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All Journal Medula Jurnal Online Mahasiswa (JOM) Bidang Pertanian Jurnal Medika Malahayati Pena Justisia: Media Komunikasi dan Kajian Hukum Alauddin Law Development Journal (ALDEV) Jurnal Sains Teknologi dalam Pemberdayaan Masyarakat Jurnal Kesehatan Tambusai Keizai Mestaka: Jurnal Pengabdian Kepada Masyarakat Innovative: Journal Of Social Science Research Majalah Cendekia Mengabdi Karimah Tauhid Jurnal Pengabdian Masyarakat Wadah Publikasi Cendekia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Muhammad Aditya, Muhammad
Fakultas Kedokteran, Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Medula

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Pengaruh Waktu Inkubasi Terhadap Daya Hambat Ekstrak Daun Binahong Pada Cutibacterium Acnes Alvista, Valentina Nancy; Sibero, Hendra Tarigan; Aditya, Muhammad; Apriliana, Ety
Medula Vol 14 No 7 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i7.1272

Abstract

Acne (Acne vulgaris) is a common skin disorder often caused by the bacterium Cutibacterium acnes. Bacterial resistance to antibiotics used in acne treatment has become a significant concern. This study evaluated the effect of incubation time on the diameter of the inhibition zone produced by binahong (Anredera cordifolia) leaf extract in inhibiting the growth of C. acnes. The well diffusion method was employed using extract concentrations of 25%, 50%, 75%, and 100%. Data analysis was conducted using a paired t-test. The results showed a significant difference (p < 0.001) in the inhibition zones formed based on variations in incubation time. The findings indicated that longer incubation times resulted in larger inhibition zones. Binahong leaf extract was found to be effective in inhibiting the growth of C. acnes, particularly at higher concentrations and with longer incubation durations. These results demonstrate the potential of binahong leaf extract as an effective acne treatment to address antibiotic resistance.
Identifikasi Kandungan Senyawa Aktif Antibakteri Ekstrak Bawang Putih dalam Menghambat Pertumbuhan Bakteri Cutibacterium acnes Penyebab Acne Vulgaris Aprianti, Shervia Dwi; Sibero, Hendra Tarigan; Aditya, Muhammad; Himayani, Rani
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1302

Abstract

Introduction: The cases of antibiotic resistance in the treatment of acne vulgaris have been steadily increasing. A study conducted by the Dermatology Clinic of Hanyang University Hospital, South Korea, showed an increase in antibiotic resistance cases in the management of acne vulgaris, with resistance rates of 30% for clindamycin and 26.7% for erythromycin. One adjunctive therapy believed to be a breakthrough in anticipating the increase in antibiotic resistance causing acne vulgaris is the use of garlic extract. This study aims to conduct antibacterial phytochemical screening of garlic extract in inhibiting the growth of Cutibacterium acnes. Methods: The antibacterial active compounds in garlic plants were identified through phytochemical screening. Meanwhile, the antibacterial test was conducted using the well diffusion method with garlic extract concentrations of 25%, 50%, 75%, and 100%. Clindamycin was used as the positive control. Results: The phytochemical screening results of garlic extract in this study revealed the presence of flavonoids, alkaloids, tannins, phenols, and terpenoids. In the antibacterial test using the well diffusion method, the largest inhibition zone was observed with clindamycin treatment, while the smallest inhibition zone diameter was recorded with 25% garlic extract concentration. Discussion: The active antibacterial compounds found in garlic extract, including flavonoids, alkaloids, tannins, phenols, and terpenoids, have been proven to inhibit the growth of Cutibacterium acnes, as indicated by the formation of inhibition zone diameters in the antibacterial test.
ACNE VULGARIS BERBASIS PATOGENESIS Centya Cheirini; Hendra Tarigan; Aditya, Muhammad; Kurniawan, Betta
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1308

Abstract

Acne vulgaris is a chronic inflammatory disease characterized by polymorphic lesions in the form of comedones, papules, pustules, nodules & cysts in predilection locations. Acne vulgaris is the third most frequent case of the 10 most common skin diseases that often come to health services. The incidence of acne vulgaris can occur due to various factors, including increased androgen hormones, increased sebum production and excessive growth of the Cutibacterium acne bacteria. Cutibacterium acnes bacteria play a role in the inflammatory process which increases the worsening of skin conditions with the enzymes and pro-inflammatory factors produced. Young people are the age who suffer from acne vulgaris more often (85%) with a range of 12-25 years. The diagnosis of acne vulgaris is generally easy to make but therapy results are often unsatisfactory. Medications that are often involved in treating acne vulgaris are the use of topical and systemic antibiotics, retinoids, and anti-clindamycin agents. The purpose of this review article is to find out more about acne vulgaris based on pathogenesis. It is hoped that a deeper understanding of the pathogenesis of acne vulgaris will be able to provide much better therapeutic options, resulting in optimal improvements in acne vulgaris therapy.  
Co-Authors ', Nurbaiti Abdul Latif Adiyati, Noor Ahmad Aini, Muhammad Noor Alloysius Vendhi Prasmoro, Alloysius Vendhi Alvista, Valentina Nancy Anggraini, Dian Isti Anggraini, Kirana Widya Anisa Ilyanawati, R. Yuniar Anita Sukmawati Aprianti, Shervia Dwi Arsanto, Hugeng Wimbo Artandi, Muhammad Aulia, Ajeng Hijiratul Azzahra, Melani Betta Kurniawan, Betta Bintang, Muhammad Audya Centya Cheirini Ermia SYO, Vivin Ety Apriliana Gilang Maulana, Muhammad Habibie, Ramadhani Alfin Hendra Tarigan Hendra Tarigan Sibero Idwar, Idwar Iwan Purnama Khairul Anwar Khairun Nisa Kirana, Indira Kurniawaty, Evi Luthfi Setiarno, Muhammad Makanoneng, Jacqueline Maria Kristina, Maria Marpudin, Ade Muh. Akbar Fhad Syahril Muhammad Amin Muhammad Sulaiman Muryaningsih, Azizah Naibaho, Nora Oktariani, Hesty Oktarina, Vivin Ermia Sarinari Yopan Oktaviany, Nadilla Pakpahan, Marisi Pratama, Ilham Okta Puspitasari, Ratna Dewi Putera, Muhammad Luthfi Setiarno Rahma Dania Rahma, Cinta Alicia Ramadani, Nova Azzahra Ramadhani, Riska Rani Himayani Rasmi Zakiah Oktarlina Rasyid Ridho, Muhammad Sayyid Rifda Ilahy Rosihan Rihi Hina, Bara Jonathan Riswati, Riga Rossa, Putri Emylia Seran, Ardi Peterson Setiarno, Muhammad Luthfi Setyawan, Filippus Cahyo Shinta Nareswari, Shinta Siswoyo, Mardi Sofyan Musyabiq Wijaya Spalanzani, Widya Sri Hidayati Supratman, Jasan Suriyanti, Lili Tangkudung, Audrey G. Ulfah, Lendra Winda Trijayanthi Utama, Winda Trijayanthi Wiwin