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All Journal International Journal of Advances in Applied Sciences Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) JEJAK CHEMICA Jurnal Teknik Kimia JITEK (Jurnal Ilmiah Teknosains) Jurnal Fitofarmaka Indonesia Jurnal Biologi Tropis IJEMS (Indonesian Journal of Environmental Management and Sustainability) Current Research on Biosciences and Biotechnology Muhammadiyah Journal of Nutrition and Food Science (MJNF) Journal of Agri-Food Science and Technology (JAFoST) Journal of Halal Science and Research eProceedings of Engineering Jurnal Pengabdian Masyarakat Bangsa Pelita: Jurnal Pengabdian kepada Masyarakat Journal of Industrial Process and Chemical Engineering (JOICHE) Indonesian Journal of Chemical Engineering As-Sulthan Journal of Education International Journal of Multidisciplinary Reseach
Adi Permadi, Adi
Universitas Negeri Semarang
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Therapeutic potential of alpha-linolenic acid from Sacha Inchi oil in cervical cancer: an in vitro study on HeLa cells Permadi, Adi; Putri, Mutiara Wilson; Akbar, Muhammad Ali
International Journal of Advances in Applied Sciences Vol 14, No 3: September 2025
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijaas.v14.i3.pp966-974

Abstract

This study investigated the potential of alpha-linolenic acid (ALA) from Sacha Inchi oil as a therapeutic agent for cervical cancer through an in vitro study on HeLa cells. Cervical cancer is one of the most common types of cancer in women, which is often caused by human papillomavirus (HPV) infection. Although chemotherapy therapy is one of the main methods in cancer treatment, this approach often causes side effects and drug resistance. ALA, which is one of the main components of Sacha Inchi oil, is known to have antioxidant and anti-cancer activities. In this study, Sacha Inchi oil was analyzed using liquid chromatography-high resolution mass spectrometry (LC-HRMS) for identification of its active components. Cytotoxic assays were performed using the MTT method on HeLa cells, which showed that ALA significantly inhibited cancer cell viability at low concentrations, with low IC50 values compared to the positive control compound cisplatin. These results suggest that ALA has potential as an effective anti-cancer agent against cervical cancer cells. This study concludes that ALA from Sacha Inchi oil can be a strong candidate in the development of safer and more effective cervical cancer therapy.
Phytochemical Test of Sacha Inchi Oil from Central Java Hadi, Mulyono; Permadi, Adi; Suharto, Totok Eka; Putri, Mutiara Wilson; Gulo, Herbert Alessandro Panias; Maema, Nadin Okta; Halimathusyakhdyah, Halimathusyakhdyah; Lupi, Ahmad
Journal of Agri-Food Science and Technology Vol. 6 No. 3 (2025): September
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jafost.v6i3.12885

Abstract

Sacha inchi oil is a seed-derived oil from the Amazon Rainforest, known for its high nutritional value and bioactive compounds. It contains essential fatty acids such as omega-3 and omega-6, along with tocopherols, polyphenols, carotenoids, and phytosterols, making it beneficial for health applications. Due to its nutritional and therapeutic properties, sacha inchi oil has gained significant attention in the food, cosmetic, and pharmaceutical industries. This study contributed to identify and analyze the bioactive compounds in sacha inchi oil extracted from seeds obtained in Central Java, Indonesia. The extraction process was carried out using a hot pressing method, followed by qualitative phytochemical analysis and LC-HRMS identification. The phytochemical tests confirmed the presence of flavonoids, alkaloids, tannins, phenolics, saponins, steroids, and terpenoids, all of which contribute to antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. However, LC-HRMS analysis did not detect flavonoids, tannins, and saponins, possibly due to their low concentration, matrix effects, or degradation during analysis. These findings highlight sacha inchi oil’s potential in nutraceutical, pharmaceutical, and cosmetic industries. Its bioactive compounds suggest its potential use in functional foods, dietary supplements, and therapeutic applications, particularly in preventing oxidative stress-related diseases. Further research is recommended to optimize extraction techniques, improve compound stability, and evaluate its bioavailability and long-term health benefits. The presence of bioactive compounds indicates that sacha inchi oil can be a valuable functional ingredient for health and medical applications, contributing to sustainable and natural health solutions.
Optimization of thin layers of coated turmeric extract (Curcuma longa L) tablets using a dipping method Permadi, Adi; Yuliani, Sapto; Wahyuningsih, Iis; Satar, Ibdal
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 1: March 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i1.20130

