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Relationship Between Risk Factors and The Incidence of Gestational Trophoblastic Neoplasia at RSUP Dr. M. Djamil Padang Year 2019-2021 Almujahid, Aldi; Syamel Muhammad; Asterina
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.2.746-753.2024

Background : Gestational Trophoblastic Neoplasia (GTN) is a tumor originating from cytotrophoblast and syncytotrophoblast that invades myometrium, damages surrounding tissue and blood vessels, and causing bleeding. Purpose : This study aims to determine the relationship between age, history of previous pregnancies, β-hCG levels, parity, and interval with last pregnancy on the incidence of GTN. Method : This research is an observational analytic study with a cross sectional research design. Univariate analysis was carried out which described the frequency distribution of variables and bivariate analysis with the chi square statistical test . Result : The results of this study showed that there was a significant relationship between age, history of previous pregnancies, β-hCG levels and parity) and the incidence of GTN, while the interval with the last pregnancy did not have a significant relationship with the incidence of GTN . Conclusion: It was concluded that age, history of previous pregnancy, β-hCG levels, and parity are risk factors for GTN.

Efficacy of EMCO Therapy on Serum β-hCG Levels in Case of Gestational Trophoblastic Neoplasm (GTN) at Dr. M. Djamil Hospital Padang 2019-2021 Siregar, Attahhal Fikrian Syadiq; Syamel Muhammad; Elly Usman
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.2.754-762.2024

Backgrounds: Etoposide, Methotrexate, Cyclophosphamide, and Vincristine (EMCO) Chemotherapy is used as an alternative therapy for patients with a diagnosis of Gestational Trophoblastic Neoplasm (GTN) at Dr. M. Djamil Hospital Padang because Actinomycin D has not been included in the National Formulation (FORNAS). Purpose: To determine the efficacy of EMCO therapy with limited Actinomycin D on serum Î²-hCG levels in Gestational Trophoblastic Neoplasm (GTN) cases at Dr. M. Djamil Padang Hospital in 2019-2021. Methods: The type of research used is numerical comparative analytics with a cross sectional approach. The number of samples was 17 GTN patients who had done EMCO chemotherapy and checked Î²-hCG levels before and after chemotherapy. The research was conducted from April to October 2022 at Dr. M. Djamil Hospital Padang. Data processing using total sampling technique and tested using Wilcoxon Test. Results: Most GTN patients were found to be <40 years old (64,7%), history of molar hydatidiform pregnancy (47,1%), last pregnancy interval <4 months (58,8%), Î²-hCG level before chemotherapy ranged from 104-105 mIU/mL (52,9%), tumor size >5 cm (58,8%), metastasis location in the internal genital tract (35,5%), and patients who did not have metastasis (52,9%). Conclusion: There was a significant decrease in Î²-hCG levels after chemotherapy using EMCO for three cycles in patients with a diagnosis of GTN.

Adjuvant Chemotherapy For FIGO Stage IIA2 Cervical Cancer : A Case Report Heryanto, Deni; Syamel Muhammad; Puja Agung Antonius
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.2.792-800.2024

Background : Cervical cancer ranked as the third most prevalent cancer among women. This case report is to examine the current status of adjuvant chemotherapy in the treatment of early-stage cervical cancer as documented in the literature. Currently, there is no established evidence supporting the therapeutic efficacy of adjuvant chemotherapy as a standalone treatment following radical hysterectomy surgery. Nevertheless, some literature recommend the use of adjuvant radiotherapy (AR), adjuvant chemotherapy (AC), or concomitant chemoradiotherapy (CCRT) as the standard adjuvant therapies for early-stage cervical cancer following radical hysterectomy with positive prognostic factor. Case report: A 53-year-old female was diagnosed with stage IIA2 in April 2021. The histology type was determined to be keratinized squamous cell carcinoma, moderately well differentiated. The patient underwent a radical hysterectomy, resulting in the acquisition of uterine and cervical tissue measuring 11x11×6 cm. The histology results revealed moderately to poorly differentiated keratinizing squamous cell carcinoma, with no invasion of the parametrium or pelvic lymph nodes with vaginal cutting margin is free of tumor growth, but lymph vascular space invasion was present. Subsequently, adjuvant chemotherapy was administered using carboplatin (AUC 5) and paclitaxel for a total of 6 cycles. After 2 years with follow-up with CT-Scan examination in April 2023 confirmed the absence of any residual mass. Conclusion: A radical hysterectomy combined with adjuvant chemotherapy has been shown to reduce the chance of recurrence or progressiveness of the disease, in which this patient did not experience a recurrence after two years of treatment

