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In Silico Analysis of the NPC1L1 Inhibitor of Catechins from Green Tea Susanti, Erna; Setyadini, Ellyvına
JURNAL INFO KESEHATAN Vol 21 No 1 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss1.965

Abstract

The main contributor to cardiovascular disease is atherosclerosis. The Liver X Receptor is one of the unexplored signaling pathways in atherosclerosis that contributes to cholesterol efflux and inhibitory inflammation (LXR). Catechin, as an LXR agonist, influences the expression of the NPC1L1 protein transporter, which inhibits cholesterol absorption. The objective of this study is to predict the NPC1L1 inhibitor of Catechins from Green Tea. The role of NPC1L1 inhibitors is to prevent atherogenesis. Molecular docking is the research method used. Pyrx's Open Babel was used for analysis. Autodock vina in Pyrx was employed for docking, and Chimera v1.8 was administered for visualization. The result of molecular interaction was assigned. Pose view was used in this study. Catechins have the potential to be an NPC1L1 inhibitor, according to the findings. The main parameters used to predict the biological effect were energy bonds, hydrogen bonds, and hydrophobic interactions of molecules with NPC1L1. All Catechins isolates had low affinity energy and a strong affinity for NPC1L1. Epigallocatechin gallate (EGCG) is the most effective inhibitor because it has the lowest binding energy and the most active sites, including Gln 200, Tyr 192, Trp 202, Cys 189, Gly 207, Asp 217, Gly 190, Phe 205, Asp 208. There are hydrogen bonds at Thr 219, Ile 218, Asn 204, Asn 211, Arg 201, and Asn 204. The interaction energy between NPC1L1 and EGCG is -7.5 kCal/mol. Based on the results of the in-silico analysis, the researchers concluded that Catechins have the potential to be an NPC1L1 inhibitor. Further research into molecular dynamic simulation and in vivo analysis is required to demonstrate the synergistic effect of Catechins as an inhibitor of atherogenesis.
The effect of the reciprocal teaching model on the ability to write explanatory texts Santi, Novi; Parlina, Iin; Alia; Susanti, Erna
Indonesian Research Journal in Education |IRJE| Vol. 9 No. 02 (2025): IRJE |Indonesian Research Journal in Education
Publisher : Universitas Jambi, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/irje.v9i02.41477

Abstract

This research aims to determine and describe the influence of the reciprocal teaching model on the ability to write explanatory texts. This research employed a pre-experimental using a one-group pretest-posttest design. The population was all the seventh-grade students of Madrasah Tsanawiyah Negeri 1 Ogan Komering Ilir. The sample in this research was one class, VIIC, with 30 students. The data collection technique used was a performance test written in explanatory text. Before receiving instruction using the reciprocal teaching model, the test results showed a score of 64.93 for the ability to write explanatory text. After learning to listen through the reciprocal teaching model, the score increased to 79.10. The data shows the average test results for the ability to write explanatory texts before being taught using the reciprocal teaching model and after being taught to listen using a higher reciprocal teaching model, namely 79.10>64.93. Based on the analysis results, it shows that t-test 8.357 > t-table 1.699 with a validity degree of 29 (df 29) with a significance probability below <0.05. The results mean that H0 is rejected, and Ha is accepted.  
ACTIO PAULIANA LAWSUIT CONCERNING THE TRANSFER OF ASSETS BY INSOLVENT DEBTORS: AN ANALYSIS OF SUPREME COURT DECISION NUMBER 26 PK/PDT.SUS-BANKRUPTCY/2020 Kacita, Sisillia; Susanti, Erna; Damanik, Amsari
Jambura Journal Civic Education Vol 5, No 2 (2025): Vol.5 No.2 November 2025
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jacedu.v6i2.35646

