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All Journal Majalah Kedokteran Bandung Indonesian Journal of Urology Berkala Ilmu Kesehatan Kulit dan Kelamin Majalah Obstetri dan Ginekologi Majalah Patologi Indonesia Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Pengabdian Masyarakat dalam Kesehatan Indian Journal of Forensic Medicine & Toxicology Narra J Indonesian Journal of Cancer Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Folia Medica Indonesiana

Gondo Mastutik

Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Airlangga

Author-ID : 515102

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Profil Ekspresi p16ink4a dan Tipe Human papillomavirus (HPV) pada Pasien Kondilomata Akuminata Wanita Afria Arista; Dwi Murtiastutik; Trisniartami Setyaningrum; Gondo Mastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 2 (2018): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Kondilomata akuminata (KA) merupakan penyakit infeksi menular seksual yang disebabkan oleh Human papillomavirus (HPV) dengan gejala berupa pertumbuhan tunggal atau multipel pada daerah anogenital. HPV risiko tinggi mempunyai kemampuan untuk berkembang menjadi keganasan, sedangkan HPV risiko rendah sangat jarang menimbulkan keganasan. Pemeriksaan p16ink4a digunakan untuk mendeteksi HPV yang berpotensi kearah keganasan. Deteksi genotipe HPV dengan menggunakan PCR memiliki sensitivitas yang sangat tinggi. Tujuan: Mengevaluasi profil ekspresi p16INK4a pada lesi KA pada wanita dengan infeksi HPV tipe risiko rendah, risiko tinggi, dan infeksi multipel HPV. Metode: Penelitian deskriptif, observasional, cross sectional dengan melakukan pemeriksaan p16INK4a dan genotyping HPV dengan teknik PCR lesi KA pada wanita. Hasil: Satu pasien dengan HPV risiko rendah (HPV 6 dan 11) memiliki gambaran p16ink4a negatif, 4 pasien memiliki gambaran p16ink4a sporadis, dan 2 pasien memiliki gambaran p16ink4a fokal, 1 pasien dengan HPV 18 memiliki gambaran p16ink4a difus, 1 pasien dengan infeksi multipel HPV 6,81,82,89 memiliki gambaran p16ink4a fokal, 4 pasien dengan infeksi multipel HPV memiliki gambaran p16ink4a difus. Simpulan: Terdapat 5 pasien dengan gambaran p16INK4a yang difus. p16ink4a yang difus menunjukkan bahwa pada pasien tersebut memiliki kemampuan untuk berkembang menjadi keganasan.

Distribution Genotype High Risk (HR) And Low Risk (LR) Human Papillomavirus (HPV) at Condyloma Acuminata Gondo Mastutik; Alphania Rahniayu; Dwi Murtiastutik; Afria Arista; Trisniartami Setyaningrum; Nabiha Missaoui; Suhartono Taat Putra
Biomolecular and Health Science Journal Vol. 4 No. 1 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i1.26250

Introduction: Condyloma acuminata that is also known as genital warts are one of the most common sexually transmitted that caused by infection of Human papillomavirus (HPV). Persistent infection of Low Risk (LR) or High risk (HR) HPV is a risk factor for progress into benign or malignant cancer. The objective is to analyze distribution of genotype LR-HPV and HR-HPV at condyloma acuminata in anogenital region. Methods: A cross sectional study using were 36 lesions from men and women of condyloma acuminata patients. All subject signed the informed consent and ethic obtained from our institution, number 382/Panke.KKE/V/2016. The specimen was used to histopathological examination and to identified 40 genotypes of HPV using a reverse line blot assay.Results: The All patients were diagnosed as condyloma acuminata, some with focus dysplasia and koilocytosis. All patients were positive for HPV, including LR-HPV were HPV 6, 11, 42, 54, 61, 81,87,89 and HR-HPV were HPV 18, 26, 45, 51, 52, 66, 67, 68B, 69, 82. The single infection of LR-HPV was 44.4%, multiple infection LR/LR-HPV was 13,9% and the multiple infection of LR/HR-HPV was 41.7%. The LR-HPV infected 70,6% and HR-HPV infected 29,4%. Conclusion: LR-HPV is the major infection of condyloma acuminata, in single infection or multiple infection with HR-HPV. The most common infections were HPV 11, followed by HPV 6, HPV 18, HPV 51, and HPV 82. The determination of genotype of HPV can be used to predict the malignant transformation.

