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All Journal Jurnal Pangan dan Gizi Indonesian Journal of Human Nutrition Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Amerta Nutrition Jurnal Riset Kesehatan Poltekkes Depkes Bandung Community Development Journal JURNAL GIZI DAN KESEHATAN Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Molekul: Jurnal Ilmiah Kimia Prosiding Seminar Nasional Unimus Prosiding Seminar Nasional Pengabdian kepada Masyarakat (SINAPMAS) Journal of Innovation and Teacher Professionalism JPM Pambudi
Yunita Rakhmawati
Universitas Negeri Malang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Amerta Nutrition

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Efek Protektif Tepung Pisang, Singkong dan Jagung terhadap Hepatotoksisitas Tikus Jantan Malnutrisi: Protective Effect of Banana, Cassava, and Corn Flours on Hepatotoxicity of Malnourished Male Rats Mohammed, Najib; Lestari, Sri Rahayu; Susanto, Hendra; Rakhmawati, Yunita
Amerta Nutrition Vol. 8 No. 3 (2024): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v8i3.2024.398-408

Abstract

Background: Malnutrition-induced hepatotoxicity is defined as liver damage caused by insufficient nutrition, which results in oxidative stress and damage to liver cells. Objectives: The present study aimed to investigate the protective effects of banana, cassava, and corn flours on hepatotoxicity induced by malnutrition in male rats. Methods: Twenty-four male rats were divided into six groups (n=4): (1) rats received 30 g/rat normal feed daily for 45 days; (2) rats received 30 g malnutrition feed daily for 45 days; rats received 30 g/rat malnutrition feed daily for 15 days and then treated with normal feed (3), banana flour (4), cassava flour (5), and corn flour (6), for 30 days. The malnutrition groups received a diet with protein deficiency for 15 days, then were treated with a diet according to each treatment group. The liver enzymes were analyzed, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Furthermore, the liver's histopathological changes in each group were evaluated using Hematoxylin eosin staining. Results: The AST levels in malnourished male rats significantly (p<0.05) increased (240.75±67.23 U/L) compared to the control group (170.00±33.52 U/L). While, the ALT levels (66.75±12.69 U/L) were decreased compared to the control group (98.75±26.61 U/L). Furthermore, malnutrition diet in rats caused significant changes in liver histology, including inflammatory cell infiltration, necrosis, congestion of the central vein, cytoplasmic vacuolization, and widened hepatic sinusoid. Interestingly, normalized AST and ALT levels and improved liver histology were observed in malnourished rats after receiving normal feed and flour of banana, cassava, and corn. Conclusions: Banana, cassava, and corn flours exhibited hepatoprotective activity on malnutrition-induced hepatotoxicity in malnourhised male rats.
Co-Authors Abdul Ghofur Abdul Gofur Abdul Gofur Ade Wahyu Pratama Agung Witjoro Agus Dharmawan Aisyah Khoirunnisa Ajeng Daniarsih Ajeng Radhita Putri Azella Alif Rosyidah El Baroroh Amalia Nur Rahma Anggraini, Dinar Arsy Annisa, Yuslinda Arik Anggara Arindra Nirbaya Baroroh, Alif Rosyidah El Dahniar Nur Aisyah Daradjatul Aulia Dea Aflah Samah Deny Setiawan Dewi Sekar Miasih Dimas Nur Ramadhani Dini Wijayanti Dio Rizki Nadar Putra Fachrunnisa, Rifka Farid Akhsani Febriandri Annisa Murti Ginna Megawati Hayuana, Wachidah Hendra Susanto Hendrawan Hendrawan Indra Kurniawan Saputra Indradewa, Rhian Istaufa, Inna Milki Amnun Izzalqurny, Tomy Rizky Kartikasari, Nur'aini Lelitawati, Mardiana Mardiana Lelitawati Mellinda Setiani Nusa Diennata Miasih, Dewi Sekar Mohammed, Najib Muhamad Syaikhu Alam Muhammad Andry Prio Utomo Nadila Sekar Zahida Nenes Prastita Nesya Adiva Nurhasanah Nik Malek, Nik Ahmad Nizam Ningrum, Sansan Hastuti Nur'aini Kartikasari Nursasi Handayani Paramita, Farah Putri Elok Septiana Dewi Qomaria, Durrotul Rahmi Masita Rinata, Viska Rizqia Az Zahra, Aulia Rozana, Kennis Rudianto, Rony Salsabila Fitriani, Amelia Septa Katmawanti, Septa Siti Imroatul Maslikah Siti Imrotul Maslikah Siti Nur Fatimah Sri Rahayu Lestari Sri Wahyuni, Oktavia Suharti Sulisetijono Sulisetijono Surmita, Surmita Tsania Wardah Maulidiyah Umi Fitriyati Utami Sri Hastuti Wachidah Hayuana Wahyuni, Dilla Santhia Yasmin Amira, Muthia Yuslinda Annisa Zahida, Nadila Sekar Zahra Anggita Pratiwi Zahra Firdaus