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All Journal PHARMACON Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Pendas : Jurnah Ilmiah Pendidikan Dasar JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Saintifik : Jurnal Matematika, Sains, dan Pembelajarannya JFIOnline Jurnal Farmasi Higea Jurnal Pengabdian Masyarakat Multidisiplin Pharmaceutical Sciences and Research (PSR) Edunity: Kajian Ilmu Sosial dan Pendidikan Journal of Pharmaceutical and Sciences. Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam
Retno Wahyuningrum
Universitas Muhammadiyah Purwokerto
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Tinjauan potensi aktivitas ramuan herba sambiloto, herba meniran, dan daun kumis kucing dalam penanganan diabetik neuropati: Narative Review Anita Purnama Sari; Elza Sundhani; Retno Wahyuningrum
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.940

Abstract

Diabetic neuropathy is one of the most common microvascular complications among patients with diabetes mellitus, characterized by damage to peripheral nerves due to persistently high blood sugar levels, excessive oxidation and inflammation. Conventional treatments are often not effective enough in comprehensively addressing this problem, so strategies using medicinal plants are emerging as promising options. This study aims to review the potential pharmacological activities of three medicinal plants, namely sambiloto (Andrographis paniculata), meniran (Phyllanthus niruri), and cat's whisker (Orthosiphon aristatus), in the treatment of diabetic neuropathy. This study was conducted using the Narrative Review method with a literature search of two databases PubMed and ScienceDirect with an interval of publication years 2016-2026. A total of 16 articles were selected. The three types of plants showed significant pharmacological properties, including as antioxidants, anti-inflammatory, hypoglycemic, and neuroprotective. Sambiloto functions through andrographolide compounds that inhibit the NF-κB pathway and increase Nrf2 antioxidant activity. Meniran has an effect in lowering blood glucose levels and increasing the performance of antioxidant enzymes. Cat whisker plays a role in glucose control, kidney care, and inflammation in the system.  The results of this study are expected to provide an overview of additional therapies in overcoming diabetic neuropathy through the workings of Sambiloto, meniran, and cat's whiskers have complementary potential. The combination of these three plants offers a diverse approach, but further research is needed to assess synergistic effects, safety, and the most appropriate formulation as a modern herbal treatment.
EDUKASI CEK "KLIK” UNTUK MEMASTIKAN KEAMANAN JAMU DAN PRODUK PANGAN KEPADA ANGGOTA PKK KELURAHAN TANJUNG KABUPATEN BANYUMAS Retno Wahyuningrum; Dwi Hartanti; Shintia Lintang Charisma
Jurnal Pengabdian Masyarakat Multidisiplin Vol 8 No 2 (2025): Februari
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jpm.v8i2.5500

Abstract

The abundance of herbal medicine and food products available on the market, along with easy access to obtain them, requires vigilance regarding the safety of products consumed by consumers. Ensuring the safety of herbal medicine and food products is essential, given the discovery of several illegal cases, such as the addition of pharmaceutical chemicals, products without distribution permits, and violations of efficacy claims. The addition of in herbal medicine or food products poses serious health risks to consumers. Therefore, consumers must be cautious in selecting products before use. Considering the importance of choosing safe herbal medicine and food products, all relevant parties must focus on educating the public about how to select and ensure the safety of such products. The method used in this program is counseling about "KLIK" check (Packaging, Label, Distribution Permit, and Expiry Date) by providing leaflets, starting with a pre-test and ending with a post-test to assess participants' understanding of the educational material. Educational materials were delivered through leaflets, team presentations, and examples of herbal medicine and food products. The aim of this program is to increase knowledge and understanding of vigilance in selecting and ensuring the safety of products to prevent undesirable consequences from the use of illegal herbal medicine and food products. Analysis of the pre-test and post-test results showed an improvement in participants' knowledge and understanding. It can be concluded that this program enhanced public knowledge, particularly among members of the PKK, regarding caution and precision in choosing good and safe herbal medicine and food products.
EFEKTIVITAS PEMBELAJARAN MENDALAM DITINJAU DARI KEMAMPUAN BERPIKIR KOMPUTASIONAL DALAM PELAJARAN MATEMATIKA PADA SISWA SEKOLAH DASAR Arifin, Nurdin; Adianto, Samsul; Wahyuningrum, Retno; Jannah, Nur Aulia Miftahul
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 11 No. 03 (2026): Volume 11 Nomor 03, September 2026 Posted
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v11i03.58197

