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All Journal PROSIDING SEMINAR NASIONAL WARTA Biomedika Pharmacon INDONESIAN JOURNAL OF PHARMACY Jurnal Penelitian Sains Teknologi JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Kreativitas PKM Jurnal Ilmu Kefarmasian Indonesia Jurnal Ners Science Midwifery Abdi Geomedisains Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Prosiding Seminar Nasional Pengabdian Masyarakat Inovasi Jurnal Pengabdian Masyarakat (IJPM) Usadha Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia
Tanti Azizah Sujono
Universitas Muhammadiyah Surakarta
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
THE PROTECTIVE EFFECT OF SARANG SEMUT (Myrmecodia tuberose) TUBERS INFUSION ON GENTAMICIN-PIROXICAM INDUCED NEPHROTOXICITY IN RATS Tanti Azizah Sujono
Indonesian Journal of Pharmacy Vol 25 No 2, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (832.497 KB) | DOI: 10.14499/indonesianjpharm25iss2pp91

Abstract

Kidney is very important organ for blood filtration. Impaired renal function often results in chronic kidney disease. Sarang semut (Myrmecodia tuberosa) is traditionally used to cure various diseases. This research was conducted to determine the effect of sarang semut infusion in nephrotoxicity rats models by gentamicin-piroxicam. Thirty male Wistar rats were divided into 6 groups. Group I as normal control (CMC Na was treated orally for 7 days), group II was treated sarang semut infusion dose of 1g/kgBW orally for 7 days, group III as nephrotoxic control was injected by gentamicin 100mg/kgBW intraperitoneally and piroxicam 3.6mg/kgBW orally daily for 7 days and group IV until VI were rats simultaneously treated with sarang semut infusion at the dose of 1, 2, and 4g/kgBW, respectively and induced by gentamicin-piroxicam daily for 7 days. Parameters of kidney function such as serum creatinine and blood urea nitrogen (BUN) levels were measured on day 0 and 7 using spectrophotometer. The rats were then sacrificed, kidneys tissue were removed for examination of renal index and kidney histology. These results showed that sarang semut tubers infusion at the dose of 1, 2, and 4g/kgBW reduced BUN and creatinine levels on induced-nephrotoxic rats. Creatinine level was reduced significantly to 1.76±0.13; 0.86±0.15; 0.60±0.07mg/dL, respectively. The creatinine level of nephrotoxic control was 5.16±0.27mg/dL. BU level decreased significantly to 55.66±6.22; 18.49±2.61; 16.81±1.24mg/dL, respectively. Meanwhile the BUN level of nephrotoxic control was 276.65±50.52mg/dL. Rat histological profile of the three doses tratment showed improvement in renal cell after administration of sarang semut infusion for 7 days. 
Co-Authors . Haryoto . Haryoto, . . MUHTADI . Muhtadi A Anifatussaa'dah Agung Endro Nugroho Ahmad Fauzi Ambarwati Andi Suhendi Anifatussaa'dah, A Anindya, Talitha Ahnaf Anjati, Yasinta Widia Ardalia Rinanda Oktaviani Arief Nurrochmad Arifah Sri Wahyuni Asti Arum Sari Azis Saifudin Azzahra, Annisa Alya Balqis, Moetia Rahman Basusena, Rahardian Surya Burhanudin Ichsan Citra, Tia Mella Dedi Hanwar Desi Rahmawati Dewi, Adinda Putri Sari Dewi, Syochi Jannati Pramudya Dwi Sarbini Dzafira, Laila Eka Prasnaparamita W Em Sutrisna Emsutrisna, E Endang Lukitaningsih Erna Herawati Erna Herawati, Erna Fahriza Mei Trihatmoko Fakhrudin, Muh. Fanny Atika Rizki Faridita khoirun Nisa' Fidhia Nur Rifaini Firdaus, Farhand Ahmad Fitriani, Rizki Ainun Fortuna, Tista Ayu Haliza Arzeti Nurseptiria Hana, Ulya Rosa Handayani, Eka Wuri Harindasari, Amorita Azzah Haryoto - Haryoto Haryoto Haryoto, H Haya Nabilah Utama Hertaliyana, Junita Ayu HI, Marsilia Rosa Sinensis Hidayah Karuniawati Ichsan, Burhanudin Ida Maesaroh Ida Maesaroh, Ida Ika Trisharyanti Dian Kusumowati Ilham Ramadhan Isnaniyah, Dhevi Zahra Latifatul Jeli Marlita Katarina Lulu Widyanti Khusnul Khotimah khusnul khotimah Kusumastuti, Lina Ayu Laila Dzafira LANGKAH SEMBIRING Lina Ayu Kusumastuti Listiana Masyita Dewi Mariska Sri Harlianti Marsilia Rosa Sinensis HI Marsya, Vitania Maryati, M Merlindasari, Aulia Pungky Muhammad Da'i Muhtadi - Muhtadi Muhtadi Muhtadi, M Muslihah, Sayyidah Nurul Neni Lugki Nian Tary Nisa', Faridita khoirun Nurseptiria, Haliza Arzeti Oktaviani, Ardalia Rinanda Peni Indaryudha Peni Indaryudha, Peni Peni Indrayudha Pratama, Wilson Candra Teguh Raafika Studiviani Rachmalia, Fauniza Marwa Rahardian Surya Basusena Rahmadani, Sandika Rahmatullah, Wahyu Ratna Yuliani Ratna Yuliani Raudatul Patimah Raudatul Patimah, Raudatul Retno Sintowati - Rifaini, Fidhia Nur Rima Munawaroh Rizki Ainun Fitriani Rizki, Fanny Atika Roshitasari, Eva Sanjaya, Muhammad Riyanto Sari, Erlinda Novita Sartono Putro Sativa, Wieke Rachma Sayyidah Nurul Muslihah Setyo Nurwaini Shofiah, Mira Sri Wahyuni Studiviani, Raafika Subagus Wahyuono Subekti, Istiara Syahputri, Janies Arly T.N. Saifullah Sulaiman T.N. Saifullah Sulaiman, T.N. Saifullah Tary, Neni Lugki Nian Tia Mella Citra Tista Ayu Fortuna Trihatmoko, Fahriza Mei Ujiantya, Sabrina Dian Parasika Ullya Nur Wahyu Hidayah Ullya Nur Wahyu Hidayah, Ullya Nur Wahyu umi laelatul qomar Utama, Haya Nabilah Vitania Marsya Wahyu Utami Wahyu Utami, Wahyu Wati, Abil Lia Wulan Rahmadhani, Wulan