CA-125 Examination as a Predictor the Resectability of Advanced Stage of Ovarian Cancer Muhammad, Syamel; Rudy Setiawan, Muhammad; Savannah, Aisha
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 2 April 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i2.2081

Objective: To describe the prompt and successful treatment of an extrauterine pregnancy case in a tertiary-level hospital in Indonesia. Methods: We report a case of prompt and successful management of unruptured tubal pregnancy in the dr. Soetomo General Hospital Surabaya. Results: A 32-years-old woman presented with lower abdominal pain and vaginal bleeding one days before admission. She was sexually active, used no contraceptives, and had a history of one miscarriage. On examination, she was hemodynamically stable. A bimanual exam revealed cervical motion tenderness and pain. A high human chorionic gonadotropin (hCG) level (1,725 IU/L) and a left-sided mass, highly suspected as an extrauterine gestational sac confirming a 6 week, 1 days age of pregnancy without sign of free fluid in the abdomen nor fetal heart rate on ultrasound, prompted diagnostic laparoscopy. We found a tubal pregnancy located on the ampullae of the left fallopian tube with minimal hemoperitoneum (50 ml). A chromopertubation test was done to ensure a patent right fallopian tube, so we did a salpingectomy. The patient recovered well and was discharged home on day 2 post-procedure. Conclusion: Early diagnosis is vital and feasible to prevent morbidity and mortality in women with ectopic pregnancy. All sexually active women complaining painful abdomen or vaginal bleeding must be examined for an ectopic pregnancy to enable early diagnosis and prompt treatment. A laparoscopic surgery done by a trained individual provided a safe and minimally invasive intervention to this case. Keywords: case report, ectopic pregnancy, laparoscopy, salpingectomy, tubal pregnancy

Factors Related to Husband's Involment in Antenatal Care Visits in High Risk Pregnant Women Nurhalimah Juneldi; Vaulline Basyir; Rosfita Rasyid; Syamel Muhammad; Rozi Sastra Purna; Hasmiwati
Indonesian Journal of Advanced Research Vol. 3 No. 2 (2024): February 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijar.v3i2.8250

High-risk pregnancy is a pregnancy that can cause harm and complications to the mother and fetus during pregnancy, childbirth or after delivery compared to normal pregnancy and childbirth. The aim of this research is to determine "Factors Associated with Husband's Involvement in Antenatal Care Visits for High Risk Pregnant Women". The design in this research is cross-sectional. The sample in the study was 187 people. The validated questionnaire was used in collecting data for this research. and analyzed univariately using frequency distribution, bivariate using chi-square test, and multivariate using logistic regression test. The research results showed that age (p=0.875), education (p=0.004), income (p=0.015). Based on the multivariate results, it was found that the most dominant factor related to husband's involvement in antenatal care visits was education with the highest OR value of 0.139.

Connection Age with Behavior use Method Contraception Long Term in Active KB Acceptors in the Family Planning Village Program in Sungai Penuh City Kiran Nandini; Vaulline Basyir; Firdawati; Rima Semiarty; Syamel Muhammad; Ilmiawati
Indonesian Journal of Advanced Research Vol. 3 No. 2 (2024): February 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijar.v3i2.8252

The Long Term Contraceptive Method (MKJP) is an effective contraceptive method used to plan, postpone, and terminate pregnancy. MKJP is considered effective because the failure rate is low compared to non-MKJP contraception. The factor of couples of childbearing age in using contraception cannot be separated from the behavioral factors of each individual. This research aims to determine the relationship between age and the behavior of using MKJP among active family planning acceptors in the family planning village program in Sungai Penuhcity. The design of this research is a cross-sectional study. The sample in this study was 354 people. Data was collected using a questionnaire and analyzed using chi-square. The research results showed a relationship between age (p= 0.003) and MKJP usage behavior.

