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Journal : bioma

Association of TCF7L2 Gene Polymorphism With Non Obesetype 2 Diabetes Mellitus in Javanese Population Yuniastuti, Ari; Susanti, R; Nugrahaningsih, Nugrahaningsih; R, Rahmatika Saputri
Bioma : Jurnal Ilmiah Biologi Vol 12, No 2: October 2023
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/bioma.v12i2.15365

Abstract

Type 2 diabetes is characterized by insulin deficiency due to inadequate insulin secretion or decreased tissue response to insulin at one or more points. Three important factors that influence the pathogenesis of type 2 DM are individual factors or ethnic genetics, factors of pancreatic β cell damage and insulin resistance factors. The TCF7L2 gene is a gene that codes for TCF7L2 protein, a group of proteins that act as transcription factors in the Wnt signal pathway. TCF7L2 gene polymorphism occurs when cytosine is replaced with thymine in the intron 3 position in wild-type due to alternative splicing.The purpose study was to determine the frequency of TCF7L2 gene polymorphism in Javanese type 2 non-obese DM patients in Semarang. Detection of TCF7L2 gene polymorphism was carried out on 49 people with type 2 non-obese DM patients and 38 people not with type 2 DM using the PCR-RFLP method. The restriction enzyme used is Rsa1. The allele frequency of TCF7L2 gene polymorphism was analyzed by Chi-square and analysis of sample characteristics was carried out with Odds Ratio. The results showed that there were significant differences in the allele frequency of TCF7L2 gene polymorphism and in the characteristics of age, KGD and systole between case subjects and control subjects. From this study it was concluded that TCF7L2 gene polymorphism is associated with the type 2 DM through interactions between genetic factors (T allele) and life style.
Co-Authors - Suprapti, - A Yuniastuti A.A. Ketut Agung Cahyawan W Adhi, Nino Aditya Marianti Aji Purwinarko, Aji Alhukam, Nabilla Arsya Ali Rizqi, Nur Kholish Ali Rizqi, Nur Kholish Alya Rizky Puspaningrum Ana Fitria Ananda, Ananda Anandha Anandha Anandha Anandha, Anandha Andi Suhardiyanto Andreas Priyono Budi Prasetyo Andry Setiawan Angga Ari Wibowo Ani Rusilowati Ari Yuniastuti Ariesta, Putri Ariesta, Putri ARIF INDIARTO, ARIF Arlinda, Dyken Dwi Asri, Widi Aulia, Innarotul Aulia, Maliqa Azkiyah, Nimas Catur BAHRAIN DWI MASITHO, BAHRAIN DWI Bahtiar, Denny Herbianto Cahyati, Widya Hari Cahyo, Reza Dwi Cahyo, Reza Dwi Chasnah Chasnah, Chasnah Chatarina Umbul Wahyuni Dewi Mustikaningtyas Dewi, Nuriana Rahmani DIAN LESTARI Dimarti, Safira Chairani Dita Selviana, Dita Doni Saputro E Hidayat, E E.S.,, Sri Mulyani Endah Peniati ENDANG TRI MARGAWATI Enni Suwarsi Rahayu F Widhi Mahatmanti Fachry Abda El Rahman Farikhul Ulum Felintina Yuniarti, Felintina Fidia Fibriana Fifti Istiklaili, Fifti Firdausi, Aulya Della Fitri Arum Sasi, Fitri Arum Gita Ria Octafia, Gita Ria Hammam, Bagus Hardi Saputro, Iwan Hasani, Azharu Alfi I Gusti Ngurah K Mahardika I Gusti Ngurah Kade Mahardika I Wayan T Wibawan I-W.T Wibawan Ibnul Mubarok Ilhan Satria Wirayudha Indriawati, Indriawati Irna Kinayungan, Irna Isnaeni, Lili Astuti Isnaeni, Lili Astuti Isti Hidayah Iswari, R S Kusuma, Fitriana Dian Kusuma, Putri Patria Larasanti, Firna Larasanti, Firna M.T Suhartono Maggy T Suhartono Mahardika Prasetya Aji Maman Rachman Margareta Rahayuningsih Nugroho Edi K Mega Fatimah Rosana Moh. Aris Munandar, Moh. Aris Muyasaroh, Kun Maisarotun Na’ima, Mirtaati Nahar, Akhmad Lutfi Nahar, Akhmad Lutfi Naim, Fatchun Nezar, Muhammad Rofiq Ning Setiati Nissa, Ma’isyatun Nugrahaningsih Nugrahaningsih Nugrahaningsih WH, Nugrahaningsih Nur Halimah Nur Kusuma Dewi Nur Rahayu Utami Oktaviani, Esa Pramesti Dewi Pratiwi, Retno Herningrum Priyantini Widiyaningrum PUJI LESTARI Pukan, Krispinus Putri, Amalia Nurina R, Rahmatika Saputri R.D Soejoedono RAHMA FERDIANA, RAHMA Rahmatih, Aisa Nikmah Rahmatih, Aisa Nikmah Rahmawati, Esa Mara Rahmawati, Sinta Kurnia Ratih Puspita Dewi Retna Utami Retno D Soejoedono Retno Sri Iswari Rizki Puspita Dewi, Rizki Puspita Rohmah, Amalia Nor Romadhoni, Mar`atush Sholihah RS Iswari S.Pd. M Kes I Ketut Sudiana . Sa’adah, Siti Rofiatus Salfia, Mega Samsul Nizar Saraswati, Ifah Saraswati, Ifah Septiana Anggraini, Septiana Setiadi, Eka Setiajid Setiajid Setiajid Setiajid, Setiajid Shinta Widyastuti, Shinta Sigit Saptono Sipi Ruruh Faizah Siti Harnina Bintari Sri Sukaesih Sri Utami Sriyadi Sriyadi, Sriyadi Sulistyo, Danu Sumarno . Sunarto Sunarto Suryo Pratikwo Suryonegoro, Bayu Murti Sutikno Sutikno Tafrika Donita Talitha Widiatningrum Tijan Tijan, Tijan Tri Budi Kurniawan, Tri Budi Trisna, Mila Tuti Widianti Umi Isnaeni, Umi Utami, Anisa Dyah Wahyuni, Desiy Ema Dwi Wardono, Hari Rudijanto Indro Widya Hary Cahyati Wijaya, Ifan Badra Wijayanti , Yuni Wiwi Isnaeni Wulan Christijanti Wulandari K. E, Yenni Tyas Yohanes Nong Bunga Yuliana, Lusia Retno Yuliana, Lusia Retno Yuliantika, Atika Yuni Wijayanti Yustinus Ulung Anggraito Zaenafree, Intan Zakyani, Nova N