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All Journal Kertha Negara : Journal Ilmu Hukum Folia Medica Indonesiana Jurnal NERS Jurnal Farmasi Klinik Indonesia Journal Of Vocational Health Studies Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Ilmu Kefarmasian Indonesia Majalah Patologi Indonesia Darmabakti Cendekia: Journal of Community Service and Engagements Majalah Biomorfologi (Biomorphology Journal) Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Jurnal Syntax Transformation Indian Journal of Forensic Medicine & Toxicology Pharmaceutical Sciences and Research (PSR) Sewagati Jurnal Pengabdian Masyarakat Bangsa Journal of Clinical Microbiology and Infectious Diseases
Imam Susilo
Department Of Anatomical Pathology, Faculty Of Medicine, Airlangga University/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Protein Expression Er (Estrogen Receptor) in Breast Cancer Degree of Malignancy Mild, Moderate, and Severe Imam Susilo
Jurnal Ners Vol. 7 No. 1 (2012): April 2012
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (442.699 KB) | DOI: 10.20473/jn.v7i1.4004

Abstract

Introduction: Mammary carcinoma is the most common malignancy and main mortality cause in women. Hormonal status (ER and PR expression) was long used as patient suitability for hormonal therapy. However, lately there have been many patients with ER and PR negative. This study wanted to prove the relevance of protein expression of ER (estrogen receptor) with the histopathological degree of malignancy of breast invasive ductal cancer and the prognosis of breast cancer with ER protein expression of positive and negative.Methods: In this retrospective and cross sectional analytical study retrieved data about hormonal status (ER expression) and histopathological grading of infiltrating ductal carcinoma patients. This study consisted of 201 patients with mammary carcinoma who referred to medical records Department Pathology Anatomic of Faculty Medicine Airlangga University/Dr. Soetomo General Hospital Surabaya on 1 January 2010–31 December 2010 and their medical record suitable with inclusion criterias. The data was categorized into several groups based on the ER expression result.Results: Most of the sample was in 41–50 year age group (37.31%), and 54,7% of them were in poor expression. The relationship of estrogen receptor (ER) with the degree of histopathology infiltrating ductal carcinoma patients, obtained p-value = 0.001 (p < 0.5) and the 2 × 2 table is only moderate and severe degrees compared with the results of ER expression results obtained p = 0.001 (p < 0.5) and odds ratio of 0.362 (CI: 0194-0675).Conclusion: This study found significant correlation between ER expression with histopathological grading of infiltrating ductal carcinoma patients.
Ekspresi Interleukin 1 dan Tumor Necrosis Factor Alpha pada Pemberian Ropivacain Di Sekitar Luka terhadap Proses Penyembuhan Luka Ardiansyah; Arie Utariani; Christrijogo Sumartono; Bambang Pujo Semedi; Imam Susilo
Jurnal Syntax Transformation Vol 2 No 02 (2021): Jurnal Syntax Transformation
Publisher : CV. Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jst.v2i2.223

Abstract

Luka merupakan gangguan integritas jaringan akibat trauma. Penanganan nyeri pasca trauma yang tidak memadai, seperti pembedahan, akan mengakibatkan gangguan penyembuhan luka. Salah satu faktor penting dalam penyembuhan luka fase akut pada 3 hari pertama adalah ekspresi Tumor Necrosis Factor (TNF) -a dan Interleukin (IL) -1. TNF-a dan IL-1β merupakan dua sitokin inflamasi utama yang bekerja secara sinergis untuk memperkuat respon inflamasi dan memiliki efek mempercepat penyembuhan luka. Nyeri dapat meningkatkan β endorfin oleh kelenjar hipofisis anterior dan mempunyai efek menekan makrofag, sehingga aktivitasnya menurun. Penurunan ini mengakibatkan penurunan aktivitas sitokin yang dilepaskan oleh makrofag seperti TNF-α, IL-1, IL-6, IL-8, TGF β; Sehingga bisa menghambat penyembuhan luka. Tujuan penelitian ini adalah untuk membuktikan pengaruh injeksi infiltrasi ropivacaine dalam meningkatkan IL-1 dan TNF-a. ekspresi dalam proses penyembuhan luka. Metode: 24 ekor tikus Wistar jantan dibagi menjadi 2 kelompok (Kelompok Perlakuan (P) dan Kelompok Kontrol (K)), kemudian dibuat luka insisi ketebalan superfisial pada punggung masing-masing tikus. Kelompok kontrol tidak diberikan suntikan infiltrasi ropivacaine, sedangkan kelompok perlakuan diberikan. Setiap kelompok dibagi menjadi 2 sub kelompok yang masing-masing terdiri dari 6 ekor mencit, diterminasi pada hari ke-3 dan ke-7. Kemudian dilakukan evaluasi histopatologi untuk mengetahui apakah terdapat peningkatan ekspresi IL-1 dan TNF-a di sekitar jaringan luka sayatan. Data yang terkumpul kemudian dianalisis dengan menggunakan program SPSS. Hasil: Pemberian infiltrasi ropivacaine pada luka insisi dengan ketebalan superfisial meningkatkan penyembuhan luka yang ditandai dengan peningkatan jumlah ekspresi IL-1 dan TNF-a pada hari ke 3 setelah insisi. Kesimpulan: Suntikan infiltrasi ropivacaine disekitar luka sayatan memiliki efek menguntungkan pada proses penyembuhan luka superfisial tikus Wistar hari ketiga
Analisis Kesalahan Siswa dalam Menyelesaikan Soal Sistem Persamaan Linier Dua Variabel Di Tinjau Dari Gaya Belajar Sandi Ardiya Rasitullah; Arie Utariani; Christrijogo Sumartono; Bambang Pujo Semedi; Imam Susilo
Jurnal Syntax Transformation Vol 2 No 02 (2021): Jurnal Syntax Transformation
Publisher : CV. Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jst.v2i2.224

