunjukkan bahwa fortifikasi dengan menggunakan teknik mikroenkapsulasi menghasilkan fortifikasi yang lebih stabil, tidak merubah bahan pangan pembawa fortifikan secara fisik dan kimia. Oleh karena itu pembuatan mikroenkapsulasi fortifikan dinilai lebih efisien dan efektif dalam mengatasi masalah defisiensi zat gizi mikro.Vitamin A and iron are essential micronutrients needed by the body. Deficiency of intake and absorption of micronutrients can lead to disturbances in health, growth and other functions in the body. Fortification is one of the government programs to cope with the deficiency of vitamin A and iron. Both compounds are often used as fortificants, but their present promotes undesirable reaction in foodstuffs. Vitamin A is susceptible to high temperature, light and air (oxygen), while iron can result in detrimental effects on the color and smell. Therefore, the protection of fortificants against environmental effect in food system is highly required, and encapsulation is a promising technique. Previous studies showed that microencapsulation technique produced more stable compounds and unchanged chemical and physical characteristics of fortified food. For this reason, microencapsulation in fortified food is considered as efficient and effective way in addressing micronutrient deficiencies.

UJI PERBEDAAN MEDIA DAN KONSENTRASI BAP TERHADAP PERTUMBUHAN TUNAS PISANG RAJA SECARA KULTUR IN VITRO Lucky Prayoga; Sugiyono Sugiyono
Agritech: Jurnal Fakultas Pertanian Universitas Muhammadiyah Purwokerto Vol 12, No 2 (2010): AGRITECH
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/agritech.v12i2.990

A research with aims of obtaining which better between MS and Gamborg (B5) as the media in raja banana in vitro culture and knowing how much BAP needed in order to gain a most optimal growth of raja banana in in vitro culture. The research has been done in Plant Physiology Laboratory Biology Faculty General Soedirman University from April up to July 2010. Completely Randomized Design has been used with split plot design. As the main plot were media; i.e. MS media (M1) and Gamborg (B5) media (M2). As the sub plot were BAP concentration (K); consist of K0: 0 2M, K1: 5 2M, K2: 10 2M, K3: 15 2M, K4: 20 2M and K5: 25 2M. Each treatment repeated three times and each repeating treatments consist of three sub-samples. It could be concluded from the result that raja banana in vitro culture might be done in MS or Gamborg (B5) media. The best concentration of BAP in stimulating the forming and the growth of raja banana shoots in in vitro culture was 15 2M. Key words : BAP, Gamborg (B5) medium, MS medium, Raja banana shoot raja

Respon beberapa Varietas Padi terhadap Stress Garam Sugiyono Sugiyono; Siti Samiyarsih
Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Vol 22, No 2 (2005)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mib.2005.22.2.93

A study on the Responses of Several Rice Varieties toward Salt Stress has been carried out with a view to: 1) study the effect of salt stress on the physiological and anatomical responses of several rice varieties; 2) determine salt tolerant rice variety(ies). Research results showed that there were both physiological and anatomical changes on salt-stressed rice. Those changes were determined by the level of salt concentration given. The higher the concentration the more obvious the changes appeared. There was a dramatic decrease in the total chlorophyll content of the salt-stressed leaf, coupled by a sharp decrease in the chlorophyll a/b ratio. Salt stress also resulted in the decrease in mesophyll thickness, and in turn leads to the decrease of leaf’s length and width. In general, salt stress resulted in the decrease of plant growth, as indicated by the decrease of plant’s fresh and dry weights, eventual plant’s death was therefore imminent. The rice varieties used were sensitive to salt stress since an exposure of 50 mM NaCl has already resulted in the interference of rice growth.

Pengaruh Pemberian Sitokinin Terhadap Pertumbuhan Palea dan Lemma Padi Melaui Kultur In Vitro Kamsinah Kamsinah; Triani Hardiyati; Sugiyono Sugiyono
Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Vol 26, No 2 (2009)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mib.2009.26.2.117

A research has been carried out with the aims to: 1. study the influence of both the kind and concentration of cytokinins on palea and lemma growth in in vitro culture; 2. study the influence of palea and lemma age towards external application of cytokinin in in vitro culture; and3. determine the best palea-lemma age, kind and concentration of cytokinin which resulted the best growth of palea and lemma in in vitro culture. The used experimental method was Completely Randomised Design (CRD) with factorial treatment pattern. The applied treatment consisted of three factors i.e. palea-lemma age (U): (55, 60, and 65 days after planting); kind of cytokinin (S): (BAP and Kinetin); and Cytokinin Concentration (K): (0, 5, 10, and 15 M) with 3 replications. The observed variables were the palea and lemma growth with the parameters were palea-lemma length and width. The results showed that the kind of cytokinin had influenced the growth of palea-lemma in in vitro culture, and kinetin has better influence on the palea-lemma growth. The age of the palea-lemma determined the responsiveness of the palea-lemma towards external application of cytokinin. Older palea-lemma showed less responsive than younger ones towards external application of plant growth regulators. Moreover, the treatment combination (U1S2K2) (10 µM Kinetin applied to 55-day-old rice palea-lemma) had the best effect on increasing the size of palea-lemma of IR 64 rice.

