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All Journal Litera Jurnal Ilmiah Farmasi Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences FLYWHEEL : Jurnal Teknik Mesin Untirta Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Berkala Arkeologi Jurnal Media Pertanian Literasi: Jurnal Ilmiah Pendidikan Bahasa, Sastra Indonesia dan Daerah Metalingua: Jurnal Penelitian Bahasa JURNAL ILMIAH HUKUM DIRGANTARA Jurnal Kesehatan Indonesia Nusantara Hasana Journal Jurnal Buana Farma Jurnal Bangkit Indonesia Jurnal Indonesia Sosial Sains Inisiatif: Jurnal Ekonomi, Akuntansi Dan Manajemen SEUNEUBOK LADA: Jurnal ilmu-ilmu Sejarah, Sosial, Budaya dan Kependidikan Jurnal bintang manajemen Jurnal Manajemen Dan Bisnis Ekonomi DIMASEKA Berkala Arkeologi Justice Dialectical Jurnal Online Skripsi Manajemen Rekayasa Konstruksi (JOS-MRK)
Sugeng Riyanto
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Polymorphism of Plasmodium Falciparum Dihydrofolate Reductase and Dihydropteroate Synthase Genes among Pregnant Women with Falciparum Malaria in Banjar District, South Kalimantan Province, Indonesia Fitriah Fitriah; Sriwijayanti Sulistyawati; Sugeng Riyanto; Budiono Budiono; Sukmawati Basuki; Yoes P Dachlan; Haruki Uemura
Journal of Tropical Life Science Vol. 2 No. 3 (2012)
Publisher : Journal of Tropical Life Science

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Abstract

Pregnant women are highly vulnerable to malaria infection in its endemic areas, particularly infection by Plasmodium falciparum that can cause premature, low birth weight, severe anemia in pregnant women, and death. Sulfadoxine-pyrimethamine (SP) for Intermittent Preventive Treatment for pregnant (IPTp) is used for malaria control in pregnancy recommended by the World Health Organization that has already been implemented in Africa. The P. falciparum resistance to SP has been reported in several malarial endemic areas, and mutations in the genes of Plasmodium falciparum Dihydrofolate Reductase (Pfdhfr) and Dihydropteroate Synthase (Pfdhps) are shown to be associated with parasite resistance to SP treatment. Genetic analysis of Pfdhfr and Pfdhps genes in pregnant women infected with P. falciparum has not yet been examined in Indonesia. The cross-sectional study was conducted at two subdistricts, Sungai Pinang and Peramasan, in Banjar district of South Kalimantan Province, where 127 pregnant women were recruited from 2008 to April 2010. Two important mutations in Pfdhfr gene (amino acid positions at N51 and S108) and three in Pfdhps gene (A437, K540 and A581) were analyzed by nested PCR-RFLP method. All of the seven pregnant women samples infected with P. falciparum presented PfDHFR 108N and PfDHPS 437G mutations. One of the samples had the additional mutation at PfDHPS 540, in which Lys is substituted by Glu. These results suggested that P. falciparum might present only some resistance to SP at Sungai Pinang and Peramasan subdistricts, Banjar District, South Kalimantan province, Indonesia. Although there were limited number of samples, this study showed only few mutations of Pfdhfr and Pfdhps genes in P. falciparum at Banjar district, South Kalimantan Province, that suggests SP might be effective for IPTp in this area. Thus, further analysis of the other mutation sites in Pfdhfr and Pfdhps genes and in vivo efficacy study of SP with more sufficient sample numbers will be necessary to confirm this preliminarily result.Keywords: PfDHFR and PfDHPS genes, Pregnant women, Falciparum malaria
Co-Authors Abdullah, Fandi Achmad Abdul Aziz Bakhtiar Adhi Widyakto adila zaidayanti Adinyamas, Sabgiar Agung Endro Nugroho Agung Hendro Nugroho AGUNG SETIAWAN Agus Sugiarto Agustin Dita Lestari Akhmad Mahyuni Akhmad Suryadi Alfia Rahma Alumni STIKES Husada Borneo Amir Firmansyah Angela Meike Kawer Anggara Mahatma Wicaksono Anisa Aprilliyanti Araz Meilin Ardiyati, Novita Mania Arifani Siswidiasari Armin Naibaho Ashari, Faridudin Atika Dwi Nor Aini Awang Yudha Sastra Ayu Fadilatul Miladiah Azzam Syachfiarnsyah Bagio Azzam, Fariz Hikmatyar Bobby Asukmajaya Bramastyo Bayu Aji Yohana Budiono Budiono Citra Rizkiana Dadang Suganda Dandung Novianto Denny Ardiansyah Destiana Utarindasari Dica Hermawan Setiaji Edwin, Alief Maulid Efendi, Medi Elfrida Hasna Ermas Estiyana Fachry Abda El Rahman Fadjar Purnomo Febridiansyah, Febridiansyah Fitriah Fitriah Haruki Uemura Inova Nurhaliza Jan Setiawan Jibrani Hisbullah Johanes Asdhi Poerwanto Joko Setiono Joko Trijanto Kamalina Din Jannah Kazutaka Maeyama Lia Septiliana M Hamizan Najib Arwani M. Noor Mareta Windia Prahesti Maulana, Ahmad Rozy Moch. Khamim Moch. Sholeh Mochammad Yudha Nur Fawaid Mohd. Aspollah Hj. Sukari Muhhalimah Muhhalimah Mutiara Kusuma Wardani Nani Darmayanti Nasamsir Nasamsir Nastalia, Rimadian Nawir Rasidi Neni Probosiwi Novita Hendrawati Nur Fahma Laili Nurul Nurhanisah Pamungkas, Alfin Putra Prasetia, Frendy Anjas Puskesmas Gambut Putra Akhmad Rizki Tri Adinda Qomariah Qurrata, Avicenna Rahimah Embong Rahmat Rahmat Rahmi Noerdiana Hidayati Riki Nasrullah Rusman Efendi Saputra, Richo Siti Ulfi Sri Galuh Banawa Sriwijayanti Sulistyawati STIKES Husada Borneo SUGIHARTI Sukmawati Basuki Sunarto Suryanto Suryawardana, Edy SUSANTO Suselo Utoyo Syafik Safira Febrianti Taufiq Rochman Thoriq Amrulloh Wagiati Wahiddin Wahya Wahya Widyakto, Adhi Yance Anas Yoes P Dachlan Yogha Sary Ariefiantho J Zulfachmi, Zulfachmi