Abstract

Penelitian ini bertujuan untuk mengetahui jenis kesalahan yang dilakukan siswa yang memiliki gaya belajar berbeda pada soal cerita sistem persamaan linier dua variable di kelas VIII MTs Al – Mu’ ini Sesela. Penelitian ini menggunakan metode kualitatif dengan jenis penelitian deskriptif yaitu studi kasus. Data dikumpulkan dengan instrumen tes, wawancara, dan angket. Subyek dalam penelitian ini sebanyak 3 orang siswa. Tehnik analisis data untuk tes dan wawancara yaitu reduksi data, penyajian data, dan penarikan kesimpulan dan verifikasi, sedangkan angket menggunakan tehnik analisis statistik deskriptif kuantitatif. Hasil penelitian dari analisis hasil tes adalah siswa gaya belajar visual jenis kesalahannya pada tahap memahami, transformasi, keterampilan proses, dan penulisan jawaban. Siswa gaya belajar auditori jenis kesalahannya pada tahap transformasi, keterampilan proses, dan penulisan jawaban. Dan siswa gaya belajar kinestetik jenis kesalahannya pada tahap membaca, transformasi, keterampilan proses, dan penulisan jawaban. Sedangkan hasil dari analisis wawancara adalah siswa gaya belajar visual jenis kesalahannya pada tahap memahami, keterampilan proses, dan penulisan jawaban. Siswa gaya belajar auditori jenis kesalahannya pada tahap memahami, transformasi, keterampilan proses, dan penulisan jawaban. Dan siswa gaya belajar kinestetik jenis kesalahannya pada tahap transformasi, keterampilan proses dan penulisan jawaban.
The Effectiveness of GABA Agonist in Decreasing Expression of NR2B Subunit of N-Methyl-D-Aspartate (NMDA) Receptor in Neuropathic Mice by Partial Sciatic Nerve Ligation (PSNL) Method FIFTEEN APRILA FAJRIN; JUNAIDI KHOTIB; IMAM SUSILO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (634.019 KB)

