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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Althea Medical Journal Journal on Mathematics Education (JME) Indonesian Journal of Urology Agrivet Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Kesehatan Andalas Global Medical and Health Communication Techno LPPM Planta Tropika JIPM (Jurnal Ilmiah Pendidikan Matematika) Journal of Medicine and Health Jurnal SOLMA JMM (Jurnal Masyarakat Mandiri) JTAM (Jurnal Teori dan Aplikasi Matematika) Jurnal Agrotek UMMat YARSI Medical Journal Majalah Patologi Indonesia Jurnal Agro Wiralodra Jurnal Abdi Insani JK Unila (Jurnal Kedokteran Universitas Lampung) Didaktika: Jurnal Pemikiran Pendidikan Jurnal Agro Dedikasi Masyarakat (JADM) Postulat : Jurnal Inovasi Pendidikan Matematika Jurnal Lingkar Mutu Pendidikan Kingdom (The Journal of Biological Studies) Jurnal Pendidikan MIPA Journal on Mathematics Education

Sri Suryanti

Department Of Anatomical Pathology, Faculty Of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung

Author-ID : 395219

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Hubungan Imunoekspresi Epidermal Growth Factor Receptor (EGFR) dengan Stadium Dukes pada Karsinoma Kolorektal Fenny Ariyanni; Sri Suryanti; Abdul Hadi Hassan; Bethy S Hernowo
Majalah Patologi Indonesia Vol 24 No 1 (2015): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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ABSTRAK Latar belakang Epidermal growth factor receptor (EGFR) berperan dalam patogenesis dan progresivitas karsinoma kolorektal. Stadium Dukes menunjukkan luas penyebaran tumor dan digunakan sebagai pedoman terapi. Pada stadium Dukes A tumor masih terbatas pada tunika submukosa, stadium Dukes B tumor sudah menembus tunika muskularis dan stadium Dukes C sudah bermetastasis ke kelenjar getah bening. Penggunaan kemoterapi adjuvan pada stadium Dukes B masih kontroversi sehingga hanya diberikan pada stadium Dukes B yang high risk. Diperlukan penanda molekuler yang dapat menunjukkan tumor yang agresif. Pada penelitian ini akan diteliti hubungan imunoekspresi EGFR dengan stadium Dukes pada karsinoma kolorektal. EGFR diharapkan dapat digunakan menjadi penanda karsinoma kolorektal yang agresif. Metode Pewarnaan imunohistokimia EGFR dilakukan terhadap 45 blok parafin karsinoma kolorektal yang dilakukan kolektomi (masing-masing stadium Dukes A, B, C 15 kasus). Hasilnya dihubungkan dengan stadium Dukes. Hasil Pada stadium Dukes A sebanyak 2 kasus (13%) menunjukkan imunoekspresi positif dan stadium Dukes B sebanyak 8 kasus (53%) menunjukkan imunoekspresi positif dan pada stadium Dukes C sebanyak 11 kasus (73%) menunjukkan imunoekspresi positif. Imunoekspresi EGFR secara statistik (p=0.004, uji Chi-Square) lebih sering ditemukan pada stadium Dukes C. EGFR berperan penting dalam diferensiasi dan proliferasi sel. Pada sel normal pengaktifan sinyal EGFR menyebabkan proliferasi sel, migrasi, metastasis, penghindaran apoptosis dan angiogenesis. Kesimpulan Imunoekspresi EGFR lebih sering ditemukan pada stadium Dukes C dibanding Dukes A dan B. Kata kunci: EGFR, imunoekspresi, karsinoma kolorektal, stadium Dukes. ABSTRACT Background Epidermal growth factor receptor immunoexpression may clarify the effects of the pathogenesis and determine the prognosis of colorectal carcinoma (CRC). Dukesâ€™ stage explained the extension of the tumor. Dukesâ€™ stage A was defined as malignant tumour in which growth extends into the submucosa, but not into the muscle coat; Dukesâ€™ stage B was defined as the tumour growth extends into the muscle coat; and Dukesâ€™ stage C was defined as the presence of lymph node metastases. Adjuvant chemotherapy in Dukesâ€™ stage B is controversial, which only given to high-risk Dukesâ€™ stage B. Hence, we need to identify high-risk Dukesâ€™ stage B. This research will study association EGFR clone H11 and CRC Dukesâ€™ stage. Methods Immunohistochemistry was performed in paraffin-embedded specimens of 45 cases colorectal carcinoma (each Dukesâ€™ stage A, B, C was 15 cases) for the assesment of clone H11 EGFR expression. The results were correlated with colorectal carcinoma Dukesâ€™ stage. Results At Dukesâ€™ stage A there were 2 cases (13%) showed positive immunoexpression and Dukesâ€™ stage B there were 8 cases (53%) showed positive immunoexpression and Dukesâ€™ stage C there were 11 cases (73%) showed positive immunoexpression. clone H11. EGFR clone H11 immunoexpression (p=0.004, Chi-Square test) was significantly more frequent in Dukesâ€™ stage C. EGFR play an important role in cell differentiation and proliferation. The activation of EGFR signaling would lead to cell proliferation, migration, metastasis, evasion of apoptosis or angiogenesis. Conclusion EGFR immunoexpression was more frequent in colorectal carcinoma Dukesâ€™ stage C explain clearly that EGFR play important role in pathogenesis colorectal carcinoma. Key words: colorectal carcinoma, Dukesâ€™ stage, EGFR, immunoexpression.

