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All Journal Hemera Zoa Damianus Journal of Medicine Jurnal Kedokteran Anatomica (Anatomica Medical Journal) JPSCR : Journal of Pharmaceutical Science and Clinical Research Health and Medical Journal SANITAS: Jurnal Teknologi dan Seni Kesehatan Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Makara Journal of Health Research Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Urban Health Research Mitramas Jurnal Pengabdian dan Pemberdayaan Masyarakat Mitramas Jurnal Pengabdian dan Pemberdayaan Masyarakat
Tena Djuartina, Tena
Departemen Anatomi, Fakultas Kedokteran Dan Ilmu Kesehatan Unika Atma Jaya
Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Pemberian Dosis Tinggi D-galactose Jangka Pendek secara Intraperitoneal untuk Menginduksi Proses Aging pada Tikus Jantan Kartika, Ronald Winardi; Sidharta, Veronika Maria; Djuartina, Tena; Timotius, Kris Herawan; Sartika, Chyntia Retna; Rika, Ignatio
Health and Medical Journal Vol 5, No 3 (2023): HEME September 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v5i3.1370

Abstract

Pendahuluan: Injeksi D-galaktosa (D-gal.i.p.) intraperitoneal yang dapat mempercepat penuaan telah digunakan untuk mengembangkan model penuaan. Penelitian sebelumnya menggunakan D-galaktosa jangka panjang selama 4 minggu untuk menginduksi penuaan pada mencit menimbulkan kesulitan waktu dan biaya pengobatan. Para peneliti sedang mencoba mencari tahu apakah pemberian D-gal dosis tinggi dalam jangka pendek. aku p. pada tikus mampu menginduksi tanda-tanda signifikan yang mirip dengan penuaan alami, yaitu peningkatan stres oksidatif dan myostatin. Tujuan dari penelitian ini adalah untuk mengetahui jalur penuaan otot pada tikus akibat pemberian D-galaktosa dosis tinggi dalam waktu singkat. Metode: Rancangan penelitian studi eksperimen, in vivo, dilakukan di laboratorium terpadu FKIK Universitas Katolik Atma Jaya Jakarta menggunakan 22 ekor tikus Sprague Dawley, jantan, umur 6-12 minggu, berat 200-350 gram. Sebelas ekor tikus diinduksi intraperitoneal (G-ip) D-galaktosa 300 mg/kg/hari selama 7 hari. 11 ekor tikus sisanya diinduksi dengan NaCl 0,9% i.p (N-ip). Pada penelitian ini pengukuran berat badan, lingkar gastrocnemius, CRP dan kadar myostatin blood elisa dibandingkan antara hari ke 7 dan hari ke 0 untuk melihat efek sistemik injeksi D. Galaktosa. Data dianalisis menggunakan SPSS versi 20. Hasil: Pemberian D-gal jangka pendek. i.p secara signifikan meningkatkan peradangan sistemik. dan tingkat myostatin. Pada kelompok perlakuan terjadi peningkatan aktivitas superoksida dismutase meskipun lebih rendah dibandingkan NaCl 0,9% i.p. kelompok. Kesimpulan: Dosis Tinggi Waktu singkat D-gal. injeksi mungkin membuat penuaan alami yang dapat berkembang pada tikus paling cepat satu minggu.
Potential Antihyperlipidemia Effect of Lactoferrin in Hyperlipidemia-Induced Male Sprague–Dawley Rats Jusni, Louis Fabio Jonathan; Chandra, Valencia; Djuartina, Tena; Notario, Dion; Arieselia, Zita; Hananta, Linawati
Makara Journal of Health Research Vol. 26, No. 3
Publisher : UI Scholars Hub

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Abstract

Background: Hyperlipidemia is a condition that is characterized as an increase in total cholesterol and triglyceride levels in the blood. Lactoferrin is a protein that can serve as an antioxidant. This study aims to determine whether lactoferrin can reduce total cholesterol and triglyceride levels. Methods: This study used 24 Sprague–Dawley rat strains, which were divided into six groups: normal group; negative control; positive control; and dose groups 1, 2, and 3. The normal group was given standard feed, whereas the other group was given high cholesterol and fat. The positive control group and dose groups 1, 2, and 3 were given 1.5 mg/kg BW of simvastatin and 100, 200, and 400 mg/kg of BW lactoferrin, respectively. After 6 weeks, total cholesterol and triglyceride levels were measured. Results: This study showed that lactoferrin doses of 100, 200, and 400 mg/kg BW could significantly reduce total cholesterol and triglyceride levels (p < 0.05). Lactoferrin could also significantly reduce activated Kupffer cell and steatosis area in the liver (p < 0.05). Conclusions: Lactoferrin can reduce total cholesterol and triglyceride levels. Thus, further research is needed to address the existing bias and confirm that lactoferrin can reduce cholesterol and triglyceride levels.
Effects of Coffee Consumption on Acne Vulgaris Severity in Atma Jaya Medical Students in Jakarta, Indonesia Natasha, Tiffanie; Wijaya, Lorettha; Djuartina, Tena; Arieselia, Zita
Journal of Urban Health Research Vol. 3 No. 1 (2024): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i1.5467