Analgesic Effect Study of Young Coconut Water (Cocos nucifera L.) on Mice (Mus musculus) Induced with Pain using Acetic Acid Dini Indah Berlianti; Danti Nur Indiastuti; Gondo Mastutik; Shaohong Lai
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.30176

Introduction: Pain signals tissue damage that is capable of reducing thequality of life. Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are known as effective analgesic drugs which have various side effects, therefore natural minerals are used as an alternative medicine for pain and inflammation, one of which is known to be coconut water. Hence this research was conducted to find out the differences of the analgesic effect between young coconut water (Cocos nucifera L.) with non-selective and COX-2 selective NSAID on mice induced with pain from acetic acid 0.6% 1 ml/100gBW of mice.Methods: True experimental, conducted at the Pharmacology Laboratory in Faculty of Medicine of Airlangga University involving the sample of 48 mice (6 groups). The recorded data was tested using the oneway ANOVA methodology before then continued with the posthoc test of LSD.Results: The addition of young coconut water (Cocos nucifera L.) with the dosage of 3 ml/100gBW, 4 ml/100gBW, and 4.5 ml/100gBW of mice doesn't give any significant analgesic effect even though the analgesic protection percentage increases accordingly to its dosage (12.32%, 18.72%, 26.88%), but non-selective and COX-2 selective NSAID give significant analgesic effect (p<0.05) on mice induced with pain from acetic acid 0.6% 1 ml/100gBW of mice.Conclusion: There are differences in the analgesic effect of young coconut water (C. nucifera L.) with non-selective and COX-2 selective NSAID on mice induced with pain from acetic acid 0.6% 1 ml/100gBW of mice.

EARLY DETECTION OF BREAST CANCER AT PUBLIC HEALTH CENTER IN REJOSO, NGANJUK Gondo Mastutik; Sjahjenny Mustokoweni
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 6 No. 1 (2022): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v6i1.2022.61-68

The objective was to convey knowledge about procedures for early detection of breast cancer and screening of breast cancer as an effort to reduce the number of cases of advanced breast cancer. The activity was held at the Public Health Center in Rejoso, Nganjuk and was attended by 71 participants. The participants' understanding was measured by a questionnaire containing questions about breast cancer risk factors and knowledge about breast cancer. Questionnaires were given as pre-test and post-test. After attending the lecture presentation, there was an increase in understanding of 11%. Participants in this activity based on the risk factors of not having children and x-ray radiation, all of them do not have a risk of developing breast cancer. Furthermore, based on data on breastfeeding less than 6 months, aged more than 25 years, had a tumor in the breast, and had a family suffering from breast cancer, the participants in this activity had a risk of breast cancer that were 16.67%, 88.1%, 7.14%, and 14.29% respectively.This activity can increase public understanding of procedures for early detection of breast cancer so that people can carry out breast self-examinations at home every month. In this activity, participants can perform breast examinations by medical personnel so that they can help the community to carry out free breast examinations at community health centers.

RAGAMAN GENETIK GEN POLIMERASE VIRUS HEPATITIS B PADA PASIEN HEPATITIS B KRONIK DENGAN PENGOBATAN TELBIVUDIN Gondo Mastutik; Juniastuti Juniastuti; Ali Rohman; Mochamad Amin; Poernomo Boedi Setiawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1097

