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Journal : International Journal of Public Health Excellence (IJPHE)

 1 
Antidiabetic Effectiveness Test of Ethanol Extract of Brown Leaves (Theobroma Cacao L.) Against Mice (Mus Musculus) Gunawan, Muhammad; Safriana; Tanjung, Siti Aisyah; Andilala
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 2 (2024): January-May
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v3i2.775

Abstract

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion, insulin action or both. DM sufferers are increasing from year to year, accompanied by increasing costs of therapy, therefore, as an alternative to controlling blood glucose levels, use natural ingredients such as cocoa leaves. The aim of this research was to determine the effectiveness of ethanol extract of cocoa leaves (Theobroma cacao L.) in reducing blood glucose levels in mice that had been induced by Aloxan. The research method used was experimental research. The research stages were sample collection, sample identification, making simpilicia, examining the characteristics of simpilicia, making extracts using maceration using 96% ethanol solvent, and testing the antidiabetic effect of EEDC in mice induced by alloxan at a dose of 175 mg/kg. bb intraperitoneally. Diabetic mice were divided into 5 groups, each group consisting of 5 mice that were given the test material 50 mg/KgBB of ethanol extract of brown leaves; 100 mg/KgBB; and 200 mg/KgBB, Metformin 65 mg/KgBB, and CMC 0.5%. Next, blood glucose levels were measured on days 3, 6, 9, 12, and 15, the percentage reduction in blood glucose levels was calculated, then the data was analyzed using the One-Way ANOVA method and Duncan's test, to see real differences between treatments. The research results showed that simplicia, the ethanol extract of brown leaves contains flavonoids, alkaloids, tannins, steroids/triterpenoids, saponins and glycosides. Cocoa leaf ethanol extract has effectiveness in lowering glucose levels, at the 5th and 6th hours it shows good effectiveness at a dose of 200 mg/KgBW of (72.16 ± 0.1.51)% and (82.80 ± 0.73 )%, not significantly different from metfromin 65 mg/KgBB of (74.45 ± 1.51)% and (83.29 ± 1.01).
Antidiabetic Effectiveness Test of Ethanol Extract of Brown Leaves (Theobroma Cacao L.) Against Mice (Mus Musculus) Gunawan, Muhammad; Safriana; Tanjung, Siti Aisyah; Andilala
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 2 (2024): January-May
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v3i2.775

Abstract

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion, insulin action or both. DM sufferers are increasing from year to year, accompanied by increasing costs of therapy, therefore, as an alternative to controlling blood glucose levels, use natural ingredients such as cocoa leaves. The aim of this research was to determine the effectiveness of ethanol extract of cocoa leaves (Theobroma cacao L.) in reducing blood glucose levels in mice that had been induced by Aloxan. The research method used was experimental research. The research stages were sample collection, sample identification, making simpilicia, examining the characteristics of simpilicia, making extracts using maceration using 96% ethanol solvent, and testing the antidiabetic effect of EEDC in mice induced by alloxan at a dose of 175 mg/kg. bb intraperitoneally. Diabetic mice were divided into 5 groups, each group consisting of 5 mice that were given the test material 50 mg/KgBB of ethanol extract of brown leaves; 100 mg/KgBB; and 200 mg/KgBB, Metformin 65 mg/KgBB, and CMC 0.5%. Next, blood glucose levels were measured on days 3, 6, 9, 12, and 15, the percentage reduction in blood glucose levels was calculated, then the data was analyzed using the One-Way ANOVA method and Duncan's test, to see real differences between treatments. The research results showed that simplicia, the ethanol extract of brown leaves contains flavonoids, alkaloids, tannins, steroids/triterpenoids, saponins and glycosides. Cocoa leaf ethanol extract has effectiveness in lowering glucose levels, at the 5th and 6th hours it shows good effectiveness at a dose of 200 mg/KgBW of (72.16 ± 0.1.51)% and (82.80 ± 0.73 )%, not significantly different from metfromin 65 mg/KgBB of (74.45 ± 1.51)% and (83.29 ± 1.01).
Co-Authors Adiansa, Nopa Akbar Haknas Nugraha Ambali Azwar Siregar Anggraini, Kharisma Apridiansyah, Yovi Aryeshi Putri Aulia, Syafitri Bagas F, Muhammad Cut Fatimah Cut Fatimah David Maria Vironika, Nuri Devi Purnama Sari Dewi Safitri Dewi Safitri Dian Zulkarnain Lubis Dinda Ilyasa Fatihah Dwiki Novriadi Elly Hertita Fadhillah Lubis, Muhammad Arif Fadillah, Rizka Fadlikal Ilham Aditma, Afredo Fatimah, Cut Fitria, Devi Nur Fitria, Monica Desi Fitriani Nasution Fitriani Nasution Fitriani Nasution, Fitriani Fitriani, Enny Gibran, M Khalil Gibran, M. Khalil Gunawan Gunawan Gunawan, M Handayani, Sri Happy, Happy Hasanah, Mardhiati Hasniar Hasniar, Hasniar hidayah, agung kharisma Husni Rifqo, Muhammad Juansen, Monsya Juhardi , Ujang Juhardi, Ujang Juliana Sion Sihombing Juliantika Khomariah, Putri Ayu Kirman Kirman Kirman Kirman, Kirman Lili Nurmaliza Lili Nurmaliza Lubis, Muhammad Arif Fadhillah Lubis, Nur Azizah M. Gunawan M. Gunawan Mahfuzy, AR. Walad marhalim, marhalim Marwiyah, Rizky Masni Masni Mayanda, Suci Mayang Sari Melati Yulia Kusumastuti Mhd Ikhsan Rifki Mohamad Aji Prasetia Mona Melinda Monica Desi Fitria Muhammad Arif Fadhillah Lubis Muhammad Bagas Fahriansyah Muhammad Gunawan Muhammad Gunawan Muhammad Gunawan Muhammad Nizam Nawawi Muntahanah, Muntahanah Nur Azizah Lubis Nurhapiani Nurhapiani Nurhapiani, Nurhapiani Nursiah Oki, M. Pahrizal, Pahrizal Putra, Toto Dwi Putri Ayu Indah Setyarini Ransesta, Lingga Rismawati Rizky Marwiyah Ruseni Safriana Safriana Safriana Safriana Safriana Safrina Safrina, Safrina Salim Salim Salsabila Maydina Samran, Samran Sarkawi, Sarkawi Selfi Setyarini, Putri Ayu Indah Shopiana, Sella SIHOMBING, JULIANA SION Siregar, Ambali Azwar Siti Aisyah Tanjung Sumardi Suprianto Suprianto Surya Ade Saputera Tanjung, Siti Aisyah Ujang Juhardi Wijaya, Ardi Winda Wardani Wijaya