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All Journal Jurnal Gizi dan Pangan Jurnal Anestesiologi Indonesia JURNAL GIZI INDONESIA Journal of Nutrition College Jurnal Kesehatan Masyarakat Media Ilmu Keolahragaan Indonesia Jurnal Keolahragaan Journal of Biomedicine and Translational Research JURNAL PENDIDIKAN KEPERAWATAN INDONESIA GIZI INDONESIA JOURNAL SPORT AREA Jurnal Ilmu Keperawatan Komunitas Jurnal Health Sains Jurnal Locus Penelitian dan Pengabdian Jurnal Kebidanan dan Keperawatan Aisyiyah JHeS (Journal of Health Studies) JSSF : Journal of Sport Science and Fitness
Hardhono Susanto
Jurusan Bagian Anatomi Fakultas Kedokteran Universitas Diponegoro
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Successful High-Risk Pulseless-Balloon Aortic Valvuloplasty Procedure in Uncorrected Pulmonary Atresia with Severe Congenital Aortic Stenosis and Low Left Ventricular Function Sofia, Sefri Noventi; Bahrudin, Bahrudin; Riwanto, Ignatius; Susanto, Hardhono; Soetadji, Anindita; Baskoro, Adhi Gunawan; Prawara, Ananta Sidhi; Satyagraha, Muhammad Thifan; Kurniawati, Yovie; Prakoso, Radityo
JAI (Jurnal Anestesiologi Indonesia) Vol 17, No 3 (2025): JAI (Jurnal Anestesiologi Indonesia)
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jai.v0i0.72347

Abstract

Background: Pulmonary atresia with ventricular septal defect (PA-VSD) and severe bicuspid aortic stenosis is an uncommon condition that presents significant surgical challenges. The dual obstruction leads to chronic pressure overload, resulting in ventricular hypertrophy and decreased systolic function. A low left ventricular ejection fraction (LVEF) increases the risk of mortality during surgical interventions. Percutaneous balloon aortic valvuloplasty (PBAV) poses additional risks due to the intentional induction of pulselessness during balloon inflation. This case report aims to detail the perioperative management strategies employed during PBAV in a patient with PA-VSD, severe aortic stenosis, and low LVEF.Case: We present a 19-year-old female patient weighing 45 kg with shortness of breath and fatigue. Her oxygen saturation was measured at 90% across all extremities. Electrocardiogram (ECG) findings indicated sinus rhythm with biventricular hypertrophy and incomplete left bundle branch block (LBBB). Chest X-ray revealed cardiomegaly and pulmonary artery dilation, while echocardiography confirmed PA-VSD, severe aortic stenosis with a mean pressure gradient (mPG) of 55 mmHg, and an LVEF of 41.3%. A percutaneous pulseless-BAV was performed using a Tyshak balloon via an antegrade transvenous femoral approach under fluoroscopy and transesophageal echocardiography guidance.Discussion: Anesthesia management focused on gradual medication titration, minimizing patient movement during the procedure, and ensuring comfort due to transesophageal echocardiogram (TEE) probe insertion. A temporary pacemaker was placed in the right ventricular apex for pacing at 220 beats per minute until cardiac arrest occurred post-balloon inflation, and defibrillation successfully restored spontaneous circulation.Conclusion: This case illustrates that PBAV in uncorrected PA-VSD with severe aortic stenosis and low LVEF is feasible despite its inherent risks when conducted by a skilled team utilizing careful judgment throughout the procedure.
STUDI KUALITATIF PERSEPSI DAN PENGALAMAN HIDUP DENGAN DIDIAGNOSIS DIABETES MELITUS MUNTAMAH, UMMU; Purwaningsih, Puji; Susanto, Hardhono; Ediati, Annastasia; Dwiantoro, Luky
Jurnal Ilmu Keperawatan Komunitas Vol. 6 No. 2 (2023)
Publisher : Persatuan Perawat Nasional Indonesia (PPNI) Jawa Tengah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32584/jikk.v6i2.2252