Abstract

Turmeric extracts have many benefits, such as an anti-oxidant, anti-inflammatory, and neuro-protector for dementia. The turmeric extracts can be prepared in the form of a thin layer of coated tablets through a dipping method using the dip coating and Simplex lattice design (SLD) methods. The quality of the thin layers of coated tablets is much related to the formulation in the coating process. This research aims to formulate and optimize the coating composition of HPMC, PEG-400, and dip time. Consequently, the TSLT meets the standard requirements. The core tablets were made by using the wet granulation method with the formulation of turmeric extract, erosol, lactose, gelatin, and aquades. Before the core tablets had been produced, the eligibility of granules was initially evaluated based on the standard requirements. Subsequently, the core tablets that meet the standard requirements were printed and replicated. The coating processes on core tablets were performed by dipping into the coating solution in the various duration of dipping times: 5, 30, and 60 seconds. The coating solution consists of HPMC, PEG-400, glycerine, sunset yellow, and distillate water. Then, produced TSLTs were evaluated based on the hardness, friability, and disintegration time. The best optimization process for the mixture of HPMC and PEG-400 indicates a more positive value of R (R = 0.2024).
Qualitative and Quantitative Analysis of Lecithin Content and Bioactive Chemical Compenents of Corn Oil From Dompu District Ramadhan, M. Kaisar Sutomo; Permadi, Adi; Sulistiawati, Endah
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7494

Abstract

Indonesia is one of the Asian nations that has an abundance of vegetation that can be utilized as food yields and medication. One of the plants that can be utilized as neighborhood food is the Corn plant (Zea mays L.), corn is one kind of food crop that has for some time been known and developed. Dompu Regency, located in the province of West Nusa Tenggara,  is one of the largest corn producers in Indonesia. From this statement, a revolution is needed for the development of the food industry sector, namely the development of processed products from corn raw materials, namely corn oil. Corn oil extraction is carried out by the Maceration Method, a simple extraction process carried out by soaking the simplicia in a solvent for a certain time at room temperature and protected from light. Development in finding the percentage level (%) of lecithin LC-HRMS (Liquid Choromatography High-Resulution Mass Spectrometry), Among the Compounds: Percentage level (%) of bioactive lecithin compounds from major (main) components: 1-[(11Z)-octadecenoyl]-sn-glycero-3-phosphocholine (C26H52NO7P) = 8.882%, 1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC (C26H50NO7P) = 6.874%, 1 Palmitoy-Phospadicholine (C24H50NO7P) = 1.898%, 1-Oleoyl-2-hydroxy-sn-glycero-3-PE (C23H46NO7P) = 1.161%, 2-monolinolenin (C21H36O4) = 0.577, (2R)-2-Hydroxy-3-(phosphonooxy)propyl (11Z,14E)-11,14-icosadienoate (C23H43O7P) = 0.386 %, 1-Stearoylglycerol (C21H42O4) = 0.072.
Biokonjugasi AmineQDs untuk Penargetan Spesifik Sel Kanker Permadi, Adi
Journal of Industrial Process and Chemical Engineering (JOICHE) Vol 3, No 1 (2023)
Publisher : Institut Teknologi Adhi Tama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31284/j.joiche.2023.v3i1.7536