Peran EGFR sebagai Prediktor Sensitivitas Radioterapi pada Adenokarsinoma Serviks Fennisia Wibisono; Sri Suryanti; Bethy S. Hernowo
Majalah Patologi Indonesia Vol 25 No 3 (2016): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Latar belakang Karsinoma serviks menduduki urutan pertama dari kejadian keganasan pada wanita dan merupakan masalah penting dalam onkologi ginekologi di Indonesia. Mayoritas pasien karsinoma serviks termasuk adenokarsinoma serviks datang pada stadium lanjut dan radioterapi merupakan salah satu modalitas terapinya. Keberhasilan radioterapi dinilai dari respons radioterapi yang dipengaruhi beberapa faktor prognostik, yaitu keadaan umum, stadium, histopatologi dari tumor, adanya gangguan fungsi organ, dan beberapa petanda molekular seperti epidermal growth factor receptor (EGFR). Saat ini sedang dikembangkan studi-studi mengenai EGFR berhubungan dengan sensitivitas radioterapi namun hasilnya masih kontroversi. Aktivasi sinyal EGFR dapat menginduksi terjadinya radioresistensi pada adenokarsinoma serviks. Tujuan dari studi penelitian ini adalah untuk menganalisis korelasi antara ekspresi EGFR, dan sensitivitas radioterapi adenokarsinoma serviks. Metode Penelitian ini merupakan studi retrospektif, cross sectional, dan analisis korelasional. Sampel penelitian sebanyak 32 blok parafin yang berasal dari pasien adenokarsinoma serviks yang telah mendapatkan radioterapi dan merupakan sampel yang tersimpan di Departemen Patologi Anatomik RSUP Dr. Hasan Sadikin Bandung, periode Januari 2007-Mei 2014. Pada sampel tersebut dilakukan pulasan imunohistokimia EGFR. Hasil Analisis statistik antara ekspresi EGFR dan sensitivitas radioterapi adenokarsinoma serviks menunjukkan adanya perbedaan bermakna (p=0,000). Kesimpulan Ekspresi EGFR dapat digunakan sebagai prediktor sensitivitas radioterapi karsinoma serviks. Kata kunci : adenokarsinoma serviks, EGFR, radioterapi.

