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All Journal VALENSI Jurnal Pendidikan dan Pembelajaran Khatulistiwa (JPPK) Alchemy : Journal of Chemistry Proceeding International Conference on Global Resource Conservation Jurnal Ijtimaiyya GEA, Jurnal Pendidikan Geografi MANAJERIAL PEDAGOGIA Jurnal Kartika Kimia Metalurgi Pharmacoscript Indonesia Natural Research Pharmaceutical Journal (INRPJ) Jurnal Inovasi Pendidikan MH Thamrin Indo-MathEdu Intellectuals Journal MASALIQ: Jurnal Pendidikan dan Sains ARZUSIN: Jurnal Manajemen dan Pendidikan Dasar Al-DYAS : Jurnal Inovasi dan Pengabdian kepada Masyarakat Jurnal Pengabdian Pada Masyarakat Blantika : Multidisciplinary Journal Bhinneka Multidisiplin Journal Pharmacon: Jurnal Farmasi Indonesia
Nani Suryani
Pusat Aplikasi Teknologi Isotop dan Radiasi - BATAN
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Journal : Pharmacon: Jurnal Farmasi Indonesia

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Stimulant Activity of White Pepper (Piperis albi Fructus) Ethanol Extract In Vivo Khaerunnisa, Arini; Jayantie, Dhyneu Dwi; Sutihat, Sutihat; Hida, Nurul; Suryani, Nani
Pharmacon: Jurnal Farmasi Indonesia Vol. 21 No. 1 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i1.2411

Abstract

Caffeine is a stimulant substances that can stimulate the central nervous system (CNS) increasing concentration, and reducing drowsiness. The use of caffeine generally comes from coffee plants which can increase gastrin secretion. Long-term use of caffeine can cause side effects such as feelings of anxiety, irritability, insomnia and faster heart rate. An alternative stimulant that has limited side effects is needed. White pepper (Piperis albi fructus) is potential as stimulant. The extract of White pepper contained piperine compound. Piperine can potentially be a stimulant because it can stimulate the formation of energy in the body. The purpose of this study was to determine the in vivo stimulant activity of ethanol extract White pepper in male white mice. The method used in this research is Natatory exhaustion. 25 test animals were divided into 5 groups. The doses used are white pepper extract 0.32; 0.65 and 1.3 mg/20 g BW, caffeine 0.26 mg/20 g BW and 0.5% CMC-Na. Data analysis with SPSS 16 with the Kruskal-Wallis test and the Mann-Withney test. The results of the stimulant activity test of white pepper ethanol extract at a dose of 0.32; 0.65 and 1.3 mg/20 g BW for male white mice with the DDY strain with an average % increase in stamina of 63.92; 120.81 and 179.31%,mean while in the positive control of caffeine by 232.55% and the negative control of CMC-Na by 21.10%. White pepper ethanol extract dose of 1.3 mg/20 g BW has stimulant activity which is not significantly different from caffeine positive control.
Co-Authors Ade Sumiardi Agus Setiawan Ahmad Bukhori, Ahmad Al-Faroji, Didin Syahrudin Anisah Anita Rakhman, Anita Anjani, Ega Ardianti, Dini Arini Khaerunnisa Ashari, Tiara Hadi Basril Abbas Boriboon, Gumpanat Cory Novi Cuarni, Cuarni Dra. Retno MLIS. Sayekti Ernawati, Eneng Elda Euis Widiati EVA RIZA, EVA Fadillah, Hendry Noer Firdaus, Rizki Amsyarul Hida, Nurul Indriatmoko, Dimas Danang Irfan Fajrul Falah Irwansyah, Asep Jayantie, Dhyneu Dwi Juliani Junaedi, Candra Jundullah, Jundullah Kartika, Eka Yulli Khairunnisa, Siti Hana Adlina Khumaedi, Muhammad Sigit Komalasari Komalasari Kurniati, Iim Lukman Hadi, Lukman Maryana, Maya Muslih Fathurrahman Nugraha, Deska Dwi Nuramalia, Sifa Nurhayati, Ghina Siti Oktafiani, Dwi Putri Puspita, Aan Puspitasari, Putri Ratih Renaldy, Renaldy Rohimah, Iyar Sabrina, Mariam Setiawan, Anissa Ariyanti Shopal, Odi Siswanti, Dwi Marwati Juli Siti Kholipah Siti Marhamah, Siti Siti Nurbayti Sopiah, Sopiah Sri Nurhayati Sulistriyani, Sulistriyani Sutihat, Sutihat Swastika Oktavia Tarso Rudiana, Tarso Tuti Rostianti Maulani U.S, Sumarlin Utami, Syifa Nurul Veronika, Vara Yessy Warastuti Yuminar Priyanti, Nina Yuni, Anisa Sriwandita Yuntina, Lily Yustika, Rd. Widya Zhorif, Sherina Arestia