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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Ekonomi Jurnal Tata Rias ProNers Empathy : Jurnal Fakultas Psikologi Jurnal Media Gizi Indonesia (MGI) Paediatrica Indonesiana Jurnal Riset Akuntansi dan Keuangan SAR (Soedirman Accounting Review): Journal of Accounting and Business Management and Economics Journal (MEC-J) NUR EL-ISLAM : Jurnal Pendidikan dan Sosial Keagamaan International Journal of Community Service Learning Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ International Journal of Public Budgeting, Accounting and Finance MABIS: Manajemen dan Bisnis JURNAL TEKNOLOGI INFORMASI Jurnal Pendidikan dan Kebudayaan Jurnal Riset Akuntansi dan Manajemen Malahayati (JRAMM) Indonesian State Law Review (ISLRev) Jurnal Pengabdian Masyarakat dalam Kesehatan Narra J Proceeding Biology Education Conference Arus Jurnal Sosial dan Humaniora Jurnal Teknologi Lingkungan Lahan Basah Jurnal Akuntansi, Manajemen dan Perbankan Syariah International Journal of Trends in Mathematics Education Research (IJTMER) Jurnal Andragogi Pedagogi dan Pemberdayaan Masyarakat JAPB JEPEmas: Jurnal Pengabdian Masyarakat (Bidang Ekonomi) JURNAL REKAYASA KIMIA & LINGKUNGAN Fatih: Journal of Contemporary Research Indonesian State Law Review (ISLRev) Didacticofrancia: Journal Didactique du FLE Journal of Vocational and Career Education Jurnal Tata Rias
desy wulandari
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Low Levels of Vitamin D correlate with Hemoglobin A1c and Interleukin-10 Levels in Pediatric Type 1 Diabetes Mellitus Patients Wulandari, Desy; Cahyono, Haryudi A.; Widjajanto, Edi; Puryatni, Anik
Journal of Tropical Life Science Vol 4, No 3 (2014)
Publisher : Journal of Tropical Life Science

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Abstract

Low Levels of Vitamin D correlate with Hemoglobin A1c and Interleukin-10 Levels in Pediatric Type 1 Diabetes Mellitus Patients Desy Wulandari; Haryudi A. Cahyono; Edi Widjajanto; Anik Puryatni
Journal of Tropical Life Science Vol. 4 No. 3 (2014)
Publisher : Journal of Tropical Life Science

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Abstract

Vitamin D is reported to affect immune system and prevent autoimmunity. Some studies show that low vita­min D levels in patients with type 1 diabetes are associated with glycemic control and inflammatory status. The study was cross sectional design with subjects T1DM patients aged 1-18 years, and healthy subjects with similar age. Plasma levels of vitamin D (25(OH)D3) was measured using ELISA. Glycemic control measured by hemoglo­bin A1c (HbA1c). Inflammatory status measured by examination of IL-10 using ELISA method. Comparison of vitamin D levels, HbA1c levels and IL-10 levels were analyzed by independent samples t-test. The relationship be­tween vitamin D levels, HbA1c, and IL-10 were analyzed by Pearson's correlation. Our subjects were 20 T1DM patients and 20 healthy controls. Our study showed that vitamin D (25(OH)D3) levels was significantly lower than in healthy controls (20.82±5.53 ng/ml vs 33.14±2.17 ng/ml; p=0.000), HbA1c levels was significantly higher than in healthy controls (10.08±5.02% vs 5.02±0.18%; p=0.000), IL-10 levels was significantly lower than in healthy controls (16.50±4.57 ng/ml vs 73.52±7.11 ng/ml; p=0.000). Vitamin D levels were correlated with HbA1c (p= 0.000; r= -0.871), correlated with IL-10 (p= 0.000; r= 0.853). HbA1c levels were correlated with IL-10 levels (p= 0.000; r= -0.878). Low vitamin D levels are common in T1DM patients. There were significant differences in vitamin D levels, IL-10, and HbA1c among T1DM patients compared to normal subjects. Vitamin D levels were associated with HbA1c levels and IL-10 levels in T1DM.
Increase in Serum Ferritin Level as a Marker of Disease Activity in Pediatric Sys-temic Lupus Erythematosus (pSLE) Patients: Serum Ferritin Level as a marker of disease activity in pSLE Desy Wulandari; Wisnu Barlianto; Susanto Nugroho; Tita Luthfia Sari
Journal of Tropical Life Science Vol. 13 No. 2 (2023)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.13.02.11

