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Effects of Golden Sea Cucumber Extract (Stichopus Hermanii) on Fasting Blood Glucose, Plasma Insulin, and MDA Level of Male Rats (Rattus Norvegicus) Induced with Streptozotocin Prawitasari, Dita Sukmaya; Safitri, Indri; Notopuro, Harianto
Folia Medica Indonesiana Vol. 55 No. 2 (2019): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.112 KB) | DOI: 10.20473/fmi.v55i2.24586

Abstract

Diabetes mellitus (DM) is one of disease that its incidence increases every year worldwide. The condition of DM can cause various complications caused by oxidative stress. Stichopus hermanii (SH) or golden sea cucumber extract contains antioxidant compounds that have been proven to reduce oxidative stress conditions. The purpose of this study was to investigate the effect of Stichopus hermanii extract on condition of diabetes mellitus by looking at changes in fasting blood glucose, plasma insulin, and malondialdehyde levels in animal models of Wistar rats. This study was a laboratory experimental study using Randomized Control Trial Design with Post-test only control group design. Thirty-five male Wistar rats divided into five groups, i.e normal control group, positive control, negative control and two treatment groups with SH extract dose 8.5 and 17 mg / kgBW for 14 days once daily after induction of Streptozotocin at the Biochemistry Laboratory of the Faculty of Medicine, Airlangga University. Fasting blood glucose level was measured by a glucometer, plasma insulin measured by ELISA and MDA level was measured by a spectrophotometer. Data were analyzed statistically by using One Way ANOVA test and Kruskal Wallis. There were significant results of SH extract can reduce fasting blood glucose (Kruskal Wallis, p=0.030) and MDA (Kruskal Wallis, p=0.042) but not in plasma insulin (ANOVA, p=0.130). The lowest MDA level occurs in the K4 group that given SH extract dose 17 mg/kg BW than another experimental group. As the conclusion, this study showed SH extract can decrease fasting blood glucose and oxidative stress in diabetic-induced rats.
ANALISIS HIDROGEOLOGI DAN GERAKAN MASSA TANAH BERDASARKAN METODE GAYABERAT SEBAGAI EVALUASI PENATAAN RUANG KALIAWI, BANDAR LAMPUNG Rizka, Rizka; Agustina, Lea Kristi; Mazmuloh, Hot; Sihombing, Andreas Pujian; Naufaldi, Muhammad Iqbal; Putraloka, Arvico; Prasetyo, Ervan; Safitri, Indri; Ilham, Ahmad Rowatul; Bashkara, Oktavian Teguh
Bulletin of Scientific Contribution Vol 18, No 3 (2020): Bulletin of Scientific Contribution : GEOLOGY
Publisher : Fakultas Teknik Geologi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/bsc.v18i3.30846

Abstract

Informasi model bawah permukaan dapat digunakan untuk penataan ruang dengan memahami aspek geologi dan potensi bencananya. Metode gayaberat dapat dijadikan solusi untuk mendapatkan model bawah permukaan di daerah Kaliawi yang terletak di pusat kegiatan perekonomian Kota Bandar Lampung. Pengukuran gayaberat telah dilakukan sebanyak 24 titik di Kaliawi. Berdasarkan hasil pengolahan data gayaberat diperoleh peta Complete Bouguer Anomaly (CBA) dan peta anomali regional, Kaliawi yang memiliki pola penurunan dari Tenggara ke arah Barat Laut. Nilai anomali rendah mayoritas berada di daerah Barat dan ditafsirkan merupakan batuan sedimen sedangkan anomali tinggi mayoritas berada di daerah Timur dan diduga merepresentasikan cerminan konfigurasi batuan dasar yang memiliki litologi basalt-andesit. Berdasarkan pemodelan ke depan gayaberat diperoleh nilai densitas sedimen 2.3 gr/cc dan batuan dasar (basalt-andesit) dengan nilai densitas 2.8 gr/cc. Nilai anomali gayaberat yang rendah berpotensi menjadi akuifer. Nilai anomali gayaberat yang rendah juga merupakan zona lemah dan rawan terjadi gerakan massa tanah. Sehingga untuk penataan ruang Kaliawi, daerah Barat direkomendasikan sebagai zona konservasi dan sedikit permukiman sedangkan daerah Timur dapat digunakan menjadi area permukiman penduduk.Kata Kunci: Gayaberat, perkotaan, Kaliawi
Implementasi Sensor Warna Tcs3200 untuk Meningkatkan Pembelajaran Anak Usia Dini Di Taman Kanak-Kanak Raudhatul ‘Ilmi Koto Gadang Lubuk Malako SAFITRI, INDRI
Jurnal Pustaka AI (Pusat Akses Kajian Teknologi Artificial Intelligence) Vol 4 No 3 (2024): Pustaka AI (Pusat Akses Kajian Teknologi Artificial Intelligence)
Publisher : Pustaka Galeri Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55382/jurnalpustakaai.v4i3.833