Abstract

The purpose of this study is to determine the effectiveness of deep learninh from the mathematical computational thingking ability of students at SD Negeri 004 North Samarinda. Based on the results of observations made at SD Negeri 004 Nort Samarinda, there is a problem namely the lack of students’ mathematical computational thingking skills during the learning process. The reseacrh methode is a pre-experiment with a pretest-posttest one group design. The results obtained after the treatment mere given increased with an average student test of 83, so the students’ mathematical computational thingking ability was good. Based on test 1 one sample t-Test the average score of the students’ mathematical computational thingking ability tes tis more than 70. The results of test 2, namely the proportion test, stated that more than 75% of students got a score of more than 70. The test results of the 3 paired sample t-Test average on the posttest score are more than the pretest score. Thus deep learning is effectively reviewed from the mathematical computational thingking ability of students.
Perbandingan Efektivitas Penangkal Radikal Bebas Ekstrak Beras Merah Dengan Ekstrak Beras Hitam Pada Formula Masker Gel Peel-off Siti Farah Hardiyati; Indri Hapsari; Retno Wahyuningrum
Edunity: Kajian Ilmu Sosial dan Pendidikan Vol. 5 No. 8 (2026): Edunity: Social and Educational Studies
Publisher : PT Publikasiku Academic Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57096/edunity.v5i8.558

Abstract

Radikal bebas dapat terbentuk akibat faktor pemicu stres seperti sinar ultraviolet, radiasi, aktivitas fisik, dan stres oksidatif. Untuk mencegah radikal bebas yang tak terkendali, tubuh secara spontan memproduksi zat antioksidan. Namun, ketika kulit terpapar radikal bebas dalam jumlah yang besar dari lingkungan, antioksidan endogen tidak cukup untuk menangkalnya. Salah satu bahan alami yang dapat dimanfaatkan adalah beras. Beras tidak hanya merupakan sumber energi dan protein, tetapi juga sumber vitamin, mineral, asam ferulat, tokoferol, y-oryzanol, dan berbagai antioksidan. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dalam menangkal radikal bebas dari bahan alami yaitu ekstrak beras merah dan ekstrak beras hitam yang diformulasikan dalam bentuk sediaan masker gel peel-off. Metode yang digunakan untuk menentukan aktivitas antioksidan adalah metode DPPH (2,2-diphenyl-1-picrylhydrazyl). Parameter pengujian yang digunakan meliputi uji organoleptik, uji homogenitas, uji pH, uji viskositas, uji daya sebar, uji waktu pengeringan, uji stabilitas (cycling test), dan uji iritasi. Hasil uji aktivitas antioksidan menunjukkan nilai IC50 sebesar 26,34 ppm untuk ekstrak beras merah dan 26,98 ppm untuk ekstrak beras hitam; sedangkan untuk sediaan masker gel peel-off, nilai IC50 yang diperoleh adalah 29,58 ppm untuk ekstrak beras merah dan 30,53 ppm untuk ekstrak beras hitam. Berdasarkan penelitian ini, disimpulkan bahwa ekstrak beras merah memiliki aktivitas antioksidan yang lebih tinggi dalam menangkal radikal bebas dibandingkan ekstrak beras hitam, baik dalam bentuk ekstrak murni maupun dalam sediaan masker gel peel-off.
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL KAYU NANGKA (Artocarpus heterophylla Lmk.) TERHADAP Bacillus subtilis DAN Escherichia coli Refriana Setya Pratiwi; Tjiptasurasa Tjiptasurasa; Retno Wahyuningrum
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), Vol. 08 No. 03 Desember 20
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v8i03.1125