Abstract

This study seeks to examine the application of the actio pauliana lawsuit concerning the transfer of assets by bankrupt debtors, with a particular focus on Supreme Court Decision Number 26 PK/Pdt.SusBankruptcy/2020. This decision serves as a representation of the legal protection mechanism for creditors within the bankruptcy process. The research employs a normative juridical method, concentrating on the analysis of written legal norms pertinent to the annulment of the debtor's legal actions. The approach includes a statutory analysis to assess the alignment of the decision with Article 1341 of the Civil Code and Article 41 of Law Number 37 of 2004 on Bankruptcy and Suspension of Debt Payment Obligations. Data sources comprise primary data, including laws and regulations, court decisions, and bankruptcy legal documents, while secondary data is derived from literature, scientific journals, academic articles, and expert legal opinions. The findings indicate that in Supreme Court Decision Number 26 PK/Pdt.Sus-Bankruptcy/2020, the debtor's asset transfer was declared null and void as it satisfied all elements of actio pauliana. These elements include the execution of legal actions during the debtor's insolvency, resulting in creditor losses, absence of legal obligations, and lack of good faith by both the debtor and the asset recipient. Consequently, the transferred assets are reinstated to the bankruptcy estate as a means of restoring creditor rights in the debt settlement process. This research affirms that actio pauliana is a crucial instrument in ensuring legal protection for creditors and plays a strategic role in upholding proportional justice, legal certainty, and the integrity of the bankruptcy process in Indonesia.
Exploring the Impact of Digital Transformation on Brand Loyalty in Emerging Markets Rahmayeni, Zulwida; Khairi, Awalul; Susanti, Erna
Jurnal Informatika Ekonomi Bisnis Vol. 7, No. 4 (December 2025)
Publisher : SAFE-Network

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37034/infeb.v7i4.1338

Abstract

This study examines the impact of digital transformation on brand loyalty in emerging markets, where digital adoption is expanding but remains uneven across consumer segments. The research aims to analyze whether digital transformation initiatives contribute to stronger brand loyalty by enhancing consumer experiences and long-term engagement. A quantitative research design is employed using a cross-sectional survey of consumers who interact with brands implementing digital platforms, mobile applications, and online engagement tools. Data are collected through a structured questionnaire and analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM) to test the proposed relationship. The results indicate that digital transformation has a positive and statistically significant effect on brand loyalty, demonstrating that higher levels of perceived digital integration and responsiveness are associated with stronger consumer commitment and repeat purchase intentions. The findings highlight that digital transformation functions not only as an operational improvement but also as a strategic instrument for strengthening brand–consumer relationships. This study provides practical insights for firms in emerging markets to position digital transformation as a core branding strategy and contributes empirically to the limited literature on digital transformation and brand loyalty within emerging market contexts.
Exploring the Impact of Digital Transformation on Brand Loyalty in Emerging Markets Rahmayeni, Zulwida; Khairi, Awalul; Susanti, Erna
Jurnal Informatika Ekonomi Bisnis Vol. 7, No. 4 (December 2025)
Publisher : SAFE-Network

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37034/infeb.v7i4.1338

Abstract

This study examines the impact of digital transformation on brand loyalty in emerging markets, where digital adoption is expanding but remains uneven across consumer segments. The research aims to analyze whether digital transformation initiatives contribute to stronger brand loyalty by enhancing consumer experiences and long-term engagement. A quantitative research design is employed using a cross-sectional survey of consumers who interact with brands implementing digital platforms, mobile applications, and online engagement tools. Data are collected through a structured questionnaire and analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM) to test the proposed relationship. The results indicate that digital transformation has a positive and statistically significant effect on brand loyalty, demonstrating that higher levels of perceived digital integration and responsiveness are associated with stronger consumer commitment and repeat purchase intentions. The findings highlight that digital transformation functions not only as an operational improvement but also as a strategic instrument for strengthening brand–consumer relationships. This study provides practical insights for firms in emerging markets to position digital transformation as a core branding strategy and contributes empirically to the limited literature on digital transformation and brand loyalty within emerging market contexts.
Analisis Hukum Bagi Hak Pekerja Pasca Putusan Pengadilan Hubungan Industrial Berdasarkan Teori Keadilan (Studi Kasus Putusan Nomor 37/Pdt.Sus-PHI/2023/PN Smr) Sugiharto, Grisela Mawa Aqilah; Arifudin, Nur; Susanti, Erna
UNES Law Review Vol. 7 No. 4 (2025)
Publisher : Universitas Ekasakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31933/unesrev.v7i4.2443