Abstract

Penelitian ini bertujuan untuk mengimplementasikan sensor warna TCS3200 guna meningkatkan proses pembelajaran bagi anak usia dini di Taman Kanak – kanak Raudhatul I’lmi, Koto Gadang Lubuk Malako. Anak – anak usia dini sedang berada dalam fase penting dalam perkembangan kognitif, khususnya dalam mengenali berbagai warna. Selain itu, penerapan teknologi ini juga dapat membantu mengembangkan kemampuan motorik halus dan kognitif anak melalui kegiatan belajar yang lebih interaktif dan menarik. Dengan demikian, implementasi sensor warna TCS3200 diharapkan dapat memberikan kontribusi positif dalam metode pembelajaran yang lebih modern dan inovatif di lingkungan Pendidikan anak usia dini. Kata kunci : Sensor Warna TCS3200, Pembelajaran Anak Usia Dini, Pembelajaran Interaktif, Teknologi Dalam Pendidikan.
Enhancing Competitive Advantage Through Marketing Strategies: A Multi-Site Study of Pakesang, Tanawan, Ummi Habibie Safitri, Indri; Hermawan, Agus; Siswanto, Ely
Journal of Applied Business, Taxation and Economics Research Vol. 4 No. 6 (2025): August 2025
Publisher : PT. EQUATOR SINAR AKADEMIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54408/jabter.v4i6.438

Abstract

Marketing strategy is the key to achieving sustainable competitive advantage, both for goods and services companies. This study aims to determine the marketing strategy in increasing competitive advantage in local potential SMEs in Ternate City, a multi-site case study on SMEs: Pakesang, Tanawan, and Ummi Habibie. Using a qualitative approach with a multisite case study method, this research explores the variations and similarities of phenomena in three locations. Data analysis techniques include SWOT analysis with IFAS matrix, EFAS, and SWOT diagram, as well as QSPM analysis to determine strategy priorities. Results show that the three SMEs have implemented the STP strategy and marketing mix with a focus on local culture-based product excellence and personalized service. All three were in a favorable position in the SWOT analysis, allowing for the implementation of an aggressive growth strategy. Key recommendations include optimizing digital channels, modernizing production tools, product differentiation, and strengthening local supply chains. Synergy between SMEs and local governments is also recommended to strengthen the business ecosystem.
Pengaruh Kegiatan Tambang Masyarakat Terhadap Lingkungan di Desa Parempei Kecamatan Rungan Kabupaten Gunung Mas Kalimantan Tengah Azizah, Najwa; Safitri, Indri; Kukarnia, Septio; Kevin, Sebastian; Wijaya, Dody Ariyantho Kusma
AL-MIKRAJ Jurnal Studi Islam dan Humaniora Vol. 5 No. 01 (2024): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i01.6361

