Article Per Year (5 Year)
p-Index From 2021 - 2026
4.997
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Udayana Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Indonesian Journal of Pharmaceutical Science and Technology Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Kelautan Tropis JURNAL PENGABDI SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Al-Khidmah BULETIN AL-RIBAATH PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Journal Syifa Sciences and Clinical Research (JSSCR) Media Karya Kesehatan Indonesian Journal of Pharmaceutical Education Sasambo Journal of Pharmacy Pharmaceutical Sciences and Research (PSR) Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Journal Pharmacy of Tanjungpura Berita Biologi
Siti Nani Nurbaeti
Faculty Of Medicine, Universitas Tanjungpura
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 41 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 41 Documents
Search

 1   2   3   4   5 
POTENTIAL ANTIBACTERIAL ACTIVITY OF Sapindus rarak DC FRUIT AGAINST ESBL (EXTENDED SPECTRUM BETA LACTAMASE) PRODUCING Escherichia coli: IN SILICO AND IN VITRO STUDIES Nugraha, Fajar; Kurniawan, Hadi; IH, Hariyanto; Fajriaty, Inarah; Nurbaeti, Siti Nani
Berita Biologi Vol 24 No 3 (2025): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2025.13496

Abstract

The increasing Antimicrobial Resistance (AMR) drives the need of new antibacteria as drug candidate to eradicate resistant bacteria such as ESBL (Extended Spectrum Beta-Lactamase) producing Escherichia coli. Extract and fraction of Sapindus rarak fruit contains numerous saponin compounds, which exert potential antibacterial effect by binding to the bacterial cell membrane. The purpose of this research is to analyze and evaluate Sapindus rarak fruit extract and fraction antibacterial effects through in silico and in vitro approach. Molecular docking is conducted to identified compounds contained in Sapindus rarak fruit against Penicillin Binding Protein (PDB ID: 6NTZ) using Autodock Tools. Antibacterial testing of Sapindus rarak fruit extract and fraction is also conducted with disc diffusion and microdilution. In silico docking study resulted in potential activity from raraoside A and rarasaponin V, which showed affinity tinggi through their binding energy whilst interacting with the active site of the receptor protein. No inhibition zone was detected on extract and fraction, yet lowest minimum inhibition concentration (MIC) was detected at 2.5×104μg/mL on water and n-hexane fraction Sapindus rarak fruit ethanol extract. This weak antibacterial effect tends to happen to crude extract than to compound isolates. Hence, Sapindus rarak fruit fraction exhibits weak antibacterial effect on ESBL producing E. coli, but certain isolates might be potential to be further researched. Sapindus rarak fruit isolates such as raraoside A and rarasaponin V is potential to solve antimicrobial resistance by acting as a plant based antibiotic.
Co-Authors Adelita Ahyanurri Adnan Pramudio Agus Fitriangga Agustriangga, Muhammad Rafly Albianus Febri Tarung Andhi Fahrurroji Apridamayanti, Pratiwi Ardianto, Verdi Arif Wicaksono Aulia Faradilla Benny Wijaya Sunggono Benny Wijaya Sunggono, Benny Wijaya Cristin, Bella Deisberanda, Fortunata Saesarria Dhenaya Pradina Dwi I. Prayitno Eka Kartika Untari Elisabeth indah Mulatsih Entang Nurqolbiah Entang Nurqolbiah Entang Nurqolbiah, Entang Faisal Kholid Fahdi Fajar Nugraha Fajar Nugraha Fajar Nugraha Fajriati, Inarah Fajriaty, Inarah Faradilla, Aulia Fauzan, Suhaimi Fitri, Aulia Kemala Goh, Sri Wahyuni Hadi Kurniawan Hadi Kurniawan, Hadi Hadi, Kurniawan Hafrizal Riza Hafrizal Riza, Hafrizal Hariyanto IH Hidayat, Kartika Nur IH, Harianto Indah Aprianti Indri Kusharyanti Indriyani, Risa Isnindar Isnindar Khalishah, Hana Laksono Trisnantoro Liza Pratiwi Luliana, Sri M Rafly Agustriangga Mauludia Mauludia Melania Niken Safira Muhammad Andre Reynaldi Mulatsih, Elisabeth indah Nia Anzini Nia Risnawati Novia Novia Pratiwi Apridamayanti Prayitno, Dwi Imam Putri, Arsalna Daersa Rafika Sari Rafika Sari Rico Arianto Risa Indriyani Ropiqa, Meri Safrilla Anggraeni Septira Murtiningsih Shoma Rizkifani Sri Wahdaningsih Thamrin Usman Tiara Bella Pratiwi Veronika, Vina Winda Rahmalia Yuswar, Muhammad Akib