Article Per Year (5 Year)
p-Index From 2021 - 2026
3.522
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences ACTA VETERINARIA INDONESIANA Jurnal Sain Veteriner Jurnal Veteriner Media Kedokteran Hewan ARSHI Veterinary Letters Pharmacoscript Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Community Development Journal: Jurnal Pengabdian Masyarakat Indonesian Journal of Applied Research (IJAR) Jurnal Buana Farma Eduvest - Journal of Universal Studies Jurnal Veteriner dan Biomedis Current Biomedicine Indonesian Journal of Chemical Science
Madyastuti, Rini
Divisi Farmakologi Dan Toksikologi, Sekolah Kedokteran Hewan Dan Biomedis, IPB University, Bogor, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary

Published : 29 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search
Journal : Jurnal Veteriner

 1 
Aktivitas Ekstrak Etanol Daun Alpukat Terhadap Zat Nefrotoksik Ginjal Tikus (ACTIVITIES STUDY OF ETHANOL EXTRACTS OF AVOCADO LEAVES (PERSEA AMERICANA MILL) TO NEPHROTOXIC COMPOUND OF RAT’S KIDNEY) Ietje Wientarsih; Eva Harlina; Rini Madyastuti Purwono; Ikrar Trisnaning Hardi Utami
Jurnal Veteriner Vol 15 No 2 (2014)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.647 KB)

Abstract

Based on WHO’s data, about 80% peoples in the word use plant’s extract as herbal medicine. Avocadoleaves has used as herbal medicine which is works as diuretikum, reduce stone in renal, and cure sprue.The purpose of this research is to study activities of ethanol extract of avocado leaves to ethylene glycolinduction on rat’s kidney by histopatologically. This experiment was continuing Adha’s research (2009)with research design as follows: twenty male rats were divided into 4 groups, negative control group (KN),positive control group (KP), treated group I by ethanol extract of avocado leaves 100 mg/kg BW (E100), andtreated group 2 by 300 mg/kg BW (E300). Sampling kidney were fixed in BNF 10% for histopathologicalslide and stained by Hematoxylin-Eosin. The kidney histopathological changes were edema of glomerulus,and protein deposit in the lumen, hyalin droplet and necrotic tubules. The results showed that ethanolextract of avocado leaves can’t significantly to reduce glomerulus edema with percentage cases 31.9% and33.5% for E100 and E300 and tend not to reduce the occurrence of protein deposits in the lumen of thetubule. Ethanol extract of avocado leaves tend to reduce the incidence of tubular necrosis and it wassignificantly different from the KP group (p <0.05). It is caused by flavonoid in etanol extract of avocadoleaves works as diuretikum and antioxidant.
Infusum Daun Alpukat Sebagai Inhibitor Kristalisasi Kalsium Oksalat pada Ginjal (THE AVOCADO LEAVES INFUSUM AS INHIBITOR ON RENAL CALCIUM OXALATE CRYSTALIZATION) Rini Madyastuti; Setyo Widodo; Ietje Wientarsih; Eva Harlina
Jurnal Veteriner Vol 16 No 4 (2015)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (603.328 KB)

Abstract

Urine crystal is a crystal nucleus which tend to form urine stone. The case of urine stone seems to beincreased every year. Crystallization could induce acute tubular necrosis which impact on renal dysfunction.The signs of this condition are high level of urea, creatinine and decrease glomerulus filtration rate. Theobjective of this research was to evaluate the effects of infusum Persea americana Mill as an inhibitorcrystallization which induced by ethylene glycol on white male rats. 20 male rats were divided into 4groups; K1 as negative group received only distilled water ad libitum, K2 as positive group receiveddistilled water containing ethylene glycol, K3 (dose 5%) and K4 (dose 10%) as treatment groups receivedwater containing ethylene glycol and avocado leaves infusion. Phytochemsitry screening of infusion avocadoleaves consisted of flavonoid, saponin, tanine and quinone. Result of analysis showed that the level ofureum and creatinine on K2 was higher than K3 and K4 group. The increased level could be inhibited byinfusion avocado leaves. The measurement of glomerular filtration rate in treatment groups wassignificantly different (p<0.05). Descriptive histopathology observation showed that renal lesio in grouptreatment (K3 and K4) were declined. Large crystal calcium oxalate on K2 group was observed by usingpolarized microscope, whereas small crystal calcium oxalate were seen in the infusion of avocado leavesgroups. These result showed the ability of infusion of avocado leaves as an inhibitor on the growth ofcrystallization calcium oxalate
Gambaran Serum Ureum, dan Kreatinin pada Tikus Putih yang diberi Fraksi Etil Asetat Daun Alpukat (THE PROFIL OF SERUM, UREUM AND CREATININE OF AETHYL ACETATE FRACTION AVOCADO LEAVES IN WHITE RATS) Ietje Wientarsih; Rini Madyastuti; Bayu Febran Prasetyo; Dian Firnanda
Jurnal Veteriner Vol 13 No 1 (2012)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (112.848 KB)

