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All Journal Jurnal Gizi dan Pangan Jurnal Anestesiologi Indonesia JURNAL GIZI INDONESIA Journal of Nutrition College Jurnal Kesehatan Masyarakat Media Ilmu Keolahragaan Indonesia Jurnal Keolahragaan GIZI INDONESIA JOURNAL SPORT AREA Indonesian Journal of Medicine Jurnal Ilmu Keperawatan Komunitas Jurnal Health Sains Diponegoro International Medical Journal (DIMJ) Jurnal Locus Penelitian dan Pengabdian Jurnal Kebidanan dan Keperawatan Aisyiyah JHeS (Journal of Health Studies) Eduvest - Journal of Universal Studies JSSF : Journal of Sport Science and Fitness

Hardhono Susanto

Jurusan Bagian Anatomi Fakultas Kedokteran Universitas Diponegoro

Author-ID : 395976

Aerospace Engineering Humanities Automotive Engineering Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Environmental Science Health Professions Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Green Synthesis of Silver Nanoparticles as a Wound Healing Agent: a Systematic Review of the Biological Activities Priambodo, Galih; Samekto, Widiastuti; Subagio, Agus; Susanto, Hardhono; Dwiantoro, Luky
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.1.612

Background: The implication of nanotechnology includes silver nanoparticles to medical sciences, and has a revolutionary impact on therapeutic and diagnostics management. Many studies reported that silver nanoparticle (AgNPs) application can accelerate the wound healing process. This study aimed to systematically review the biological activities of silver nanoparticles as a wound-healing agent.Subjects and Method: This article was a systematic review study conducted by searching for articles from online databases such as EBSCO, PubMed, Science Direct, and World Scientific. Populations: laboratory animals; Intervention: green synthesis of silver nanoparticles; Comparison: a standard ointment for wounds such as povidone-iodine, etc; Outcome: wound healing. The independent variable is the green synthesis of silver nanoparticles, and the dependent variable is wound healing. The inclusion criteria for this study were full articles using an experimental study, with the publication year until 2022. The data extraction was focused on the biological activities of silver nanoparticles and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations for systematic reviews.Results: A total of 8 articles reviewed in this study were from countries: Egypt, India, Saudi Arabia, Singapore, and China. The green synthesis of AgNPs was accomplished using a natural aqueous extract from leaves such as Azadirachta indica, Tridax procumbens, the combinations of Catharanthus roseus and Azadirachta indica, Scutellaria barbata, the fungus Fusarium verticillioides, or cyanobacterial platforms (ex: Phormidium sp., Synechocystis sp, and arthrospira sp polysaccharides). All studies were animal-based experimental with wounds infected with bacteria and inflicted in regards to the experiment. All trials resulted in favor of the AgNPs ointment treated group compared to the untreated group or the standard ointment group.Conclusion: Our review suggested that all studies about the efficacy of AgNPs as wound-healing therapy showed positive results.Keywords: biological activities, silver nanoparticles, wound healing.Correspondence: Galih Priambodo. Faculty of Medicine, Universitas Diponegoro. Jl. Prof. Sudarto, Tembalang, Kec. Tembalang, Kota Semarang, Central Java. Email: g2_37@yahoo.co.id. Mobile: 085229998999.Indonesian Journal of Medicine (2023), 08(01): 100-113https://doi.org/10.26911/theijmed.2023.08.01.10

Successful High-Risk Pulseless-Balloon Aortic Valvuloplasty Procedure in Uncorrected Pulmonary Atresia with Severe Congenital Aortic Stenosis and Low Left Ventricular Function Sofia, Sefri Noventi; Bahrudin, Bahrudin; Riwanto, Ignatius; Susanto, Hardhono; Soetadji, Anindita; Baskoro, Adhi Gunawan; Prawara, Ananta Sidhi; Satyagraha, Muhammad Thifan; Kurniawati, Yovie; Prakoso, Radityo
JAI (Jurnal Anestesiologi Indonesia) Vol 17, No 3 (2025): JAI (Jurnal Anestesiologi Indonesia)
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jai.v0i0.72347

