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All Journal PROSIDING SEMINAR NASIONAL WARTA Biomedika Pharmacon INDONESIAN JOURNAL OF PHARMACY Jurnal Penelitian Sains Teknologi JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Kreativitas PKM Jurnal Ilmu Kefarmasian Indonesia Jurnal Ners Science Midwifery Abdi Geomedisains Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Prosiding Seminar Nasional Pengabdian Masyarakat Inovasi Jurnal Pengabdian Masyarakat (IJPM) Usadha Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia
Tanti Azizah Sujono
Universitas Muhammadiyah Surakarta
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Science Midwifery

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Testantidiabetic activity of a combination of 70% ethanol extract of meniran leaves (Phyllanthus Niruri L.) and glibenclamide in male white Wistar rats induced by alloxan Azzahra, Annisa Alya; Sujono, Tanti Azizah
Science Midwifery Vol 12 No 1 (2024): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i1.1504

Abstract

Diabetes mellitus is a metabolic disease that causes hyperglycemia due to impaired insulin function (insulin resistance). The use of glibenclamide has side effects in the form of hypoglycemic and weight gain. This study aims to determine the activity of a combination of 70% ethanol extract of meniran leaves (EEDM) and glibenclamide in reducing blood glucose and body weight of rats against the use of single glibenclamide. A completely randomized design method was used involving 28 rats divided into 7 groups. Normal control (KN) was given distilled water; negative control (K(-)) was given distilled water; positive control (K(+)) was given glibenclamide 1 mg/kgBW, EEDM treatment group doses of 5; 10; 20 mg/kgBB and a combination group of glibenclamide and EEDM 5 mg/kgBB. Alloxan 150 mg/kgBW intraperitoneally (ip) and 30% glucose solution orally were used to induce the hyperglycemic rat model. Blood sugar levels and body weight were checked on days: 0, 7, 14 after treatment. Based on the results of statistical tests showed that EEDM all doses and combinations have antidiabetic activity (p<0.05). The use of a combination of glibenclamide 1 mg/kgBB and ethanol extract of meniran leaves 5 mg/kgBB can also overcome the side effects of weight gain from the use of glibenclamide alone.
Co-Authors . Haryoto . Haryoto, . . MUHTADI . Muhtadi A Anifatussaa'dah Agung Endro Nugroho Ahmad Fauzi Ambarwati Andi Suhendi Anifatussaa'dah, A Anindya, Talitha Ahnaf Anjati, Yasinta Widia Ardalia Rinanda Oktaviani Arief Nurrochmad Arifah Sri Wahyuni Asti Arum Sari Azis Saifudin Azzahra, Annisa Alya Balqis, Moetia Rahman Basusena, Rahardian Surya Burhanudin Ichsan Citra, Tia Mella Dedi Hanwar Desi Rahmawati Dewi, Adinda Putri Sari Dewi, Syochi Jannati Pramudya Dwi Sarbini Dzafira, Laila Eka Prasnaparamita W Em Sutrisna Emsutrisna, E Endang Lukitaningsih Erna Herawati Erna Herawati, Erna Fahriza Mei Trihatmoko Fakhrudin, Muh. Fanny Atika Rizki Faridita khoirun Nisa' Fidhia Nur Rifaini Firdaus, Farhand Ahmad Fitriani, Rizki Ainun Fortuna, Tista Ayu Haliza Arzeti Nurseptiria Hana, Ulya Rosa Handayani, Eka Wuri Harindasari, Amorita Azzah Haryoto - Haryoto Haryoto Haryoto, H Haya Nabilah Utama Hertaliyana, Junita Ayu HI, Marsilia Rosa Sinensis Hidayah Karuniawati Ichsan, Burhanudin Ida Maesaroh Ida Maesaroh, Ida Ika Trisharyanti Dian Kusumowati Ilham Ramadhan Isnaniyah, Dhevi Zahra Latifatul Jeli Marlita Katarina Lulu Widyanti khusnul khotimah Khusnul Khotimah Kusumastuti, Lina Ayu Laila Dzafira LANGKAH SEMBIRING Lina Ayu Kusumastuti Listiana Masyita Dewi Mariska Sri Harlianti Marsilia Rosa Sinensis HI Marsya, Vitania Maryati, M Merlindasari, Aulia Pungky Muhammad Da&#039;i Muhtadi - Muhtadi Muhtadi Muhtadi, M Muslihah, Sayyidah Nurul Neni Lugki Nian Tary Nisa', Faridita khoirun Nurseptiria, Haliza Arzeti Oktaviani, Ardalia Rinanda Peni Indaryudha Peni Indaryudha, Peni Peni Indrayudha Pratama, Wilson Candra Teguh Raafika Studiviani Rachmalia, Fauniza Marwa Rahardian Surya Basusena Rahmadani, Sandika Rahmatullah, Wahyu Ratna Yuliani Ratna Yuliani Raudatul Patimah Raudatul Patimah, Raudatul Retno Sintowati - Rifaini, Fidhia Nur Rima Munawaroh Rizki Ainun Fitriani Rizki, Fanny Atika Roshitasari, Eva Sanjaya, Muhammad Riyanto Sari, Erlinda Novita Sartono Putro Sativa, Wieke Rachma Sayyidah Nurul Muslihah Setyo Nurwaini Shofiah, Mira Sri Wahyuni Studiviani, Raafika Subagus Wahyuono Subekti, Istiara Syahputri, Janies Arly T.N. Saifullah Sulaiman T.N. Saifullah Sulaiman, T.N. Saifullah Tary, Neni Lugki Nian Tia Mella Citra Tista Ayu Fortuna Trihatmoko, Fahriza Mei Ujiantya, Sabrina Dian Parasika Ullya Nur Wahyu Hidayah Ullya Nur Wahyu Hidayah, Ullya Nur Wahyu umi laelatul qomar Utama, Haya Nabilah Vitania Marsya Wahyu Utami Wahyu Utami, Wahyu Wati, Abil Lia Wulan Rahmadhani, Wulan