Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

3.112

P-Index

This Author published in this journals

All Journal Kertha Negara : Journal Ilmu Hukum Folia Medica Indonesiana Jurnal NERS Jurnal Farmasi Klinik Indonesia Journal Of Vocational Health Studies Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Ilmu Kefarmasian Indonesia Majalah Patologi Indonesia Darmabakti Cendekia: Journal of Community Service and Engagements Majalah Biomorfologi (Biomorphology Journal) Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Jurnal Syntax Transformation Indian Journal of Forensic Medicine & Toxicology Pharmaceutical Sciences and Research (PSR) Sewagati Jurnal Pengabdian Masyarakat Bangsa Journal of Clinical Microbiology and Infectious Diseases

Imam Susilo

Department Of Anatomical Pathology, Faculty Of Medicine, Airlangga University/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Author-ID : 396487

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

Published : 27 Documents Claim Missing Document

Claim Missing Document

Articles

1 2 3

NEUROGENIC MODULATION BY NEUROKININ-1 RECEPTOR ANTAGONIST, CP-96,345 TO INHIBIT RHEUMATOID ARTHRITIS DEVELOPMENT IN ADJUVANT INDUCED ARTHRITIS RAT MODEL Wirasasmita, Yuyun; Rahmadi, Mahardian; Susilo, Imam; Khotib, Junaidi
Folia Medica Indonesiana Vol. 52 No. 2 (2016): APRIL - JUNE 2016
Publisher : Universitas Airlangga

Rheumatoid arthritis (RA) is a chronic form of persistent inflammation. Meanwhile, Substance P is the most associated neuropeptide in neurogenic inflammation and hyperalgesia commonly found in chronic pain. Substance P act by binding to neurokinin-1 receptor. The present study was conducted to evaluate the effect of neurokinin-1 receptor antagonist (CP-96,345) on Adjuvant Induced Arthritis rat model, induced by Complete Freund's Adjuvant (CFA). The objective is to attenuate neurogenic inflammation which in turn will increase the latency time of hyperalgesia response, decreases neurokinin-1 receptor expression, and inhibits the development of RA in AIA rat model. Rats were intra-articularly injected with CFA 1 hour after the administration of CP-96,345 either by 0.63 µg/gr; 1.25 µg/gr; or 2.5 µg/gr also intra-articularly. Caliper measurements and hot-plate test were performed on day 0, 3, 5, 7, 9, 11, and day 13. Expression of neurokinin-1 receptor in joint tissue were evaluated by immunohistochemistry, and RA progress in joint tissue were observed hystopathologically. CP-96,345 at 2.5 µg/gr significantly increases the latency of hyperalgesia response time on CFA induced rats (p=0.044) and decreased the neurokinin-1 receptor expression in joint tissue (p=0.029) compared to CFA induced rats. There was no significant difference for caliper measurements and RA progress between CFA incduced rats and treated group. Conclusively, CP-96,345 increases the latency of hyperalgesia response time and decreases the NK-1 receptor expression in rat joint but could not inhibit RA progression.

THE POTENCY OF ALPHA LIPOIC ACID AS ANTI INFLAMMATORY ON THE COMPLETE FREUND'S ADJUVANT-INDUCED RHEUMATOID ARTHRITIS IN RAT MODEL Megawati, Selvi; Rahmadi, Mahardian; Susilo, Imam; Khotib, Junaidi
Folia Medica Indonesiana Vol. 52 No. 2 (2016): APRIL - JUNE 2016
Publisher : Universitas Airlangga

Rheumatoid arthritis (RA) is an autoimmune diseases which is characterized by chronic inflammation of the synovial tissue in joints. This research was designed to investigate the effect of alpha lipoic acid as antioxidant on rats with complete freund's adjuvant (CFA)-induced RA by intra articular injection of complete freund's adjuvant (CFA). ALA was administered orally once a day for 7 days at 30, 60 and 120 mg doses a week after CFA injection. The severity of arthritis was evaluated by joint diameter and latency time on thermal stimulation. Joint diameter and latency time on thermal stimulation will measured on day 0, 3, 5, 7, 10, 12 and 14. Measurement of malondialdehyde (MDA) level in plasma was performed using thiobarbituric acid (TBA) method to assess lipid peroxidation. Histology of joint was examined by microscope following hematoxylin-eosin staining. The result showed that treatment with ALA at 30 mg and 60 mg significantly decreased the joint diameter compared to CFA group (p=0.003; p=0.001 respectively) and rat's latency time on thermal stimulation was also significantly increased compared to CFA group (p=0.015; p=0.026 respectively). Measurement of MDA in CFA group and ALA group had no significant difference. Histological staining indicated that the recovery of the synovial membranes of joint in ALA group had no effect. Results indicated that ALA has the effect to suppress the development of inflammation in RA but not through oxidative stress pathway.

