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All Journal Farmaka Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Kesehatan Masyarakat JURNAL PHARMASCIENCE Majalah Obat Tradisional Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY Edukasi: Jurnal Pendidikan Jurnal Fitofarmaka Indonesia JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Epidemiologi Kesehatan Komunitas Al-Khidmah PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) GERVASI: Jurnal Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia Jurnal Jamu Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Sasambo Journal of Pharmacy Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Komunitas Pharmaceutical Sciences and Research (PSR) Jurnal Natural Jurnal Vokasi Kesehatan Jurnal Pendidikan Kesehatan (e-Journal) Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu Journal of Pharmascience
Eka Kartika Untari
Departemen Farmasi, Fakultas Kedokteran, Universitas Tanjung Pura
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Evaluasi Rasionalitas Penggunaan Obat Antihipertensi di Puskesmas Siantan Hilir Kota Pontianak Tahun 2015 Untari, Eka Kartika; Agilina, Alvani Renata; Susanti, Ressi
Pharmaceutical Sciences and Research Vol. 5, No. 1
Publisher : UI Scholars Hub

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Abstract

Hypertension is widely known as cardiovascular disease. In addition to resulting heart failure, hypertension can result in kidney failure and cerebrovascular disease. This study was aimed to determine the percentage of treatment rationality of hypertensive patient treatment outpatient in Puskesmas Siantan Hilir Pontianak 2015 which includes the appropriate indication, appropriate drug, appropriate patient, and appropriate dose based on the guideline JNC 7. This study was cross-sectional study using medical records of outpatient hypertension patients in 2015. The total of sample analyzed in this research were 92 medical records of hypertension patients from 118 medical records. The percentage of using the angiotensin converting enzym inhibitor (captopril) was 47.46%; calcium channel blocker (amlodipine) was 34.75%; thiazid diuretic (hydrochlorothiazid) was 16.10%; loop diuretic (furosemid) was 0.85%; and potassium sparing (spironolactone) was 0.85%. The rasionality of hypertensive therapy in patients in this study were 100% appropriate indication; 70.65% appropriate drug; 100% appropriate patient; and 98.91% appropriate dose. The conclusion of this study is that overall treatment that meets all four rational treatment criterias was 69.56%.
Potensi Ekstrak Etanol Daun Petai (Parkia speciosa Hassk.) Terhadap Kadar Superoksida Dismutase (SOD) Pada Plasma Tikus yang Mengalami Stres Oksidatif Butarbutar, Ruth Haryati; Robiyanto, Robiyanto; Untari, Eka Kartika
Pharmaceutical Sciences and Research Vol. 3, No. 2
Publisher : UI Scholars Hub

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Abstract

Cigarette smoke is free radicals superoxide resources that contains, hydrogen peroxide, hidrosil and peroksil. Superoxide dismutase (SOD) is an enzymatic antioxidants that protect cells from oxidative stress by catalyzing superoxide dismutase (O2 *) into O2 and H2O2 . This study aims to determine the potential of ethanolic extract petai leaves against plasma SOD enzyme activity in animals exposed by cigarette smoke. The simplicia extracted by maseration using ethanol 96%. Thirty-six rats Sprague Dawley strain were divided into six groups: normal group was not given treatment, negative group received 10% CMC-Na, positive control group received vitamin E, and treatment group received ethanolic extract petai leaves of 50; 100; 250 mg / kgBW of mice. All rats were treated for 14 days. SOD activity was measured by UV-Visible spectrophotometer at a wavelength of 505 nm. Statistical analysis using One Way ANOVA. The mean value of SOD activity to the normal, negative control, positive control and the group receiving the ethanolic extract petai leaves dose of 50; 100; 250 mg/kg in a row is 37 979 ± 3708; 59 932 ± 3085; 48 552 ± 1234; 57 239 ± 2102; 50 774 ± 1632; 59 124 ± 4849. The results show ethanolic extract petai leaves the most influence on the activity of SOD is a dose of 100 mg/kg.
Efek Fraksi n-Heksana Kulit Hylocereus polyhizus Terhadap Kadar Malondialdehida Tikus Stres Oksidatif Sari, Wirna Maya; Wahdaningsih, Sri; Untari, Eka Kartika
Pharmaceutical Sciences and Research Vol. 1, No. 3
Publisher : UI Scholars Hub