Infection caused by hepatitis B virus (HBV) is still a major global health problem and can cause liver cirrhosis and hepatocellularcarcinoma as well. Telbivudine is one among the drugs used to treat the disease routinely. However, using this drug in a long term therapymight cause mutations in HBV polymerase gene that decreases the effectiveness of the therapy. Here with the researchers report the geneticvariations of the gene isolated from telbivudine-which is used treated chronic hepatitis B patients in Surabaya, Indonesia. The blood serawere collected at Dr. Soetomo hospital from 10 telbivudine-treated and 10 untreated chronic hepatitis B patients. The DNA viral wasisolated and purified from each serum. Sequence polymerase gene at nucleotides 455 to 796 was amplified by PCR, and then analyzedbio informatically to determine their mutation profile. This study revealed a point mutation in HBV25 sample at nucleotide A1525G thatgives rise to I509V modification. Such mutation is also observed in a sequence that is available in Gen Bank with an accession numberAY641562. Additionally, the researchers found point mutations A1554G, T1593C, and C1629T in HBV25 sample and a point mutationA1554G in HBV20 sample. However, these mutations are silent. To conclude, the mutation in HBV polymerase gene among telbivudinetreatedchronic hepatitis B patients in Surabaya is known as A1525G.

Infection of Cytomegalovirus in Cholestasis Infant with Biliary Atresia Lasmauli Situmorang; Bagus Setyoboedi; Sjamsul Arief; Gondo Mastutik
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 2 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i2.1496

Biliary Atresia (BA) is extrahepatic cholestasis that results in death within the first two years if the diagnosis andintervention are delayed. The etiology and pathogenesis of BA are still undetermined. Viral infections, includingCytomegalovirus (CMV), are presumed to be one of the causes. Cytomegalovirus infection is more common in intrahepaticthan extrahepatic cholestasis such as BA. There are limited data about Cytomegalovirus infection in cholestatic infants withBA. This study compared the incidence of CMV infection in cholestatic infants with biliary atresia and non-biliary atresia.A cross-sectional study was performed in December 2017 - August 2018 in cholestatic infants aged 1-6 months. Liverbiopsy, histopathological examination followed by PCR CMV examination were performed on cholestatic infants. Theresults of the PCR examination were compared between BA and non-BA infants. Statistical analysis of Chi-Square, t-testindependent and Mann-Whitney U resulting in p<0.05 were stated as significant. Thirty-seven children were obtainedduring the study period, consisting of sixteen children with BA and twenty-one children with non-BA. Biliary atresia waspredominantly found in female than male children, despite no differences were found between the groups (p=0.163). Therewere differences in body weight (p=0.002) age (p=0.009), birth weight (p=0.02) and gestational age (p=0.03) betweenchildren with BA and non-BA. There was no significant difference in the incidence of CMV infection in cholestatic infants withBA and non-BA (p=0.338). Cytomegalovirus infection in cholestatic infants with BA was less than non-BA cholestatic infants.

THE MUTATION STATUS OF KRAS GENE CODON 12 AND 13 IN COLORECTAL ADENOCARCINOMA (Status Mutasi Gen Kras Kodon 12 dan 13 di Adenocarcinoma Kolorektal) Gondo Mastutik; Alphania Rahniayu; Anny Setijo Rahaju; Nila Kurniasari; Reny I’tishom
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1177

Kanker kolorektum merupakan salah satu kanker yang tersering di dunia. Target molekuler untuk pengobatan kanker kolorektumyaitu Epidermal Growth Factor Receptor (EGFR) dengan pemberian antibodi monoklonal anti-EGFR. Pemberian pengobatan ini tidakdapat memberikan efek dampak di pasien dengan status gen KRAS bentuk mutan, sehingga perlu dilakukan pemeriksaan status mutasigen KRAS. Telitian berupa deskriptif dengan pendekatan potong lintang yang bertujuan untuk mendapatkan data status mutasi genKRAS kodon 12 dan 13 di pasien adenocarcinoma colorectal. Deteksi mutasi KRAS dilakukan dengan teknik Polymerase Chain ReactionRestriction Fragment Length Polymorphism (PCR RFLP) yang dikonfirmasi dengan sekuensing. Sampel telitian adalah 30 blok parafinyang diperoleh dari Rumah Sakit Dr.Soetomo Surabaya masa waktu Januari-Desember 2013. Setelah dilakukan ekstraksi DNA terdapat21 sampel yang dapat digunakan untuk pemeriksaan lanjutan. Hasil PCR RFLP menunjukkan terdapat 7/21 mutasi pada kodon12 dan tidak terdapat mutasi gen KRAS pada kodon 13. Mutasi pada kodon 12 yaitu GGT>GCT, GGT>GGA dan GGT>GAT yangmenyebabkan perubahan asam amino Gly12Ala, Gly12Gly dan Gly12Asp. Simpulan telitian ini adalah mutasi gen KRAS kodon 12 padaadenocarcinoma colorectal di Rumah Sakit Dr. Soetomo Surabaya sebanyak 33%.

