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All Journal MNJ (Malang Neurology Journal) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Kesehatan Prima Majalah Kedokteran Neurosains Journal of Pain, Vertigo and Headache Journal of Global Pharma Technology Journal of General Procedural Dermatology and Venereology Indonesia IJRETINA - International Journal of Retina Magna Neurologica
Shahdevi Nandar Kurniawan, Shahdevi Nandar
Neurology Department, Medical Faculty, Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Journal : Journal of Global Pharma Technology

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Neuropathy in Vitamin Deficiency Shahdevi NK
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Neuropathy is a disorder of the motor nerves, sensory disorders and also autonomic and tendon reflexes. The Neuropathy that occurs can be caused by systemic diseases (diabetes, hypothyroidism), drugs, infections and also vitamin deficiencies. Vitamins are organic components with a high level of potential. Vitamins themselves are classified into 2 which are air soluble and fat-soluble, for fat-soluble vitamins, there are vitamins A, D, E, K and for vitamin B complex including vitamins that are soluble in air. Vitamin B plays an important role as a co-factor or co-enzyme in various metabolic processes in the body. A continuous lack of vitamins will cause damage to the peripheral nervous system so that symptoms of neuropathy appear. Deficiency of vitamin E and vitamin B can cause damage to the nervous system and neuropathy occurs. Vitamin B which has several kinds, such as B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantonetate), B6 (pyridoxine), B7 (biotin), B9 (folate) and B12 (cobalamin) where this B vitamin has a neurotrophic function. Vitamin B cannot be produced by mammals, so we can get this vitamin through food and supplementation. Vitamins themselves function to maintain the body's physiological functions and also maintain optimal health. Keyword: Neuropathy, Vitamin, Thiamine, Cobalamin, Pyridoxine.
The Effect of Nimodipine to Reactive Oxygent Species (ROS) in SHSY-5Y Cell-Line Culture Expressed by Chronic Hyperglycemia Shahdevi NK
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Diabetes mellitus is a metabolic disease with a chronic hyperglycemia condition. Diabetic peripheral neuropathy is a condition that arises from long-term damage due to chronic and hyperglycemia combination of various factors and pathways. One of them is the occurrence of oxidative stress caused by an increase in ROS intracellular. The accumulation of ROS can activate other pathways and result in an ion imbalance Ca2+. Nimodipine is a type L calcium channel blocker which has neuroprotective properties. Therefore, nimodipine is expected to reduce the expression of ROS in neurons that occur due to chronic hyperglycemia conditions. Objective: To determine the effect of nimodipine on ROS in culture of SH-SY5Y-induced cell-line neurons chronic hyperglycemia. Methods: Experimental research with in vitro methods using the exposed SH-SY5Y neuronal cell line chronic hyperglycemia. The study sample was divided into 9 groups, the control normoglycemic group, hyperglycemia control 25 mM and 50 mM, normoglycemia with nimodipine 10 nM and 100 nM, hyperglycemia 25 mM with nimodipine 10 nM and 100 nM, and 50 mM hyperglycemia group with nimodipine 10 nM and 100 nM. Nimodipine is given for 30 minutes on Sh-Sy5Y cells that have previously been exposed to hyperglycemia conditions chronic for 6 days. The intensity of intracellular ROS was observed by immunohistochemical methods on the sixth day. Results: In comparison of normoglycemic conditions (5 mM) and hyperglycemia 25 mM, normoglycemic conditions 5 mM resulting in a significantly higher ROS intensity (p <0.05). Whereas in comparison normoglycemia (5 mM) and hyperglycemia 50 mM had a significant increase in ROS intensity (p <0.05). Expose glucose 5 mM can increase ROS expression due to a series of processes due to hypoglycemic conditions. Exposure to high doses of glucose (50 mM) can increase ROS formation. Giving nimodipine to cells able to reduce the intensity of ROS on glucose exposure 5 mM, 25 mM and 50 mM significantly (p <0.05). Conclusion: Chronic hyperglycemia conditions can increase the formation of ROS in SH-SY5Y and cell cultures nimodipine can significantly reduce ROS levels.Keywords: Nimodipine, SH-SY5Y, ROS, Hyperglycemia, Neuropathy. 