Abstract

This study aims to develop an AmineQDs bioconjugation technique to enhance specific cancer cell targeting. AmineQDs were synthesized using a solvothermal method, modified with amine groups, and conjugated with folic acid via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide- N-hydroxysuccinimide(EDC-NHS) carbodiimide activation. This bioconjugation process aims to improve the selectivity of QDs toward cancer cells, enabling more effective detection and therapy. Characterization results indicated successful bioconjugation, but the fluorescence of QDs was quenched after conjugation, likely due to electronic structure changes or self-quenching. Further evaluation of reaction conditions, including pH and buffer types, is needed to maintain optical stability. With proper optimization, AmineQDs have the potential to serve as highly accurate and efficient nanotechnology-based cancer diagnostic and therapeutic agents.
Determination of Routin Compound Content of Moringa Folium (Moringa oleifera) using Several Extraction Methods Hasnaeni, Hasnaeni; Rosandy, Andi Rifki; Apridamayanti, Pratiwi; Permadi, Adi; Rumaisha, Sanda
Jurnal Fitofarmaka Indonesia Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1106

Abstract

Extraction has been carried out from Moringa folium using the Microwave-Assisted Extraction (MAE), Ultrasound-Assisted Extraction (UAE) and Reflux Extraction (RE) methods. Moringa Folium has many uses, including as a chemopreventive agent. In this research, identification was carried out to determine the compounds in Moringa folium. Extraction uses the MAE, UAE, and Reflux methods. The of chemical compound content was determined using HPLC and standardized of rutin. The identification results showed that the Moringa folium spectra were similar to the routine spectra.
STABILITAS WARNA DAN PERUBAHAN pH WEDANG UWUH SIAP MINUM SELAMA PENYIMPANAN Septiyani, Retnosyari; Rahayu, Wahidah Mahanani; Permadi, Adi
(JITEK)Jurnal Ilmiah Teknosains Vol 10, No 1/Mei (2024): Jitek
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/jitek.v10i1/Mei.18790

Abstract

Wedang uwuh is a traditional drink from Yogyakarta with various product forms. Ready-to-drink wedang uwuh is a more practical and economical alternative for consumption, but with limited color stability around 1 day. This research aims to examine the color stability of ready-to-drink wedang uwuh at varying temperatures and brewing times, at room and cool temperature, and with sugar or Na-benzoate addition. The experiment was carried out in a Completely Randomized Design with a variety of brewing conditions of temperature (75°C, 85°C, and 95°C) and time (10, 15, and 20 minutes) at material and water ratio of 1:1 (wv), followed by filtration and storage. The filtrate was then observed for changes in color for 7 days. Brewing condition with best color stability at 85oC for 20 minutes were then treated with the addition of sugar or sodium benzoate and then tested for pH and color for 9 days storage in cool and room temperature. The research results showed that all samples (original, sugar added, and Na-benzoate added) had pH color change during storage, but original and Na-benzoate added had the best stability. Ready-to-drink wedang uwuh stored in cold temperature had better red color stability than room storage.
Effect of pH on Swelling Ratio and Fluorescence of Quantum Dots (QDs) Based Hydrogel (CuInS2/ZnS QDs) Permadi, Adi; Hadi, Sofyan; Sinaga, Alexander MT; Pitoyo, Joko; Chang, Jia-Yaw
CHEMICA: Jurnal Teknik Kimia Vol. 10 No. 2 (2023): August 2023 [Available online since October 02, 2023]
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26555/chemica.v10i2.27801