Abstract

Gold mining carried out by local communities has a negative impact on environmental conditions, especially pollution in the Kahayan River basin. The purpose of this study was to describe the pollution control carried out by the government in the Rungan River basin which was polluted due to gold mining activities carried out by the community in Parempei Village, Central Kalimantan. The research method used in this study was the observation method. The use of mercury by local gold miners on a small scale is the main cause of pollution in the Rungan River basin, so that it exceeds the acceptable water quality standards. The findings of this study indicate that the efforts made by the government in overcoming pollution in the Rungan River basin are still lacking, which is also caused by several factors such as the lack of binding government affirmation regarding river pollution control, lack of public awareness in protecting the environment, and poor practices in imposing sanctions and law enforcement for miners.
Analisa Koordinasi Setting Proteksi Over Current Relay (OCR) Outgoing 20 kV dan Recloser pada Trafo II 60 MVA Feeder RBG 01 di Gardu Induk 150 kV Rembang Safitri, Indri; Gunawan, Gunawan; Nugroho, Agus Adhi
Elektrika Vol. 12 No. 1 (2020): April 2020
Publisher : Universitas Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (753.311 KB) | DOI: 10.26623/elektrika.v12i1.2136

Abstract

According to energy observers from the Institute for Essential Services Reform (IESR) the number of electricity consumers in Indonesia has increased by an average of 6-7% annually followed by an increase in the area of its services. An increasingly broad network is directly proportional to the potential for interference with the transmission and distribution system. The 150 KV Rembang substations is part of the Java-Bali Interconnection electrical system in northern Central Java that supplies electricity to the Rembang and surrounding areas. Rembang 150 KV substation on May 24, 2019, RBG 01 feeder experienced a disturbance behind the RB1-32 recloser and it was recorded that in 2019 PMT it had been tripped 4 times. Besides, there has been a change in equipment in the form of transformer II. These problems indicate the potential for interference that is not anticipated by the protection system, namely Over Current Relay and recloser.  This study evaluates the setting of an outgoing 20 KV OCR protections and recloser on transformer II RBG 01 feeder Rembang 150 KV substation. The scenarios used are calculations with large variations of short-circuit current based on% distance, as well as the calculation of OCR and recloser settings with IEC 60255 standards. Setting currents in the protection equipment is regulated based on current conductivity (KHA) and load current on the recloser. The coordination of the protection settings resulting from this resetting will be compared to the conditions on the ground.  Existing (field) OCR outgoing feeder RBG 01 condition TMS OCR value = 0.228 seconds, Iset = 480 A, and t op = 0.3 seconds. The existing OCR recloser condition TMS OCR value = 0.120 seconds and Iset = 400 A. The results of OCR coordinating outgoing feeder RBG 01 obtained TMS OCR value = 0.135 seconds, Iset = 585 A, and t operation = 0.3 seconds. OCR recloser resetting conditions obtained TMS OCR value = 0.10 seconds, Iset = 240 A and t operation = 0.198 seconds. The resetting conditions have met the IEC 60255 standard because recloser working time is smaller than outgoing work time.
PENGARUH ARUS KAS OPERASI, BEBAN OPERASIONAL, HARGA POKOK PENJUALAN, DAN SALES GROWTH TERHADAP PERTUMBUHAN LABA Prasetyaningrum, Dhea; Safitri, Indri; Melisa, Nessa; Halawa, Victorius
Jurnal Ilmiah Wahana Pendidikan Vol 10 No 12 (2024): Jurnal Ilmiah Wahana Pendidikan 
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.12511664