Validitas Pemeriksaan Imunositokimia HMGA2 dalam Penegakan Diagnosis Nodul Jinak dan Ganas Tiroidpada Sediaan Biopsi Aspirasi Jarum Halus Yenni Wisudarma; Hasrayati Agustina; Sri Suryanti; Bethy S. Hernowo
Majalah Patologi Indonesia Vol 26 No 1 (2017): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Latar belakang Tindakan biopsi aspirasi jarum halus (BAJAH) merupakanpemeriksaan preoperatif baku yang sederhana dan relatif lebih murah dalam penegakan diagnosis karsinoma tiroid, tetapi diagnosis sitologi BAJAH tersebut tidak selalu mudah. Penelitian ini bertujuan untuk mengetahui validitas pemeriksaan imunositokimia HMGA2 dalam penegakan diagnosis sediaan BAJAH nodul tiroid jinak, ganas dan indeterminate. Metode Penelitian ini merupakan penelitian uji diagnostik yang dilakukan terhadap 62 kasus nodul tiroid yang terdiri dari 18 kasus karsinoma papiler,13 kasus nodul folikular jinak dan 31 kasus indeterminate (27 kasus follicular neoplasmdan 4 kasus suspicious for papillary carcinoma) yang didiagnosis tahun 2011-2014 dan telah dilakukan pemeriksaan histopatologi pasca operasi sebagai konfirmasi diagnosis. Pemeriksaan imunositokimia HMGA2 dilakukan terhadap semua kasus dengan metode cell transfer. Hasil Akurasi, sensitivitas, spesifisitas, nilai duga positif dan nilai duga negatif pemeriksaan imunositokimia HMGA2 dalam diagnosis nodul tiroid masing-masing adalah 85,5%, 79,4%, 92,8%, 93,1% dan 78,8%. Sedangkan untuk kasus indeterminate, akurasi, sensitivitas, spesifisitas, nilai duga positif dan nilai duga negatif pemeriksaan imunositokimia HMGA2 adalah 77,4%, 68,7%%, 86,7%, 84,6% dan 72,2%. Kesimpulan Pemeriksaan imunositokimia HMGA2 relatif spesifik dan sensitif dalam menegakkan diagnosis preoperatif nodul tiroid termasuk pada kasus indeterminate. Kata kunci : biopsi aspirasi jarum halus, HMGA2, indeterminate, nodultiroid.

Korelasi antara Imunoekspresi Retinoid Acid Receptor (RAR) Alfa dan Ki-67 dengan Stadium Klinis dan Diferensiasi Retino-blastoma Friska Mardianty; Sri Suryanti; Bethy S Hernowo
Majalah Patologi Indonesia Vol 26 No 1 (2017): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Latar belakang Retinoblastoma merupakan keganasan mata tersering pada anak usia dibawah 5 tahun dan 50-60% kasus retinoblastoma di negara berkembang berakhir dengan kematian. Terapi saat ini sangat tergantung dengan stadium klinis dan walaupun telah diberikan terapi yang sesuai, masih ditemukan kasus rekurensi atau metastasis. Vitamin A diketahui banyak berperan untuk mata, dan telah terbukti pula vitamin A berperan pada karsinogenesis di beberapa keganasan lainnya. RAR alfa adalah reseptor dari retinoid acid yang salah satu fungsinya adalah sebagai anti proliferasi, sedangkan Ki-67 adalah petanda untuk menilai indeks proliferasi dari suatu sel. Tujuan penelitian ini dapat menilai adakah hubungan RAR dan Ki-67, berdasarkan diferensiasi dan stadium klinis pada retinoblastoma. Metode Penelitian ini dilakukan secara retrospektif dengan desain analisis korelasi terhadap 40 kasus retinoblastoma yang memenuhi kriteria penelitian, periode januari 2010-november 2014 di Departemen Patologi Anatomik RS Hasan Sadikin, Bandung. Seluruhnya dilakukan pulasan imunohistokimia RAR alfa dan Ki-67 dikorelasikan dengan stadium klinis dan diferensiasi sel. Hasil penelitian dianalisis statistik dengan uji Coefficient Contingensy dan kriteria Guillford. Hasil Hasil penelitian ini seluruhnya memberikan imunoekspresi positif pada RAR alfa dan Ki-67. Didapatkan imunoekspresi Ki-67 berkorelasi positif terhadap diferensiasi (p=0,042 dan R=0,370), namun tidak terdapat korelasi bermakna dengan stadium klinis, sedangkan pada pemeriksaan RAR alfa tidak terdapat korelasi bermakna baik dengan stadium klinis maupun tipe diferensiasi sel. Kesimpulan Tipe yang tidak berdiferensiasi menunjukkan indeks proliferasi yang lebih tinggi dibandingkan tipe yang berdiferensiasi. Kata kunci : diferensiasi, Ki-67, RAR alfa, retinoblastoma, stadium.