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Excessive free radical production will lead to oxidative stress. One of the indicators used to determine stress oxidative is malondialdehyde (MDA). Hylocereus polyhizus peel is potential used natural exogenous antioxidant. The aim of this research was to study the effect of n-hexane fraction of H.polyhizus peel on MDA level and to determine the dose that could reduce the MDA level. H.polyhizus peel was macerated with chloroform, fractionated with n-Hexane. Rats were divided into 7 groups : normal, negative, positive control vitamin E (18 mg/ kgbw), positive control quercetin (4 mg/200gbw), H.polyhizus peel extract group treated with dose I (10mg/ 200gbw), dose II (20 mg/200gbw) and dose III (40 mg/200gbw). Each group consist of 4 rats and induced to oxidative stress by 10 minute swimming each day and food restriction for 5 days. Measurement of MDA level are using Spectrophotometer UV-Vis in 532 nm. MDA levels were analyzed using One way Anova and LSD test. The data shown that MDA level at normal, negative, positive vitamin E, positive kuersetin, dose I, II, III group is 0.042; 0.051; 0.034; 0.042; 0.038; 0.039; 0.042 µg/ml. The n-Hexane fraction of red dragon fruit peel was a potent antioxidant because posessing the ability to lowering the MDA level on stress oxidative rats.
Efek Fraksi n-Heksana Kulit Hylocereus polyrhizus TerhadapAktivitas Katalase Tikus Stres Oksidatif Untari, Eka Kartika; Wahdaningsih, Sri; Damayanti, Agustia
Pharmaceutical Sciences and Research Vol. 1, No. 3
Publisher : UI Scholars Hub

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Abstract

Production of excess free radicals cause oxidative damage and degenerative diseases. Catalase enzyme is one of the endogenous intracellular antioxidant that can be reduced by oxidative stress conditions. The peel of red dragon fruit (Hylocereus polyrhizus) as a potent exogenous antioxidants could support the internal enzyme activity to prevent free radicals. The aim of this research was to determine the effect of n-hexane fraction of H.polyrhizus’s peel and the dose that could increase activity of catalase. The peel was maserated with chloroform, then fractionated by n-hexane. Stress condition was achieved by five days fasting and swimming for 10 mins/day to test animals. UV-Vis spectrophotometer was used to measure the activity of catalase. The rats were divided into 6 groups: normal control, negative control, dose I (10 mg/200 gBB), dose II (40 mg/200 gBB), positive control quercetin as (4 mg/200 gBB) and vitamin E (17.64 mg/kg). The activity of catalase enzyme in the normal control is 29.4 units/ml; negative control is 7.08 units/ml; dose I is 14.42 units/ml; dose II is 14.79 units/ml’quercetin is 28.18 units/ml; and vitamin E is 71.29 units/ml. Our conclusion is the activity of the catalase enzyme rat under oxidative stress can be increased by the n-hexane fraction of H. polyrhizus.
Antibakteri Fraksi n-Heksana Kulit Hylocereus polyrhizus Terhadap Staphylococcus epidermidis dan Propionibacterium acnes Wahdaningsih, Sri; Untari, Eka Kartika; Fauziah, Yunita
Pharmaceutical Sciences and Research Vol. 1, No. 3
Publisher : UI Scholars Hub

