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All Journal Indonesian Journal of Chemistry Collaborative Medical Journal (CMJ) AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT JURNAL FARMASIMED (JFM) Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Indah Sains dan Klinis Mejuajua Journal of Health and Medical Science Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Pengmas Kestra (JPK) FARMASAINKES Jurnal Indah Sains dan Klinis Indonesian Journal of Science and Pharmacy
Debi Meilani
Institut Kesehatan Medistra Lubuk Pakam
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Journal : Jurnal Indah Sains dan Klinis

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Aktivitas Antibakteri Ekstrak, Fraksi Kloroform dan Fraksi n-Heksan Daun Kemangi terhadap Staphylococcus aureus dan Eschericia coli Melati Yulia Kusumastuti; Debi Meilani; Suhendra Tawarnate
Jurnal Indah Sains dan Klinis Vol 2 No 1 (2021): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v2i1.11

Abstract

Basil (Ocimum citriodorumVis.) is a plant which is their leaves are commonly eaten as fresh vegetables and have many benefits. Basil leaves contain secondary metabolite compounds that have antibacterial activity such as flavonoids, tannins, saponins, alkaloids, and steroids. The purpose of this study was to known the antibacterial activity of some fractions of basil leaves against Escherichia coli and Staphylococcus aureus and see which fraction was more active. This research included extraction by maceration method using ethanol 96%, then ethanol extract was fractionated using n-hexane and chloroform, phytochemical screening, then tested for antibacterial activity against E. coli and S. aureus by used agar diffusion method. Phytochemical screening showed ethanol extractcontained alkaloids, saponins, flavonoids, tannins, and steroids; chloroform fraction contained alkaloids, flavonoids, saponins, and tannins; and n-hexane fraction contained steroids. The results of the antibacterial activity test showed ethanol extract and chloroform fraction had antibacterial activity. Meanwhile, the n-hexane fraction did not have antibacterial activity. The concentration of 500 mg/ml of chloroform fraction and ethanol extract on S. aureus resulted from an inhibition zone around 24.67-26.90 mm. Furthermore, E. coli produced 22.67-23.84 mm. Ethanol extract had higher antibacterial activity than the chloroform fraction against E. coli and S. aureus
Evaluasi Stabilisator Agar-Agar dan CMC Sediaan Sirup Markisa Berastagi Suprianto; Muhammad Gunawan; Melati Yulia Kusumastuti; Cut Fatimah; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 3 No 1 (2022): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/b1pzvs47

Abstract

Fruit syrup is made from a sugar solution, the taste and aroma are determined by the freshness of the fruit. Fruit commonly used in making syrup has an attractive color, aroma and distinctive taste. Passion fruit (Passiflora edulis Sims.) has a distinctive taste and aroma, so it is widely processed into syrup. This study was to evaluate CMC and Agar-Agar stabilizers in the passion fruit syrup formula. Evaluation includes color, appearance, texture, taste and aroma and hedonic tests are carried out. The results showed that there were significant differences in the color, appearance, texture, taste and aroma of passion fruit syrup. Stabilizers CMC and Agar-Agar make the color, texture and appearance of the syrup better and more attractive. The result of hedonic test for ideal syrup concentration is S3 with 4 g of Agar and 6 g of CMC. The higher the concentration of CMC and Agar, the greater the viscosity of the syrup. The concentration of CMC and Agar-agar in a mixture of fruit juices gave significantly different effects on color, texture, appearance, taste and aroma
Formulasi dan Evaluasi Sediaan Sabun Padat Antiseptik Ekstrak Etanol Daun Kunyit Suprianto; Sumardi; Debi Meilani; Sri Rahayu
Jurnal Indah Sains dan Klinis Vol 3 No 1 (2022): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v3i1.44