Characteristics of Renal Cell Carcinoma in Dr. Hasan Sadikin General Hospital Bandung, 2010–2014 Dicky Suryana Putra; Sri Suryanti; Aaron Tigor Sihombing
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Background: Data characteristics for renal cell carcinoma are mostly derived from developed countries. However, data from developing countries, specifically in Indonesia have not been fully described. This study aimed at describing renal cell carcinoma (RCC) characteristics based on age, gender, and histopathology type in Dr. Hasan Sadikin General Hospital Bandung.Methods: This was a descriptive study conducted in August–October 2015. The data were collected from histopathology medical records of patients who had been diagnosed with RCC at Department of Pathology Anatomy Dr. Hasan Sadikin General Hospital Bandung, from 2010 to 2014. Total sampling was used as sampling method. Only RCC records that had complete variables; which were age, gender, and histopathological type; included in this study.Results: There were 25 cases of renal cell carcinoma discovered in this study, 17 cases discovered in men and 8 cases discovered in women. The histopathology type found in this study was clear cell renal cell carcinoma (12 cases), papillary renal cell carcinoma (8 cases), chromophobe renal cell carcinoma (3 cases), and carcinoma of the collecting ducts of bellini (2 cases). There were no cases found below the age range 2–29 years old and above the age range 70–79 years old.Conclusions: Men have higher incidence than women with the ratio of 2:1. Peak incidence is found on the age range 50–59 years old. The most common histopathology type is clear cell renal cel carcinoma.[AMJ.2016;3(4):644–8] DOI: 10.15850/amj.v3n4.953

Maternal Characteristics and Histopathological Features of Placenta Accreta Spectrum in Dr. Hasan Sadikin General Hospital Bandung, Period 2015–2020 Yuktiana Kharisma; Hasrayati Agustina; Sri Suryanti; Birgitta Maria Dewayani; Bethy Suryawati Hernowo
Althea Medical Journal Vol 9, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v9n1.2631

Background: The placenta accreta spectrum (PAS) incidence has inclined today. The PAS is divided into three histopathological classifications, including accreta, increta, and percreta, associated with maternal, fetal morbidity, and mortality. This study aimed to explore the maternal characteristics and histopathological features in PAS at Dr. Hasan Sadikin General Hospital Bandung.Methods: This descriptive observational study involved 135 cases from January 2015–December 2020 at Dr. Hasan Sadikin General Hospital that met the inclusion criteria. The PAS histopathological classification was evaluated based on maternal characteristics such as age, parity, cesarean section (CS), and miscarriage. Results: The incidence of placenta accreta from 2015 to 2020 was 37.0%, whereas increta was 43.4%, followed by percreta at 19.3%. The maternal age of placenta accreta and increta mainly occurred at the age of 30–34 years with the prevalence of 40% and 46%, respectively, whereas percreta was aged 35–39 yo (27%). Most parities in placenta accreta, increta, percreta were three. Interestingly, 93% of cases had a CS history. Furthermore, the miscarriage history for accreta was 18%, increta 29% and percreta 38%. Conclusion: The highest incidence of PAS in Dr. Hasan Sadikin General Hospital is placenta increta, which mainly occurs at the age of 30–34 years. Almost all PAS patients have a history of CS; however, most of the patients do not have a miscarriage history.