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Abstract

Acne can be caused by Staphylococcus epidermidis and Propionibacterium acnes. By using antibiotic for the acne theraphy in a long term period can cause resistance, organ detriment and imunohypersensitivity. Red dragon fruit’s peel (Hylocereus polyrhizus) is one of natural materials which can be used for alternative antibacterial. This study aims to determine the antibacterial activity of n-Hexane fraction of red dragon fruit’s peel against S. epidermidis dan P. acnes by the method of disc diffusion Kirby-Bauer. Red dragon fruit’s peel powder macerated within chloroform, and macerate then fractionated with n-Hexane. Phytochemical screening result red dragon fruit’s peel contains terpenoid and alkaloid. Clindamycin 4µg/disk were used for positive control while DMSO 10% were used for negative control. Data analyzed by using R-Commander program 3.0.3 version.This research show that n-Hexane fraction of red dragon fruit’s peel have antibacterial activity against P. acnes where the averagezone of inhibition obtained from the concentrations from 20; 40; and 80 mg/mL in a row were 9 mm; 10,25 mm; and 10,5 mm. In while, for S epidermidis n-hexane fraction of red dragon fruit’s peel didn’t have antibacterial activity.
Efek Ekstrak Etanol Daun Premna cordifolia terhadap Malondialdehida Tikus yang Dipapar Asap Rokok Adyttia, Asri; Untari, Eka Kartika; Wahdaningsih, Sri
Pharmaceutical Sciences and Research Vol. 1, No. 2
Publisher : UI Scholars Hub

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Abstract

Free radical from cigarrete smoke cause lipid peroxidation that could be identified by increasing levels of Malondialdehida (MDA). Premna cordifolia leaves known having antioxidant activity in in vitro study. This study aimed to know the effect of P. cordifolia leaves extract on the levels of MDA after exposure to cigarette smoke. The simplicia extracted by maseration using 70% ethanol. Twenty four male wistar rats were divided into six groups, i.e. : control normal, negative control, positive control received cigarette smoke exposure and vitamin E (18mg/kg BW) and three groups received cigarette smoke exposure and P. cordifolia leaves extract with doses 200; 400; 600 mg/kg BW. All rats were treated for 14 days. Measurement of MDA level using Spectrophotometer UV-Vis in 532,2 nm. MDA levels in the normal group was 0.0094±0.080 ppm; negative group was 13,733±2,829 ppm; positive group was 0,051±0,045 ppm; dose 200; 400; 600 mg/kg BW were 9,142±2,364; 0,120±0,019; 0,053±0,041 ppm. The MDA level was analyzed by the Kruskal-Wallis test and following by Mann-Whitney test. The result showed that MDA level of group receiving P. cordifolia leaves extract significantly (p < 0,05) lower than negative control group. These result show P. cordifolia leaves extract can reducing the MDA level on the rats that exposed by cigarette smoke.
Hylocereus polyrhizus effect on catalase and malondialdehyde in rats with oxidative stress SRI WAHDANINGSIH; EKA KARTIKA UNTARI
Jurnal Natural Volume 21 Number 3, October 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1156.051 KB) | DOI: 10.24815/jn.v21i3.19474

Abstract

The excessive production of free radicals causes oxidative damage and degenerative diseases. Whereas, catalase is a macromolecule with a specific activity, but Malondialdehyde (MDA) is a small molecule with no activity. The peels of red dragon fruit (H. polyrhizus) are potential to be natural exogenous antioxidants. This research aimed to determine the effects of methanol fraction from H. polyrhizus peels on catalase activity and MDA level. The peel was macerated using chloroform and fractionated using methanol. The stress condition was done through five-day fasting and ten-minute swimming per day. The activity of catalase and MDA was measured using UV-Vis spectrophotometer. Thirty five rats were divided into 7 groups: normal, negative, dose I (5 mg/200gBW), dose II (10 mg/200gBW), dose III (20 mg/200gBW), positive control (quercetin) (4 mg/200gBW) and vitamin E (17.64 mg/kg). The activity of catalase in the normal, negative, vitamin E, and quercetin, dose I, II, and II respectively were: 28.37; 7.8; 24.85; 34.33; 59.92; 28.18; and 70.85 Unit/mL. The average MDA level in the groups respectively were: 0.042; 0.051; 0.034; 0.042; 0.037; 0.033; 0.030 μg/mL. The result of One Way ANOVA test showed that the catalase activity in dose III was significantly different than normal group; the MDA levels in all groups were significantly different than normal group. This research revealed that methanol fraction from H. polyrhizus peels is a potent antioxidant for its capacity to increase the activity of catalase and reduce the MDA level in rats with oxidative stress.
PERSEPSI PENYAKIT DAN KUALITAS HIDUP PASIEN GAGAL GINJAL KRONIK DI RSUD SOEDARSO PONTIANAK Eka Kartika Untari; Ayu Pratiwi; Muhammad Akib Yuswar
Jurnal Vokasi Kesehatan Vol 7, No 2 (2021): Juli 2021
Publisher : Poltekkes Kemenkes Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jvk.v7i2.636