Abstract

Backgraund: Diabetes Mellitus and Diabetes Distress are global problems that were interconnected. Someone who was diagnosed with DM, will be placed in a stress condition because the patient feels difficult with the many demands for self-care with DM. Objective: This study aims to explore the experience and understanding of diabetes, feelings after being diagnosed with diabetes, efforts made when facing difficulties. Methods: This research is a qualitative study. We used semi-structured interviews. This report was written following COREQ guidelines. Thematic analysis was applied to analyze the data. Results: there were four themes; 1) understanding the right DM is important to provide adequate understanding so that diabetes self-care activities can be carried out correctly, 2) attitude and behavior as well as inaccurate information can trigger situations that are threatening to cause severe diabetes, 3) the right efforts to deal with threatening situations can prevent the occurrence of severe diabetes, and 4) the role and support of others to help solve problems effectively as expected. Conclution: The perception and experience of patients living with diabetes mellitus is to assume that DM is a diabetes disease that is difficult to cure. The perceived response is shock, sadness, bore, stress, and fear
Mapping the Research Landscape of Natural Compounds for Tuberculosis Treatment: A Bibliometric Approach Hakam, Abdul; Susilaningsih, Neni; Mexitalia, Maria; Susanto, Hardhono; SyarofilAnam, Moh.
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 5 (2025): JURNAL LOCUS: Penelitian & Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i5.3981

Abstract

Tuberculosis (TB) remains a global health crisis, exacerbated by rising drug resistance in Mycobacterium tuberculosis. While conventional therapies like BPaL/BPaLM regimens and shorter rifapentine-based treatments show promise 11–33, the need for novel anti-TB agents persists. Natural compounds, particularly from biodiverse regions like Indonesia 77, offer untapped potential, yet prior bibliometric analyses lack comprehensive integration of computational and multi-omics approaches to guide future research. This study maps the research landscape of natural compounds for TB treatment (2015–2025) through bibliometric analysis, identifying gaps and proposing AI-driven, multi-disciplinary strategies to accelerate drug discovery. PubMed-derived data (23 articles) were analyzed using VOSviewer to visualize co-authorship, keyword co-occurrence, and thematic clusters. Trends in authorship, geographic contributions, and research foci (e.g., molecular docking, drug resistance) were evaluated. China dominated research output (11/23 studies), with clusters emphasizing computational methods (e.g., virtual screening), bacterial enzymes, and animal models. Keyword analysis revealed a strong focus on drug resistance and synergism, yet limited exploration of AI, multi-omics, or ethnopharmacology. Notably, studies like Romulo et al. (2018) highlighted Indonesian plants’ anti-TB potential 77, but systematic integration with modern technologies remains underexplored. This study identifies a critical gap: the need to merge traditional natural compound research with AI-aided drug design, multi-omics (e.g., transcriptomics 1616), and nanodelivery systems. By proposing a framework that bridges computational predictions (e.g., molecular docking 1515) with experimental validation, this research advances a novel, scalable approach to combat drug-resistant TB, leveraging global biodiversity and cutting-edge technologies.
Model spiritual care with an adaptation theory approach Callista Roy on cortisol levels Kusuma, Aria Nurahman Hendra; Pudjonarko, Dwi; Sujianto, Untung; Susanto, Hardhono; Ibrahim, Kusman; Dwidiyanti, Meidiana
JHeS (Journal of Health Studies) Vol. 9 No. 2 (2025): September
Publisher : Universitas 'Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/jhes.4283

Abstract

Ischemic stroke is a cause of physical disability. These defects result in impaired biopsychosociospiritual adaptation in stroke patients. The inability to adapt will cause an anxiety reaction which triggers an increase in cortisol levels. The spiritual care model helps patients find meaning and purpose in life as well as an optimistic attitude so that they have better adaptability. This type of research is Quasy Experimental with a pretest-posttest control group design. The study population was ischemic stroke patients in the Outpatient Department of Dr. Regional General Hospital. Moewardi Surakarta. The total sample consisted of 60 respondents, divided into 30 control group respondents and 30 intervention group respondents, who received a spiritual care model intervention in the outpatient room of Dr RSUD. Moewardi Surakarta. The research results show the influence of the Spiritual Care Model Using Callista Roy's Adaptation Theory Approach on Cortisol Levels in Ischemic Stroke Sufferers with a significance value of 0.043 < 0.05. The Spiritual care model influences the amygdala, which stimulates the hypothalamus through the hypothalamic-pituitary-adrenal (HPA) axis, thereby inhibiting the excretion of corticotropin-releasing factor (CRF). The pituitary gland then stimulates adrenocorticotropic hormone (ACTH), which reduces cortisol. This research has a contribution that spiritual care interventions can improve the adaptability of biopsychosocial rehabilitation of stroke patients. This research has a contribution that spiritual care interventions can improve the ability to adapt biopsychosocial rehabilitation of stroke patients.
The Effect of Administration Ginger and Lemongrass Drink on Interleukine 6 Football Player After Exercise adnan, Miftahul; Afifah, Diana Nur; Anjani, Gemala; Susanto, Hardhono; Noer, Etika Ratna; Widodo, Sumardi
Journal of Sport Science and Fitness Vol. 10 No. 2 (2024): Journal of Sport Science and Fitness
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jssf.v10i2.15662

