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All Journal Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Sains dan Teknologi Pangan Jurnal Penelitian Farmasi Indonesia JURNAL PENDIDIKAN TAMBUSAI TEKNOLOGI PANGAN : Media Informasi dan Komunikasi Ilmiah Teknologi Pertanian Jurnal Katalisator JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Health Sains Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmaceutical Sciences and Research (PSR) SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Jurnal Katalisator Jurnal Farmasi Indonesia Borneo Journal of Pharmacy Jurnal Bakti Nusantara Jurnal Kefarmasian Indonesia Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Melzi Octaviani
Sekolah Tinggi Ilmu Farmasi Riau
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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UJI INHIBITOR ENZIM TIROSINASE EKSTRAK DAN FRAKSI DAUN KEDABU (Sonneratia ovata Backer) SECARA IN-VITRO Mustika Furi; Ainun Alfatma; Rahma Dona; Armon Fernando; Fina Aryani; Rahayu Utami; Septi Muharni; Husnawati; Wira Noviana Suhery; Melzi Octaviani
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 2 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i2.529

Abstract

Kedabu leaves (Sonneratia ovata Backer) are known contain secondary metabolites, one of which is phenolic, flavonoid and antioxidant activity. Phenolic, flavonoids and antioxidant are known to inhibit the tyrosinase enzyme. The tyrosinase enzyme is involved in the process of melanogenesis which produces melanin. Melanin can cause hyperpigmentation. To prevent hyperpigmentation, tyrosinase inhibitors are needed. This study aimed to test the tyrosinase enzyme inhibitor in ethanol extract, n-butanol fraction, ethyl acetate fraction, n-hexane fraction of kedabu leaf (Sonneratia ovatta Backer) using L-tyrosine as a substrate. The method used to get ethanol extract using ethanol maceration, while some fractions are obtained using the fractionation method. The test was carried out using L-tyrosine and kojic acid as a positive control with absorption measurements using microplate reader at a wavelength of 492 nm. The results showed that the best tyrosinase inhibitory activity was produced by the ethyl acetate fraction with an IC50 value of 18,82 g/mL, followed by the n-butanol fraction with an IC50 value of 24,42 g/mL, and the n-hexane fraction with an IC50 value. 28,77 g/mL, ethanol extract with an IC50 value of 99,09 with a strong category for all samples compared with kojic acid as a positive control with an IC50 value of 30,09 g/mL.
Aktivitas Antijamur Fraksi N-Heksana Kulit Buah Citrus sinensis (L.) Osbeck Melzi Octaviani; Wiwin Suryani; Nofri Hendri Sandi
Jurnal Ilmu Farmasi dan Farmasi Klinik No 1 (2024): JIFFK Special Edition Suppl. 2
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v2i1.9991

Abstract

The sweet orange (Citrus sinensis (L.) Osbeck) is a fruit that is loved by all walks of life because of its sweet taste. The flesh part of the fruit is consumed, while the fruit peel is discarded. However, the fruit peel also contains secondary metabolites, which have various biological activities. The peel of this sweet orange fruit contains secondary metabolites of alkaloids, flavonoids, phenolics, steroids, and terpenoids. This study aims to determine the antifungal activity of the n-hexane fraction against Trichophyton mentagrophytes and Candida albicans using the disc diffusion method and the Minimum Inhibitory Concentration (MIC). The results of measuring the diameter of the inhibition zone formed on the fungus Trichophyton mentagrophytes at a concentration of 50; 25; 12.5; 6.25; 3.125 and 1.5625% w/v, respectively 12.29±0.08; 11.14±0.12; 9.54±0.17; 7.01±0.12; 6.19±0.03; 6.06 ± 0.03 mm, with a MIC of 1.5625 %. Results of measuring the diameter of the inhibition zone formed against Candida albicans fungi respectively 9.97 ± 0.02; 9.05±0.18; 8.32±0.38; 7.09±0.07; 6.00±0.00; 6.00±0.00 mm, with a MIC of 6.25%. The results of data analysis using one-way ANOVA statistics showed that there was a significant difference (p<0.05) between variations in the concentration of the test fraction with positive control and negative control. Based on the research that has been carried out, it can be concluded that the n-hexane fraction of sweet orange peel has activity in inhibiting the growth of the test fungus, with the best antibacterial activity at a concentration of 50% w/v.
Pengaruh penambahan sari buah naga merah pada yoghurt susu kedelai serta uji aktivitas antibakteri Melzi Octaviani; Felycia Wardi; Emma Susanti

