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All Journal Indonesian Journal of Conservation JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Kimia Riset Jurnal Fitofarmaka Indonesia Jurnal Penjaskesrek CARADDE: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Pharmacoscript Jurnal Farmamedika (Pharmamedica Journal) SULUH: Jurnal Abdimas Indonesia Natural Research Pharmaceutical Journal (INRPJ) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Mitra Mahajana: Jurnal Pengabdian Masyarakat PROFICIO: Jurnal Pengabdian Masyarakat Pharmaceutical And Biomedical Sciences Journal (PBSJ) Capacitarea : Jurnal Pengabdian Kepada Masyarakat Abdi Implementasi Pancasila: Jurnal Pengabdian kepada Masyarakat Ranah Research : Journal of Multidisciplinary Research and Development Jurnal Ilmiah Multidisiplin Indonesia Jurnal Ilmiah Farmasi Simplisia Aktual : Jurnal Pengabdian Kepada Masyarakat Jurnal Kesehatan Bakti Tunas Husada Aisyah Journal Of Physical Education International Journal of Contemporary Sciences (IJCS) Journal of Natural Product for Degenerative Diseases Indonesian Journal of Jamu
Andri Prasetiyo
Universitas Pancasila
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Other

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Journal : Jurnal Fitofarmaka Indonesia

 1 
Uji Aktivitas Penghambatan Dipeptidyl peptidase-4 (DPP-4) Senyawa dari Lima Tanaman Indonesia secara In-silico Andri Prasetiyo; Shirly Kumala; Esti Mumpuni; Raymond R. Tjandrawinata; Lilik Sulastri
Jurnal Fitofarmaka Indonesia Vol 10, No 1 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i1.884

Abstract

ABSTRAKTeknik komputasi virtual screening dapat digunakan untuk memprediksi dan menjelaskan aktivitas senyawa apa yang berperan dalam penghambatan DPP-4. Lima tanaman Indonesia seperti Caesalpinia sappan, Mutingia calabura, Rheum palmatum, Ficus religiosa dan Tinospora crispa telah terbukti memiliki aktivitas penghambat dipeptidyl-peptidase-4 (DPP-4) secara in-vitro akan tetapi belum ada penjelasan senyawa apa yang berperan terhadap aktivitas tersebut. Penelitian ini bertujuan untuk memprediksi dan menjelaskan senyawa-senyawa dari lima tanaman yang memiliki aktivitas penghambatan DPP-4 secara In-silico. Metode docking menggunakan perangkat lunak Molegro Virtual Docker dengan 16 protokol kombinasi pencarian algortima dan fungsi nilai. Sebelum Docking dilakukan validasi metode dengan cara redocking native ligand protein penghambat DPP-4 dengan kode PDB 3G0B, kemudian dilanjutkan docking secara bersamaan 151 senyawa dari lima tanaman Indonesia dan 1 ligan standar alogliptin dengan reseptor dipeptidy lpeptidase-4 (kode PDB: 3G0B) dengan metode docking yang valid. Hasil validasi metode menunjukkan 16 protokol kombinasi memberikan nilai RMSD < 1 Å. Hasil docking berdasarkan rerank score paling rendah dan kemiripan interaksi residu asam amino dibandingkan ligan standar Alogliptin menunjukkan tiga senyawa 6'-O-Lactoyl Borapetoside B (rerank score -99.78 kcal/mol) dan Borapoteside A (rerank score -98.76 kcal/mol) dari tanaman Tinospora crispa dan Rhaponticin (rerank score -99.37) dari tanaman Rheum Palmatum  sedangkan ligan standar Alogliptin memiliki rerank score -93.14 kcal/mol dengan interaksi residu asam amino Glu206, Glu206, Tyr547, Tyr632. Metode docking dengan mvd terbukti valid dan Physcion 8-gentiobioside, Luteolin 4'-metil eter 7-glukosida, 6'-O-Lactoyl borapetoside B, Rhaponticin dan Tinocrispol A diprediksi memiliki aktivitas penghambatan DPP-4.Kata Kunci: docking, penghambat DPP-4, Tinospora crispa, Rheum palmatum
Aktivitas Penghambatan Enzim α-Glukosidase Senyawa β-Sitosterol dari Fraksi Etil Asetat Daun Salam [Syzygium polyanthum (Wight.) Walp Sulastri, Lilik; Zulfadhli, Muhammad; Alwie, Rakhmat Ramdhani; Ramani, Sofyan; Prasetiyo, Andri; Simanjuntak, Vino Soaduon
Jurnal Fitofarmaka Indonesia Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i1.981