Abstract

Gagal ginjal kronik merupakan penyakit kronis yang disertai berbagai komplikasi dan menyebabkan pasien mengalami polifarmasi sehingga mempengaruhi persepsi pasien tentang penyakit dan kualitas hidupnya (QoL). Pengukuran persepsi penyakit dan QoL penting dilakukan karena dapat mempengaruhi kepatuhan pasien dan sebagai evaluasi keberhasilan suatu terapi yang diberikan kepada pasien. Penelitian ini bertujuan untuk mengetahui persepsi pasien tentang penyakit, QoL, serta hubungan antara persepsi penyakit dan kualitas hidup pasien gagal ginjal kronik di RSUD Soedarso Pontianak. Metode penelitian menggunakan desain studi analitik observasional dengan pendekatan cross-sectional. Sampel berjumlah 51 responden, dengan menggunakan teknik purposive sampling. Pengumpulan data diperoleh melalui hasil wawancara, instrument B-IPQ, Instrument EQ-5D dan rekam medik. Hubungan antara persepsi penyakit dan kualitas hidup dianalisis menggunakan Fisher’s Exact Testdengan tingkat kemaknaan 95 % (α = 0,05). Hasil penelitian menunjukkan pasien lebih cenderung memiliki persepsi negatif (54,90 %). Sementara untuk QoL, pasien cenderung memiliki kualitas hidup yang baik (72,55 %). Hasil dari uji statistik menunjukkan tidak ada hubungan yang bermakna antara persepsi penyakit dan kualitas hidup pasien gagal ginjal kronik di RSUD Soedarso Pontianak (p value 0,058>0.05) 
Hylocereus polyrhizus effect on catalase and malondialdehyde in rats with oxidative stress SRI WAHDANINGSIH; EKA KARTIKA UNTARI
Jurnal Natural Volume 21 Number 3, October 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v21i3.19474

Abstract

The excessive production of free radicals causes oxidative damage and degenerative diseases. Whereas, catalase is a macromolecule with a specific activity, but Malondialdehyde (MDA) is a small molecule with no activity. The peels of red dragon fruit (H. polyrhizus) are potential to be natural exogenous antioxidants. This research aimed to determine the effects of methanol fraction from H. polyrhizus peels on catalase activity and MDA level. The peel was macerated using chloroform and fractionated using methanol. The stress condition was done through five-day fasting and ten-minute swimming per day. The activity of catalase and MDA was measured using UV-Vis spectrophotometer. Thirty five rats were divided into 7 groups: normal, negative, dose I (5 mg/200gBW), dose II (10 mg/200gBW), dose III (20 mg/200gBW), positive control (quercetin) (4 mg/200gBW) and vitamin E (17.64 mg/kg). The activity of catalase in the normal, negative, vitamin E, and quercetin, dose I, II, and II respectively were: 28.37; 7.8; 24.85; 34.33; 59.92; 28.18; and 70.85 Unit/mL. The average MDA level in the groups respectively were: 0.042; 0.051; 0.034; 0.042; 0.037; 0.033; 0.030 μg/mL. The result of One Way ANOVA test showed that the catalase activity in dose III was significantly different than normal group; the MDA levels in all groups were significantly different than normal group. This research revealed that methanol fraction from H. polyrhizus peels is a potent antioxidant for its capacity to increase the activity of catalase and reduce the MDA level in rats with oxidative stress.
The Economic Evaluation of Rare Disease Medicines Skarayadi, Oskar; Untari, Eka Kartika; Octaviani, Peppy; Larasati, Niken
Jurnal Kesehatan Masyarakat Vol 19, No 3 (2024)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v19i3.41661