Background: Pulmonary atresia with ventricular septal defect (PA-VSD) and severe bicuspid aortic stenosis is an uncommon condition that presents significant surgical challenges. The dual obstruction leads to chronic pressure overload, resulting in ventricular hypertrophy and decreased systolic function. A low left ventricular ejection fraction (LVEF) increases the risk of mortality during surgical interventions. Percutaneous balloon aortic valvuloplasty (PBAV) poses additional risks due to the intentional induction of pulselessness during balloon inflation. This case report aims to detail the perioperative management strategies employed during PBAV in a patient with PA-VSD, severe aortic stenosis, and low LVEF.Case: We present a 19-year-old female patient weighing 45 kg with shortness of breath and fatigue. Her oxygen saturation was measured at 90% across all extremities. Electrocardiogram (ECG) findings indicated sinus rhythm with biventricular hypertrophy and incomplete left bundle branch block (LBBB). Chest X-ray revealed cardiomegaly and pulmonary artery dilation, while echocardiography confirmed PA-VSD, severe aortic stenosis with a mean pressure gradient (mPG) of 55 mmHg, and an LVEF of 41.3%. A percutaneous pulseless-BAV was performed using a Tyshak balloon via an antegrade transvenous femoral approach under fluoroscopy and transesophageal echocardiography guidance.Discussion: Anesthesia management focused on gradual medication titration, minimizing patient movement during the procedure, and ensuring comfort due to transesophageal echocardiogram (TEE) probe insertion. A temporary pacemaker was placed in the right ventricular apex for pacing at 220 beats per minute until cardiac arrest occurred post-balloon inflation, and defibrillation successfully restored spontaneous circulation.Conclusion: This case illustrates that PBAV in uncorrected PA-VSD with severe aortic stenosis and low LVEF is feasible despite its inherent risks when conducted by a skilled team utilizing careful judgment throughout the procedure.

STUDI KUALITATIF PERSEPSI DAN PENGALAMAN HIDUP DENGAN DIDIAGNOSIS DIABETES MELITUS MUNTAMAH, UMMU; Purwaningsih, Puji; Susanto, Hardhono; Ediati, Annastasia; Dwiantoro, Luky
Jurnal Ilmu Keperawatan Komunitas Vol. 6 No. 2 (2023)
Publisher : Persatuan Perawat Nasional Indonesia (PPNI) Jawa Tengah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32584/jikk.v6i2.2252

Backgraund: Diabetes Mellitus and Diabetes Distress are global problems that were interconnected. Someone who was diagnosed with DM, will be placed in a stress condition because the patient feels difficult with the many demands for self-care with DM. Objective: This study aims to explore the experience and understanding of diabetes, feelings after being diagnosed with diabetes, efforts made when facing difficulties. Methods: This research is a qualitative study. We used semi-structured interviews. This report was written following COREQ guidelines. Thematic analysis was applied to analyze the data. Results: there were four themes; 1) understanding the right DM is important to provide adequate understanding so that diabetes self-care activities can be carried out correctly, 2) attitude and behavior as well as inaccurate information can trigger situations that are threatening to cause severe diabetes, 3) the right efforts to deal with threatening situations can prevent the occurrence of severe diabetes, and 4) the role and support of others to help solve problems effectively as expected. Conclution: The perception and experience of patients living with diabetes mellitus is to assume that DM is a diabetes disease that is difficult to cure. The perceived response is shock, sadness, bore, stress, and fear

Mapping the Research Landscape of Natural Compounds for Tuberculosis Treatment: A Bibliometric Approach Hakam, Abdul; Susilaningsih, Neni; Mexitalia, Maria; Susanto, Hardhono; SyarofilAnam, Moh.
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 5 (2025): JURNAL LOCUS: Penelitian & Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i5.3981