Abstract

Physical exercise can increase the production of free radicals. Free radical can trigger oxidative stress and inflammation. Ginger and lemongrass has bioactive compound that function as antioxidant and antiinflammatory. This study aim to determine the effecs of giving ginger and lemongras drink on IL6 level in football player. Quasi experimental study with pre and post control group design. The subject were 24 football player divided 2 namely control and intervention group. The intervention group given a ginger and lemongrass drink. The control group was only given brown sugar drink. The intervention are given after exercise for 28 days. Blood samples were collected and tested after exercise. Interleukine 6 were measured using the ELISA Method. Our result showed there was differences in interleukine 6 after giving ginger and lemongrass drink (p=0.004). The delta of interleukine 6 level after intervention was 3.24 pg/ml. Conclusion this research are there was a decrease in interleukine 6 level after giving ginger and lemongrass drink for 28 days to football players after exercise.
Profile of Physical Fitness in Student Football Athletes Through Vo2 Max and FVC Lung Parameters in Sons South Sumatra Rahima, Rahima; Susanto, Hardhono; Flora, Rostika; Bahrudin, Udin
Jurnal Health Sains Vol. 4 No. 11 (2023): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v4i11.1102

Abstract

Fit physical condition is needed in every sport, especially in soccer which is known to be one of the dynamic sports with dominant movements using anaerobic energy, and also aerobic energy to be able to last throughout the game for a long duration. Every player is required to have excellent physical fitness which is certainly supported by maximum aerobic capacity. For an athlete, aerobic capacity is mandatory to be increased as much as possible, especially in adolescence, because at this time it can contribute to an increase in aerobic capacity of up to 30-35% compared to adults and the elderly, The purpose of this study was to determine the profile of the physical fitness level of athlete students through VO2Max parameters and Forced Vital Capacity / FVC lung in football athlete students at Sriwijaya State Sports School (SONS) Sumatra South. This type of research is a descriptive analysis and data collection is carried out by laboratory using a treadmill device with the Bruce method which is the gold standard in cardiopulmonary fitness assessment and a spirometry tool to measure the forced vital capacity of the lungs. The subjects in this study amounted to 33 male students from the sport of football. The results of the data analysis showed that the majority of SONS football athlete students had a fitness level with less category (96.9%) and very less category (3.1%), the predicted value of Forced Lung Vital Capacity with normal category was 66.7% and the remaining 33.3% in the category below normal. The average count (mean) of pulmonary FVC value is = 2.86 liters, with a maximum value of 3.82 liters and a minimum value of 1.46 liters. It can be concluded that the level of physical fitness in SONS soccer players is still low, for that it is necessary to increase the maximum aerobic capacity and lung capacity of athlete students as much as possible through an intense and systematic training program.
The effect of red pomegranate provision on malondialdehyde and blood lactic acid level in rats with maximum physical activity Zainuddin, Ahmad; Susanto, Hardhono; Rosidi, Ali
Jurnal Gizi dan Pangan Vol. 14 No. 2 (2019)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (241.084 KB) | DOI: 10.25182/jgp.2019.14.2.77-82