Publisher : Program Studi Ilmu dan Teknologi Pangan, Universitas Yudharta, Pasuruan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35891/tp.v15i1.4349

Abstract

Food is one of the most important needs for humans because it relates to daily nutritional needs. The solution to this problem is to consume food with good nutritional content supported by appropriate food processing innovations. Milk can be drunk directly or processed into various forms of food and drinks with milk-based ingredients, such as yogurt. This study aims to make yogurt products from soy milk using red dragon fruit juice as a substitute for sugar and to test their antibacterial activity in inhibiting Salmonella typhi and Shigella dysenteriae bacteria. This study used a completely randomized design (CRD) with 3 treatments, namely the addition of red dragon fruit juice with concentrations of 5%, 10%, and 15%, 3 replications, and the diffusion method for testing antibacterial activity. The results showed that the best yoghurt formula was obtained from F3 (yoghurt with the addition of 15% concentration of red dragon fruit juice). The panelist hedonic test gives values ranging from slightly like to like for color, aroma, taste, and texture; for organoleptic F3, these are: color (dark pink), taste (sour), texture (liquid-thick), and aroma (typical); pH 3.49; TAT 1.39%; Lactic Acid Bacteria (LAB) 2.09 x 1010 CFU/mL; and also had an average diameter of inhibition of 18.96 mm against Salmonella thypi (P<0.05) and 20.10 mm against Shigella dysenteriae (p<0.05). Soy milk yogurt with the addition of varying concentrations of red dragon fruit juice has antibacterial activity.
Penyuluhan Pentingnya Pengetahuan Menjaga Kesehatan Ginjal Masyarakat di Stadion Utama Riau Novita, Gressy; utari, Mayang; Octaviani, Melzi; Dona, Rahma; Anggraeni, Silvana; Kasnaidi, Ahmad Faisal; Jonang, Aqila Rifdah; Khairiah, Kinanti Bahy; Sasnita, Nadya Ayu; Novita, Nova; Sari, Novita; Rizki Annisa A; Septiani Nindia Putri; Suci Anggela Soraya
Jurnal Bakti Nusantara Vol. 2 No. 3 (2025): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jbn.v2i3.87