Abstract

Undang-Undang Penyelesaian Perselisihan HI merombak sistem penyelesaian perselisihan perburuhan yang ada, membagi perselisihan menjadi empat jenis. Salah satu masalah yang muncul adalah Pemutusan Hubungan Kerja (PHK), yang mempengaruhi kehidupan pekerja dan keluarganya. Karyawan berhak atas uang pesangon dan prosedur PHK harus sesuai undang-undang. Pekerja melakukan upaya hukum setelah di PHK dan mengajukan aduan ke Dinas Ketenagakerjaan. Proses berakhir dengan putusan pengadilan, tetapi pengusaha tidak mematuhi putusan untuk mempekerjakan kembali pekerja. Tujuan yaitu untuk menganalisisa Putusan Pengadilan Hubungan Industrial Nomor 37/Pdt.Sus-PHI/2023/PN Smr berdasarkan Teori Keadilan dan menganalisis upaya hukum untuk memenuhi Keadilan studi Putusan Pengadilan Nomor 37/Pdt.Sus- PHI/2023/PN Smr. Hasil dan pembahasan Keputusan PHK dapat merugikan pekerja secara ekonomi dan mental. Hubungan kerja dijalankan berdasarkan perjanjian. Masalah hukum sering muncul, terutama terkait PHK. Penyelesaian dapat dilakukan melalui perundingan dan mediasi. Serikat pekerja dapat mengajukan kasus ke pengadilan. Analisis keputusan dari sisi keadilan penting untuk melindungi hak pekerja. Kesimpulan berisikan jawaban atas pertanyaan penelitian. Kesimpulan harus menjawab tujuan khusus. Bagian ini dituliskan dalam bentuk esai dan tidak mengandung angka.
Penelusuran Kreativitas Bakat dan Minat Sebagai Bimbingan Karir Peserta Didik di SMK X Kota Payakumbuh Melalui Tes Riasec Fitriany, Rany; Khairiyah, Ummil; Susanti, Erna
ABDINE: Jurnal Pengabdian Masyarakat Vol. 6 No. 1 (2026): ABDINE : Jurnal Pengabdian Masyarakat
Publisher : Institut Teknologi dan Bisnis Riau Pesisir

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52072/abdine.v6i1.1814

Abstract

Kegiatan pengabdian Masyarakat ini bertujuan untuk memberikan Layanan bimbingan karir. Layanan ini di sekolah menengah sering menghadapi berbagai kendala, terutama keterbatasan waktu layanan yang umumnya hanya dilakukan satu kali dalam seminggu serta rasio guru bimbingan dan konseling dengan jumlah siswa yang belum ideal. Kondisi tersebut menyebabkan proses pendampingan karir belum dapat dilaksanakan secara optimal dalam membantu siswa mengenali potensi diri, minat, dan bakat yang dimiliki sebagai dasar perencanaan masa depan. Oleh karena itu, kegiatan bimbingan karir melalui tes minat dan bakat dilakukan untuk membantu siswa memperoleh gambaran yang lebih jelas mengenai potensi dirinya, baik dalam kesiapan memasuki dunia kerja, berwirausaha, maupun melanjutkan pendidikan ke jenjang yang lebih tinggi. Kegiatan ini menggunakan metode tes psikologi penelusuran kreativitas, bakat, dan minat yang meliputi tahap persiapan, pelaksanaan tes, pengolahan data (skoring), serta penyampaian laporan hasil kepada pihak sekolah. Peserta kegiatan berjumlah 31 siswa kelas XI TJKT I. Instrumen yang digunakan adalah Skala Minat Kewirausahaan dan Tes Minat Bakat SDS-Holland (RIASEC). Hasil analisis menunjukkan bahwa tipe minat dominan siswa adalah Realistic (R) sebesar 45%, diikuti Artistic (A) sebesar 16%, Social (S) dan Conventional (C) masing-masing sebesar 13%, Investigative (I) sebesar 7%, serta Enterprising (E) sebesar 6%. Hasil kegiatan menunjukkan bahwa siswa memperoleh pemahaman yang lebih baik mengenai potensi dirinya sehingga lebih yakin dan percaya diri dalam merencanakan pendidikan dan karir di masa depan
PENGARUH MEDIA LABORATORIUM VIRTUAL PHET TERHADAP MOTIVASI BELAJAR IPA PADA SISWA SMPN 2 JOMBANG Rizki Krismayanti, Yuly; Susanti, Erna; Isnawati, Isnawati
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 9 No. 2 (2024): Volume 09 No. 2 Juni 2024
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v9i2.14018