Abstract

Penelitian ini bertujuan untuk menganalisis pengaruh arus kas operasi, beban operasional, harga pokok penjualan, dan pertumbuhan penjualan terhadap pertumbuhan laba pada perusahaan. Metode analisis yang digunakan dalam penelitian ini adalah regresi linier berganda dengan menggunakan data keuangan perusahaan selama periode tertentu. Hasil penelitian menunjukkan bahwa arus kas operasi memiliki pengaruh positif yang signifikan terhadap pertumbuhan laba. Artinya, peningkatan arus kas operasi dapat berkontribusi pada peningkatan laba perusahaan. Selain itu, beban operasional dan harga pokok penjualan juga berpengaruh signifikan terhadap pertumbuhan laba, namun dengan arah yang berlawanan. Semakin tinggi beban operasional atau harga pokok penjualan, semakin rendah pertumbuhan laba perusahaan. Di sisi lain, pertumbuhan penjualan tidak secara signifikan mempengaruhi pertumbuhan laba. Meskipun peningkatan penjualan mungkin memberikan kontribusi positif terhadap laba, namun dampaknya tidak begitu kuat seperti halnya arus kas operasi, beban operasional, dan harga pokok penjualan. Penelitian ini dapat memberikan wawasan kepada manajer keuangan dan pemangku kepentingan lainnya tentang faktor-faktor yang dapat mempengaruhi pertumbuhan laba perusahaan. Oleh karena itu, manajemen perusahaan disarankan untuk lebih memperhatikan manajemen arus kas operasi, pengendalian beban operasional, dan strategi penetapan harga pokok penjualan guna meningkatkan kinerja keuangan dan pertumbuhan laba perusahaan.
Effect of Solo Garlic Extract (Allium Sativum) on Malondialdehyde (MDA) in Rats (Rattus Norvegicus) Exposed to Cigarette Smoke Kinasih, Dewangga Sakti Satria; Meliana, Ahila; Safitri, Indri
Jurnal Kesehatan Prima Vol. 18 No. 1 (2024): FEBRUARY
Publisher : poltekkes kemenkes mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jkp.v18i1.1497

Abstract

Cigarette smoke is one of the oxidant sources which cause stress oxidative. Cigarettes contain more than 4500 gases and chemicals that have negative effect on human body. Stress oxidative is marked by various parameters, one of which is malondialdehyde (MDA). As natural plant, solo garlic has a potential as antioxidant because contain a lot of active compounds. This study determines the effect of solo garlic on MDA level of Rattus norvagicus which exposed to cigarette smoke. This study is experimental animal study which use randomized posttest only control group design. Twenty-five rats were included and divided into five groups, such as negative control, positive control, and the treatment groups. Solo garlic administrated at doses of doses of 2.5, 5, and 10 (mg/200gBW/day) respectively. The statistical result showed that solo garlic extract can reduce the MDA level of treatment groups (p=0.000). This study concluded that solo garlic extract can reduce the MDA levels of rats to cigarette smoke. The significant effect was obtained at a dose of 10 mg/200gBW/day.
Pengembangan Soal Literasi Numerasi Konteks Budaya Bangka Bagi Siswa SD Rachma Kurniasi, Eka; Hevitria, Hevitria; Fauziani, Meilidya; Safitri, Indri
PINUS: Jurnal Penelitian Inovasi Pembelajaran Vol 8 No 2 (2023): Volume 8 Nomor 2 Tahun 2023
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/pn.v8i2.18985

Abstract

Literacy and numeracy are important skills of the 21st century. Problems at the elementary level regarding numeracy still need to be developed. This development concerns numeration content and the context of regional culture that need to be included in the questions. This study aims to develop numeracy literacy questions in the cultural context of Bangka Belitung for elementary school students. The research method chosen is development research with the ADDIE development model. The procedure carried out in the Analysis stage is analyzing the SK and KD of fourth grade elementary school in mathematics, analyzing student needs, analyzing the needs of numeracy literacy questions in the 2013 curriculum and the independent curriculum. In the design phase, the researcher made a prototype of numeracy literacy questions in the cultural context of Bangka Belitung. The development stage is validated by material experts and evaluation experts regarding the questions that have been developed. The implementation phase was carried out by small-scale and large-scale tests on the subject of 4th grade elementary school students. The evaluation stage is carried out formative evaluation at each stage of development. The results of the study were 5 questions of numeracy literacy in the cultural context of Bangka Belitung with media expert validation of 87% stating it was valid, evaluation expert validation stating 92% valid. On a small scale, 79% of student responses stated that it was feasible and on a large scale, 82% stated that it was feasible. Test the quality of the items, namely construct validity, it is stated that all items are valid. While reliability is stated as a matter of reliability. This study gives the result that students have difficulty in understanding their literacy. However, on numeracy content, students find it not difficult to do it. When reading the questions students feel proud that some places or foods they know and encounter everyday can be studied in mathematics.