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Journal : Jurnal Ilmiah Medicamento

Aktivitas Analgesik Topikal Gel Ekstrak Etanol 70% Daun Mint (Mentha piperita) pada Mencit Putih (Mus musculus) dengan Metode Hot Plate Sawu, Sirilus Deodatus; Wibowo, Wibowo; Irawan, Fransisca Elsia One
Jurnal Ilmiah Medicamento Vol 11 No 1 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i1.9900

Abstract

Pain is one of the most common health problems, affecting approximately one-third of the global population. Pain management is generally carried out through the administration of analgesic drugs, which are classified into two major groups: opioid and non-opioid analgesics. However, the use of these drugs is associated with adverse side effects and a risk of dependence. One potential alternative is the development of natural-based analgesics, such as mint (Mentha piperita) leaves. To date, there have been no studies evaluating the effectiveness of ethanol extract of mint leaves as a topical analgesic. This study aimed to assess the topical analgesic activity of ethanol extract of mint leaves formulated into a gel dosage form. Analgesic activity was evaluated using a hot plate-induced pain model in male white mice. Gels containing 5%, 10%, and 15% concentrations of the extract were tested and compared with a negative control (gel base) and a positive control (Voltaren® gel). Observations at 30 minutes post-application revealed that the mean latency times of the 10% and 15% extract groups, as well as the positive control group, were significantly different from the negative control group (p-value < 0.05). The difference in the percentage of maximal possible effect (%MPE) between the 10% and 15% extract groups was relatively small, suggesting that the 10% concentration was sufficient to produce an optimal analgesic effect. In conclusion, the 10% ethanol extract of mint leaves in gel form exhibited topical analgesic activity and holds potential for development as a topical analgesic gel formulation.
Co-Authors Achmad Syukkur Adi Sambowo, Kusno Aditya Rio Prabowo Adnovaldi, Yudha Adorini, Melati Agatha Intan Permatasari, Agatha Intan Agus Setiya Budi, Agus Setiya Agustiantoro, Adib Noor Ahdi Aji Sutrasno, Muhammad Irsyad Al Afif, Akhmad Fauzi Al Afif, Akhmad Fauzi Anastasia Sri Sulartri Andi Latif , Syarifuddin Andika, Venny Kurnia Andrew Giovanni Yustijanto Andriyanto, Firman Anisyah, Luluk Anto, Sardi Apriawang, Dicky Arda, Darmi Ardi, Tri Yuswo Ardiantya Sudarsono, Cristhofer Ardini, Nur?arina Arif Fathoni, Ahmad Rijal Ary Setyawan As'ad, Sholihin Asyikin, Asyhari Auliyaa Robbani, Brilyan Gusmi Binti Ishak, Ismarulyusda Bramatio Putra, Cristopher Brigitta Amelia Linardi Buana, Muhammad Arjunov Ramadhan Genta Chrismaningwang, Galuh Debby Novita Sari, Debby Novita Debora, Oda Dewi Nurhanifah, Dewi Dharmawan, Emir Ahmad Do, Quang Thang Edy Purwanto Elizabeth Kurniasari Susanto Elliza, Ismailah Nur Elliza, Ismailah Nur Elsia, Fransisca Endah Safitri endah, endah Eunike Narulita Sitompul, Eunike Narulita Fadhil, Bayu Dian Fadillah, Yuda Fatoni, Luth Fian Febriana F, Mareta Fitri, Siti Nurlita Fredy Saputra, M Khalid Gishela Kristianna De Jong GM, Andhiny Gunawan, Purnawan Gunawan, Purnawan Gusanti, Winda Guterres, Sandro Hadiyanto, Muchamad Hapsari, Sherli Pramudhita Hapsari, Wahyu Hardianti, Hilda Hartopo, Hartopo Hasana, Ani Riani Hasiholan, Simon Edward Hendro Aryanto Heni Prasetia Hidayat, Claudia Hijrah Hijrah Ihsan Kamaruddin, Muh. Irawan, Fransisca Elsia One Istiyan Primasatya, Dewana Ivan Kristianto Gunawan, Ivan Kristianto Jikriyansyah, Muhamad Jovancha, Nancy Ratu Kamaruddin, Muh Ihsan kevin julianto tejakusuma, kevin julianto Krisyanti, Martini Indah Kurnia Andika , Venny Lahardo, Devanus Lathifah, Putri Lupita, Nawang Christy Luthfi Rifai, Muhammad Luthfiana, Haya Mailani, Mailani Mangaya Takke, Jessy Andre Mardiyanto, Dwi Mardiyanto, Dwi Maria Kurni Menga Marwan, Jubery Maulana, Delvi Maulana, Sultan Maulidiya, Azzah Khoridah Mediyanto, Antonius Mediyanto, Antonius Michael Julian Wirawan Midansih, Ken Mujtahid Kaavessina, Mujtahid Munandar, Aries Mustawa Kamal, Muhammad Imam Musyaffa, Dwi Nuur Muttaqie, Teguh Muttaqin, Muhammad Afaza Navelia, Eriszha Berti Nikmah, Wachidatun Nur Budianto, Markus Koko Nurisyah, Nurisyah Nurkhasan, Sains Satria Nurlina Nurlina Nurul Muhayat One Irawan, Fransisca Elsia Prasetyo, Handy Pratama, Fajri Prayitno, Slamet Putri, Apriani Widya Putri, Rebeca Fransisca Prahesti Putri, Rizki Syahrani Radito, Fiqih Ramadhan, Brilliano Wahyu Ramadhan, Muhammad Naufal Rashad, Huesca Renata, Rezha Rendy, Stefano Riani Hasana, Ani Rika Febriani, Rika Ronald Adiguna Halim, Ronald Adiguna Rosana, Rita Sabrina, Nindya Annisa Santoso, Nehemia Herbert Saraswati, Anita Sari, Dian Ayu Angling Satria, Rinzano Genta Sawu, Sirilus Deodatus Sebastian Hadi Santoso Sefira Yovalia, Sefira Septian, Frezha Nur Setiono Setiono Setiya Budi, Agus Setyawan, Bagus Hendri Setyawan, Bagus Hendri Siti Fatonah Solihin Solihin Sonia Anggraini Saputra Sri Wulan, Sarinah Stefanus Adi Kristiawan Stevanus Indraguna Sayono Su'udi, Amir Sugiarto, Torianzyah Putra Bimandiri Sugiyanto - Sunarmasto, Sunarmasto Supardi Supardi Suprapto Suprapto Suryawan, Nurmantian Suryo Anom, Lilik Hendri Sutrisno, Didid Hendro Syaufina, Tengku Reiva tanri, andi Totok Apriyanto, Totok Triloka Wulandari, Dewi Trisnasari, Zulfa Utami, Shabina Aulia Utami, Shabina Aulia Valentin, Silviana Wibawa Endra Juwana, Wibawa Endra Wicaksono, Wahyu Satrio Widiatmoko, Widiatmoko Widodo, Satrio Kiat Wijaya, Dhimas Widya Taruna Wijaya, Winny Winarno, Ahmad Yusuf Windyarti, Koes A Yahya, Muhammad Syaiful Yessica Widyatama Oei Yunita Yunita