Abstract

Penyakit ginjal merupakan salah satu masalah kesehatan global yang semakin meningkat prevalensinya. Penyakit ginjal kronik menempati urutan ke-12 sebagai penyebab kematian tertinggi di dunia, dengan tren peningkatan setiap tahunnya. Di Indonesia, prevalensi penyakit ginjal kronis mencapai 0,38%, namun diperkirakan angka sebenarnya lebih tinggi mengingat banyak kasus tidak terdeteksi pada tahap awal. Penyebab dari meningkatnya angka penderita penyakit ginjal di Indonesia adalah karena pola hidup yang tidak sehat, kurangnya pengetahuan dan terbatasnya akses informasi tentang cara mencegah penyakit ginjal. Pengabdian masyarakat ini bertujuan untuk mengedukasi masyarakat tentang kesehatan ginjal dan cara pencegahannya. Metode yang digunakan adalah penyuluhan secara langsung menggunakan media leaflet dan diskusi. Materi edukasi adalah mengenai kesehatan ginjal, mulai dari cara menjaga kesehatan ginjal, mengetahui gejala dan faktor resiko penyebab penyakit ginjal tersebut. Evaluasi kegiatan dilakukan dengan memberikan tes awal dan tes akhir. Berdasarkan hasil pretes dan postes dapat disimpulkan bahwa terdapat pengaruh pemberian penyuluhan secara langsung menggunakan media leaflet terhadap pengetahuan masyarakat di Stadion Utama Riau. Hal ini dapat dilihat pada uji Wilcoxon pada skor pretest dan posttest yaitu dengan nilai p value 0,000 (p<0,05). Melalui pengabdian ini, diharapkan masyarakat dapat lebih memahami pentingnya menjaga kesehatan ginjal serta mengubah pola hidup mereka menjadi lebih sehat. Pada akhirnya, seiring dengan meningkatnya pengetahuan masyarakat, maka diharapkan terjadi penurunan angka penderita penyakit ginjal di Indonesia.
Edukasi dan Konsultasi Terkait Waktu Penggunaan Obat Antihipertensi bagi Pasien yang Menjalankan Ibadah Puasa untuk Menunjang Kesehatan Anggraini, Deni; Octaviani, Melzi; Sinata, Novia; Idzan, Nur Kamilah; Repuja, Dira; Fitri, Eliza; Safitri, Elsa; Annisa, Annisa; K, Della Yunita Sary.; Amanda, Denisya; Ezuela, Deska Z; Anggraini, Dhiva; Sari, Fatwa Aulia
Jurnal Pendidikan Tambusai Vol. 9 No. 2 (2025): Agustus
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jptam.v9i2.31482

Abstract

Puasa Ramadhan mengubah pola makan dan waktu penggunaan obat secara signifikan, terutama pada pasien dengan penyakit kronis seperti hipertensi. Edukasi penggunaan obat antihipertensi sangat penting agar pasien tetap memperoleh efek terapi optimal selama berpuasa. Kegiatan ini bertujuan untuk meningkatkan pemahaman masyrakat khususnya lansia, tentang waktu konsumsi obat antihipertensi selama bulan Ramadhan kegiatan dilaksanakan pada 15 maret 2025 di UPT PSTW Husnul Khotimah, Pekanbaru, dalam bentuk sosialisasi dan konsultasi. Hasil evaluasi menunjukkan peningkatan pemahaman peserta setelah edukasi
Pengaruh penambahan sari buah naga merah pada yoghurt susu kedelai serta uji aktivitas antibakteri: The effect of addition red dragon fruit juice on the soy milk yogurt and antibacterial activity Melzi Octaviani; Wardi, Felycia; Susanti, Emma
TEKNOLOGI PANGAN : Media Informasi dan Komunikasi Ilmiah Teknologi Pertanian Vol 15 No 1 (2024)
Publisher : Program Studi Ilmu dan Teknologi Pangan, Universitas Yudharta, Pasuruan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35891/tp.v15i1.4349