Abstract

This research aims to determine the effect of using PhET virtual laboratory media on science learning motivation in junior high school (SMP) students. The subjects of this research were students in class VIII-B SMPN 2 Jombang. Increasing students' learning motivation is seen from students' activeness, percentage of classical completion and students' responses regarding the virtual media of the PhET laboratory. The instruments used were observation sheets and questionnaire sheets. This type of research is classroom action research. This class action research was carried out in 2 cycles. The results obtained in this research were that there was an increase in students' learning motivation in cycle I and cycle II. The results obtained in cycle I showed that students' learning motivation was still in the low category. In cycle II, learning motivation increased to the very high category. Increasing student learning motivation is also seen from student learning outcomes. The average learning outcome in cycle I was 78.56 while the learning outcome in cycle II was 82.03. The conclusion of this research is that the PhET laboratory virtual media can increase students' learning motivation.
Co-Authors Adhi Susano Aditya Hermawan, Aditya Alia Alusyanti Primawati Amelia, Deni Amukti, Enggal Triya Ananda, Muhammad Rizky Apriyanti , Nike Arifah, Salsabila Budi Ashoka, Izza Fauzia Aulya, Muhammad Choirida, Alma Damanik, Amsari Denada Futri Talia Dewi Kumala Sari Eko Nursalim, Eko Emilda Kuspraningrum Endang Susilowati Fakhri, Arsyad Raziq Fauziyah, Tryana Fitriany, Rany Hardani, Ika Harisriwijayanti , Harisriwijayanti Hediati, Febri Noor Huriadana, Asra Irwansyah Irwansyah Isnawati Isnawati Kacita, Sisillia Kartika, Avrillia Cindy Khairi, Awalul Khairiyah, Ummil Khairunnisa, Ummul Kyrani, Velysha Rania lestari, winda Mahanem Mat Noor, Mahanem Mat Mahendra, Yusril Mardhiyah, Mardhiyah Mardiyah Mardiyah Minggarwati, Trian Sidha Nour Athiroh Abdoes Sjakoer Nur Arifudin Nurul Aziz Pratiwi Parlina, Iin Perdana Oskar, Dimas Pianda, Didi Pratama, George Christian Rahmayeni, Zulwida Ramadhan, Majida Ramadhani, Saskia Nadya Ravelby, Thesa Alif Ridianita, Cyntia Risma Aprinda Kristanti Rizki Krismayanti, Yuly Roihatul Mutiah Sa'pang, Grecia Melisa Safitri, Adinda Hariana Safitri, Malikah Sanjaya, Infan Santi, Novi Sasmitha, Rahmat Mubaroh Mulya Setiadi, Antonius Adji Prayitno Setyadini, Ellyvına Simamora, Priskila Putri Sugiharto, Grisela Mawa Aqilah Suhery, Suhery Suryana, Rafdi Susilowati, Ervan Suwandhani, Deni Syukri Hidayatullah Syukriah Syukriah, Syukriah Tombi, Johan Tri Noval Hendrian Triana, Lily Triyana, Lily Wardana, Khristyawan Wisnu Wibowo, Yosi Irawati Wisnudari, Elly Dian Yonita, Riza Yosua, Ricard Michail