Abstract

The primary objective of this research was to examine the effect of provision of red pomegranate juice on the levels of malondialdehyde (MDA) and blood lactic acid in Wistar rats with maximum physical activity. The study employed a true experiment design. The pretest-posttest with control group design was done on 35 rats given maximum physical activity and treatment for 28 days. The rats were divided into 5 groups: the control group, group with treatment of multivitamin, group with treatment of red pomegranate 2 ml, 4 ml, and 6 ml. The MDA level was measured by TBARS method and lactic acid levels were analysed using ELISA. Comparison statistical analysis was done using paired t-test, while comparison of mean differences between treatment groups were tested using One-way ANOVA, and followed by LSD as the post hoc test. Provision of red pomegranate juice in a variety of doses significantly decreased the levels of MDA and blood lactic acid (p<0.05). The highest MDA level decrease occurred in the group treated with multivitamin (68.02%) and the highest decrease in the levels of blood lactic acid occurred in the group with 6 ml red pomegranate juice (25.94%). Based on the findings, it can be concluded that red pomegranate juice can lower the levels of MDA and blood lactic acid significantly in rats with maximum physical activity.
Low sEng Level in Preeclampsia with MFTHFR Gene Polymorphism Suggesting a Protective Factor Pramono, M. Besari Adi; Faradz, Sultana MH; Suhartono, Suhartono; Susanto, Hardhono; Rachmawati, Banundari; Pramono, Noor
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.29375

Abstract

Background: Preeclampsia is one of the most serious complications of pregnancy and the leading cause of maternal and fetal mortality. Various studies have shown that Glutathione Peroxidase (GPx) deficiency and increased Soluble endoglin (sEng) level are consistently associated with the incidence of preeclampsia. Several studies also show the role of MTHFR A1298C and C677T gene polymorphisms in preeclampsia.Objective: This study investigated association between blood GPx, sEng levels, MTHFR A1298C and C677T gene polymorphisms in Preeclampsia.Methods: This analytic observational case-control study was conducted on 70 cases of preeclampsia and 70 controls. Blood GPx and sEng levels were measured using Enzyme Linked Immunosorbent Assay (ELISA). MTHFR A1298C and C677T gene polymorphism was genotyped using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The data obtained were analyzed using the Mann-Whitney U test, chi-square test, and independent T-test.Results: There were no significant differences in GPx levels or MTHFR A1298C/C677T genotype distribution between groups. sEng levels were significantly higher in the preeclampsia group than controls (p=0.001). ROC analysis identified a cut-off of 7.75 ng/mL. Among preeclampsia patients, those with the MTHFR 1298AC/CC genotypes had lower sEng levels than wildtype (p=0.027), suggesting a potential protective effect. No association was found for C677T.Conclusion: We found no significant difference in GPx level, MTHFR A1298C and C677T gene polymorphism between preeclampsia and control group. Soluble endoglin (sEng) level in the preeclampsia group (mean: 11.0±5.22) were significantly different (p=0.001) compared to the control group (mean: 8.1±5.31). Increased level of sEng is associated with incidence of preeclampsia. A key finding in this study is the significantly lower sEng levels observed in preeclampsia patients carrying the MTHFR 1298AC and 1298CC alleles compared to the control group (p=0.027). This indicates a protective factor where in preeclampsia with MTHFR gene alleles 1298AC and 1298CC sEng levels are lower compared to wildtype.
The Effect of Tactile – Kinesthetic Stimulation on Bone Mineralization, Osteocalcin Levels and Body Height Among Stunting Children Aged 6-11 Months Sutarmi, Sutarmi; Susanto, Hardhono; Mexitalia, Maria; Medise, Bernie
Jurnal Pendidikan Keperawatan Indonesia Vol 10, No 1 (2024): Volume 10, Nomor 1, Juni 2024
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/jpki.v10i1.71210

Abstract

Introduction: Stunting is growth faltering caused by as poor nutrition, recurrent infections, a lack of psychosocial stimulation. Growth faltering is associated to bone growth disorder.  In order to prevent and overcome stunting not only nutrition but also an adequate stimulation is needed. Objective: This study looked at the effects of tactile–kinesthetic stimulation on bone mineralization, osteocalcin levels and body height among stunting children. Methods: Eighty (80) stunting children (mean of age 8 ± 1,71) were randomly assigned into two groups. Tactile–Kinesthetic Stimulation (TKS) was administrated by trained parents twice daily for three months in the intervention group. The control group was given a routine care of stunting program from public health center. The bone mineralization (osteocalcin serum) and length of body in both groups were measured at enrollment and after week twelve. Results: During three (3) months TKS period, the intervention group had a significant increment in length and osteocalcin serum compared to control group (p 0.005) at 3.17 cm and 11.5 ng/ml respectively. Moreover, this study also showed that providing TKS demonstrated a strong correlation in a positive direction to length. The TKS treatment could increase the body height of stunting children by 86.5%. There was a positive correlation among osteocalcin levels, intake of vitamin A, protein and calcium on improving length (p0.05). Conclusion: TKS was significantly effective in promoting bone mineralization particularly osteocalcin levels and length among stunting children. There was also a strong correlation that TKS could elevate the length of 0.865-times. 
Nutrition intake, insulin-like growth factor-1 hormone levels, somatotype score, and strength performance of adolescent athletes Zetta, Adelia Paradya; Susanto, Hardhono; Noer, Etika Ratna; Muniroh, Muflihatul; Widyastiti, Nyoman Suci
Journal Sport Area Vol 9 No 3 (2024): December
Publisher : UIR Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25299/sportarea.2024.vol9(3).17017