Abstract

The plant of findings turmeric (Curcuma longa) are often used as a traditional medicinal. The part of the turmeric plant that is often used is the rhizome. In addition to turmeric rhizome, turmeric leaves are also used as a flavoring dish. Among the benefits of turmeric leaves is as an antimicrobial. Soap is a surfactant used for washing and cleaning. Antiseptics are inhibitors for the growth and development of microorganisms that live on the surface of the body. The study was to determine which ethanol extract of turmeric leaves could be formulated into antiseptic solid soap preparations. This study used an experimental method, turmeric leaves were extracted with 70% ethanol. The formula made are 2.5%, 5%, 7.5%. The quality of the soap preparation was carried out by organoleptic tests, acidity, high foam and irritation. The results test showed that the solid soap did not have the aroma of turmeric leaves, the pH of the soap was 9.9-10.5; foam height with a concentration of 7.5% which is 7.3 cm; and solid soap preparations ethanol extract of turmeric leaves did not cause irritation. The extract of turmeric leaves can be formulated into solid soap preparations. It is recommended to add perfume to the formulation of solid soap preparations of turmeric leaf extract as an antiseptic.
Analisis Biaya Efektif Terapi Diare Pasien Rawat Inap RS Putri Hijau Medan Muhammad Gunawan; Suprianto; Melati Yulia Kusumastuti; Sumardi; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 3 No 1 (2022): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v3i1.46

Abstract

Diarrhea is characterized by the excretion of liquid stools with a frequency of three or more times a day, due to gastrointestinal infections due to food and water contaminated with microorganisms, or directly from humans due to poor sanitation. This study was to determine the characteristics of diarrhea patients, treatment and cost-effectiveness of treatment at Putri Hijau Hospital, Medan. The non-experimental research is descriptive and retrospective in nature of financial patient medical records from July to December 2018. Cost Effectiveness Analysis as a method of cost analysis. The characteristics of the patients obtained were 14 women (46.670%) and 16 men (53.33%). The effectiveness of New Diatabs (92.30%) and New Diatabs Metronidazole (94.11%). The cost of therapy with New Diatabs is Rp. 1,547,771/patient and New Diatabs Metronidazole is Rp. 1,562,590/patient. Average cost-effectiveness New Diatabs Rp. 190,345 and New Diatabs Metronidazole Rp. 183,060, so it is concluded that the cost-effective therapy is the use of the combination of New Diatabs Metronidazole compared to New Diatabs.
Uji Ekstrak Kulit Buah Mangga Arum Manis dalam Etanol pada Tumbuh Kembang Escherichia coli dan Salmonella typhi Mandike Ginting; Suprianto; Siti Fatimah Hanum; Debi Meilani; Maya Sartika
Jurnal Indah Sains dan Klinis Vol 3 No 2 (2022): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v3i2.56

Abstract

Antibacterial interferes with growth and development and even kills by interfering with microbial metabolism. The peel of Mangifera indica L.var. arum manis contains antibacterial flavonoids. Research for the detection of antibacterial activity of mango peel extract of arum manis varieties in ethanol on E. coli and S. typhi. The well diffusion method was used with concentrations of 20.0%, 30.0% and 40.0%; chloramphenicol as a positive control. The diameter of the inhibition zone as an indicator of E. coli activity was 12.83 mm; 12.93 mm; and 13.91 mm, against S. typhi 11.60 mm; 12.52 mm; and 13.40 mm at these concentrations, respectively. Ethanol extract of Mangifera indica L. var. arum manis has antibacterial activity of E. coli and S. typhi with strong inhibitory power, and without differences in concentration
Deteksi Antibakteri Fraksi Ekstrak Etanol Folium Sambung Nyawa (Gynura procumbens) pada Salmonella typhi Yosi Darmirani; Wibman Tambunan; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 4 No 3 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i3.02

