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Putu Oky Ari Tania
Bagian Biomedik Penelitian Biomolekuler Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
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Journal : Biota

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Anti-Proliferative Compound Candidate of White Turmeric (Curcuma zedoaria) Putu Oky Ari Tania; Candra Rini Hasanah Putri; Ayling Sanjaya; Titiek Sunaryati; Deddy Hartanto; Erlix R Purnama; Meivy Isnoviana
Biota Vol 9 No 2 (2023): Jurnal Biota 2023
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/Biota.v9i2.13746

Abstract

Malignant disease or cancer progression burden the community after decades. This tumor formation or tumorigenesis involves cell proliferation. Protein Kinases (MAPK9s) is key proteins of regulating the growth and viability of cells physiologically and pathologically. Rhizomes of Curcuma zedoaria or zedoary or white turmeric is used as a health supplement. The aim of this study was to obtained candidate proteins for anti-proliferative using the docking method between the protein MAPK9 and the active compound obtained from the crude extract of white turmeric i.e. demethoxycurcumin, curcumenol and germacrone. The result s hows that complex MAPK-demethoxycurcumin have the lowest binding affinity -8.4 Kkal/mol, while MAPK-curcumenol was -8 Kkal/mol, and MAPK-Germacrone was -6.2 Kkal/mol, it determined the potential activity cell proliferation.
Co-Authors AFAF BAKTIR Agusniar Furkani Listyani Agusniar Furkani Setiyawati Ahista Saskirana Putri Ahnaf Farel Al Raihaan akhmad sudibya, akhmad Amirotul Khifana Andiani Andiani Andra Agnez Al Aska Athaya Azalia Yasirah Ayling Sanjaya Ayly Soekanto Azka, Andra Agnes Al Cahyadi, I Kadek Angga Dwi Candra Rini Hasanah Putri Candra Rini Hasanah Putri Colin, Muhammad Deddy Hartanto Dorta Simamora Emanuel, Endrayana Putut Laksminto Emilia Devi D. Rianti Emilia Devi Dwi Rianti Emilia Devi Dwi Rianti Emilia Devi Dwi Rianti Emillia Devi Dwi Rianti, Emillia Devi Dwi Enny Willianti, Enny Erlix R Purnama Erny Erny Erny Erny Fadilla Lutvi Aryanti Febtarini Rahmawati Febtarini Rahmawati Fuad Ama Furkani, Agusniar Hardiyono Hardiyono Hardiyono Hardiyono Hardiyono Hardiyono HARMAN AGUSAPUTRA Harsono Wiradinata Haru Setiawan I Kadek Putra Dwipayana I Made Subhawa Harsa Ibrahim Njoto, Ibrahim Inawati Inawati, Inawati Indra Firismanda Dermawan Kadek Adi Sudarmika Ketut Ayesha Edelwise Prayoga Listyawati, Agusniar Furkani Loo Hariyanto Raharjo, Loo Hariyanto Lusiani Tjandra Marcela Anindita Masfufatun Masfufatun Masfufatun Maverick Nathanael Adirangga Meivy Isnoviana Muhammad Collin Nadila, Sucia Ni Kadek Evita Vara Rosieana Ni Made Ayu Gea Niquita Noer Kumala Indahsari, Noer Kumala Nugraha, Wima Handika Nur Sri Wahyuni Olivia Rahayu Ramadhani Pramita Laksitarahmi Isrianto Puja Ayu Misuari Puja Ayu Misuari Putra, Wisnu Pratama Putut Laksminto Emanuel Rini Purbowati Sakri, Brian Manggala Satya Yudhayana Satya Yudhayana Sianny Suryawati, Sianny Sudarmika, Kadek Adi Sukma Sahadewa, Sukma Syeira Rigita Noptavia Theodora Theodora Titiek Sunaryati Titiek Sunaryati Titiek Sunaryati, Titiek Wahyuni Dyah Parmasari, Wahyuni Dyah