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All Journal Global Medical and Health Communication Jurnal Penelitian Pendidikan IPA (JPPIPA) Sumatera Medical Journal Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Integrasi Kesehatan dan Sains Jurnal Riset Kedokteran Bandung Conference Series : Medical Science
Meike Rachmawati
Fakultas Kedokteran, Universitas Islam Bandung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Journal : Sumatera Medical Journal

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Subacute Toxicity of Yellow Flower Extract (Cananga odorata) on the Histopathology of White Rat Heart (Rattus norvegicus) Mani, Suresh; Akbari Ganie, Ratna; Keumala Sari, Dina; Meutia Sari, Liza; Rachmawati, Meike; Muhammad, Noorzaid
Sumatera Medical Journal Vol. 6 No. 2 (2023): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v6i2.11931

Abstract

Background: The inflammatory process is influenced by chemical mediators such as Nitric Oxide (NO), cytokines, and arachidonic acid metabolites. The therapeutic effect of herbal plants comes from phytochemicals with strong antioxidant activity. Objective: To examine the phytochemical content and anti-inflammatory effects of Cananga odorata. Methods: This was a two-stage study: in vitro and in vivo. Anti-inflammatory activity is related not only to antioxidant properties but also to suppression of nitric oxide and pro-inflammatory cytokines. This effect is being explored using various herbal plants. One such plant is Cananga odorata (ylang flower), a tropical plant with fragrant petals that grows easily. Results: The total phenol content was 1.06% w/w. Antioxidant activity measured using DPPH method showed an IC50 of 808.86 ppm, indicating weak antioxidant activity. In rats, the extract reduced blood glucose levels but had no effect on lipid profiles. Toxicity testing showed no toxic effects. Histological analysis showed no differences between cardiovascular disease model mice and standard-fed mice. Conclusion: The ethanol extract of Cananga odorata did not show toxicity in the heart histopathology of white rats.
Co-Authors Abdul Hadi Hassan Abdul Hadi Hassan Abdul Hadi Hassan Abdul Hadi Hassan Adhi Nugraha Akbari Ganie, Ratna Alaydrus, Syafika Amri Junus Andre Akbar Mubarok Andriane, Yuke Annisa Rahmah Furqaani Anugrah, Aninditya Putri Aryanti Aryanti Ayu Prasetia Azlia Salsabila Rahadian Putri Darmayanti Dewi, Mira Dyani Dipayana, I Made Dzikru Rahmah Robbika Az-Zahra Dzikru Rahmah Robbika Az-Zahra Ermina Widiyastuti Fajar Awalia Yulianto Faqiekha Jauziyah Al-Faghiyah Farah Faza Aulia Fasyah Rizki Putri Gunantara, Tito Harvi Puspa Wardani Hasrayati Agustina Hauradarry Aurella Permadi Hendro Sudjono Yuwono Herri S. Sastramihardja Ismawati Ismawati Ismawati Ismet Muchtar Nur Joni Tandi, Joni Julia Hartati Keumala Sari, Dina Khusnul Mulya Kautsar Laila, Nazmy Noor M. Nurhalim Shahib Magfira Mani, Suresh Mariyani Melati, Rina Meta Maulida Damayanti Meutia Sari, Liza Mia Kusmiati Mia Kusmiati Muhammad Alief Abdul ‘Aziiz Muhammad Ilham Halim Muhammad, Noorzaid Navira Salsabila Putri Niluh Puspita Dewi, Niluh Puspita Nur Azizah Nuzirwan Acang Raden Anita Indriyanti Raden Ganang Ibnusantosa Radina, Faqih Rahmi, Fadhilat Sabila Ratna Damailia Rizky Alifian Ramadhan Rizky Rizal Alfarysyi Robian, Rian Sabrina Ayu Fitria Santun Bhekti Rahimah Sari, Ajeng Kartika Shofa Nabila Bilqist Komarudin Siddiq, Tita Barriah Sri Suryanti Taufik Muhammad Fakih Titik Respati Uci Ari Lantika Wardani, Yunira Wida Purbaningsih Widiyastuti, Ermina Winni Maharani wirawan, Wayan Yani Triyani Yanti Daryanti Yuktiana Kharisma Yuliet Yuliet Yuniarti Yuniarti Zidan Zuhdi