Abstract

Background: Folium Sambung Nyawa, a native plant in Indonesia, is known for its abundant medicinal properties. Among its various secondary metabolites, flavonoids stand out, being polyphenolic compounds found in numerous plants and foods. Flavonoids exhibit a wide range of bioactive properties, including antibacterial, anti-inflammatory, anti-diabetic, anti-cancer, anti-ageing, and antioxidant effects. Objective: This study aimed to assess the antibacterial potential of Sambung Nyawa Leaf extract fractions against Salmonella typhi bacteria. Methods: The antibacterial activity was evaluated using the paper disc diffusion method to determine the inhibition zones. Three fractions---n-hexane, ethyl acetate, and water---were tested at concentrations of 10%, 20%, and 30% each, along with negative controls (DMSO) and positive controls (Chloramphenicol). Results: Flavonoid examination using synode reagent yielded positive results. Among the fractions tested, the 30% ethyl acetate fraction exhibited the most promising antibacterial activity, with an inhibition zone of 7.65 mm, indicating strong efficacy against Salmonella typhi bacteria. Conclusion: The findings suggest that the ethyl acetate fraction of the concentrated Sambung Nyawa leaf extract possesses potent antibacterial properties against Salmonella typhi bacteria
Formulasi Sediaan Masker Pelembab Ekstrak Etanol Kulit Pisang Mas (Musa acuminata L.) Debi Meilani; Cucu Arum Dwi Cahya; Aminah Syarifuddin; Regina Elyanda Tampubolon
Jurnal Indah Sains dan Klinis Vol 3 No 3 (2022): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v3i3.03

Abstract

Background: Moisturizing cosmetics are care cosmetics that aim to maintain structure and function from various influences. One of the cosmetic preparations for facial skin care is a facial mask. Objective: The research is aimed at formulating and evaluating the Mas banana peel extract moisturizing mask formulation formula. Method: Formulation is carried out by adding the extract to the moisturizing preparation formula and evaluating it, including pH, dry time, spreadability, stickiness, moisture and irritation. Results: The results showed that the Mas banana peel ethanol extract mask preparation obtained had a pH of 6.1 - 6.5, dry time of 16.9 - 25.0 minutes, spreadability of 4.98 - 33.49 cm2, and very adhesive power. firm, average humidity 31.5 -52.9%, no irritation to the skin. Conclusion: A moisturizing mask from the ethanol extract of mas banana peel is effective as a skin moisturizer, equivalent to cosmetics containing 2% glycerin, does not cause skin irritation, has a standard cosmetic pH, and has good spreadability and adhesion
Analisis Vitamin C Daging dan Kulit Buah Semangka Merah dan Kuning (Citrullus vulgaaris Schard) dengan Spektrofotometri UV Lidiya Sasmaita Sihotang; Suprianto; Samran; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 5 No 2 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i2.06

Abstract

Latar Belakang: Iklim tropis negara Indonesia karena terletak di daerah khatulistiwa yang memberi peluang berbagai tanaman tumbuh dengan subur, termasuk buah-buahan. Umumnya, vitamin C merupakan salah satu kandungan yang terdapat pada buah-buahan, yang berperan sebagai antioksidan. Sekian banyaknya buah-buahan, slah satunya buah semangka (Citrullus vulgaris Schard). Buah semangka juga dimanfaatkan untuk menurunkan tekanan darah bagi penderita hipertensi, karena kandungan air dan kaliumnya yang tinggi sehingga mampu menstabilisasikan tekanan darah. Tujuan: Tujuannya untuk mendeteksi keberadaan dan kuantitas vitamin C pada daging dan kulit buah semangka merah dan kuning. Metode: Metode yang digunakan meliputi uji kualitas dan kuantitas masing-masing dengan pereaksi warna dan spektrofotometri UV. Hasil: Penelitian memberi informasi pada daging dan kulit buah semangka terdapat vitamin C dengan tanda ada perubahan warna maupun pengendapan kuning-merah bata dan coklat. Vitamin C dari daging dan kulit buah semangka merah dan kuning masing-masing adalah 50,688; 42.482; 34.764; dan 42,152 gr/L. Kesimpulan: Daging maupun kulit buah semangka merah dan kuning ditemukan vitamin C.
Dampak Pewarna Ekstrak Etanol Buah Naga Merah (Hylicerius polyhizus) terhadap Lip Balm Minyak Bunga Kenanga (Cananga oil) Meilani, Debi; Suprianto, Suprianto; Samran, Samran
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.02