GENOTIPE DAN SUBTIPE VIRUS HEPATITIS B PENDERITA YANG TERINFEKSI KRONIK AKTIF Gondo Mastutik; Juniastuti Juniastuti; Ali Rohman; Mochamad Amin; Poernomo Boedi Setiawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 2 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i2.1077

Chronic activivity of Hepatitis B Virus (HBV) infection can lead to liver cirrhosis or hepatocellular carcinoma. The objective of thisstudy was to know by analyzing the distribution of HBV genotypes and subtypes from hepatitis B patients suffering from chronic activehepatitis B infection in Surabaya. The HBV genotypes were determined by comparing the S gene sequences to those kept in the GeneBank. The phylogenetic tree was constructed by means of the unweighted-pair group method using arithmetic averages. Furthermore,the subtypes were deduced based on the prediction of amino acid residues 116 to 183 of HBsAg on multiple sequences alignment withClustalW2. This study involved 20 sera obtained from patients suffering chronic active hepatitis B infection. After PCR and sequencing,it was found that 13 samples could be used for sequence analysis. The results showed that all sequences were clustered into HBV genotypeB. The subtype adw2 was identified from 12 of 13 sequences, whereas one (1) belonged to ayw1. The subtype adw2 is most prevalent inIndonesia, namely in the islands of Sumatra, Java, South Kalimantan, Bali, Lombok, Ternate, and Morotai, while ayw1 is found in theislands of Nusa Tenggara and Moluccas. Based on this study, it was found that the patients with HBV subtype adw2 were from Surabaya, whereas with ayw1 was from Nusa Tenggara. It can be concluded that the HBV infected patients with chronic active hepatitis B inSurabaya have the genotype B with subtype adw2 which was originally from Surabaya, whereas, ayw1 was a patient originally fromNusa Tenggara.

EARLY DETECTION OF BREAST AND CERVICAL CANCER OF THE RESIDENTS OF PROPPO PAMEKASAN DISTRICT Dyah Fauziah; Alphania Rahniayu; Nila Kurniasari; Anny Setijo Rahaju; Etty Hary Kusumastuti; Gondo Mastutik; I Ketut Sudiana
Jurnal Pengabdian Masyarakat Dalam Kesehatan Vol. 3 No. 1 (2021): APRIL 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpmk.v3i1.21584

Introduction: Breast cancer and cervical cancer are common cancers in females. Both of these cancers can be detected early. Early detect vion can reduce cancer morbidity and mortality. The community outreach activities are required to increase knowledge about breast cancer and cervical cancer, in addition to screening as preventive efforts for these two cancers.Methods: The activity of raising knowledge about the prevention and early detection of breast cancer and cervical cancer was carried out through community counseling to 94 females who were members of the PKK and young females in the Kecamatan Proppo, Kabupaten Pamekasan. Pre and post tests were given before and after the community counseling. After the community counseling, 86 participants were screened for breast cancer by clinical palpation and 46 participants were screened for cervical cancer using the pap smear method.Results: The result of the post test showed a 27.53% increase in knowledge. The results of the pap smear examination on participants showed 96% concluded as Papanicolau Class II, 2% Class I, and 2% Class IV. The patient with class IV results was referred to an obstetrician.Conclusion: Community counseling about breast self examination (BSE) and Pap smear can increase people's knowledge about early detection of breast cancer and cervical cancer.