Abstract

Quantum dots (QDs) are semiconductor materials possessing a distinct electrical order and physical dimensions less than the excitation of the Bohr radius. The innovative combination of hydrogel and QDs has a broad range of applications in critical areas like the environment, health, and energy. QDs hydrogel has been applied as a biosensor and in the waste processing industry. The main characteristics of QDs hydrogel are fluorescence and swelling ratio. In the waste processing industry, the swollen hydrogel provides a more porous matrix that allows heavy metal to penetrate the hydrogels via passive diffusion. In the biosensor application, QDs hydrogel can be used as active sensors by changing the fluorescence properties when reacting with analytes, or by conjugating antibodies to the dot surface to act as passive label probes. This study aims to study the effect of pH on the fluorescence and swelling ratio of CuInS2/ZnS hydrogel.  CuINS2/ZnS hydrogel is synthesized by sonication a mixture consisting of QDs (CuInS2/ZnS), N-(3-aminopropyl) methacrylate, polyethylene glycol methacrylate, methylene bis acrylamide, and ammonium persulfate solution for 5 min with amplitude of 20 kHz. CuInS2/ZnS acts as QDs component, while N-(3-aminopropyl) methacrylate, polyethylene glycol methacrylate, methylene bis acrylamide, and ammonium persulfate act as hydrogel synthesizing components. The QDs hydrogel was then immersed in water with varying pH to observe the effect of pH on fluorescence and swelling ratio. The results show that increasing pH will reduce the swelling ratio and increase the fluorescence strength. CuInS2/ZnS hydrogel has a maximum swelling ratio at a pH of 5 and provides strong fluorescence at pH of 7, 9, and 11. The result also revealed that CuInS2/ZnS hydrogel has sufficient fluorescence and swelling ratio characteristic at the pH level of the biological fluid of the human body namely 7.35-7.45, this suggests the biological application of CuInS2/ZnS hydrogel such as for drug delivery and biosensing.
Evaluation and Comparison Anti-aging Facial Serum from Algae Extract Permadi, Adi; Aziz, Abdul; Ramadani, Noorpani; Nazzal, Sami; Maryudi, Maryudi; Suharto, Totok Eka
CHEMICA: Jurnal Teknik Kimia Vol. 10 No. 3 (2023): December 2023 [Available online since December 26, 2023]
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26555/chemica.v10i3.27898

Abstract

The demand for cosmetics in Indonesia is quite high so cosmetics can now be said to be a primary need. Therefore, various cosmetic products have emerged that are cheap and provide instant results but ignore the health aspects of the user. Several cosmetic products make a breakthrough by using natural ingredients. One natural material that can be used is microalgae which can produce bioactive compounds and has a relatively faster production process compared to other natural materials. In this research, the microalgae used were Chlorella sp. and Spirulina sp., and Sargassum sp. This research aims to make a serum based on the Chlorella sp., Spirulina sp. and Sargassum sp. microalgae. The research results showed that the standard testing of simplicial facial serum extracts of Spirulina sp., Chlorella sp., and Sargassum was by SNI No. 16-4399-1996.[ASUS1] [AP2]  All the metrics analyzed, such as organoleptic characteristics, pH, specific gravity, viscosity, active compounds, and microbiological contamination, have successfully fulfilled the required requirements in SNI no. 16-4399-1996.. The results of antioxidant activity testing showed that Chlorella sp. had higher antioxidant activity than the other three types of samples. However, the antioxidant results obtained are still very low and relatively weak, which means this serum does not fully contribute to antiaging. Further research needs to be carried out to obtain serum from microalgae with high levels of antioxidants, including by using fresh simplicia, elevated algae concentration or optimizing the operating conditions.     [ASUS1]Please add short information about the main results, whether the serum satisfies the standard or not, which parameters, etc. [AP2]Has been added
Utilization of the heat from combustion of water for the heating process in water desalination Permadi, Adi; Syamsuddin, Arief; Widyaningrum, Trianik; Satar, Ibdal; Suharto, Totok Eka; Pitoyo, Joko
International Journal of Advances in Applied Sciences Vol 13, No 1: March 2024
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijaas.v13.i1.pp134-140