Abstract

Economic evaluation of rare diseases and orphan drugs has gained prominence among scientists, managers, and the general public. This challenging problem requires evaluation and analysis from a variety of perspectives. Economic assessment of technologies can support decision-making and resource allocation. The research objective describes and discusses several important issues when addressing economic evaluation in rare diseases and orphan drugs. The method used in this article review is to search the Pubmed, Scopus, and ScienceDirect databases using specific keywords for research articles published in English between 2016 and 2021. We found 537 studies that economically evaluated the cost of treating rare diseases. The selected studies met the eligibility criteria that had been established. To assess the quality of the selected papers, we used a 10-point checklist derived from Drummond's criteria for economic evaluation. Seven papers were reviewed from the initial 20 articles that met the eligibility criteria, and 537 records were initially found across the three databases. The quality of the selected papers ranged from 70% to 100% in meeting Drummond's 10-point checklist. The conclusion of this research is to consistently and continuously identify cost-effective and cost-saving solutions that may help achieve good clinical outcomes and reduce the burden of disease. Future research should focus on the clinical implementation of interventions along with accompanying economic evaluations.
Co-Authors A.A. Ketut Agung Cahyawan W Agilina, Alvani Renata Agustia Damayanti Agustia Damayanti Agustia Damayanti Agustia Damayanti, Agustia Alvani Renata Agilina Anas Putri Maria Natasya Panamuan Apridamayanti, Pratiwi Asri Adyttia Asri Adyttia Asri Adyttia Asri Adyttia, Asri Ayu Pratiwi Butarbutar, Ruth Haryati Ediati Sasmito Egida Rachmadani Gamayanti, Tasiana Gisela Hadi Kurniawan, Hadi Hati, Anita Kumala Herlina, Tutun Intan Khairunnisa Irene Mahwal Khairunnisa, Intan Kusuma, Ria Liberti, Oktaviona Winda Meilita, Dewi Melda Mery Andiriyani Monika Rosmimi Muhammad Akib Yuswar Muhammad Akib Yuswar Muhammad Akib Yuswar Muhammad Akib Yuswar Nabilla Putri Pratiwi Nanang Munif Yasin Nera Umilia Purwanti, Nera Umilia Niken Larasati Novi Permata Sari Nurmainah Nurmainah Nurul Mar&#039;atus Sholihah Octaviani, Peppy Oskar Skarayadi, Oskar Pinasti Utami, Pinasti pramestutie, hananditia rachma Pratiwi Apridamayanti Pratiwi Apridamayanti, Pratiwi Pratiwi, Nabilla Putri Rachmadani, Egida Rafika Sari Rafika Sari Rafika Sari Ratna Widyaningrum Ria Kusuma Rise Desnita, Rise Rizka Humardewayanti Asdie Robiyanto Robiyanto, Robiyanto Robiyanto, Robiyanto Rosmimi, Monika Ruth Haryanti Butarbutar Safitri Caesaria Samudra, Nizam Elang Sholihah, Nurul Mar'atus Shoma Rizkifani Siti Nani Nurbaeti Sri Amalia Sri Amalia Sri Amalia, Sri Sri Mulyaningsih Sri Wahdaningsih Sri Wardaningsih Susanti, Ressi Susanti, Ressi Tri Murti Andayani Vanie, Vanie Veronika, Vina Wirna Maya Sari Wirna Maya Sari Wirna Maya Sari Wirna Maya Sari, Wirna Maya Yunita Fauziah Yunita Fauziah Yunita Fauziah Yunita Fauziah, Yunita Yuswar, M. Akib Yuswar, Muhammad Akib