FORMULASI TABLET HISAP EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocotum Ruiz & Pav.) DENGAN PEMANIS SORBITOL-LAKTOSA-ASPARTAM Akhmad Jazuli; Yulias Ninik Windriyati; Sugiyono Sugiyono
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

ABSTRAK Sirih merah (Piper crocotum Ruiz & Pav.) adalah salah satu tanaman obat yang biasa digunakan untuk mengobati penyakit diantaranya batuk. Untuk memudahkan penggunaan maka dibuat dalam bentuk sediaan tablet hisap. Penelitian ini bertujuan untuk mengetahui sifat fisik tablet hisap ekstrak etanol daun sirih merah dengan pemanis sorbitol-laktosa-aspartam dan respon rasanya. Ekstrak daun sirih merah diperoleh secara perkolasi dengan penyari etanol 70%. Tablet hisap dibuat dengan metode granulasi basah dengan 5 formula yang mengandung pemanis sorbitol-laktosa sebagai fase internal yakni : FI (0%-82%), F II (20,5%-61,5%), F III (41%-41%), F IV (61,5%-20,5%), F V (82%-0%) dan aspartam sebagai fase eksternal sebanyak 10%. Granul diuji sifat fisiknya meliputi kecepatan alir, sudut diam, dan kompresibilitas. Tablet hisap diuji sifat fisiknya meliputi keseragaman bobot, kekerasan, kerapuhan, waktu melarut dan uji tanggapan rasa. Data tersebut dibandingkan dengan Farmakope Indonesia dan pustaka lainnya. Selain itu data sifat fisik tablet dianalisis secara statistik menggunakan uji Kruskal Wallis, dilanjutkan uji Mann Whitney dengan taraf kepercayaan 95%. Uji tanggapan rasa dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa penggunaan pemanis sorbitol-laktosa-aspartam menghasilkan tablet hisap yang memenuhi persyaratan sifat fisik tablet. Formula V dengan sorbitol-laktosa (82%-0%) dan aspartam 10% dapat diterima oleh 90% responden. Kata kunci : Ekstrak Etanol Daun Sirih Merah, Sorbitol-laktosa-aspartam, Tablet hisap,.

PERBANDINGAN DISOLUSI ASAM MEFENAMAT DALAM SISTEM DISPERSI PADAT DENGAN PEG 6000 DAN PVP yulias ninik; sugiyono sugiyono; widhi astuti; maria faizatul
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.1 JUNI 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Mefenamic acid is an analgetic that insoluble in water, therefore several approaches are required to improve the dissolution and bioavailability. The aim of this research is to know the dissolution of mefenamic acid in solid dispersion system with PEG 6000 and PVP. Solid dispersion of mefenamic acid-PEG 6000 were prepared by fusion method and mefenamic acid-PVP by solvent evaporation method with contain PEG 6000 or PVP for FI (20%), FII (40%), FIII(60%), FIV (80%) and FV (100%) respectively were compared with the weight of mefenamic acid. The powder of solid dispersion systems were investigated for its recovery and dissolution in medium fosfat buffer pH 7.4 until 60 minutes. Pure mefenamic acid and the physical mixture with polimer were used as compared powders. The result of dissolution testing were revealed by Dissolution Efficiency (DE60). The result showed that both PEG 6000 and PVP can increased the dissolution of mefenamic acid from solid dispersion systems. The DE60 of mefenamic acid-PEG 6000 from FI 38,81%; FII 51,05%; FIII 62,87%; FIV 75,63%; FV 87,03%; and the physical mixture of FV 58,84% respectively. Meanwhile the DE60 mefenamic acid-PVP from FI 26,76%; FII 37,78%; FIII 45,23%; FIV 62,41%; FV 82,71%; and the physical mixture of FV 26,44% respectively. Keywords : mefenamic acid, PEG 6000, PVP, solid dispersion, dissolution