Co-Authors Abdul Gofur Afiyfah Kaysa Waafi Al-Rasyid, Harun Aldita Husna Violita Aldita Husna Violita Andaru Cahya S Anggraini, Vivi Laras Anggraini, Vivid Prety Anisa Syahfitri Hanum Annisatul Hakimah Asmiragani, Syaifullah Auliya Nur Muthmainnina Badrul Munir Badrul Munir, Badrul Basya Adnani Basyar Adnani Chomsin Sulistya Widodo Chozin, Iin Noor Dalhar, Mochamad Damayanti, Ria DAMAYANTI, ZUHRIA PUSPITA Dessika Rahmawati Devi Annisa Devita Anggraeni Soeroso Dewi Permata Sari Dheka Sapti Iskandar Dhelya Widasmara Didi Candradikusuma Dini Jatiya Anggraini, Dini Jatiya Dwi, Pratiwi Suryanti Dyah Kusuma Wardhani Edi Widjajanto Eko Arisetijono Ekowati Retnaningtyas F, Fahimma Fahrani Yossa Prachika Farida Widyastuti Fitria Nikmahtustsani, Mulika Ade Gerry Gunawan, Gerry Gonius, Andry Gyang Hanandita Gusti Putri Hanestya Oky Hermawan, Hanestya Oky Hani Susianti Harbiyanti, Novita Titis Hardi Adiyatma Harun Al Rasyid Helena Era Millennie Heri, Sutanto Herwinda Brahmanti Husnul Khotimah Husnul Khotimah I Ketut Suada Irawan Satriotomo Irsyah Dwi Rohmayanti Izza Ayudia Hakim Janet, Karensa Abby Jatmiko, Sarazata Indi Rozaany Kadek Putri Paramita Abyuda Kartika Agustina Kinesya, Billi Lestari, Dwi Indriani Machlusil Husna Machlusil Husna, Machlusil Made Ayu Hariningsih Sunaga Masruroh Rahayu Masruroh Rahayu Masruroh Rahayu Masruroh Rahayu Masruroh Rahayu Masruroh Rahayu, Masruroh Masykur, Umar Jundullah Maziya, Yulianda Mega Yulia Rusmayanti Michelle Anisa Misnasari, Putri Priela Mochammad Istiadjid Eddy Santoso Mokhamad Fahmi Rizki Syaban Mondiani, Yeni Quinta Muhammad Welly Dafif Nadia Artha Dewi Nadiya Elfira Bilqis, Nadiya Elfira Nasution, Ali Napiah Nata Sanjaya Nectarine Natasya Regitta Yasmin Nidia Suriani Nurvia Andriani Petrarizky, Alfred Julius Pramesti, Fathia Annis Pratiwi, Made Dinda Pringga, Gutama Arya Pudji, Rosalyna Purbasari, Bethasiwi Putri, Dwi Sandhi Aulia Pramesti Putri, Laily Ardhianti Putri, Mutiara Kristiani R, Rahmad Rahma, Annisa Rahmasari, Herisa Rahmawati, Dessika Raisa, Neila Reza Rachmantoko Rislan Faiz Muhammad Rislan Faiz Muhammad Ristiawan Muji Laksono Rizki Rahamatullah Noer Rodhiyan Rakhmatiar Rulli Rosandi Safira Dita Arviana Sari, Atika Windra Sari, Diane Tantia Sari, Diane Tantia Sela Pricilia Siti Nurlaela Sri Budhi Rianawati Sri Budhi Rianawati, Sri Budhi Sri Budi Rianawati Suratmono, Mia Fajarningtyas Syafiatul Azizah Titin Andri Wihastuti Tri Wahju Astuti, Tri Wahju Vely Eva Meria Wa Ode Intan Nur Octina Wahyuni Ramadhani Suaib Widiatmoko, Arif Widodo Mardi Santoso Widodo Mardi Santoso, Widodo Mardi Wirathmawati, Andina Yudiansyah, Anggi Gilang Yuyun Yueniwati Zahra, Farah Shabri Alifia Zamroni Afif