Abstract

Introduction: Acne vulgaris is a common multifactorial skin disease. With diet as one of the possible factors, the rising habit of coffee consumption may have its own effects on acne. In present time, there is a lack of study between coffee consumption and acne vulgaris as well as the relationship between the two topics. This study aimed to analyze the effects of coffee consumption on acne severity. Methods: A cross-sectional study was conducted from September to December 2022 on 106 Atma Jaya medical students in Jakarta, Indonesia, who has acne and consumed coffee in the past month when the study was performed. The students were asked to fill a questionnaire about demographic and filtering questions along with questions about coffee consumption in the past month based on Diet History Questionnaire III (DHQ III). Acne lesion observations on the face, upper back, and chest were then performed on every individual to calculate acne severity based on Global Acne Grading System (GAGS). Results: Students who only drank black coffee tend to have lower acne severity score (mean±SD: 19.69±5.68) than those who drank coffee mixtures beverages (mean±SD: 25.41±5.11) (p-value<0.001). There was a significant negative correlation between acne severity scores and amount of black coffee consumed (p-value=0.001). On the other hand, there was a significant positive correlation between acne severity scores and amount of coffee mixtures beverages consumed (p-value<0.001). Conclusion: The results of this study show that the types and amount of coffee consumed had significant effects on acne vulgaris severity in medical students. Keywords: acne vulgaris - black coffee - coffee mixtures
Hubungan Paparan Whole Body Vibration Dengan Low Back Pain Pada Pengemudi Ojek Online Tena Djuartina; Anthony Yauwono; Robi Irawan; Andreas Steven
Majalah Kedokteran Indonesia Vol 70 No 10 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, V
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.10-2020-301

Abstract

Introduction: Low back pain is a condition characterized by pain and stiffness on lumbosacral region. Whole body vibration is a mechanical vibration transmitted to whole body. Whole body vibration is a risk factor for low back pain. To determine the relationship of whole body vibration with low back pain.Method: Using cross-sectional method for 27 online ojek driver in Jakarta. Respondent filled the Nordic Musculoskeletal Questionnaire (NMQ). Vibration from the motorcycle measured with smartphone application. Data analysis using Fisher Exact test.Result: There are seven respondent with LBP and vibration exceeding ELV, four respondent with LBP and vibration not exceeding ELV, four respondent without LBP and vibration not exceeding ELV and 12 respondent without LBP and vibration not exceeding ELV.Conclusion: There is correlation between whole body vibration and low back pain.
Therapeutic Potential of Bovine Lactoferrin to Reduce Brain Malondialdehyde Levels in Hyperlipidemia-Induced Sprague-Dawley Rats Telium, Havian Daulung; Djuartina, Tena; Notario, Dion; Hananta, Linawati
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.72048

Abstract

Hyperlipidemia is a medical condition that can trigger various diseases, one of which is a neurodegenerative or neurological disease. Lactoferrin is known to have multiple protective activities, one of which is antioxidant. This study aimed to determine the potential of lactoferrin bovine to decrease brain MDA levels in Sprague-Dawley (SD) rats induced by hyperlipidemia. This study was an in vivo experimental study using 24 male SD rats divided into six groups: normal, negative control, positive control, low-dose bovine lactoferrin (LLF), intermediate-dose bovine lactoferrin (ILF), and high-dose bovine lactoferrin (HLF). The diet in the normal group was the standard diet, and the other groups were induced by a high-fat diet (HFD). The intervention for the positive control group was simvastatin. In contrast, LLF, ILF, and HLF groups were given bovine lactoferrin doses of 100, 200, and 400 mg/kgBW, respectively. After seven weeks, all rats were necropsied, and their brains were taken to be tested for malondialdehyde (MDA) levels with an MDA assay kit using a spectrophotometer. Data was then analyzed using Shapiro-Wilk and Levene test and continued with one-way ANOVA and post-hoc Tukey test. There were significant differences (p<0.05) between the negative control group (269.99±13.50 nmol/g weight) and every bovine lactoferrin groups (219.92±22.99 nmol/g weight, 151.60±23.43 nmol/g weight, 158.16±12.33 nmol/g weight, respectively) in reducing brain MDA levels. In summary, all bovine lactoferrin groups (100, 200, and 400 mg/kgBW) significantly reduced brain MDA levels of SD rats in hyperlipidemia condition.
Co-Authors ., Vetinly Ahmad Aulia Ahmad Aulia Alfred Sutrisno, Alfred Andreas Steven Andreas Steven Andrew Wijaya Anthony Yauwono Ari Fahrial Syam Ari Fahrial Syam Bambang Pontjo Priosoeryanto Blandina, Maria Bernadetta Nadya Budianto, Iskandar R. Chandra, Valencia Dion Notario Dyonesia Ary Erfen Gustiawan Suwangto, Erfen Gustiawan Gosal, Ervina Heidy Heidy Herlina Uinarni Ignatio R. Haryono Irawan, Robi Iskandar Rahardjo Budianto Jenny Lauvita Jusni, Louis Fabio Jonathan Kartika, Ronald Winardi Kris Herawan Timotius Linawati Hananta, Linawati Lorettha Wijaya Maria Dara Novi Handayani, Maria Dara Novi Narwati, Yulia Tanti Natasha, Tiffanie Nawanto Agung Prastowo Panggabean, Nadine Lefina Poppy Kristina Sasmita R. Budianto, Iskandar Riki Tenggara Rita Dewi Robi Irawan Santi, Bryani Titi Sartika, Chyntia Retna Sasmita, Poppy K. Sugiharto, Liliana Sulichatiani Sutino, Vinsensius Syarief Darmawan Sylvia Wijaya Sylvia Wijaya Telium, Havian Daulung Tri Isyana Tungga Dewi Tri Isyani Tungga Dewi Veronika Maria Sidharta Vienna Christantia Zita Arieselia