Unraveling the Angiogenic Landscape in Endometrioid Endometrial Carcinoma: VEGF Expression, Histopathological Differentiation, and Lymphovascular Invasion as Key Players Mustika Sari; Aswiyanti Asri; Tofrizal; Henny Mulyani; Syamel Muhammad; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1340

Background: Endometrioid endometrial carcinoma (EEC) is a prevalent gynecological malignancy whose prognosis is influenced by factors including histopathological grade and lymphovascular invasion (LVI). Angiogenesis, crucial for tumor growth and metastasis, is significantly mediated by vascular endothelial growth factor (VEGF). This study aimed to investigate the expression of VEGF in EEC and its correlation with histopathological differentiation and LVI. Methods: This observational analytical study employed a cross-sectional design using 36 archival paraffin block samples of EEC diagnosed between January 2022 and December 2024 at the Anatomical Pathology Laboratory of Dr. M. Djamil General Hospital Padang. Cases were selected via simple random sampling from a population of 59. Histopathological grade (Grade 1, 2, or 3 based on FIGO architectural and nuclear criteria) and LVI (negative, focal, or substantial) were re-evaluated from Hematoxylin-Eosin (H&E) stained slides. VEGF expression was assessed by immunohistochemistry, scored semiquantitatively based on the percentage of positive tumor cells and staining intensity, and categorized as low or high. Data were analyzed using Chi-square tests, with p<0.05 considered statistically significant. Results: The mean age of patients was 54.36 years, with the highest prevalence in the 51-60 age group (41.7%). Grade 3 tumors were most common (38.9%), followed by Grade 2 (33.3%) and Grade 1 (27.8%). LVI was present in 47.2% of cases, predominantly focal (38.9%). High VEGF expression was observed in 58.3% of EEC cases. A statistically significant association was found between high VEGF expression and higher histopathological grade (p=0.000), with 66.7% of Grade 3 tumors showing high VEGF expression. No significant association was found between VEGF expression and LVI (p=0.080). Conclusion: High VEGF expression significantly correlated with higher histopathological grades in EEC, suggesting its role in tumor aggressiveness and dedifferentiation. However, a significant association with LVI was not established in this cohort. VEGF expression warrants further investigation as a potential prognostic biomarker and therapeutic target in EEC.

Unraveling the Angiogenic Landscape in Endometrioid Endometrial Carcinoma: VEGF Expression, Histopathological Differentiation, and Lymphovascular Invasion as Key Players Mustika Sari; Aswiyanti Asri; Tofrizal; Henny Mulyani; Syamel Muhammad; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1340

Background: Endometrioid endometrial carcinoma (EEC) is a prevalent gynecological malignancy whose prognosis is influenced by factors including histopathological grade and lymphovascular invasion (LVI). Angiogenesis, crucial for tumor growth and metastasis, is significantly mediated by vascular endothelial growth factor (VEGF). This study aimed to investigate the expression of VEGF in EEC and its correlation with histopathological differentiation and LVI. Methods: This observational analytical study employed a cross-sectional design using 36 archival paraffin block samples of EEC diagnosed between January 2022 and December 2024 at the Anatomical Pathology Laboratory of Dr. M. Djamil General Hospital Padang. Cases were selected via simple random sampling from a population of 59. Histopathological grade (Grade 1, 2, or 3 based on FIGO architectural and nuclear criteria) and LVI (negative, focal, or substantial) were re-evaluated from Hematoxylin-Eosin (H&E) stained slides. VEGF expression was assessed by immunohistochemistry, scored semiquantitatively based on the percentage of positive tumor cells and staining intensity, and categorized as low or high. Data were analyzed using Chi-square tests, with p<0.05 considered statistically significant. Results: The mean age of patients was 54.36 years, with the highest prevalence in the 51-60 age group (41.7%). Grade 3 tumors were most common (38.9%), followed by Grade 2 (33.3%) and Grade 1 (27.8%). LVI was present in 47.2% of cases, predominantly focal (38.9%). High VEGF expression was observed in 58.3% of EEC cases. A statistically significant association was found between high VEGF expression and higher histopathological grade (p=0.000), with 66.7% of Grade 3 tumors showing high VEGF expression. No significant association was found between VEGF expression and LVI (p=0.080). Conclusion: High VEGF expression significantly correlated with higher histopathological grades in EEC, suggesting its role in tumor aggressiveness and dedifferentiation. However, a significant association with LVI was not established in this cohort. VEGF expression warrants further investigation as a potential prognostic biomarker and therapeutic target in EEC.