Abstract

Food is one of the most important needs for humans because it relates to daily nutritional needs. The solution to this problem is to consume food with good nutritional content supported by appropriate food processing innovations. Milk can be drunk directly or processed into various forms of food and drinks with milk-based ingredients, such as yogurt. This study aims to make yogurt products from soy milk using red dragon fruit juice as a substitute for sugar and to test their antibacterial activity in inhibiting Salmonella typhi and Shigella dysenteriae bacteria. This study used a completely randomized design (CRD) with 3 treatments, namely the addition of red dragon fruit juice with concentrations of 5%, 10%, and 15%, 3 replications, and the diffusion method for testing antibacterial activity. The results showed that the best yoghurt formula was obtained from F3 (yoghurt with the addition of 15% concentration of red dragon fruit juice). The panelist hedonic test gives values ranging from slightly like to like for color, aroma, taste, and texture; for organoleptic F3, these are: color (dark pink), taste (sour), texture (liquid-thick), and aroma (typical); pH 3.49; TAT 1.39%; Lactic Acid Bacteria (LAB) 2.09 x 1010 CFU/mL; and also had an average diameter of inhibition of 18.96 mm against Salmonella thypi (P<0.05) and 20.10 mm against Shigella dysenteriae (p<0.05). Soy milk yogurt with the addition of varying concentrations of red dragon fruit juice has antibacterial activity.
Isolation and Antibacterial Activity Isolate of The Endophytic Fungi of Shallot Tubers (Allium cepa L.) Against Pathogen Bacteria Octaviani, Melzi; Jannah, Miftahul; Wulandari, Rizki; Utami, Rahayu; Fadhli, Haiyul
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 2, AUGUST 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Shallots (Allium cepa L.) are widely known by the public as a kitchen spice and traditional medicine. Shallots have antibacterial activity. Compounds that have antibacterial properties can be obtained by isolating endophytic microbes. Endophytic microbes are microbes that live in plant tissue, are able to form colonies in plant tissue without having detrimental effects on the host, and can produce secondary metabolites like the host. Phytochemical screening of shallot tubers showed that they contained alkaloids, flavonoids, and phenolics. This research aims to isolate and identify endophytic fungi from shallot tubers and determine the antibacterial activity of these endophytic fungal isolates. Endophytic fungi were isolated using the direct planting method, and then pure isolates were identified macroscopically and microscopically. Antibacterial activity testing was carried out using the agar diffusion method against the bacteria Staphylococcus aureus, Staphylococcus epidermidis, Bacillus cereus, Escherichia coli, Salmonella typhi, and Shigella dysenteriae. There were 4 isolates of endophytic fungi produced during the isolation process, namely FEAC-U1 (Aspergillus), FEAC-U2 (Penicillium), FEAC-U3 (Trichophyton), and FEAC-U4 (Rhizopus). FEAC-U1 isolate showed the highest activity against Staphylococcus epidermidis, Bacillus cereus, and Shigella dysenteriae. FEAC-U2 isolate showed the highest activity against Salmonella typhi. FEAC-U3 isolate showed the highest activity against Staphylococcus aureus and Escherichia coli. The results of antibacterial activity testing on four isolates of shallot tuber endophytic fungi were able to inhibit the growth of the test bacteria.
Co-Authors Adriani Susanty agistia, nesa Agusri Boestari Ainun Alfatma Ainun Nurain Nurdin Akmal Djamaan Amanda, Denisya Anggraeni, Silvana Anggraini, Dhiva Annisa Annisa Armon Fernando Asiska Permata Dewi Della Ariska Deni Anggraini Denni Anggraini Eliza Fitri Emma Susanti Emma Susanti Emma Susanti Emrizal Erenda Yuneistya Erizal Zaini Ezuela, Deska Z Fadila Fadila Felycia Wardi Fina Aryani, Fina Furi, Mustika Ginta Rio Maranti Gressy Novita Haiyul Fadhli Husnawati Idzan, Nur Kamilah Jonang, Aqila Rifdah K, Della Yunita Sary. Kasnaidi, Ahmad Faisal Khairiah, Kinanti Bahy Masnun, Lidiatil Meiriza Djohari, Meiriza Miftahul Jannah Muharani, Siska Musyirna Rahmah Nst Musyirna Rahmah, Musyirna Nadilla Alfitri Nasution, Musyirna Rahmah Neni Frimayanti Nofri Hendri Sandi Nova Novita Novita Dewi Novita Sari Rahayu Utami Rahayu Utami Rahayu Utami Utami Rahima Rahma Dona ramadhan, alfitrah Repuja, Dira Rickha Octavia Rizki Annisa A Rizki Wulandari Rustini Rustini Rustini Rustini Safitri, Elsa Sari, Fatwa Aulia Sasnita, Nadya Ayu Septi Muharni Septiani Nindia Putri Sinata, Novia Suci Anggela Soraya Syafrina Syafrina utari, Mayang Wardi, Felycia Wildan Khairi Mukhtadi Winda Yusma Ameliah Wira Noviana Suhery Wiwin Suryani Yuneistya, Erenda