Abstract

The volume of municipal waste has become a national problem so far, so a solution is needed to reduce the waste problem. One solution to reduce the volume of municipal waste is to burn waste. However, the combustion needs to be designed to take advantage of the heat generated by combustion. In this study, the process of burning waste with various types of waste materials was carried out. The heat of burning waste is used to evaporate 1 liter of seawater and the seawater vapor is cooled to produce distilled water. The volume of distilled water and the precipitated salt were weighed. The results of the research from the variation of 6 types of waste materials obtained that the type of clothing waste material gave the fastest time, which was 43.75 minutes, the amount of distilled water was 931 ml, and salt deposited as much as 30 grams. The test results on distilled water showed that almost all parameters met the requirements of drinking water and obtained a salt content of 84%. Further processing by adjusting the hardness is needed to process distilled water into clean water and the addition of iodine can be considered to produce iodized salt.
Co-Authors Abdul Aziz Afwiyah, Fadhilah Agung Kurniawan Al Haq, Permata Aulia Alamsyah, Tegar Ali, Fitra Mara Andi Rifki Rosandy Aprilla, Annisa Hera Aprillia Syahputri, Arina Ardina Fitri Sugianti Arwini, Arwini Azhar, Sella Angelina Baswara, Ahmad Raditya Cahya Budiastuti, Pramudita Chang, Jia-Yaw Chasanah, Alfi Dewi, Kartika Tunggal Dimas, Doni Djamaluddin Perawironegoro Endah Sulistiawati Fadilah, Haqi Miftah Fatma Nuraisyah, Fatma Fausta, Ahnaf Zaki Febian, Muhammad Izzul Firdaus, Stradivary Firdaus, Stradivary Maulida Gulo, Herbert Alessandro Panias Hadi, Mulyono Halimathusyakhdyah, Halimathusyakhdyah Hapsari, Intan Tri Hasnaeni hasnaeni, Hasnaeni Hayuningtyas, Ratih Hendry Pangestu Iis Wahyuningsih Iqbal Ramadhan, Iqbal Irawan, Ichsanul Fikri Umar Iswahyudi Hidayat Joko Pitoyo Khairi, Amalya Nurul Khasanah, Fitri Nur Latifatunnajib, Sukma Lubnah, Ifa Lukhi Mulia Shitophyta Lupi, Ahmad Maema, Nadin Okta Mahendra, Abang Muhammad Wahyu Mariska, Novia Maryudi Maryudi Masila, Maya Laffayza Daeng Ma’arif, Sandhy Aulia Mufti Khakim, Mufti Muhammad Ali Akbar, Muhammad Ali Munawaroh, Annisa Luthfiana Mustaqim, Luthfi Mutiara Wilson Putri Nafi’, Zahrotun Nazzal, Sami Novitasari, Putri Rachma Nur Halimah NURUL HIDAYAH Oemardy, Zalfadhia Luthfia Pawenang, Denta Kesdik Prastiwi, Salma Maulidya Pratiwi Apridamayanti, Pratiwi Pratiwi, Margaretha Herlin Pratomo, Zaki PURWANTI PURWANTI Putri, Aninda Cahaya Putri, Mutiara Wilson Rahayu, Wahidah Mahanani Rahman, Zulfan Hanif Rahmawati, Daniar Ramadani, Noorpani Ramadhan, M. Kaisar Sutomo Ramadhan, Muhammad Kaisar Sutomo Ramadhan, Rafli Rosyidah, Ummy Rullyansyach, Mochammad Rumaisha, Sanda Safitri, Harminah Sapsuha, Nurkhalisah Sapto Yuliani Satar, Ibdal Satria, Rizky Adi Septiyani, Retnosyari Setyanto, Barry Nur Sholihah, Laila Melati Nur Sinaga, Alexander Maruli Tua Sinaga, Alexander MT Sirajuddin, Muhammad Mar’ie Siti Jamilatun Siti Nur Azizah, Siti Nur Sofiana, Nurani Sofyan Hadi Sumardani, Wahyu Bintoro Suyadi Suyitno Suyitno Syamsuddin, Arief Syaputri, Dhayu Carista Totok Eka Suharto Totok Eka Suharto Trianik Widyaningrum W, Hamizagha Nur Abid Wahyuni, Denik Putri Wantini Wardana, Mikael Dia Wibisono, Ilham Kukuh Widyasmoko, Hamizagha Nur Abid Wilson, Mutiara Winarni Winarni Wulandana, Rachmadian Wulandari, Annisa Desna Yanti, Dinda Putri Dwi Zahrul Mufrodi, Zahrul