PENGARUH VARIASI KADAR GETAH SAGU (Metroxylon sagus Rottb) SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIK DAN PELEPASAN TABLET DEXAMETHASON sugiyono sugiyono; Irawan Sukma
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Sago resin is the exudat from the plant sago (Metroxylon sagus Rottb.) from of gels and substances classified as anionic polysaccharides, colloidal nature with consistency and power of adhesive material resembling, it can be used as a binder tablets. This study aims to determine the effect of differences levels of sago resin variation as the ingredient binder dexamethason tablet the physical properties and release. Sago resin comes from the plant of sago then filtered (cleaned of impurities), blended into a fine powder to the next level with mucilago made FI (1%); FII (3%); FIII (5%); FIV (7%) and FV (10%). The sago resin mucilago is used a binder in the manufacture of granule with wet granulation method. The physical properties tested of the granule include flow time, repose of angle and compresibility. Tablets obtained its physical an chemical properties of the tested include uniformity of weight, hardness, friability, disintegration time, disolution and determination of concentration the active substances. The data obtained analyzed by comparing the theoretical approach with the relevant literature and statistically analyzed using corellation regretion alalyzed with a level of 95% The results obtained showed that the granules and tablets of all formulas meet the requirements of physical and chemical properties of a good tablet. The addition concentration of the sago resin as a binder causes the tablet hardness and disintegration time there is a significant difference between the formulas, while the release of the active substance and content uniformity tablets is not influenced by the increase in the concentration of sago resin. Keywords: Sap Sago, Wet Granulation, Dexamethason Tablet

PENGARUH VARIASI KADAR AMILUM GARUT (Maranta arundinaceae Linn) SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIK DAN KIMIA TABLET PARASETAMOL Sugiyono Sugiyono; Pipit Murdiyani; Yulias Ninik Windriyati
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Starch had a characteristic that could be used as a binder. Arrowroot starch containing amylose and amylopectin which could be used as a binder. Paracetamol had the flow properties and compactibility badly, it was necessary to make granules by wet granulation method (Voigt, 1984). This study aimed to determine the influence of variations in levels of arrowroot starch as a binder to the physical and chemical properties of paracetamol tablets. This research was conducted by mixing paracetamol with mucilago amylum arrowroot (FI: 5%, FII: 7.5%, FIII: 10%, FIV: 12.5%, and FV: 15%) and were given lactose, sifted, and dried. Granules sifted back, plus primogel and magnesium stearate. Mixed granules tested flow rate, rupose angle and tapping index . The granules was then into tablet and then their physical properties were observed, including weight uniformity, hardness, brittleness, and dissolving time.The active substance content was decided based on Farmakope Indonesia Edisi III. The data gathered were then analyzed theoretically by comparing then against what were stated in the literature and statistic cally tested by using one way ANAVA with a confidence degree of 95%, which was then furthered by using the Tuckey test. The result that the starch contained in the arrowroot could be used as a paracetamol tablet binder. Tablets of all formulas met the requirements of a good tablet physical properties. Hardness and tablet disintegration time increased with increasing levels of arrowroot starch as binder, while the fragility of the tablet decreased. Key words: arrowroot amylum, binder, Tablet parasetamol

ANALISIS KANDUNGAN BORAKS SEBAGAI BORON PADA GENDAR YANG DIPRODUKSI OLEH INDUSTRI RUMAH TANGGA DI DAERAH AMBARAWA sugiyono sugiyono; siti musinah; rukhanah rukhanah
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 6 NO. 1 JUNI 2009
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTGendar is a type of food produced by adding bleng, which is a chemical compound containing borax asboros. This research was intended to find out (1) the borax contents in the gendar taken from Ambarawa areas and(2) whether there were significant differences in borax levels contained in fresh gendar, dry gendar, gendar fried infresh vegetable oil and gendar fried in used vegetable oil.This was a non-experimental research with the data analyzed descriptively and analytically. The variablesmeasured were borax levels, acting is boros, contained in fresh gendar, dry gendar, gendar fried in fresh vegetableoil and gendar fried in used vegetable oil. The samples for this research were taken randomly from three householdindustried of gendar in Ambarawa areas. The contents of borax were measured using spectrophotometri UV-Vis.The analyses on the borax content in the four types of gendars (fresh gendar, dry gendar, gendar fried in freshvegetable oil and gendar fried in used vegetable oil) used Kruskall-Wallis non-parametric statistical tests followedby Mann-Whitney tests.The analyses showed that all of the four types of gendars really contained borax, as boros, but in diffirentlevels among the diffirent gendars borax contents in the four different gendars taken from Bandungan andSumowono had significant values 0,182 and 0,643 respectively (P > 0,05), contents in the four different gendarstaken from Ambarawa areas also had a significant value of 0,004 (P < 0,05), meaning also that there werestatistically significant differences in the borax contents.Keywords : Borax, Gendar, Spectrophotometri UV-Vis.