Five Years Facts of Bladder Cancer at West Java’s Top Referral Hospital, in Indonesia Vivien Kate Perix; Sri Suryanti; Aaron Tigor Sihombing
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Background: Bladder cancer is the second most common genitourinary cancer and its incidence is rising 15% annually in Indonesia. Smoking is the leading risk factor of bladder cancer and two thirds of men in Indonesia smokes. This study was conducted to describe the characteristics of bladder cancer based on sex, age and histopathology type in West Java’s Top Referral Hospital, Indonesia. Methods: This study was a descriptive study conducted during theperiod of September to November 2015 using 372 histopathological medical records of patients who had primary and secondary bladder cancer at the Pathology Department, Dr. Hasan Sadikin General Hospital Bandung from January 2010 to December 2014. Data were collected using total sampling method based on the characteristics of age, sex histopathology type, and staging of bladder cancer.Results: Out of the 372 cases, 298 cases were male and 38 cases were female with a male to female ratio of 7.8:1. The age group with the highest incidence was the 50–59 years old group. Infiltrating urothelial carcinoma was the most common histopathology type (71.1%) in primary cancers, 66.1% of cases was muscle invasive while 33.9% was non muscle invasive. Staging pT1 had the most number of cases. The most common site of origin for secondary neoplasm was cervix with adenocarcinoma as the most common histopathology type. Conclusions: Bladder cancer is more common in male than female and peaks at the sixth decade of life. Infiltrating urothelial carcinoma is the most common histopathology type. [AMJ.2017;4(1):94–9] DOI: 10.15850/amj.v4n1.1028

The Distribution of Meningioma in Dr. Hasan Sadikin General Hospital Bandung Period 2010–2013 Stephanie Victoria Gunadi; Sri Suryanti; Raden Yohana
Althea Medical Journal Vol 5, No 3 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: In neurological diseases, brain tumor is the second leading cause of death after stroke, of which the most common types of brain tumor is meningioma. There are many factors affect the prognosis of meningioma patient, including age, gender, location, and histopathological type of tumor. This study aimed to explore the distribution of meningioma based on age, gender, location of the tumor, and its histopathological type during the period of 2010–2013 in Dr. Hasan Sadikin General Hospital Bandung.Methods: This study was a quantitative descriptive study and data were collected from medical records of Department of Pathology between January 2010-December 2013. Age, gender, location, and histopathological type of meningioma were acquired. Results: There were 277 eligible cases of meningioma with an average number of cases per year were 69 cases. The ratio of men to women was 1:6.4. Meningioma was most commonly found in the age group 4150 years (38.9%), and mostly located in convexity (55.96%). The most common histopathological type of meningioma was meningotheliomatous meningioma (70%).Conclusions: The frequency of meningioma is 6 times higher in women, predominantly around the age of 50 years old. Meningioma is most commonly found in convexity, and meningotheliomatous meningioma is the most common histopathological type.

PENGARUH PENDIDIKAN KESEHATAN TERHADAP PENGETAHUAN MASYARAKAT AWAM DI RSUP DR. HASAN SADIKIN TENTANG KANKER BULI Sri Suryanti; Hasrayati Agustina; Sri Mulyati
Dharmakarya Vol 9, No 1 (2020): Maret, 2020
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/dharmakarya.v9i1.19521