Tuberculosis (TB) remains a global health crisis, exacerbated by rising drug resistance in Mycobacterium tuberculosis. While conventional therapies like BPaL/BPaLM regimens and shorter rifapentine-based treatments show promise 11–33, the need for novel anti-TB agents persists. Natural compounds, particularly from biodiverse regions like Indonesia 77, offer untapped potential, yet prior bibliometric analyses lack comprehensive integration of computational and multi-omics approaches to guide future research. This study maps the research landscape of natural compounds for TB treatment (2015–2025) through bibliometric analysis, identifying gaps and proposing AI-driven, multi-disciplinary strategies to accelerate drug discovery. PubMed-derived data (23 articles) were analyzed using VOSviewer to visualize co-authorship, keyword co-occurrence, and thematic clusters. Trends in authorship, geographic contributions, and research foci (e.g., molecular docking, drug resistance) were evaluated. China dominated research output (11/23 studies), with clusters emphasizing computational methods (e.g., virtual screening), bacterial enzymes, and animal models. Keyword analysis revealed a strong focus on drug resistance and synergism, yet limited exploration of AI, multi-omics, or ethnopharmacology. Notably, studies like Romulo et al. (2018) highlighted Indonesian plants’ anti-TB potential 77, but systematic integration with modern technologies remains underexplored. This study identifies a critical gap: the need to merge traditional natural compound research with AI-aided drug design, multi-omics (e.g., transcriptomics 1616), and nanodelivery systems. By proposing a framework that bridges computational predictions (e.g., molecular docking 1515) with experimental validation, this research advances a novel, scalable approach to combat drug-resistant TB, leveraging global biodiversity and cutting-edge technologies.

A Systematic Review of High-Intensity Interval Training Protocols and Their Effects in BMI And Metabolic Biomarkers in Obese Adolescents: A Focus on Randomized Controlled Trials Ajoekesoema, Tanti; Crisdayani, Carissa Putri; Syaravina, Elita; Rachmawati, Banundari; Susanto, Hardhono; Tulaar, Angela B. M.
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i1.26720

Background: Adolescent obesity is a growing public health concern, associated with chronic diseases such as cardiovascular disease, type 2 diabetes, and non-alcoholic fatty liver disease. High-Intensity Interval Training (HIIT) has been identified as a potential intervention to improve weight management and metabolic health in this population.Objective: To evaluate the impact of HIIT, alone or in combination with dietary advice, on weight management and metabolic health indicators, including Body Mass Index (BMI), fasting serum glucose levels, and metabolic biomarkers in adolescents with overweight or obesity.Methods: This systematic review included randomized controlled trials (RCTs) focusing on adolescents aged 16 to 19 with a BMI of 23 kg/m² or above. Studies were selected based on predefined criteria, excluding cross-over trials and quasi-randomized studies. Primary outcomes were changes in BMI, fasting serum glucose, and metabolic biomarkers. Secondary outcomes included measures of insulin resistance. The GRADE methodology was used to appraise the certainty of evidence.Results: Five RCTs were included, demonstrating that HIIT, especially when combined with dietary advice, significantly improves insulin sensitivity, reduces waist circumference, and enhances cardiometabolic health. The interventions varied in duration and intensity but consistently showed positive outcomes in physical fitness, metabolic biomarkers, and body composition.Conclusion: HIIT, particularly when integrated with dietary advice, offers a promising strategy for managing obesity and improving metabolic health among adolescents. This review supports the adoption of multidisciplinary approaches in clinical practice, aiming to enhance the overall health outcomes of adolescents with overweight or obesity.

Model spiritual care with an adaptation theory approach Callista Roy on cortisol levels Kusuma, Aria Nurahman Hendra; Pudjonarko, Dwi; Sujianto, Untung; Susanto, Hardhono; Ibrahim, Kusman; Dwidiyanti, Meidiana
JHeS (Journal of Health Studies) Vol. 9 No. 2 (2025): September
Publisher : Universitas 'Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/jhes.4283

Ischemic stroke is a cause of physical disability. These defects result in impaired biopsychosociospiritual adaptation in stroke patients. The inability to adapt will cause an anxiety reaction which triggers an increase in cortisol levels. The spiritual care model helps patients find meaning and purpose in life as well as an optimistic attitude so that they have better adaptability. This type of research is Quasy Experimental with a pretest-posttest control group design. The study population was ischemic stroke patients in the Outpatient Department of Dr. Regional General Hospital. Moewardi Surakarta. The total sample consisted of 60 respondents, divided into 30 control group respondents and 30 intervention group respondents, who received a spiritual care model intervention in the outpatient room of Dr RSUD. Moewardi Surakarta. The research results show the influence of the Spiritual Care Model Using Callista Roy's Adaptation Theory Approach on Cortisol Levels in Ischemic Stroke Sufferers with a significance value of 0.043 < 0.05. The Spiritual care model influences the amygdala, which stimulates the hypothalamus through the hypothalamic-pituitary-adrenal (HPA) axis, thereby inhibiting the excretion of corticotropin-releasing factor (CRF). The pituitary gland then stimulates adrenocorticotropic hormone (ACTH), which reduces cortisol. This research has a contribution that spiritual care interventions can improve the adaptability of biopsychosocial rehabilitation of stroke patients. This research has a contribution that spiritual care interventions can improve the ability to adapt biopsychosocial rehabilitation of stroke patients.

