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All Journal INDONESIAN JOURNAL OF PHARMACY Jurnal Surya Medika JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik JFIOnline Jurnal Ilmu Kefarmasian Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ilmiah Medicamento Journal of Holistics and Health Sciences (JHHS) Generics: Journal of Research in Pharmacy Jurnal Farmasi Sains dan Praktis Academic Hospital Journal Generics : Journal of Research in Pharmacy Jurnal Kefarmasian Indonesia
Nanang Munif Yasin
Department of Pharmacology, Faculty of Pharmacy, Universitas Gadjah Mada. Yogyakarta, 55281, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Academic Hospital Journal

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A Study on Lung Cancer Chemotherapy Regimen Administration at Universitas Gadjah Mada Academic Hospital Oktariyanto, Efel Erlambang; Yasin, Nanang Munif; Puspitasari, Ika
Academic Hospital Journal Vol 6, No 2 (2024)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v6i2.99663

Abstract

Background: One of the main ways to treat lung cancer is through chemotherapy regimens. Due to the complexity of lung cancer pathophysiology, the variability of chemotherapy given tends to cause drug interactions and toxicity in patients.Objective: Based on this, this study aims to determine the characteristics of lung cancer patients and identify chemotherapy administration patterns based on the NCCN therapy guidelines, identify interactions and side effects of chemotherapy that occur in patients diagnosed with lung cancer who are undergoing outpatient therapy at the Universitas Gadjah Mada Academic Hospital.Method: This research was carried out with a case-series design, namely by conducting a study using descriptive methods that provide an overview of patient characteristics, chemotherapy regimen patterns and their conformity to NCCN guidelines, potential drug-drug interactions (DDIs), and the incidence of side effects experienced by patients. Data was collected retrospectively through medical records of lung cancer patients undergoing outpatient treatment in the period April 2022 – April 2023 who met the inclusion and exclusion criteria.Result: There were a total of 27 patients in this study with patient characteristics predominantly in the elderly age range (> 60 years), 18 patients (66.7%), with exon 19 mutation NSCLC lung cancer type (n = 13; 92.6%), stage IV (n = 25 ; 92.6%), as well as non-smoking patients (n = 15 ; 55.6%). Chemotherapy regimen patterns at Gadjah Mada University Academic Hospital for lung cancer patients included afatinib (n = 14; 51.9%), gefitinib (n = 12; 44.4%), and cisplatin pemetrexed (n = 1; 3.7 %) with conformity reaching 100% in the accuracy of indications, dosage and usage information. In this study, it was identified that there were 2 Potential DDIs that occurred in 1 patient (3.7%) with respective risks, namely C and B which included cisplatin-furosemide and cisplatin-ondansetron interactions. Side effects were known to occur in almost all patients (n = 23; 85.2%) where side effects in the form of skin toxicity and diarrhoea were the two most frequently identified types of side effects with a percentage of 59.3% (n = 16). and 40.7% (n = 11).Conclusion: More than 90% of NSCLC showed exon 19 mutation. The most chemotherapy given to the patients was afatinib. There were a potential interaction between cisplatin and either furosemide or ondansetron.
Impact of Pharmacist Counseling Strategy On Adherence And Knowledge of Chronic Kidney Disease Patients: Quasi-Experimental Assessment Filliana, Ulfa -; Oktasari, Sholikhah Rosvita; Molidia, Sri Rahmat; Yasin, Nanang Munif; Kristina, Susi Ari
Academic Hospital Journal Vol 8, No 1 (2026)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v8i1.110980

Abstract

Background: Chronic kidney disease is a progressive condition that requires proper management to slow the decline in kidney function and reduce the risk of complications. Patients with low adherence have an increased risk of kidney progression, and knowledge level plays an important role in the treatment of kidney patients and in collaborative treatment decision-making. This study aims to evaluate the impact of a pharmacist counselling strategy on adherence and knowledge levels in CKD patients.Method: The method was quasi-experimental, with a pretest-posttest design, comparing the intervention and control groups. The intervention was carried out once a week for 1 month, using leaflets as a tool, with inclusion and exclusion criteria, among chronic kidney disease patients during September-October 2023.Result:  The study included 57 patients: 29 in the control group and 28 in the intervention group. The result showed that in the intervention group, there was an increase in knowledge, with a difference between pretest and posttest scores of Δ 8.79±7.802, compared to the control group, which showed a decrease in scores of Δ -0,49±4,932 (p=0.000). Adherence in the intervention group increased by Δ 2,71±1,822 compared to the control group, while adherence in the control group decreased by Δ -0,44±1,152 (p=0.000). A contributing factor to the patient's level of knowledge and compliance was duration of hemodialysis, p=0.032.Conclusion: The conclusion was that the pharmacist counselling strategy significantly improved CKD patient knowledge and medication adherence, and that the duration of hemodialysis significantly contributed to CKD patients' knowledge.
Co-Authors A., Diki Aprianto Abdul Arief, Thendi Aji Wibowo, Much Ilham Novalisa Ambarsari M., Paulina Andi Ameilia Sari Riandika Anni Anni, Anni As'hari, Yanuar Atana, Sanses Bambang Sigit Riyanto Boku, Yuliana Chairun Wiedyaningsih Desy Purnamasari Dewi, Endah Kusuma Dewi, Endah Kusuma Dina, Amila Djoko Wahyono Eka Kartika Untari Eri Supriyanti Faluti, Dimas Rizki Filliana, Ulfa Filliana, Ulfa - Fita Rahmawati Fitri, Febiana Melisa Geografi, Liniati Graciano Aristides Maturbongs Hakim, Sarah Nabila Haninditya, Beta Hasan, Murojil Hastha Yoga, Bambang Hati, Anita Kumala Hesaji Maranty, Hesaji Hidayatika, Annisa I Dewa Putu Pramantara I Gusti Ngurah Anom Cahyadi Putra Ika Puspita Sari Ika Puspitasari Intan Adevia Rosnarita Joko Sunowo, Joko Karundeng, Glory Claudia Kurniawati, Fivy Kurniawati, Fivy Kusumah Wardani, Sintaresmi Kusumaningsih, Riyani Lawalata, Angela Flora Stephanie Listyana, Yanverty Idda Made Krisna Adi Jaya Malina, Rachma Marseli, Cindy Maulidiah, Rizka Mazidah, Zulfa Molidia, Sri Rahmat Ni’mah, Farihatun Nopita, Rika Nurani, Melisa Rizky Nurficahyanti, Romadhina Nurjanna, Sitti Nurul Safitri Oktariyanto, Efel Erlambang Oktasari, Sholikhah Rosvita Parera, Maria Meliana Waty Pratama, Tiara Dewi Salindri Probosuseno Probosuseno, Probosuseno Pujilestari, Dwi Puspitasari, Winda Dwi Putri, Mukarromah Dita Putri, Riandita Gusnanda Putri, Wiwin Nopita Rini, Desi Setya Ristyaningsih, Anis Rizka Humardewayanti Asdie Rochmanov, Janne Saputri, Pratiwi Satibi Satibi Sembiring, Rinawati Setiawati, Margarita Krishna Susi Ari Kristina Tista Ayu Fortuna Titik Nuryastuti Tri Murti Andayani Trung, Vo Quang Wahyu Roossi Ningsih, Wahyu Roossi Wedyaningsih, Chairun Weidyaningsih, Chairun Widyastuti, Herlina Tri Widyastuti, Herlina Tri Widyati, Widyati Widyati Winarni Winarni Wiyatami, Monia Agni Yatminto, Eko Yayi Suryo Prabandari Zaimatuddunia, Irma