Kanker buli adalah masalah kesehatan masyarakat internasional dan peringkat ke lima keganaan terbanyak dan penyebab kematian tertinggi kedua karena keganasan di saluran kemih di negara-negara maju. Keterlambatan dalam diagnosis kasus kanker buli sering terjadi. Salah satu penyebab keterlambatan dalam diagnosis kanker buli adalah interval waktu ketika pasien pertama kali mengetahui gejala penyakit yang terjadi dengan saat pertama berkonsultasi tentang keluhannya kepada tenaga medis. Salah satu upaya untuk meningkatkan kesadaran individu terhadap kondisi tertentu adalah melalui upaya meningkatkan pengetahuan dalam bentuk penyuluhan kesehatan tentang kanker buli. Tujuan dari penelitian ini adalah untuk menentukan perubahan tingkat pengetahuan masyarakat awam tentang kanker buli melalui penyuluhan kesehatan. Penelitian ini menggunakan metode penelitian kuasi-eksperimental dengan desain "satu kelompok pretest-postest". Sebelum penyuluhan, mayoritas responden, 56,7%, memiliki pengetahuan kurang sementara setelah penyuluhan, pengetahuan meningkat secara signifikan.

The Role of Fibroblast Growth Factor Receptor 3 (FGFR3) and Androgen Receptor (AR) in a Non-invasive Urothelial Carcinoma Recurrences Oki Meilani Dewi; Sri Suryanti; Bethy Suryawathy Hernowo
Global Medical & Health Communication (GMHC) Vol 7, No 2 (2019)
Publisher : Universitas Islam Bandung

Urothelial carcinoma is a bladder carcinoma that took place in the urinary tract. Non-invasive urothelial carcinoma patients have high recurrence rates (50–70%). The recurrences took so many years that may lead to the high-cost treatment and low survival rate. Fibroblast growth factor receptor 3 (FGFR3) and androgen receptor (AR) known to play a role in non-invasive urothelial carcinoma and potentially act as a prognostic marker to predict recurrences. This study aimed to discover the role of FGFR3 and AR in recurrences of non-invasive urothelial carcinoma. This research used a case-control study design. Samples took from patients diagnosed with non-invasive urothelial carcinoma registered at Dr. Hasan Sadikin General Hospital Bandung 1 January 2010–30 December 2015 period. Sixty samples consisted of 30 recurrent groups, and 30 non-recurrent groups individually fixated and embedded to paraffin block for FGFR3 and AR immunohistochemistry analysis. Analysis chi-square performed with a level of confidence 95% and statistical power 95%. p values<0.05 were considered to be statistically significant. Statistical analysis showed that FGFR3 immunoexpression was found significantly low on the recurrence group (p=0.002, OR=5.50). While AR immunoexpression was found insignificant (p=1.000, OR=1.00). FGFR3 immunoexpression from samples in the recurrent group with multiple tumors found to be significantly low (p=0.031, OR=6.067). This study showed that recurrences took place when FGFR3 lowly expressed within non-invasive urothelial carcinoma samples with multiple tumors. This finding may raise a candidate to early-predict the recurrence, thus will suggest early therapy.PERANAN FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) DAN RESEPTOR ANDROGEN (RA) TERHADAP KEJADIAN REKURENSI PADA KARSINOMA UROTELIAL BULI NON-INVASIFKarsinoma urotelial merupakan karsinoma buli yang sering terjadi pada saluran kemih. Karsinoma urotelial dibagi menjadi karsinoma urotelial non-invasif dan invasif. Pasien karsinoma urotelial non-invasif mempunyai kejadian rekurensi tinggi (50–70%) dan membutuhkan waktu lama untuk memantau kejadian rekurensi sehingga membutuhkan biaya tinggi dengan angka ketahanan hidup rendah. Fibroblast growth factor receptor 3 (FGFR3) dan reseptor androgen (RA) berperan dalam terjadinya karsinoma urotelial non-invasif dan berpotensi sebagai penanda prognostik yang memprediksi rekurensi secara akurat. Tujuan penelitian ini mengetahui peranan FGFR3 dan RA terhadap kejadian rekurensi pada karsinoma urotelial non-invasif. Penelitian menggunakan rancangan case-control study. Sampel berupa blok parafin yang diagnosis sebagai karsinoma urotelial non-invasif di RSUP Dr. Hasan Sadikin Bandung periode 1 Januari 2010–30 Desember 2015. Sebanyak 60 sampel dievaluasi terdiri atas 30 sampel kelompok rekurensi dan 30 kelompok tidak rekurensi. Pemeriksaan imunohistokimia menggunakan antibodi FGFR3 dan RA. Analisis menggunakan uji chi-square dengan taraf kepercayaan 95% dan kuasa uji (power test) 95%. Nilai p<0,05 dianggap signifikan secara statistik. Pada analisis statistik, imunoekspresi FGFR3 rendah signifikan pada kelompok rekurensi (p=0,002; OR=5,50) dan imunoekspresi RA tidak signifikan (p=1,000; OR=1,00). Imunoekspresi FGFR3 rendah dengan tumor multipel signifikan pada kelompok rekurensi (p=0,031; OR=6,067). Hasil penelitian menunjukkan bahwa rekurensi terjadi ketika FGFR3 terekspresi rendah pada sampel karsinoma non-invasif dengan tumor multipel. Hal ini dapat menjadi penanda memprediksi kejadian rekurensi sehingga dapat dilakukan terapi yang lebih cepat.

