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Journal : Health Notions

The Effect of Coffee Compsumption on Superoxide Dismutase (SOD) Enzyme Expression in Wistar Rats Induced by Hyper LDL Rendra Chriestedy Prasetya; Nadie Fatimatuzzahro
Health Notions Vol 4, No 3 (2020): March
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (101.254 KB) | DOI: 10.33846/hn40303

Abstract

One of the causes of stroke is atherosclerosis. The incidence of occurrence ischemic stroke caused by atherosclerosis is 95%. Atherosclerosis is caused by oxidative stress in the endothelium due to the formation of Reactive Oxygen Species (ROS). Hyperlipidemia (hyper LDL) is one of the risk factors of elevated ROS. One of the enzymes that play a role in preventing the formation of ROS is superoxide dismutase (SOD). Coffee has a powerful antioxidant in which one of its active ingredients is chlorogenic acid that capable to inhibiting ROS formation. Fifteen wistar male divided into 3 groups. Group I (Control) were given standard fed, Group II (Hyperlipidemia) were given standart fed and hyperlipid diet, Group III (Coffee) were given standart fed and hyperlipid diet + coffee consumption. Treatment were done everyday for 30 days. Blood serum in each group was taken on day 30 and examined by ELISA superoxide dismutase (SOD). The results showed that superoxide dismutase levels in coffee group was significantly higher than hyperlipidemia group (p = 0,006). This study proves that coffee consumption can increase the production of superoxide dismutase enzyme. Keywords: atherosclerosis; coffee; hyperlipid; SOD
Co-Authors ABDUL MUNIF Achmad Gunadi Adinda Febriyanti Aditya Satriatama, Dandy Agusta, Akhmad Riandy Amandia D.P.Shita Amandia Dewi Permana Shita Anggia Rahmania, Dwi Anita Faizah Aulia Vanadia Baladraf, Thabed Tholib Bambang Sumarsono, Raden Bertung Suryadharma, Bertung Depi Praharani Desi Eri Kusumaningrum Dewi Pratiwi Dina Amalia Diva Pujiaryanti, Anindya Dwi K.Apriyono Dwi Kartika Apriyono Erawati Wulandari Faiqatin Cahya Ramadhani Farah Rachmah Aulia Wardani Farchi, Ghafran Nailul Fathul Jannah, Fathul Favinas Octa Nuri Tsalats Fiftiani Syarah Firnanda, Rara Ayu Hafiedz Maulana Heri Kristianto Hidayat, Ari I Dewa Ayu Ratna Dewanti I Dewa Ayu Susilawati Ida Bagus Suryaningrat Indiyanti, Nurul Fitria Indonesia Koes Wijayaningrat Irvan, Mohamad Juni Handajani Kusumawardhani, Amelia Laila Efendi, Anggi Laksmi Indreswari Maisyaroh Miftahul Choiron Mirsodi, Muhammad Novi Khila Firani Nur Hidayati Nurul Iffah, Astrid Ganadya Nuzulul Hikmah Peni Pujiastuti Permana Shita, Amandia Dewi Pintan Qorina Destianingrum Pranata, Dadin Gilang Pratiwi , Dewi Pratiwi, Yossy Retna Putri Tio, Aurelia Jovita Putri, Syifa Lestiya Rahardyan Parnaadji Raissa Salma Hardiani Renda Shania Alicia Rendra C.Prasetya Rendra Chriestedy Prasetya Rokhani Rokhani Romdhlo, Komsiatun Rusdianto, Andrew Setiawan Sampurna, Hadi Shinta Puri Sitanggang, Della Supriyadi Supriyadi SYARIFUDDIN SYARIFUDDIN Syawalna, Alifian Widyputra Tantin Ermawati Teguh Triwiyanto Umaimah, Ulfa Umniyya, Anisatul Viana, Eka Dasra Widiyanti, Ainurrohma Winda Amilia