The Effect of Administration Ginger and Lemongrass Drink on Interleukine 6 Football Player After Exercise adnan, Miftahul; Afifah, Diana Nur; Anjani, Gemala; Susanto, Hardhono; Noer, Etika Ratna; Widodo, Sumardi
Journal of Sport Science and Fitness Vol. 10 No. 2 (2024): Journal of Sport Science and Fitness
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jssf.v10i2.15662

Physical exercise can increase the production of free radicals. Free radical can trigger oxidative stress and inflammation. Ginger and lemongrass has bioactive compound that function as antioxidant and antiinflammatory. This study aim to determine the effecs of giving ginger and lemongras drink on IL6 level in football player. Quasi experimental study with pre and post control group design. The subject were 24 football player divided 2 namely control and intervention group. The intervention group given a ginger and lemongrass drink. The control group was only given brown sugar drink. The intervention are given after exercise for 28 days. Blood samples were collected and tested after exercise. Interleukine 6 were measured using the ELISA Method. Our result showed there was differences in interleukine 6 after giving ginger and lemongrass drink (p=0.004). The delta of interleukine 6 level after intervention was 3.24 pg/ml. Conclusion this research are there was a decrease in interleukine 6 level after giving ginger and lemongrass drink for 28 days to football players after exercise.

Progressive Training Program Improves Aerobic Capacity and Physical Fitness in Student Soccer Athletes Rahima, Rahima; Susanto, Hardhono; Flora, Rostika; Bahrudin, Udin; Sukendro, Sukendro
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.50306

The endurance of soccer players in Indonesia is generally still low. Aerobic capacity is an important component for improving physical fitness and endurance. When comparing several age groups, young players have less physical fitness. This study aimed to determine the effects of progressive training on changes in the maximum oxygen volume (VO2max) and heart rate (HR) based on recovery time. This study is quasi-experimental with a control group design and was conducted on student soccer athletes. Sixty athlete students who met the inclusion criteria were divided into a control group (n=30) and a progressive training group (n=30). The intervention consisted of progressive training for ten weeks with marathon running at distances of 150, 200, and 300 meters with rest intervals for each distance. The training load was gradually increased by increasing the number of repetitions every week. VO2 max, and Heart Rate were evaluated before and after the program. The results shown that the VO2 max was significantly different between the groups (p<0.001), and the Heart Rate of the subjects in both groups decreased from start to finish. Notably, the HR in the progressive training group was lower than the control group. In conclusion, progressive training is effective in improving aerobic capacity and physical fitness.

Profile of Physical Fitness in Student Football Athletes Through Vo2 Max and FVC Lung Parameters in Sons South Sumatra Rahima, Rahima; Susanto, Hardhono; Flora, Rostika; Bahrudin, Udin
Jurnal Health Sains Vol. 4 No. 11 (2023): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v4i11.1102

Fit physical condition is needed in every sport, especially in soccer which is known to be one of the dynamic sports with dominant movements using anaerobic energy, and also aerobic energy to be able to last throughout the game for a long duration. Every player is required to have excellent physical fitness which is certainly supported by maximum aerobic capacity. For an athlete, aerobic capacity is mandatory to be increased as much as possible, especially in adolescence, because at this time it can contribute to an increase in aerobic capacity of up to 30-35% compared to adults and the elderly, The purpose of this study was to determine the profile of the physical fitness level of athlete students through VO2Max parameters and Forced Vital Capacity / FVC lung in football athlete students at Sriwijaya State Sports School (SONS) Sumatra South. This type of research is a descriptive analysis and data collection is carried out by laboratory using a treadmill device with the Bruce method which is the gold standard in cardiopulmonary fitness assessment and a spirometry tool to measure the forced vital capacity of the lungs. The subjects in this study amounted to 33 male students from the sport of football. The results of the data analysis showed that the majority of SONS football athlete students had a fitness level with less category (96.9%) and very less category (3.1%), the predicted value of Forced Lung Vital Capacity with normal category was 66.7% and the remaining 33.3% in the category below normal. The average count (mean) of pulmonary FVC value is = 2.86 liters, with a maximum value of 3.82 liters and a minimum value of 1.46 liters. It can be concluded that the level of physical fitness in SONS soccer players is still low, for that it is necessary to increase the maximum aerobic capacity and lung capacity of athlete students as much as possible through an intense and systematic training program.