Abstract

Nephrolithiasis is one of urologic disease due to crystallization urine in urinary system. Traditionally,avocado leaves has long been used for the treatment of nephrolithiasis because flavonoid in this plant canfacilitate the watering of crushing stone in the urinary tract. The aims of this study was to determine theeffect of aethyl acetate fraction of avocado leaves on ureum and creatinine level. Twenty white male rats(Sprague dawley, weight 200-300g) were divided into four groups. Normal control group (A) was givenaquadest ad libitum. Negative control group (B) and treatments group (C and D) were given ethyleneglycol 0.75% and ammonium chloride 2% to induce the formation of calcium oxalate crystal. Group C andD were given aethyl acetate fraction with different levels (100mg/kg bb and 300mg/kg bb for fourteen days).Blood samples were taken before and after treatment. The result showed that aethyl acetate fractioncould not decrease serum blood level of ureum and creatinine. Serum blood level ureum and creatinine ingroup D increased significantly compared to group A, B, C after fourteen days treatment. The used ofethylene glycol caused acute tubular necrosis. It therefore appears that ethyl acetate solvent was not ableto extract flavonoids to prevent renal dysfunction.
Co-Authors A.S. Satyaningtijas Alauddin, Daffa Rizal Dzulfaqaar Andriyanto Andriyanto ANGGARA ALDOBRATA Anggraeni, Henny Endah Anisa Rahma, Anisa Anisa, Rahma Anita Esfandiari Aritonang, Erfan Andrianto Aulia Andi Mustika Bachmid, Salma Safitri Baharun, Rasyid Bambang Pontjo Priosoeryanto Bayu Febram Prasetyo Bayu Febran Prasetyo Budiono, Novericko Ginger Daniel Happy Putra Dea Khalissa Anidya Deny Setyo Wibowo Dian Firnanda Diaz, Fariz Arrachman DIMAS ANDRIANTO Erni H Purwaningsih Erni H Purwaningsih Eva Harlina Fadiela Salima Putri Farhamzah Fitri, Arni Diana Gunanti Hadiyanti, Cresensia Rara Hikmarizky, Firda IETJE WIENTARSIH Ikrar Trisnaning Hardi Utami Indah Kurnia Klara Isnaini, Nyimas Syifa Amira Joko Pamungkas Khoirun Nisa Kusumawati, Nina Tri LAKSMI AMBARSARI Lina Novianti Sutardi Lina Novianti Sutardi, Lina Novianti Lina Noviyanti Sutardi Maharani, Alya Rizqi May, Ng U Mega Safithri Mufida, Anis Arifatu Muhammad Agung Nulhakim Nabila Nur Nafiati Nina Kusumawati Nina Tri Kusumawati Nisa, Nunik Nida Choerun Nugraha, Salma E.P Nugroho, Radhitya Aryo Nurdiansyah, Rio Dwi Haryadi Nurhidayat Nurhidayat Nurkarimah, Dona Astari Nursaumawati, Siti Parameshtya, Sadhira Pudji Achmadi Putri, Fadiela Salima Rasyid, Baharun Riki Siswandi Rizal Arifin Akbari Saragih, Adrian Sa’diah, Siti Setyo Widodo Setyo Widodo Sugeng Santoso SUPRIYONO Supriyono, Supri Tannya, Prieske Tarigan, Ronald Tarisa, Hasnah TATI NURHAYATI Trioso Purnawarman Vadivellan, Srivaen Vetnizah Juniantito Wasmen Manalu Wilujeng, Retno Wulandari, Nenis Rahma