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All Journal HAYATI Journal of Biosciences ACTA VETERINARIA INDONESIANA Jurnal Sain Veteriner Jurnal Veteriner Media Kedokteran Hewan ARSHI Veterinary Letters Pharmacoscript Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Community Development Journal: Jurnal Pengabdian Masyarakat Indonesian Journal of Applied Research (IJAR) Jurnal Buana Farma Eduvest - Journal of Universal Studies Jurnal Veteriner dan Biomedis Current Biomedicine Indonesian Journal of Chemical Science
Madyastuti, Rini
Divisi Farmakologi Dan Toksikologi, Sekolah Kedokteran Hewan Dan Biomedis, IPB University, Bogor, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary

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Journal : Pharmacoscript

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IN SILICO STUDY OF APIGENIN AND ITS DERIVATIVES AS POTENTIAL INHIBITORS OF TNF-Α AND MMP-9 FOR BURN WOUND HEALING Baharun, Rasyid; Rini Madyastuti, Purwono; Bayu Febram, Prasetyo; Vetnizah, Juniantito
Pharmacoscript Vol. 8 No. 1 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i1.2062

Abstract

The prevalence of burns ranks fourth in trauma after traffic accidents, falls, and violence. The prevalence of burns ranks fourth in trauma after traffic accidents, falls, and violence. The healing of burn wounds results from a complex inflammatory response where pro-inflammatory cytokines, for instance, TNF-α and MMP-9, play a pivotal role. Flavonoids with strong anti-inflammatory activity are apigenin, this compound comes from plants. In this study, we evaluated apigenin and its derivatives to determine their effectiveness as burn wound healing agents using molecular docking modeling techniques. To evaluate the molecular docking of these compounds with their target proteins, we used computer-aided drug design tools such as AutoDock Vina, PyMOL, and Discovery Studio. The data showed that apigenin compounds have better affinity than natural ligands to inhibit MMP-9 which can increase the rate of the inflammatory phase of burn wound healing. These findings indicate that apigenin and its derivatives have good potential to be candidates in the development of new therapeutic interventions for burn wound healing.
Co-Authors A.S. Satyaningtijas Andriyanto Andriyanto ANGGARA ALDOBRATA Anggraeni, Henny Endah Anisa Rahma, Anisa Anisa, Rahma Anita Esfandiari Aritonang, Erfan Andrianto Aulia Andi Mustika Bachmid, Salma Safitri Baharun, Rasyid Bambang Pontjo Priosoeryanto Bayu Febram Prasetyo Bayu Febran Prasetyo Budiono, Novericko Ginger Daniel Happy Putra Dea Khalissa Anidya Deny Setyo Wibowo Dian Firnanda Diaz, Fariz Arrachman DIMAS ANDRIANTO Erni H Purwaningsih Erni H Purwaningsih Eva Harlina Fadiela Salima Putri Farhamzah Fitri, Arni Diana Gunanti Hadiyanti, Cresensia Rara Hikmarizky, Firda IETJE WIENTARSIH Ikrar Trisnaning Hardi Utami Indah Kurnia Klara Isnaini, Nyimas Syifa Amira Joko Pamungkas Khoirun Nisa Kusumawati, Nina Tri LAKSMI AMBARSARI Lina Novianti Sutardi Lina Novianti Sutardi, Lina Novianti Lina Noviyanti Sutardi Maharani, Alya Rizqi May, Ng U Mufida, Anis Arifatu Muhammad Agung Nulhakim Nabila Nur Nafiati Nina Kusumawati Nina Tri Kusumawati Nisa, Nunik Nida Choerun Nugraha, Salma E.P Nugroho, Radhitya Aryo Nurdiansyah, Rio Dwi Haryadi Nurhidayat Nurhidayat Nurkarimah, Dona Astari Nursaumawati, Siti Parameshtya, Sadhira Pudji Achmadi Putri, Fadiela Salima Rasyid, Baharun Riki Siswandi Rizal Arifin Akbari Saragih, Adrian Sa’diah, Siti Setyo Widodo Setyo Widodo Sugeng Santoso SUPRIYONO Supriyono, Supri Tannya, Prieske Tarigan, Ronald Tarisa, Hasnah TATI NURHAYATI Trioso Purnawarman Vadivellan, Srivaen Vetnizah Juniantito Wasmen Manalu Wilujeng, Retno Wulandari, Nenis Rahma