Abstract

ABSTRAK Telah dilakukan penelitian tentang aktivitas antibakteri ekstrak etanol kayu nangka (A. heterophylla Lmk.) terhadap pertumbuhan bakteri B. subtilis dan E. coli secara in vitro. Ekstraksi kayu nangka dilakukan dengan metode maserasi menggunakan pelarut etanol 70%. Uji aktivitas antibakteri dilakukan dengan metode difusi agar. Ada 5 kelompok yang diujikan, yaitu konsentrasi 1%, konsentrasi 10%, konsentrasi 100%, kontrol positif (tetrasiklin HCl) dan kontrol pelarut/ kontrol negatif Dimetilsulfoksida (DMSO 10%). Hasil penelitian menunjukkan bahwa ekstrak etanol kayu nangka tidak memiliki aktivitas terhadap pertumbuhan bakteri uji sampai dengan kadar tertinggi. Hasil uji KLT menunjukkan bahwa ekstrak etanol kayu nangka mengandung flavonoid dan alkaloid. Kata kunci: antibakteri, ekstrak etanol kayu nangka (A. heterophylla Lmk.), Bacillus subtilis, Escherichia coli. ABSTRACT Research on antibacterial activity of jackfruit wood (A. heterophylla Lmk.) ethanolic extract to B. subtilis and E. coli in vitro have been done. Jackfruit wood extraction was done with maceration method using ethanolic solvent 70%. Antibacterial activity test used agar diffution method. There were tested 5 groups of serial extract concentration 1%, 10% and 100%; positive control (tetracycline HCl) and solvent control/ negative control Dimethylsulfoxide (DMSO 10%). The result showed that ethanolic extract of jackfruit wood didn’t have antibacterial activity until the highest concentration. Thin Layer Chromatography (TLC) test showed that ethanolic extract of jackfruit wood contain flavonoid and alkaloid. Keywords: antibacterial, ethanolic extract of jackfruit wood (A. heterophylla Lmk.), Bacillus subtilis, Escherichia coli.
Co-Authors Adianto, Samsul Agusriyadin, Agusriyadin Ahmat, Norizan Aladdin, Nor-Ashila Andestia Sinaga, Risda Yunita Andestia Sinaga, Risda Yunita Anita Purnama Sari Anjar Mahardian Kusuma Apri Yudis Fitriana, Apri Yudis ARI KURNIAWAN Arifin, Nurdin Asmiyenti Djaliasrin Djalil Azis, Muhammad Israwan Aziz Priadiatna Binar Asrining Dhiani Budiman, Arif Carla Wulandari Sabandar Charisma, Shintia Lintang Djoko Wahyono Dondi Pangestu Dwi Hartanti Dwi Hartanti Dwidayati, Ari Eka Nurmala Sari Elfahmi Elfahmi, Elfahmi Elis Yuliya Sandi, Elis Yuliya Eva Feriadi Fauziah, Putri Dian Hariyanti Hariyanti Hartanti, Dwi Ika Yuni Astuti Indah Pertiwi, Indah Indri Hapsari Jalil, Juriyati Jannah, Nur Aulia Miftahul Kamaruddin, Harni Sartika Kesuma, Alfira Anggita Mutiara Komar Ruslan Wirasutisna MARLIA SINGGIH WIBOWO Maya Sari Mufti Kharismawati Muslim Sukri, Muslim Mustofa Mustofa Pratiwi, Ines Septiani Pri Iswati Utami Priadiatna, Aziz Qomariah, Annisa Refriana Setya Pratiwi Risda Yunita Andestia Sinaga Sarmoko Sarmoko Shintia Lintang Charisma Siti Farah Hardiyati Sudarso Sudarso Sundhani, Elza Suparman Suparman Syahruddin, Muh. Tjiptasurasa Tjiptasurasa Try Widyati, Try Tunru, Andi Alif Wiranti Sri Rahayu Yayi Suryo Prabandari Yulianto, Akbar Yuniar, Rita Yunita, Alfiranty