Co-Authors Aaron T Sihombing, Aaron T Aaron Tigor Aaron Tigor Sihombing Abdul H Hassan, Abdul H Abdul Hadi Hassan Abdul Hadi Hassan Abdul Hadi Hassan, Abdul Hadi Abdurrahman, Fauzan admin admin Agung Putra Wijaya, Agung Putra Agus Koesmawan Anglita Yantisetiasti Antonius Janes Ridwan, Antonius Janes Arif - Umami Azimah, Khoridatul Bethy S Hernowo Bethy S Hernowo, Bethy S Bethy S. Hernowo Bethy S. Hernowo, Bethy Bethy Suryawathy Hernowo Bethy Suryawati Hernowo Bethy Suryawati Hernowo Birgitta Maria Dewayani Deni Sutaji Dewayani, Birgitta Maria Dicky Suryana Putra Didik Indradewa Fariha Wilisiani, Fariha Fatimatul Khikmiyah Fauziyah, Nur Fennisia Wibisono Fennisia Wibisono, Fennisia Fenny Ariyanni Fenny Ariyanni, Fenny Firdaus, Ahmad Qolfathiriyus Firmansyah, Ryan Firmanto, Agung Friede Rismayanti Saragih Friska Mardianty Gatot Nyarumenteng Adhipurnawan Winarno Hasrayati Agustina Hasrayati Agustina Hikmah, Nimatul I Nengah Parta Igun, Maulana Irwani Zawawi Ismet Muchtar Nur JAKA WIDADA Jazilah, Ferina Vetty KHOLIS, SITI NUR Kurniawan, Stefanus Lestari, Adela Ayu Maf'ula, Iswatun Mantilidewi, Kemala I. Mawandha, Hangger Gahara Meike Rachmawati Mukarramah Mukarramah, Mukarramah Mulyono Mulyono Murtiyani, Sri Novian, Dwi Oki Meilani Dewi Oktavianty, Hera Perdana, Cahyo Putra Perix, Vivien Kate Putra, Dicky Suryana Putra, Zuhadur Ra’is Ariyono Raden Yohana Rahayu, Enny Rajagukgguk, Arjuna Mangaroha Reza Widyasaputra sarwo edy Setiawan, Landung Rodhy Setyastuti Purwanti, Setyastuti Setyawati, Ety Siripala, Wannaporn Siti Fauziyah Siti Nur Hidayah, Siti Nur Sofi, Maulana Sri Mulyati Sri Mulyati Sri Rejeki, Henny Standsyah, Rahmawati Erma Stephanie Victoria Gunadi Sulistijowati, Sri Handajani Teddy, Teddy Syah Putra Tiasari, Lulus Cahya Toto Nusantara Vivien Kate Perix Winarto, Bambang Yanti, Liza Puspita Yenni Wisudarma Yudhi Arifani Yuktiana Kharisma

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