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All Journal Media Kesehatan Masyarakat Indonesia Sains Olahraga : Jurnal Ilmiah Ilmu Keolahragaan JBIO: jurnal biosains (the journal of biosciences) Media Ilmu Keolahragaan Indonesia Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Biomedicine and Translational Research Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Kinestetik : Jurnal Ilmiah Pendidikan Jasmani Journal of Saintech Transfer Sumatera Medical Journal Jurnal Ners AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh SCRIPTA SCORE Scientific Medical Journal Jurnal Syntax Fusion : Jurnal Nasional Indonesia Ophthalmologica Indonesiana
Yetty Machrina
Department Of General Medicine, Faculty Of Medical, Universitas Sumatera Utara, Medan, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Mekanisme Sinergis Ekstrak Etanol Serai dan Slow Interval Training terhadap Leptin, MDA, dan Histologi Adiposit pada Obesitas: Narrative Review Raudhatul Jannah; Yetty Machrina; Dwi Rita Anggraini
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.56975

Abstract

Abstrak Latar Belakang: Obesitas merupakan faktor risiko utama sindrom metabolik yang berhubungan erat dengan stres oksidatif, resistensi leptin, dan remodeling jaringan adiposa. Kombinasi terapi herbal—khususnya ekstrak etanol serai (Cymbopogon citratus)—dan latihan fisik terstruktur berpotensi mengatasi disregulasi metabolik tersebut secara sinergis. Namun, bukti ilmiah mengenai mekanisme biologis kombinasi keduanya masih sangat terbatas. Tujuan: Review ini bertujuan menganalisis secara kritis jalur mekanistik efek kombinasi ekstrak etanol C. citratus dan slow interval training terhadap kadar serum leptin, kadar MDA, dan gambaran histologi sel adiposit pada model obesitas. Metode: Narrative review sistematis terhadap 28 artikel dari database Scopus, PubMed, ScienceDirect, dan Google Scholar (2020–2025), menggunakan kata kunci terstruktur dan kriteria inklusi–eksklusi ketat. Hasil dan Pembahasan: C. citratus mengandung senyawa bioaktif (citral, geraniol, limonene) yang terbukti menghambat peroksidasi lipid, menurunkan ekspresi TNF-α dan IL-6, serta memodulasi jalur PPARγ-adipogenesis. Slow interval training pada intensitas 50–70% HRmax mengaktifkan jalur AMPK-PGC1α, meningkatkan lipolisis, dan memperbaiki sensitivitas reseptor leptin (LepRb) melalui regulasi SOCS3. Secara sinergis, kombinasi keduanya diduga bekerja melalui reduksi stres oksidatif → normalisasi sinyal JAK2/STAT3 → pemulihan sensitivitas leptin → remodeling histomorfometri adiposit. Kesimpulan: Kombinasi C. citratus dan slow interval training memiliki potensi sinergis yang secara mekanistik dapat menurunkan MDA, memulihkan sensitivitas leptin, dan memperbaiki morfologi adiposit pada kondisi obesitas Kata Kunci: Cymbopogon citratus; leptin; malondialdehyde; slow interval training; adiposit; obesitas; stres oksidatif
Education and socialization of fast food negative impacts in preventing dysmenorrhea on adult women at Prof. Dr. Chairuddin P. Lubis Hospital, Medan, North Sumatra community Venessa Wongso; Maya Savira; Eka Roina Megawati; Dedi Ardinata; Milahayati Daulay; Nuraiza Meutia; Yetty Machrina; Selly Azmeila
Journal of Saintech Transfer Vol. 8 No. 2 (2025): Journal of Saintech Transfer
Publisher : Talenta Publisher Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jst.v8i2.20121

Abstract

Dysmenorrhea is a burden on women's health in the world due to its high prevalence. Dysmenorrhea is often associated with several risk factors, one of which is eating habits. The consumption of fast food, which has become a habit of people in the era of globalization, is reported to affect the incidence and intensity of dysmenorrhea. This Community Service aims to socialize the composition and nutritional value of healthy food, the composition and nutritional value of fast food, dysmenorrhea and how it affects daily life as well as the effect of excessive consumption of fast food on dysmenorrhea in the community which was carried out at Prof. Dr. Chairuddin P. Lubis Hospital, Medan, North Sumatra. This community service activity consists of two stages, namely providing education in the form of posters containing material and questions and answers or discussions on related health topics, then handing over the material to the community to be able to practice the knowledge gained so that people's knowledge increases and can be applied to daily life, with the hope that in the future dysmenorrhea disorders caused by excessive fast food intake which causes limitations In carrying out daily activities can be avoided and no longer become one of the largest contributors to health problems in the world and no longer a burden to women's health in the world.
Co-Authors Aditya Candra Aditya Candra Anggraini, Dwi Rita Ardinata, Dedi - Ashri Yudhistira Aznan Lelo Daulay, Milahayati Dedi Ardinata dharma Lindarto, dharma Diningrat, Diky Setya Eka Roina Megawati ELMAN BOY Gema Nazri Yanni Gema Nazri Yanni Gusbakti Rusip Gusbakti Rusip Harahap, Armansyah Maulana Harahap, Juliandi Koswara, Jocelyn Krishna Moorthi, Priya Darshini Laksmi, Lidya Imelda Lewis, Edwin - Lubis, Mahrani Maya Savira Maya Savira Mentari, Cindy Novita Sari Harahap Nuraiza Meutia Nuraiza Meutia Nurul Amalia Sofyan Pratiwi, Lisa Nabila Priawan, Indra Purba, Ambrocious Qori An-Nabil, Muhammad Rahmi Rahmi Rambe, Andrina Y.M Raudhatul Jannah Rina Amelia Ririe Fachrina Malisie Rusdiana Rusdiana Santi Syafril, Santi Selly Azmeila Selly Azmeila Sembiring, Rosita Juwita Siahaan, Sulyaprilawati Battri Sihombing, Rocky Charles Andreas Siregar, Kamal Basri Sri Sumartiningsih Syafruddin Ilyas Tarigan, Amira Permatasari Tri Widyawati, Tri Ulya, Ulfatul Venessa Wongso Yamamoto, Zulham Yaznil, Muhammad Rizki Yunita Sari Pane Yusni Yusni Zega, Elwande Hagasaro