The effect of red pomegranate provision on malondialdehyde and blood lactic acid level in rats with maximum physical activity Zainuddin, Ahmad; Susanto, Hardhono; Rosidi, Ali
Jurnal Gizi dan Pangan Vol. 14 No. 2 (2019)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

The primary objective of this research was to examine the effect of provision of red pomegranate juice on the levels of malondialdehyde (MDA) and blood lactic acid in Wistar rats with maximum physical activity. The study employed a true experiment design. The pretest-posttest with control group design was done on 35 rats given maximum physical activity and treatment for 28 days. The rats were divided into 5 groups: the control group, group with treatment of multivitamin, group with treatment of red pomegranate 2 ml, 4 ml, and 6 ml. The MDA level was measured by TBARS method and lactic acid levels were analysed using ELISA. Comparison statistical analysis was done using paired t-test, while comparison of mean differences between treatment groups were tested using One-way ANOVA, and followed by LSD as the post hoc test. Provision of red pomegranate juice in a variety of doses significantly decreased the levels of MDA and blood lactic acid (p<0.05). The highest MDA level decrease occurred in the group treated with multivitamin (68.02%) and the highest decrease in the levels of blood lactic acid occurred in the group with 6 ml red pomegranate juice (25.94%). Based on the findings, it can be concluded that red pomegranate juice can lower the levels of MDA and blood lactic acid significantly in rats with maximum physical activity.

Co-Authors Abdul Hakam Adriyan Pramono Agus Subagio Ahmad Zainuddin Ajoekesoema, Tanti Ali Rosidi Anak Agung Gede Sugianthara Anindita Soetadji Anjani, Gemala Annastasia Ediati Aria Nurahman Hendra Kusuma Arie Nugroho, Arie Arulita Ika Fibriana Bahrudin Bahrudin Banundari Rachmawati Baskoro, Adhi Gunawan Crisdayani, Carissa Putri Deny Yudi Fitranti Dewi, Ni Putu Puspita Adhytiarini Diana Nur Afifah, Diana Nur Djuara P Lubis Dwi Pudjonarko Dwiantoro, Luky Esri Rusminingsih - Etika Ratna Noer Galih Priambodo, Galih Ign. Riwanto Ignatius Riwanto, Ignatius Iqlima Safitri, Iqlima Iriyanti Harun Kurniawati, Yovie Kusman Ibrahim Mahalul Azam Maria Mexitalia Martha Irene Kartasurya Meidiana Dwidiyanti Miftahul Adnan Mohammad Zen Rahfiludin Muhammad Hatta Muniroh, Muflihatul Neni Susilaningsih Nur Amin, Nur Nurahmatika, Prisma Nyoman Suci Widyastiti Prawara, Ananta Sidhi Radityo Prakoso Rahfilludin, M. Zen Rahima Rahima Rostika Flora Rr. Sri Ratna Rahayu S.Pd. M Kes I Ketut Sudiana . Satyagraha, Muhammad Thifan Sefri Noventi Sofia Setyarsih, Liani Siti Baitul Mukarromah Solly Aryza SUKENDRO SUKENDRO, SUKENDRO Sumardi Widodo Supriyadi Supriyadi Syaravina, Elita SyarofilAnam, Moh. Tandiyo Rahayu Tulaar, Angela B. M. Udin Bahrudin, Udin Ummu Muntamah Untung Sujianto Wibowo, Judiono Widiastuti Samekto Widyastuti, Trioni Yance Anas Yuswo Supatmo Zetta, Adelia Paradya

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