Abstract

Neuropathy pain is a pain that caused by nerves injury. Nowadays, treatment for neuropathic pain change to drugs that works as GABA agonist and cause reimbalance between excitatory and inhibitory neurotransmitter in central nervous system (CNS). The present study was designed to investigate the effectiveness of gabapentin and baclofen in decreasing N-Methyl-D-Aspartate (NMDA) receptor NR2B subunit activity in neuropathic pain. Fourty mice were divided into 8 groups i.e sham, negative control, gabapentin (10, 30, 100 nmol) and baclofen (1, 10, 30 nmol). Neuropathic pain was induced by ligation of sciatic nerve with Partial Sciatic Nerve Ligation (PSNL) method). Treatments were administrated intrathecally once a day for seven consecutive days, at a week after induction. On day 15th, mice were sacrified and the spinal cord were removed quickly. The expression of NMDA receptor NR2B subunit were examined with imunohistochemistry and data were analyzed by one way anova. The result from this research was gabapentin and baclofen administration significantly decrease expression of NMDA receptor NR2B subunit in mice compared to sham group. The higher the dose, the more effective to decrease the number of neuron that express NR2B. The conclusion of this research was gabapentin and baclofen treat neuropatic pain by decreased the number of NMDA receptor NR2B subunit.
Preventive Effects of Alpha-Lipoic Acid on Lipopolysaccharide-Induced Endothelial Dysfunction in Rats Christianty, Fransiska Maria; Suharjono,; Susilo, Imam; Khotib, Junaidi
Pharmaceutical Sciences and Research Vol. 6, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Endothelial dysfunction has been considered as one of the key initial events in the pathogenesis of atherosclerosis and other cardiovascular diseases (CVDs). Several studies imply that chronic inflammation and oxidative stress play a critical role in endothelial dysfunction. The present study was designed to evaluate the preventive effect of alpha-lipoic acid (ALA) on lipopolysaccharide (LPS) induced endothelial dysfunction in rat based on malondialdehyde (MDA) level and vascular cell adhesion molecules-1 (VCAM-1) expression. Thirty Wistar rats were administered ALA for 2 weeks in different doses (30, 60, 120 mg.kg-1 BW) 1 hour before LPS 0.5 mg.kg-1 BW i.p challenge. The LPS was injected on 1st, 4th, and 9th day. MDA plasma level was analyzed with spectrophotometer λ 529 nm, and VCAM-1 expression was determined by immunohistochemistry. Pretreatment with ALA for 14 days could decrease plasma MDA level on LPS-induced endothelial dysfunction in rats. However, only one group of ALA doses, 120 mg.kg-1 BW, showed significant difference with LPS untreated group statistically. It was also found that ALA, in all treatment groups, could attenuate VCAM-1 expression. These findings suggest that ALA had a protective effect against endothelial dysfunction and may potentially prevent vascular inflammatory disease.
Pelatihan Kader PKK di Kota Probolinggo dalam Upaya Pencegahan Kematian Ibu dan Bayi serta Pencegahan Stunting Fadli, Sonny; Rangkuti , Rahmah Yasinta; Susilo, Imam; Furaidah, Erna
Sewagati Vol 8 No 4 (2024)
Publisher : Pusat Publikasi ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j26139960.v8i4.1015

Abstract

Indikator kesehatan seperti angka kematian ibu, angka kematian bayi, dan prevalensi stunting merupakan tolak ukur penting dalam pemantauan kesehatan masyarakat. Meskipun terdapat penurunan angka global dalam rasio kematian ibu, situasi di Indonesia masih mengkhawatirkan. Kegiatan pengabdian masyarakat dilakukan untuk meningkatkan pengetahuan kader PKK Kota Probolinggo dalam deteksi dini kehamilan risiko tinggi dengan menggunakan platform digital Hamilku.ID dan meningkatkan pengetahuan kader PKK tentang skrining tumbuh kembang untuk penceghan stunting. Kegiatan pengabdian kepada masyarakat dilaksanakan di Dinas Kesehatan dan P2KB Kota Probolinggo dengan diawali pre-test, pelatihan dan post-test yang melibatkan 50 kader PKK di Kota Probolinggo. Dari hasil pre-test dan post-test terhadap 30 kader PKK, didapatkan nilai mean dari 30 responden pada saaat pre-test yakni sebesar 51,3 sedangkan nilai mean dari 30 responden pada saat post-test sebesar 85,3 yang dapat menunjukkan peningkatan pengetahuan setelah dilakukan pelatihan. Dengan nilai pearson correlation sebesar 0,362 dan P(T<=t) two-tail sebesar 1,599. Terdapat peningkatan pengetahuan kader dalam hal deteksi kehamilan risiko tinggi menggunakan platform digital Hamilku.ID dan skrining tumbuh kembang pada kader PKK di Kota Probolinggo.
The Correlation Between the Level of Depression and Religious Coping Among Medical Students Class of 2020 Universitas Airlangga Muhammad Al-Farouq Yufiro Akbar; Azimatul Karimah; Imam Susilo; Purwo Sri Rejeki
Jurnal Psikiatri Surabaya Vol. 13 No. 1 (2024): May
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jps.v13i1.46284

