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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Ekonomi Jurnal Tata Rias ProNers Empathy : Jurnal Fakultas Psikologi Jurnal Media Gizi Indonesia (MGI) Paediatrica Indonesiana Jurnal Riset Akuntansi dan Keuangan SAR (Soedirman Accounting Review): Journal of Accounting and Business Management and Economics Journal (MEC-J) NUR EL-ISLAM : Jurnal Pendidikan dan Sosial Keagamaan International Journal of Community Service Learning Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ International Journal of Public Budgeting, Accounting and Finance MABIS: Manajemen dan Bisnis JURNAL TEKNOLOGI INFORMASI Jurnal Pendidikan dan Kebudayaan Jurnal Riset Akuntansi dan Manajemen Malahayati (JRAMM) Indonesian State Law Review (ISLRev) Jurnal Pengabdian Masyarakat dalam Kesehatan Narra J Proceeding Biology Education Conference Arus Jurnal Sosial dan Humaniora Pediatric Sciences Journal Jurnal Teknologi Lingkungan Lahan Basah Jurnal Akuntansi, Manajemen dan Perbankan Syariah International Journal of Trends in Mathematics Education Research (IJTMER) Jurnal Andragogi Pedagogi dan Pemberdayaan Masyarakat JAPB JEPEmas: Jurnal Pengabdian Masyarakat (Bidang Ekonomi) JURNAL REKAYASA KIMIA & LINGKUNGAN Fatih: Journal of Contemporary Research Indonesian State Law Review (ISLRev) Didacticofrancia: Journal Didactique du FLE Journal of Vocational and Career Education Jurnal Tata Rias
desy wulandari
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Narra J

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Effects of Nigella sativa on disease activity, T lymphocytes and inflammatory cytokine profiles in pediatric systemic lupus erythematosus: A randomized controlled trial Barlianto, Wisnu; Wulandari, Desy; Sari, Tita L.; Rachmaningrum, Rafika R.; Asasain, Rayi I.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1063

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse manifestations, requiring long-term treatment that can have side effects, particularly in pediatric patients. Nigella sativa (NS) has shown potential for improving SLE symptoms due to its anti-inflammatory and immunomodulatory effects. The aim of this study was to investigate the immunomodulatory effect of N. sativa oil (NSO) on disease activity, T lymphocyte activity and inflammatory cytokine profiles in pediatric SLE patients. A randomized, double-blinded, placebo-controlled clinical trial was conducted at Saiful Anwar Hospital in Malang, Indonesia, from January 2022 to January 2023. Pediatric patients with SLE were randomly assigned to receive either one gram of NSO or a placebo containing starch in capsule form as adjunct therapy alongside their SLE primary treatment. Blood samples were collected before treatment and after eight weeks of daily capsules. Disease activity was assessed using the SLE Disease Activity Index 2000 (SLEDAI-2K); flow cytometry was used to identify T helper lymphocytes, and serum cytokine levels were measured using ELISA. The statistical analysis tests were performed to compare the outcomes between groups at baseline or after the treatment, and within-group comparisons before and after the study period, as appropriate. A total of 32 patients were included in the study. A significant decrease in the SLEDAI-2K score was observed at post-treatment in both the NSO and placebo groups (p<0.001 and p=0.025, respectively). The percentage of T helper 17 (Th17) cells was significantly reduced in both the NSO and placebo groups post-treatment compared to pre-treatment (p=0.026 and p=0.034, respectively). Conversely, the post-treatment percentage of regulatory T (Treg) cells increased significantly in both groups. A significant reduction in interleukin (IL)-2 levels was observed in the NSO and placebo groups at post-treatment compared to pre-treatment (p=0.006 and p=0.046, respectively). Additionally, there were increases in IL-4 and IL-6 serum levels in both groups at post-treatment compared to pre-treatment (p<0.05). This study highlights that although disease activity was not significantly different between NSO and placebo groups, NSO could affect the inflammatory cytokine profiles in pediatric SLE patients.
Co-Authors ., Carmidah ., Carmidah ., Nurdiana ., Suliyem Abd. Rasyid Syamsuri Abdul Kholiq Adi Wiratno Adi Wiratno, Adi Aditya, Muhammad Reva Adriana . Agustina Tri Endharti Anang Endaryanto Anggawijaya, Anthony Anik Puryatni Anik Puryatni Apriani, Isna Ari Anggarani Winadi Prasetyoning Tyas Arifin, Kiswanul Asasain, Rayi I. Astuti, Margi Astuti, Rini Juni Azwin Mengindra Putera Bahrun Bahrun Bambang Jatmiko Bambang Sugeng Cahyono, Haryudi A. Carmel Meiden Carmidah . Choirul Mahfud Dara, Cesaria Rindu Dewi Purnama Sari Dian Hasanah Edi Widjajanto Edi Widjajanto Elvira Sari Dewi Fendy Suhariadi Fitriani, Fella Yunita Fitriyani, Fella Yunita Handono Kalim Hani Susianti Hartiyah, Sri Haryudi A. Cahyono Heksa Trisnawati Hesti Fibriasari Hidajati, Fitrijah Hinawati, Titik Husna, Rifqohhul I Ketut Suada Ida Bagus Ramajaya Sutawan, Ida Bagus Ramajaya Iman Harymawan Jannati, Nur Baiti Kaukab, M. Elfan Khabib, Ainun Kurniawati Mutmainah Kusdayanti, Niken Kusworini Handono Latang, Latang Machasin Machasin man, Romandhon Mardiah Maridi Maridi Maulidi, Rizky Muhammad Anshory, Muhammad Muhammad Asri Muhammad Dani Supardan Muhammad Khaibar Putra Adithia Muhammad Khumaedi Muhammad Sukirlan Mukaromah, Laili Munawaroh, Hidayatun MUNIF, AHMAD Musfiroh, Mila Fursiana Salma Nano Prawoto Ningsih, Kartika Ayu Noor Hikmah, Noor Novia Mehra Erfiza Nur Baiti Jannati Nurdiana Nurdiana Perdana Aditya Rahman Putranto, Agus Rachmaningrum, Rafika R. Rahmah Johar Riezky Maya Probosari Romandhon, Romandhon Rudi Amir, Rudi Ryan Moulana Sabrina, Laila Sari, Tita L. Sari, Tita Luthfia Satriana Satriana Setyagisna, Farhan Ardiyanta Simangunsong, Jojor Vivi Sofiana, Nia Solly Aryza Sugiarti, Rini Sunyono, Nanang Agus Susanti Susanti Susanto Nugroho Susanto Nugroho Susi Hendriani Suwarni Suwarni Suyono, Nanang Agus Tita Luthfia Sari Triwati, Anis Umami, Farida Riza Utomo, Kiki Prio Wahono, Cesarius Singgih Wisnu Barlianto Wisnu Barlianto Zahrah Hikmah, Zahrah