Kejadian depresi postpartum dan kaitannya dengan dukungan suami dan KDRT Permata Rachim, Dyan; Yanis, Amel; Muhammad, Syamel
Jurnal Kebidanan Indonesia Vol 16, No 2 (2025): JULI
Publisher : STIKES Mamba'ul 'Ulum Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36419/jki.v16i2.1465

Pendahuluan: Depresi postpartum merupakan gangguan emosional yang diakibatkan oleh mekanisme koping yang tidak memadai selama periode postpartum. Jika tidak ditangani, depresi dapat meningkatkan risiko suicide maupun infanticide. Kejadian depresi postpartum sering kali dikaitkan dengan rendahnya dukungan dari suami dan adanya Kekerasan Dalam Rumah Tangga (KDRT), yang keduanya dapat memperburuk kondisi psikologis ibu. Tujuan: Penelitian ini bertujuan untuk menganalisis terjadinya depresi postpartum dan hubungannya dengan dukungan suami dan KDRT. Metode: Desain penelitian kuantitatif dengan pendekatan cross sectional yang dilakukan di Wilayah Kerja Puskesmas Andalas Kota Padang dari Juni 2023 hingga Mei 2024. Sampel penelitian terdiri dari 152 ibu dengan bayi antara 4 minggu dan 6 bulan. Data dikumpulkan menggunakan kuesioner terstruktur, dan analisis statistik dilakukan menggunakan uji chi-square. Hasil: Hasil penelitian menunjukkan bahwa kejadian depresi postpartum di Wilayah Kerja Puskesmas Andalas Kota Padang sebesar 24,3%. Selain itu, ditemukan hubungan yang signifikan antara depresi postpartum dengan dukungan suami (nilai p 0,000) dan juga ditemukan hubungan yang signifikan antara depresi postpartum dengan kekerasan dalam rumah tangga (nilai p 0,000). Kesimpulan: Temuan ini menggarisbawahi hubungan yang signifikan antara depresi postpartum dan faktor-faktor seperti dukungan suami dan KDRT. Temuan ini menyoroti pentingnya hubungan suami istri yang suportif dan pencegahan kekerasan dalam rumah tangga dalam mengurangi kejadian depresi postpartum

Relationship of BMI and Parity with High Grade Serous Ovarian Cancer at RSUP Dr. M. Djamil Padang Murizal, Thanya Amoret Alya; Syamel Muhammad; Eka Nofita; Henny Mulyani; Selfi Renita Rusjdi; Fathiyyatul Khaira
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 2 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.2.259-266.2025

Introduction : Ovarian cancer is the 8th most common cancer in women. High grade serous carcinoma (HGSC) is a subtype of ovarian cancer with the highest case and death rate compared to other types. Therefore, a preventive approach is needed by reviewing the underlying risk factors of this cancer. Body mass index (BMI) and parity are modifiable risk factors for ovarian cancer. This study aims to determine the relationship BMI and parity on high grade serous subtype ovarian cancer at RSUP Dr. M. Djamil Padang. Method: observational analytic study with a cross sectional approach. This research was conducted at RSUP Dr. M. Djamil Padang using medical record data of epithelial ovarian cancer patients at RSUP Dr. M. Djamil Padang from 2021 to 2022 with a sample of 129 patients. The data analysis method used in this research is the Chi-square test. Result : Epithelial ovarian cancer patients are most found at >50 years old (55%), menopausal woman (65.9%), non obese (77.5%) and parous women (76%). Conclusion : There was no relationship between body mass index and parity with the incidence of ovarian cancer, subtype high grade serous, at RSUP Dr. M. Djamil Padang.

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