THE MECHANISM OF ALPHA LIPOIC ACID ON REDUCING THE MDA LEVEL AND MCP-1 EXPRESSION IN ENDOTHELIAL DYSFUNCTION OF HYPERCHOLESTEROLEMIA RAT (Rattus norvegicus) MODEL Sari, Dewi Perwito; Susilo, Imam; Khotib, Junaidi
Folia Medica Indonesiana Vol. 52 No. 3 (2016): JULY - SEPTEMBER 2016
Publisher : Universitas Airlangga

Endothelial dysfunction is an initial condition of atherosclerosis and other vascular diseases where one of the risk factors is hypercholesterolemia. Blood cholesterol levels is associated with an increase in the production of reactive oxygen species (ROS). The increasing of ROS production can cause increased oxidative stress which in turn resulting in endothelial dysfunction. Alpha lipoic acid (ALA) is one of the antioxidant compound that has been developed and studied. In this study we found that the use of ALA in Rattus norvegicus rats signifficantly lower the total cholesterol levels at dose 60 mg/kgBW (p=0.020). ALA also inhibit the expression of Monocyte Chemoattractant Protein-1 (MCP-1) at dose 60 mg/kgBW (p=0.044) and reduces the formation of Malondialdehyde (MDA) at dose 120 mg/kgBW (p=0.009), which is the initial stage of the atherogenic development and prognosis of events, thus, ALA can reduce the risk of further damage to the endothelium.

The Effect of Intravenous Glutamine Administration in Lowering AIF Expression in Renal Tubular Cells Raihan Akbar Muhammad; Imam Susilo; Eko Budi Koendhori; Bambang Purwanto
Majalah Biomorfologi Vol. 35 No. 1 (2025): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v35i1.2025.21-28

Highlights Glutamine, an amino acid, can help mitigate the side effects of cisplatin by boosting glutathione (GSH) levels, an antioxidant that counteracts oxidative stress. By reducing AIF protein expression and apoptosis, glutamine may protect kidney cells from cisplatin toxicity, potentially improving the safety of chemotherapy. Background: Cisplatin, a widely used chemotherapy that is effective for many forms of cancer, has nephrotoxic qualities that can reduce renal function. Due to its side effects, the usage of cisplatin is limited by its dose. Glutamine, an amino acid, possesses properties that can counteract the nephrotoxicity of cisplatin. Objective: This study aimed to analyze the effect of intravenous glutamine administration on the decrease of AIF expression and apoptosis in intraglomerular mesangial cells of cisplatin-exposed rats. Material and Method: Samples (n) consisting of 30 rats were divided into 3 groups, with each group containing 10 rats. Group P0 received no treatment, group P1 received an injection of cisplatin on the 7th day, and group P2 received glutamine on the 1st–7th day and an injection of cisplatin on the 7th day. After 72 h, the tissue samples were immunohistochemically processed and then observed under a light microscope with 400x magnification. AIF expression and apoptosis were measured in the Allred/H score. Result: AIF expression results were: P0 = 4,35(2,2-5,4); P1 = 5,9(4,8-6,3); P2 = 5,25(2,4-5,8). The AIF expression of P2 was found to be significantly lower (p = 0.008) than P1. Apoptosis results were: P0 = 5,2(4,7-5,5); P1 = 6,4(6,1-7,1); P2 = 5,7(4,8-5,9). The apoptosis level of P2 was found to be significantly lower (p = <0.0001) than P1. Strong correlations between the decrease in AIF expression and the apoptosis level were found (p = <0.0001). Conclusion: Glutamine contributes to the decreased AIF expression and apoptosis in intraglomerular mesangial cells of cisplatin-exposed rats.