Abstract

Background: Red dragon fruit holds promise as a natural dye alternative due to its anthocyanin content. Objective: This study aimed to evaluate the potential of ethanol extract from red dragon fruit as a dye in Lip Balm formulations and investigate how varying the concentration of this extract affects the formula. Method: The study involved extracting the dye from red dragon fruit and incorporating it into a Lip Balm preparation using natural fruit-based dyes. Results: The findings indicated that the red dragon fruit extract yielded favorable results after undergoing various tests, including organoleptic evaluation, homogeneity, melting point, irritation, and user preference. Conclusion: The extract of red dragon fruit can be utilized as a dye in Lip Balm formulations. The resulting colors range from pink to dark red, with higher concentrations of the extract producing more intense colors in the final Lip Balm product containing ylang-ylang flower oil (Cananga oil)
Korelasi Konsumsi Sidaguri dengan Kadar Asan Urat Darah Suprianto, Suprianto; Adek Chan; Joko Wibowo; Samran; Sumardi; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 6 No 1 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i1.02

Abstract

Background: Hyperuricemia as an indicator of increased blood uric acid. The prevalence rate in Indonesia is not recorded with certainty. However, the prevalence of gout reached 655,745 people out of 238,452,952 people in Indonesia, ranking first in Southeast Asia. Sidaguri flavonoids have inhibitory power against Xanthine Oxidase so that they can reduce uric acid. Objective: The study was aimed at detecting the effect and correlation of Sidaguri capsule consumption (Sida rhombifolia L) on reducing uric acid in patients. Method: The study was conducted Pretest and Posttest on 22 patients with hyperuricemia with the Easy Touch GCU Instrument. Results: The results showed that the average uric acid level before the intervention was 8.37 mg/dL and after the intervention was 6.57 mg/dL. Conclusion: Sidaguri capsules have an effect on reducing uric acid levels in patients
Co-Authors Adek Chan Ahmad Hafizullah Ritonga Alam Suhada Aminah Syarifuddin Ancel Mus Silaban Andraini, Galuh Ardiani, Rani Aritonang, Barita Ayu Khairunnisa Chan, Adek Cucu Arum Dwi Cahya Cut Fatimah Cut Fatimah Cyndi Veronica Dea Anggreini Deliwarni Rajagukguk Dewi Kartika Dian Zulkarnain Lubis Dicky Yuswardi Wiratma Dinda Sari Utami Effendy De Lux Putra Elvy Oktima Ernawaty Ginting Eva Sartika Dasopang Fatimah Sari Simatupang Febriady, Andy Fesri Damai Riang Laia Gabena Indrayani Dalimunthe Gusliani Eka Putri Harahap, Hasni Yaturramadhan Hasni, Hasni Yaturramadhan Harahap Herlina . Joko Wibowo Karnirius Harefa Khairiah, Khairiah Lidiya Sasmaita Sihotang Lubis, Minda Sari Mandike Ginting Mandike Ginting Maya Sartika Maya Sartika Melati Yulia Kusumastuti Melati Yulia Kusumastuti Miranda, Novia Anisa Muhammad Gunawan Muhammad Gunawan Nasirah Maulidia Ajhar Nasution, Lely Fitri Handayani Rafita Yuniarti Rahmi, Sofia Regina Elyanda Tampubolon Reni Aprinawaty Sirait Riza Hasyati Rotua Sumihar Sitorus Samran, Samran Siahaan, Enzo W.B Sitepu, Rahmadani Siti Fatimah Hanum Siti Nurbaya Siti Rahmi Ningrum Sofyan Syarifuddin SRI RAHAYU Sri Rahayu Suhendra Tawarnate Suhendra Tawarnate Suhendra Tawarnate Sumardi Sumardi Sumardi . Supran Hidayat Sihotang Suprianto Suprianto Syarifah Nadia Syarifuddin, Shofian Wibman Tambunan Yaturramadhan, Hasni Yessy Febriani Yosi Darmirani