Abstract

Ferritin is an acute-phase reactant that is elevated in autoimmune disorders, including systemic lupus erythematosus (SLE). However, their correlation with disease activity scores has not been confirmed. Pandemic Covid-19 makes children visitation to hospital to get the treatment of SLE were delayed. This study aimed to evaluate correlation between serum ferritin and disease activity and its role in screening for flare in pediatric SLE (pSLE) patients during pandemic Covid-19. This is a cross-sectional study conducted in Saiful Anwar General Hospital Malang. Sampling was carried out sequentially on pediatric patients who met the criteria for Systemic Lupus International Collaborating Clinics (SLICC) and were recorded between July 2021-May 2022. All patients were interviewed and assessed for disease activity using SLE Disease Activity Index 2000 (SLEDAI-2k). A score <4 was categorized as inactive disease. Biochemical, serological tests including markers of disease activity and ferritin level were measured by standard laboratory procedure. Comparison, correlation and ROC curve analyses were performed with SPSS software. There were 38 females pSLE participated in this study. The mean age of the patients were 12.6 ± 3.02 years. Serum ferritin significantly higher in active disease compared to inactive disease 84.50 ng/mL (68.00-151.75 ng/mL) ng/mL and 815.00 ng/mL (451.25-1570.00 ng/mL), a value of p<0.05 was determined to be statistically significant. A significant correlation was found between serum ferritin with SLEDAI 2K (r = 0.890, p = 0.000). Correlation was also found between serum ferritin and IgM anti-double stranded-DNA (r = 0.325, p = 0.046), but not with other laboratory and serological parameters. In ROC curve analysis, we found that Area Under The Curve (AUC) 0.989, 95%CI 0.964-1.014, p value 0,000, with cut off value 297.50 with sensitivity 85% and specificity 94.4%. Ferritin was increased in active disease   as compared to inactive disease and correlated with SLEDAI score and IgM-dsDNA. Thus, ferritin may be potential as an affordable and available marker of disease activity in pSLE during pandemic Covid-19.
Co-Authors ., Carmidah ., Carmidah ., Nurdiana ., Suliyem Abd. Rasyid Syamsuri Abdul Kholiq Adi Wiratno Adi Wiratno, Adi Adriana . Agustina Tri Endharti Anang Endaryanto Anggawijaya, Anthony Anik Puryatni Anik Puryatni Apriani, Isna Ari Anggarani Winadi Prasetyoning Tyas Arifin, Kiswanul Asasain, Rayi I. Astuti, Margi Astuti, Rini Juni Azwin Mengindra Putera Bahrun Bahrun Bambang Jatmiko Bambang Sugeng Cahyono, Haryudi A. Carmel Meiden Carmidah . Choirul Mahfud Dara, Cesaria Rindu Dewi Purnama Sari Dian Hasanah Edi Widjajanto Edi Widjajanto Elvira Sari Dewi Fendy Suhariadi Fitriani, Fella Yunita Fitriyani, Fella Yunita Handono Kalim Hani Susianti Hartiyah, Sri Haryudi A. Cahyono Hesti Fibriasari Hidajati, Fitrijah Hinawati, Titik Husna, Rifqohhul I Ketut Suada Ida Bagus Ramajaya Sutawan, Ida Bagus Ramajaya Iman Harymawan Jannati, Nur Baiti Kaukab, M. Elfan Khabib, Ainun Kurniawati Mutmainah Kusdayanti, Niken Kusworini Handono Latang, Latang Machasin Machasin man, Romandhon Mardiah Maridi Maridi Maulidi, Rizky Muhammad Anshory, Muhammad Muhammad Asri Muhammad Dani Supardan Muhammad Khaibar Putra Adithia Muhammad Khumaedi Muhammad Sukirlan Mukaromah, Laili Munawaroh, Hidayatun MUNIF, AHMAD Musfiroh, Mila Fursiana Salma Nano Prawoto Ningsih, Kartika Ayu Noor Hikmah, Noor Novia Mehra Erfiza Nur Baiti Jannati Nurdiana Nurdiana Perdana Aditya Rahman Putranto, Agus Rachmaningrum, Rafika R. Rahmah Johar Riezky Maya Probosari Romandhon, Romandhon Rudi Amir, Rudi Ryan Moulana Sabrina, Laila Sari, Tita L. Sari, Tita Luthfia Satriana Satriana Simangunsong, Jojor Vivi Sofiana, Nia Solly Aryza Sugiarti, Rini Sunyono, Nanang Agus Susanti Susanti Susanto Nugroho Susanto Nugroho Susi Hendriani Suwarni Suwarni Suyono, Nanang Agus Tita Luthfia Sari Triwati, Anis Umami, Farida Riza Utomo, Kiki Prio Wahono, Cesarius Singgih Wisnu Barlianto Wisnu Barlianto Zahrah Hikmah, Zahrah