Analysis of Neutrophil, Leukocyte, Lymphocyte, and NLR Cell Profiles in Patients Diagnosed with Chronic Gastritis Affected by Helicobacter pylori and Non-Helicobacter pylori Infection at Dr. Soetomo Hospital in Surabaya, Indonesia Nahdah Aulia Aziz; Manik Retno Wahyunitisari; Imam Susilo
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.21260

Helicobacter pylori (HP) is a prevalent cause of bacterial infections, particularly chronic gastritis in the human body. The diagnosis of gastritis relied on gastric biopsy examination, where inflammation is characterized by an increase in various inflammatory cells, including macrophage, neutrophil, lymphocyte, or plasma cells. Therefore, this research aimed to determine the profiles of neutrophil, leukocyte, lymphocyte, and neutrophil lymphocyte ratio (NLR) in chronic gastritis patients, distinguishing between those with Helicobacter pylori and non-Helicobacter pylori infection at Dr. Soetomo Hospital in Surabaya. This research adopted a retrospective method, using medical records for chronic gastritis patients at Dr. Soetomo Hospital between 2018 and 2022. The variables analyzed included Helicobacter pylori infections and values of neutrophil, leukocyte, lymphocyte, and NLR cells. The obtained data were subjected to analysis using descriptive statistics. The results showed that the majority of participants were females (61.9%), senior high school graduates (52.38%), and aged 45-59 (pre-elderly) (32.14%). In non-Helicobacter pylori group, the average values of neutrophil, leukocyte, lymphocyte, and NLR cells were 62.29 (SD = 12.17), 8.155 (SD = 4.02), 29.165 (SD = 12.31), and 3.68 (SD=4.865), respectively. In conclusion, females showed a propensity for chronic gastritis with Helicobacter pylori. It was observed that non-Helicobacter pylori chronic gastritis tended to have elevated neutrophil and leukocyte values. Meanwhile, Helicobacter pylori-related chronic gastritis tended to show increased lymphocyte and NLR values due to systemic inflammation. Helicobacter pylori was associated with conditions such as iron deficiency anemia, cardiovascular disease, diabetes, thyroid disease, and malnutrition.

Pengukuran Adekuasi Sediaan Papsmear dan Deteksi Dini Kanker Serviks di Ngoro Kabupaten Mojokerto Rahaju, Anny Setijo; Rahniayu, Alphania; Mastutik, Gondo; Kurniasari, Nila; Fauziah, Dyah; Kusumastuti, Etty Hary; Sandhika, Willy; Wiratama, Priangga Adi; Ariani, Grace; Heriyawati, Heriyawati; Sari, Aditya Sita; Ilmiah, Khafidhotul; Qonitatillah, Ana; Ridholia, Ridholia; Sudiana, I Ketut; Susilo, Imam
Jurnal Pengabdian Masyarakat Bangsa Vol. 3 No. 1 (2025): Maret
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v3i1.2127

Penelitian ini bertujuan untuk meningkatkan pemahaman masyarakat tentang deteksi dini kanker serviks dan evaluasi Pap smear, serta meningkatkan keterampilan pengambilan sampel Pap smear pada penyedia layanan kesehatan di Kecamatan Mawaddah, Kabupaten Mojokerto. Studi deskriptif observasional dengan desain cross sectional dilakukan pada 100 wanita berusia 20-70 tahun dari Rumah Sakit Mawaddah. Penilaian dilakukan sebelum dan sesudah pemaparan materi. 100 sampel Pap smear yang dikumpulkan oleh bidan setempat dievaluasi untuk menilai kecukupan spesimen menggunakan sistem Papanicolaou dan Bethesda. Kegiatan ini secara signifikan meningkatkan pemahaman tentang kanker serviks (8,05% menjadi 82,26%), sementara kegiatan pelatihan tenaga medis meningkatkan pengetahuan mengenai pengambilan sampel Pap smear (51,62% menjadi 100%). 99% dari sampel Pap smear yang dikumpulkan oleh tenaga medis di Kecamatan Mawaddah dinilai memadai dan memuaskan. Program pengabdian masyarakat yang berfokus pada deteksi dini kanker serviks melalui Pap smear, secara efektif meningkatkan pemahaman masyarakat, meningkatkan pengetahuan dan keterampilan pengambilan sampel oleh tenaga medis, yang dapat meningkatkan pula efektifitas layanan Pap smear di Rumah Sakit Mawaddah pada masyarakat.