Abstract

Introduction: Medical students are at risk of developing depression due to their demanding workload and high expectations, which can impact their academic performance and cognitive function. To prevent severe complications, students must prioritize resources for mental health support, namely religious coping as a coping mechanism. Objective: The aim of this study is proof the correlation between depression levels and religious coping in medical students class of 2020 Universitas Airlangga Methods: This research is an observational analytic study with a cross-sectional design, and random sampling was used as a sampling method, totaling to 90 subjects. Variables used were religious coping and level of depression. The data was then analysed and prevalence, correlation coefficient and p-value were acquired. The research result would be considered significant if p <0.05. Result: Out of 90 students, 32 people (35.6%) are found to have a PHQ score more than 10, indicating depression. Severity was found mostly have moderate depression, which consisted of 12 people (13.3%). For religious coping, 84 people (93.3%) use positive religious coping, and 6 people (6.7%) use negative religious coping. The level of depression correlates with religious coping with a Pearson correlation of -0.450, indicating a negative correlation with a p-value less than 0.001. Conclusion: The prevalence of depression among medical students class of 2020 Universitas Airlangga is 35.6%. Level of depression in found to significantly correlates with religious coping with an opposing direction of correlation.  
Effect of low voltage electric currents on the decrease of Klebsiella pneumoniae ESBL and non-ESBL colonies Setya Wijoyo, Dhia Lintang; Koendhori, Eko Budi; Susilo, Imam; Wardhani, Puspa
Journal of Clinical Microbiology and Infectious Diseases Vol. 3 No. 1 (2023): Available online : June 2023
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v3i1.17

Abstract

Introduction: Klebsiella pneumoniae is a gram-negative bacteria and one of the most common causes of nosocomial infections, especially in the intensive care units. The use of liberal and irrational antibiotics is shown the emergence of antibiotic-resistant Klebsiella pneumoniae. This research was conducted to evaluate if low voltage electric current on three kinds of solvent media could have an eradication effect. Methods: This was an experimental study, which was done at the Microbiology Laboratory of Harapan Kita Women and Children Hospital-Jakarta. This study used to isolate bacteria non-ESBL and ESBL Klebsiella pneumoniae, thereupon will be dissolved in saline, Aqua destillata, and Ringer Lactate, each consisting of 8 samples. Each sample received a 0.5V and 10mA DC electric current; reduction of colonies was observed at 30, 60, 120 and 240 minutes using DensiCHEK. Result: There was a decrease in the colony number of 2 bacterial groups in the first 30 minutes in all three media (p <0.01). The reduction was higher in the non-ESBL K. pneumoniae group. The decrease of bacterial colonies was higher in the Klebsiella pneumoniae group non ESBL in ringer lactate medium during 240 minutes observation compared to saline and Aqua destillata (p <0.001; p <0.001, respectively). The saline solution showed no different effect compared to aquadestillata. Conclusion: A direct current of 10 mA and 0.5 V intervention, on Ringer lactate media, could have a bacterial killing effect to Klebsiella pneumoniae non ESBL started from 30 minutes.  Klebsiella pneumoniae ESBL needed a longer duration than non ESBL.
The effect of low-electrical voltage as a method to eradicate Acinetobacter baumannii bacteria Putri, Naomi Lesmana; Koendhori, Eko Budi; Susilo, Imam; Tambunan, Betty Agustina
Journal of Clinical Microbiology and Infectious Diseases Vol. 3 No. 2 (2023): Available online: December 2023
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v3i2.20

Abstract

Introduction: Acinetobacter baumannii is one of the bacteria in critical priority according to WHO in 2017 and one of the causes of nosocomial infections in the world. These bacteria usually become resistant to antibiotics (Multi Drug Resistant Organism, MDRO), infect the bloodstream, and cause pneumonia. This study aimed to examine the effect of low-voltage electricity as a method to kill Acinetobacter baumannii by using a different electric current. Methods: This study is experimental research in the Microbiology Laboratory of RSAB Harapan Kita. Experiments were carried out using a solution of Acinetobacter baumannii non-MDRO and MDRO bacteria with a parallel design device opposite to the GPS 3030D power supply with a power of 90 W. Each tube was fitted with a 12 cm stainless steel rod conductor with a diameter of 3 mm and delivered amperage 1 mA, 2 mA, 5 mA, and 10 mA and 0.5V with each amperage performed 5 times and measured using DensiCHEK. Result: From 20 Acinetobacter baumannii non-MDRO experiments and 20 MDRO experiments, it was found that from 1 mA, 2 mA, 5 mA, and 10 mA with monitoring time of 30 minutes, 2 hours, and 4 hours, the results of bacterial eradication by DC stimulation with 5 mA and the most optimal time is 30 minutes according to what has been applied. Conclusion: Using an electric current of 5 mA and a duration of 30 minutes can reduce Acinetobacter baumannii MDRO and non-MDRO bacteria with more optimal results in the non-MDRO group.
EFFECT OF POST MORTEM INTERVAL TOWARD Î’-TRYPTASE AND CHYMASE EXPRESSION OF ANAPHYLACTIC HEART MAST CELLS Susilo, Imam; Putra, Bilqisthi Ari; Yudianto, Ahmad
Journal of Vocational Health Studies Vol. 7 No. 2 (2023): November 2023 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V7.I2.2023.107-114