Abstract

Diabetes mellitus, also known as diabetes, is an endocrine disease characterized by sustained high blood sugar levels. Diabetes is caused by the pancreas not producing enough insulin, or the body's cells becoming unresponsive to the effects of the hormone. Common symptoms include thirst, polyuria, weight loss, and blurred vision. If left untreated, the disease can lead to various health complications, such as disorders of the cardiovascular system, eyes, kidneys, and nerves. In general, the treatment of diabetes mellitus is done with insulin therapy and various synthetic drugs, but these treatments have side effects. Another alternative is treatment using herbs, including salam leaves (Syzygium polyanthum (Wight.) Walp) which can be used as an inhibitor for the α-glucosidase enzyme. This study aims to isolate and determine the levels of β-sitosterol from the ethyl acetate fraction of salam leaves which have α-glucosidase enzyme inhibitory activity. Extraction was carried out by maceration using 96% ethanol, then partitioned with ethyl acetate and water (1:1). The ethyl acetate fraction was tested for the inhibitory activity of the α-glucosidase enzyme, then isolated by column chromatography method (SiO2; i.n-hexane-ethylacetate = 10 : 1 ~ 1 : 1, ethylacetate; ii.n-hexane-ethylacetate = 5 : 1 guided by testing enzyme inhibitory activity until pure isolates were obtained. The isolates were identified by spectrophotometry (IR) compared with the standard β-sitosterol compound. The results showed that isolates F.4-5 was a β-sitosterol compound with a concentration of 177.13 mg/g extract and had α-glukosidase enzyme inhibitory activity with an IC50 of 93.7 μg/mL.
Co-Authors Ade Yeni Aprilia Aey Fadilah, Yasin Agustia, Rini Ahmad Nuruhidin Alwie, Rakhmat Ramdhani Armanjaya, Satria Audrey, Cresentia Bambang Pontjo Priosoeryanto Bastian, Arif Alexander Bella Rofi Bungsudi Desi Nadya Aulena Dhani, Muhammad Esti Mumpuni Esti Mumpuni Esti Mumpuni, Esti Evi Susanti Fadlu Rachman Fajar Ramadhan, Ziko Fitry Angger Pangestu Gayatri Indah Pramesti Gumay, Jovana Renaldy Hakim, Zainur Rahman Hutagaol, Lungguk Indriani, Aqilah Idelia Julian Rahmat Lalu Sanik Wahyu Fadil Amrulloh Lidya Luziana Lilik Sulastri Lilik Sulastri LUNGGUK HUTAGAOL Lungguk Hutagaol Luziana, Lidya Marlien Bokko Martati, Titiek Maulinda, Elvi Sahri Mawijaya, Agus Megawati - Muhamad Yamin Muhamad Yamin Muhammad Yamin Muhammad Zulfadhli, Muhammad Mulatsari, Esti Nabila Prihantini Khairunnisa Natthawani, Amitta Nawasiah, Nana Novi Yantih Noviyantih, Noviyantih NURAINI HARMASTUTI Nurmala Ahmar Nuruhidin, Ahmad Panca Bayu Chandra, Pra Pratama, Rendy Yudha Pratamaa, Yuga Rachman, Fadlu Rachmi Ridho Rahmat, Ayi Ramadhan, Islami Al-Kaffah Ramadhani, Karina Natasya Ramani, Sofyan Raymond R. Tjandrawinata Rhahmadini, Yahdi Thia Risna Rosmiyati Saeful Amin Saeful Amin Salsabila Adlina Saputra, Putri Windari Sarah Annisaa Nurwan Sari Dewi, Rika Sari, Felinda Sekar Harsti Rahmadhani Shaquille, Haikal Shirly Kumala Simanjuntak, Josua Donrio Simanjuntak, Vino Soaduon Siswandono, Siswandono Sodik, Alfan Nur Syaifurrohman, Amir Syamsudin Abdillah Syifa Aulia Taqwa, Iqbal Ananda Ulfa Isni Kurnia Utami, Santi Yanuarti Winana Kartika Dewi Wiwi Winarti Yogaswara, Amira Thufailla Zahra, Nurulita Az Ziko Fajar Ramadhan, Ziko Fajar