PENGARUH PENGGUNAAN AMILUM BIJI DURIAN (Durio Zibethinus L.) SEBAGAI BAHAN PENGHANCUR YANG DITAMBAHKAN SECARA INTERNAL-EKSTERNAL TERHADAP SIFAT FISIK DAN KIMIA TABLET IBUPROFEN Sugiyono Sugiyono; Hilda Shofia Afriliana; Yulias Ninik Windriati
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Keyword : durian seeds amylum, disintegrant, ibuprofen tablets. Amylum is a polysaccharide inside plant that was saved as a food reserves in fruit seed. One of the amylum contents is amylose, essentially insoluble in cold water but can absorb large amount of water and expand, so it can be used as a disintegrant of tablets. The aim of this research is to find out the influence of the used of durian seeds amylum as a disintegrant that be added internally-externally toward the physical and chemical properties of ibuprofen tablets.Ibuprofen tablets were prepared by wet granulation method, with levels of amylum as a disintegrant were 10% which added the intragranular-extragranular with a ratio of FI (100%:0%), FII (75%:25%), FIII (50%:50%), FIV (25%:75%), FV (0%:100%). Dried granules obtained were then tested its physical properties include flow rate, angle of repose, and compressibility. Tablets were tested in terms of physical and chemical tablets properties include weight uniformity, hardness, friability, disintegration time and active substance content of tablets. Data obtained were analyzed with a theoretical approach that is done by comparing the statistical literature and that is one way ANAVA analysis with 95% confidence level, followed by a Tuckey test.The result obtained shows that all formulation complied with the requirement of good physical and chemical properties of tablet. The added of durian seeds amylum as a tablets disintegrant with internally-externally method causes difference the physical properties of disintegration time ibuprofen tablets in significant, while at hardness and friability there is no difference in significant.

Co-Authors Abdul Rokhman Abdul Rolhim Achmad Noe'man Adolf Z. D. Siahay Afid Burhanuddin Agoes Hendriyanto Agustin Hanivia Cindy Akhmad Jazuli Alifya Asmiasti Anggun Novita Sihite Ani Kusniawati Areha Binar Febrinesa Arief Prabowo Brainadi Widjojo Arpi Pratama Bambang Hariyanto Bambang Haryanto Diah Hapsari Widyarini Diini Fitriani Doni Ahmad Saefuddin Dwi Susilo Rini Eka Danik Prahastiwi Eko Hari Purnomo Elvira Syamsir Endang Mulyati Ningsih Endang Prangdimurti Eny Ariyanto Etrya Narawati Fashihullisan M. Fitriani Fitriani Ghosa Kurnia Fistika Hadi Nugroho Hidayatul Istiqomah Hilda Shofia Afriliana Hoerip Satyagraha Husaini Usman I Gusti Putu Adi Palguna Irawan Sukma Ismiarti Ismiarti Isnaeni, Diyan Johan Oscar Ong Joko Sutrisno Kamsinah Kamsinah Khaerul Wahidin Khoirul Qudsiyah Kristiyanto, Yogi Lia Yulianasari Lies Sunarliawati Lina Erviana Lucky Prayoga Lutfia Afifatul Ainiyah Lutfia Afifatul Ainiyah M Fashihullisan M Fatchur Rochman maria faizatul Masyudzulhak Djamil MZ Mira Suminar Muhamad Solkhan Muhammad Gustriama MUHAMMAD ILHAM Muhammad Solehfuddin Mukodi Mukodi Mukodi Mukodi Mulyanto Widodo Muryan Awaludin Ngabdul Munif Niken Larasati Niva Argista Niva Argista Nurman Susilo Pipit Murdiyani Ramlan Asbar Rendie Prasetyo Retno Andhita Ananda Rio Octogi Siregar Rokhani Hasbullah rukhanah rukhanah Sari Rudijati Simson Werimon Siti Musinah Siti Samiyarsih Sri Amini SUMPENA SUMPENA Teguh Dwi Putra Tri Wahyuningsih triani hardiyati Umar Ma’ruf Vit Ardhyantama Widhi Astuti Windi Asterini Wisnu Sasangka Wiwiek Joelijani Wiwik Joelijani Yulias Ninik Windriati

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