Abstract

Background: The effects of post mortem interval on tryptase levels are unclear and have been challenging to quantify due to limited and at times contradictory research. Purpose: Analyze the effects of Post Mortem Interval (PMI) due to anaphylactic shock on the expression of β-tryptase and mast cell chymase in the heart organ. Method: This type of research was an experimental study with a randomized block design (RBD) with the same subjects and a time series for 24 hours, using 5 (five) rabbits. The measurement of β-tryptase and chymase expression was based on immunohistochemical IRS (immunoreactive score) in the heart organs of rabbits experiencing anaphylactic shock sensitization and induction of anaphylactic shock using ovalbumin. Result: Based on the results of statistical tests using univariate analysis, there was a relationship between the length of death (post mortem interval) and the expression of mast cells β-Tryptase and cardiac chymase (p-value = 0.006) and chymase (p-value = 0.002) with (p-value <0.05). The effective test time with β-tryptase markers using cardiac organs was prone to long death time of 0 - 15 hours. The effective check-up time with chymase markers using the heart organ was at a long time of death of 9 hours. Conclusion: The results of the study showed that tryptase and chymase could be used as markers of anaphylactic shock.
Co-Authors . Heriyawati Abdurahman Abdurrahman Abdurrahman Abdurrahman Adhi Dharma Wibawa, Adhi Dharma Ahmad Yudianto Alphania Rahniayu Anny Setijo Rahaju, Anny Setijo Ardiansyah Ariani, Grace Bambang Purwanto Betty Agustina Tambunan Christrijogo Soemartono Waloejo Deshinta Fitrianti Syahida Dwinka Syafira Eljatin DYAH FAUZIAH, DYAH Eko Budi Koendhori, Eko Budi Fadli, Sonny Fajrin, Fifteen A. Ferdinant Martinus Djawa Fifteen A. Fajrin Fifteen Aprila Fajrin Fitriani, Fatimah Nur Fransiska Maria Christianty Furaidah, Erna Gondo Mastutik Hanum, Safa Salsabila Hartawan, M. Wildan Nabalah Haykal, Muhammad Nazhif Hedianto, Tri Hendrarto, Bagus Adjie Dwi Heriyawati, Heriyawati Hidayah, Rizka Nurul I Ketut Suardita Ilmiah, Khafidhotul Indriani, Ratri Dwi Indriastuti, Endah Junaidi Khotib Karimah, Azimatul Karimah, Rumman Khaerana, A. Insyirah KUSUMASTUTI, ETTY HARY Mahardian Rahmadi ManikRetno Wahyunitisari Megawati, Selvi Muhammad Al-Farouq Yufiro Akbar Nahdah Aulia Aziz Nila Kurniasari Nina Mardiana Njoto, Edwin Nugroho Pamungkas, Yuri Parlindungan, Putra Gelar Prananda S. Airlangga Putra, Bilqisthi Ari Putra, Gumilar Fardhani Ami Putri Alief Siswanto Putri, Atina Irani Wira Putri, Naomi Lesmana Qonitatillah, Ana Rahmanto, Ilham Raihan Akbar Muhammad Rangkuti, Rahmah Yasinta Rejeki, Purwo Sri Ridhoi, Ahmad Ridholia, Ridholia S.Pd. M Kes I Ketut Sudiana . Safitri, Cahyani Tiara Sakina Sandi Ardiya Rasitullah Sari, Aditya Sita Sari, Dewi Perwito Semedi, Bambang Pujo Setya Wijoyo, Dhia Lintang Suharjono, Suharjono, Suharjono Sundari Indah Wiyasihati Syulthoni, Zain Budi Targanski, Constantia Lidwina Utariani, Arie Wardhani, Puspa Willy Sandhika Wirasasmita, Yuyun Wiratama, Priangga Adi Zavita Anwar