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All Journal Journal of Food and Pharmaceutical Science Jurnal Sain Veteriner Jurnal Pendidikan Indonesia Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Sains dan Teknologi Farmasi JURNAL ILMIAH PENDIDIKAN FISIKA AL BIRUNI Pharmacon Majalah Obat Tradisional JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Acta Pharmaciae Indonesia : Acta Pharm Indo Farmasains : Jurnal Ilmiah Ilmu Kefarmasian WIDYA LAKSANA PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) FITOFARMAKA: Jurnal Ilmiah Farmasi JURNAL FARMASIMED (JFM) Jurnal Komunikasi Pendidikan Optika : Jurnal Pendidikan Fisika Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Insan Farmasi Indonesia Journal of Research in Instructional AL-KHAZINI: JURNAL PENDIDIKAN FISIKA Jurnal Pengabdian Kolaborasi dan Inovasi IPTEKS Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy
Wahyu Widyaningsih
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary Other

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Journal : Pharmacon

 1 
Studi Docking Molekular Aktivitas Panghambatan Enzim Tirosinase Ubi Jalar (Ipomoea batatas L. Lam) Dwi Utami; Ryan Syahputra; Wahyu Widyaningsih
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 1 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i1.18295

Abstract

Sweet potato (Ipomoea batatas L. Lam) is a plant source of carbohydrates with chemical content of catechins, quercetin, asam klorogenat, anthocyanins, beta-carotene. These phytochemical compounds have been shown to have antioxidant activity that is closely related to tyrosinase through the oxidative stress pathway. The purpose of this study was to develop sweet potato plants as anti-tyrosinase candidates for cosmetic preparations by molecular docking of these 4 compounds to tyrosinase protein (pdb:2Y9X) with kojic acid control. The research was done in 4 stages : (1) Preparation of proteins (receptors) and ligands with Biovia Discovery Studio (2) Optimization of geometry with Avogadro and Chem 3D (3) Validation of docking and molecular docking methods for proteins (2Y9X) with Autodock-4 (5) and (4) ADMET study with pkCSM and SwissADME websites. The test results obtained the highest affinity for 3 active compounds, namely beta-carotene with (ΔG) -6.05 kcal/mol (IC) 36.72 M and quercetin has (ΔG) -5.87 kcal/mol (IC) 45.30 M . While the control kojic acid has a lower affinity of (ΔG) -5.27 kcal/mol (IC) 380.37 M. ADMET predictions provide information that the four active compounds Ipomoea batatas L. Lam meet the requirements to be developed as natural tyrosinase inhibitors based on lipophilicity (logP), topology polar surface area (TPSA), skin permeability, skin sensitivity, logKP, CYP1A2 inhibitor, lipinski rule. and bioavailability. The molecular docking study and ADMET prediction indicate that the active compound of sweet potato (Ipomoea batatas L. Lam) has the potential to be developed as a natural cosmetic ingredient.
Co-Authors Aditya Prabowo Aditya Prabowo Ainiyah, Nadia Putri Aldri Frinaldi Amelia Regina Arsyad Anasyua, Fairuz Khairunnisa arsyad, regina Astutik, Novita Santi Ayu Wulandari Azis Ikhsanudin Bachri, Mochammad Saiful Br. Sebayang, Sri Rosepda Cahya, Sella Nur Danang Prasetyaning Amukti Dara Pranidya Tilarso Daru Estiningsih Dedi Kuswandi Desi Eko Wulansari Desi Iswahyuni Desyandri Desyandri Dini Rahmawati Dwi Fitriani Dwi Retno Nengtyas Dwi Utami Erliyana, Mila Eti Nurwening Sholikhah Fadilah, Nur Aini fatima, fatma Fauzi, Muh Fajar Fauziyyah, Khusna Fitriyati, Laeli Galang Pergiawan Ramadhan Hanifah, Azka Khansa Hari Susanti Iin Narwanti Iin Narwanti Iis Wahyuningsih Indra Primardiana, Indra Irfan Yusuf Iriwi L.S Sinon, Iriwi L.S Iriwi L.S. Sinon, Iriwi L.S. Istyarini Istyarini, Istyarini Jumina Jumina Jumina Jumina Kaffah, Silmi Kintoko Kusuma, Rio Jati Laela Hayu Nurani Laela Hayu Nurani Lalu Muhammad Irham M. Paden, Thereziana marpaung, Tio Widia A. Moch Saiful Bachri Moch Saiful Bachri Moch. Saiful Bachri Moch. Saiful Bachri Muhammad Ma'ruf Muhammad Yusron Maulana El-Yunusi Mujasam Mujasam Nina Salamah Nisa Isneni Hanifa Nur Asih, Nur Nurliawaty, Lilis Pramono, Suwidjiyo Primardiana, Indra Puteriragil Atma Pertiwi, Puteriragil Atma Putri Dwi Lestari Radjab Sutrisno, Radjab Ramadhan, Muhammad Marwan Rerung, Nensy Rezza Wahyudi Rifka Salsabila Riska Riska Riza Sativa, Riza Rumansara, Tamariska Herlindo Ryan Syahputra Sapto Yuliani Sapto Yuliani Sativa, Riza Septianingsih, Ulfah Silmi Kaffah Siswanti Siswanti Sitarina Widyarini Siti Fatmawati Fatimah, Siti Fatmawati Sri Rosepda Sebayang, Sri Rosepda Suci Kurniati Sugiyanto - Sugiyanto, Sugiyanto Sumiasih Sumiasih Suwidjiyo Pramono Tio Widia Astuti Marpaung Tirza Pangkali, Tirza Ulfah Septianingsih Vivi Sofia Vivi Sofia Wiki Yuli Anita Wiki Yuli Anita Wulandari, Silviana Wulandari, Silviana Wulansari, Widyanari Febriyana Wumu, Dea Anggrainy Y.T. Allo, Alberto Yenusi, Kaleb Amaghi Yoga Yuniadi