IMPROVING KNOWLEDGE AND ATTITUDES ABOUT CERVICAL CANCER DETECTION IN JAVA'S PANTURA REGION: PENINGKATAN PENGETAHUAN DAN SIKAP TENTANG DETEKSI KANKER SERVIKS DI PANTURA PULAU JAWA Rahmanto, Ilham; Hanum, Safa Salsabila; Safitri, Cahyani Tiara; Khaerana, A. Insyirah; Targanski, Constantia Lidwina; Hendrarto, Bagus Adjie Dwi; Hartawan, M. Wildan Nabalah; Susilo, Imam
Darmabakti Cendekia: Journal of Community Service and Engagements Vol. 7 No. 1 (2025): JUNE 2025
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/dc.V7.I1.2025.1-7

Background: Early detection of cervical cancer through IVA and Pap smear examination is crucial for preventing and reducing cervical cancer mortality. However, IVA and Pap smear coverage in Indonesia, particularly in Mentaras Village, Gresik Regency, remains low. The low knowledge and attitudes of women of childbearing age towards IVA and Pap smear examinations are major obstacles to early detection. Objective: This community service aims to improve the knowledge and attitudes of women of childbearing age in Mentaras Village towards IVA and Pap smear examinations through health socialization. Method: Health socialization was conducted for 23 participants from the PKK mothers' group using PowerPoint presentations and brochures. Evaluation was performed using a post-test questionnaire to measure participants' knowledge and attitudes after the activity. Results: After the socialization, all participants (100%) demonstrated a good level of knowledge, and 91.30% showed a positive attitude towards IVA and Pap smear examinations. These results indicate that the socialization activity positively impacted participants' awareness. Conclusion: Health socialization effectively improved understanding and attitudes towards the early detection of cervical cancer. Regular similar activities are recommended to expand community participation.

Co-Authors . Heriyawati Abdurahman Abdurrahman Abdurrahman Abdurrahman Adhi Dharma Wibawa, Adhi Dharma Ahmad Yudianto Alphania Rahniayu Anny Setijo Rahaju, Anny Setijo Ardiansyah Ariani, Grace Bambang Purwanto Betty Agustina Tambunan Christrijogo Soemartono Waloejo Deshinta Fitrianti Syahida Dwinka Syafira Eljatin DYAH FAUZIAH, DYAH Eko Budi Koendhori, Eko Budi Fadli, Sonny Fajrin, Fifteen A. Ferdinant Martinus Djawa Fifteen A. Fajrin Fifteen Aprila Fajrin Fitriani, Fatimah Nur Fransiska Maria Christianty Furaidah, Erna Gondo Mastutik Hanum, Safa Salsabila Hartawan, M. Wildan Nabalah Haykal, Muhammad Nazhif Hedianto, Tri Hendrarto, Bagus Adjie Dwi Heriyawati, Heriyawati Hidayah, Rizka Nurul I Ketut Suardita Ilmiah, Khafidhotul Indriani, Ratri Dwi Indriastuti, Endah Junaidi Khotib Karimah, Azimatul Karimah, Rumman Khaerana, A. Insyirah KUSUMASTUTI, ETTY HARY Mahardian Rahmadi ManikRetno Wahyunitisari Megawati, Selvi Muhammad Al-Farouq Yufiro Akbar Nahdah Aulia Aziz Nila Kurniasari Nina Mardiana Njoto, Edwin Nugroho Pamungkas, Yuri Parlindungan, Putra Gelar Prananda S. Airlangga Putra, Bilqisthi Ari Putra, Gumilar Fardhani Ami Putri Alief Siswanto Putri, Atina Irani Wira Putri, Naomi Lesmana Qonitatillah, Ana Rahmanto, Ilham Raihan Akbar Muhammad Rangkuti, Rahmah Yasinta Rejeki, Purwo Sri Ridhoi, Ahmad Ridholia, Ridholia S.Pd. M Kes I Ketut Sudiana . Safitri, Cahyani Tiara Sakina Sandi Ardiya Rasitullah Sari, Aditya Sita Sari, Dewi Perwito Semedi, Bambang Pujo Setya Wijoyo, Dhia Lintang Suharjono, Suharjono, Suharjono Sundari Indah Wiyasihati Syulthoni, Zain Budi Targanski, Constantia Lidwina Utariani, Arie Wardhani, Puspa Willy Sandhika Wirasasmita, Yuyun Wiratama, Priangga Adi Zavita Anwar

Title

Found 27 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 27 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 27 Documents
Search