Abstract

Background Problems: Currently, there is still limited identification of nutritional intake, hormonal, and physical performance in adolescent athletes in Indonesia. Research Objectives: This study aims to identify anthropometric, nutritional intake, IGF-1 hormone level, and adolescent athletes’s performance. Methods: The research method used a cross-sectional study. A convenient sample of 58 athletes under Balai Pemusatan Pendidikan dan Latihan Pelajar. The research instrument used Bioelectrical Impedance Analysis (BIA), leg dynamometer, hand grip dynamometer, tape measure, height stature, SQ-FFQ Form, and body fat caliper. Blood samples were collected and tested by a professional laboratory. Data analysis techniques used Pearson’s test for normally distributed data and Spearman’s rank for non-normally distributed data. Findings and Results: The result of this study found a significant (p < 0.05) correlation between energy intake, anthropometric measurement of z score (BMI/Age), and endomorph score with an athlete’s muscle strength. We also found significant differences (p < 0.05) in macronutrient and micronutrient consumption in male and female athletes, and we also found significant differences in somatotype score and muscle strength in male and female athletes. Conclusion: We conclude that many athletes are not consuming the recommended levels of carbohydrates, fat, protein, and some micronutrients. We found a correlation between energy intake and fat intake with leg muscle strength. However, there was no correlation between IGF-1 hormone levels and athlete strength. Intake is thought to indirectly affect grip strength and leg strength.
Co-Authors Abdul Hakam Adriyan Pramono Ahmad Zainuddin Ali Rosidi Anak Agung Gede Sugianthara Anindita Soetadji Anjani, Gemala Annastasia Ediati Aria Nurahman Hendra Kusuma Arie Nugroho, Arie Arulita Ika Fibriana Bahrudin Bahrudin Banundari Rachmawati Baskoro, Adhi Gunawan Deny Yudi Fitranti Dewi, Ni Putu Puspita Adhytiarini Diana Nur Afifah, Diana Nur Djuara P Lubis Dwi Pudjonarko Dwiantoro, Luky Esri Rusminingsih - Etika Ratna Noer Ign. Riwanto Ignatius Riwanto, Ignatius Iqlima Safitri, Iqlima Iriyanti Harun Kurniawati, Yovie Kusman Ibrahim M. Besari Adi Pramono, M. Besari Adi Mahalul Azam Maria Mexitalia Martha Irene Kartasurya Medise, Bernie Meidiana Dwidiyanti Miftahul Adnan Mohammad Zen Rahfiludin Muhammad Hatta Muniroh, Muflihatul Neni Susilaningsih Noor Pramono Nur Amin, Nur Nurahmatika, Prisma Nyoman Suci Widyastiti Prawara, Ananta Sidhi Radityo Prakoso Rahfilludin, M. Zen Rahima Rahima Rostika Flora Rr. Sri Ratna Rahayu S.Pd. M Kes I Ketut Sudiana . Satyagraha, Muhammad Thifan Sefri Noventi Sofia Setyarsih, Liani Siti Baitul Mukarromah Sultana MH Faradz Sumardi Widodo Supriyadi Supriyadi Sutarmi, Sutarmi SyarofilAnam, Moh. Tandiyo Rahayu Udin Bahrudin, Udin Ummu Muntamah Untung Sujianto Wibowo, Judiono Widyastuti, Trioni Yance Anas Yuswo Supatmo Zetta, Adelia Paradya