Correlation of miR-150, hsa-let-7e, and miR-146a and gene expression of IL-6, IL-8, IP-10, and MIP-1β during dengue virus infection Sri Masyeni; Kuntaman Kuntaman; Aryati Aryati; Muchlis AU Sofro; Usman Hadi; Gondo Mastutik; Windu Purnomo; Agus Santosa; Benediktus Yohan; Erni Juwita Nelwan; R. Tedjo Sasmono
Narra J Vol. 1 No. 1 (2021): April 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i1.31

Growing evidence suggests that microRNAs (miRNAs) play a pivotal role in viral infection. The objective of this study was to assess the association between the expression of miR-150, hsa-let-7e, and miR-146a on cytokine expression during dengue infection. Dengue virus (DENV) strain SJN-006, a serotype 2 DENV strain of the Cosmopolitan genotype, isolated in Bali, Indonesia, was used to infect peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals. The relative gene expressions of miR-150, hsa-let-7e, and miR-146a as well as the gene expression of cytokines (IL-6, IL-8, IP-10, and MIP-1β) were determined using quantitative real time - polymerase chain reaction (qRT-PCR) at 6, 12 and 24 hours post infection (hpi). Correlations between the microRNAs and cytokines were analyzed by means of causality tests. Our data suggests that miR-150 and hsa-let-7e were significantly higher in infected-PBMCs after 12 hpi compared to the uninfected-PBMCs (p<0.05). The causality tests demonstrated that miR-150 and hsa-let-7e were negatively correlated with IL-8 expression, meanwhile miR-146a was the contrast. DENV infection was negatively and positively correlated with miR-150 and hsa-let-7e, respectively, after 24 hpi. In conclusion, our data demonstrates the vital role of miR-150, hsa-let-7e, and miR-146a in regulating IL-8 expression with possible different pathways.

Co-Authors , Isnin Anang Marhana Afria Arista Afria Arista Afria Arista, Afria Agung Dwi Suprayitno Agus Santosa Agus Santosa Ali Rohman Alphania Rahniayu Aniek Meidi, Aniek Anny Setijo Rahaju, Anny Setijo Ariani, Grace Arifa Mustika Aryati , Aryati Aryati Aryati Aryati Aryati Bagus Setyoboedi Benediktus Yohan Bilqis Inayatillah Budi Harjanto Budi Harjanto Cempaka Harsa Sekarputri Dewi Sartika A. W. Dini Indah Berlianti Dwi Murtiastutik DYAH FAUZIAH, DYAH Erni J. Nelwan, Erni J. Erni Juwita Nelwan, Erni Juwita Faisal Amir Faisal Amir Faroek Hoesin Fira Soraya Heriyawati, Heriyawati Heru Fajar Trianto I'tishom, Reny Ilmiah, Khafidhotul Imam Susilo Indiastuti, Danti Nur Iqhrammullah, Muhammad Isnin Anang Marhana Jennifer Susanto Juniastuti Juniastuti Khafidhotul Ilmiah Khafidhotul Ilmiah Kuntaman Kuntaman Kusumastuti , Etty Hary Kusumastuti, Etty Hari KUSUMASTUTI, ETTY HARY Lasmauli Situmorang Leonita Agustin Hambalie M Hasinuddin Markus Kore Masyeni, Sri Mochamad Amin MOCHAMAD AMIN Mochamad Amin Muchlis AU Sofro Nabiha Missaoui Nila Kurniasari Nila Kurniasari Nurma Yuliyanasari, Nurma Poernomo Boedi Setiawan Prasetyo, Rizki Eko Purnama, Yugi Hari Chandra Purnomo, Windu Qonitatillah, Ana R. Tedjo Sasmono Rahmi Alia Rahmi Alia Rahmi Alia Rahmi Alia, Rahmi Renny I’tishom Ridholia Ridholia, Ridholia Rizki Eko Prasetyo S.Pd. M Kes I Ketut Sudiana . Sari, Aditya Sita Sasmono, R. Tedjo Shaohong Lai Sjahjenny Mustokoweni, Sjahjenny Sjamsul Arief Sofro, Muchlis AU Sofro, Muchlis AU. Sri Masyeni, Dewa Ayu Putri Suhartono Taat Putra Sunaryo Hardjowijoto Sutrisno Sutrisno Tamam Jauhar Trianto, Heru Fajar Trisniartami Setyaningrum Usman Hadi Willy Sandhika Windu Purnomo Wira Santoso Ongko Wiratama, Priangga Adi Yohan, Benediktus Yugi Hari Chandra Purnama

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