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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Jurnal FARMAKU (Farmasi Muhammadiyah Kuningan) Jurnal Abdi Insani Jurnal Mandala Pengabdian Masyarakat Sciences of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Indonesian Journal of Jamu
Niluh Puspita Dewi, Niluh Puspita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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Anti-Cancer Activity Of The Combination Of Marine Mineral Consentrates And α Mangostin On Prostate Cancer Line DU 145 And HEK 293 By WST-8 Method Agustina, Giska Putri; Alaydrus, Syafika; Dewi, Niluh Puspita
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.8518

Abstract

Marine mineral concentrates have good activity against normal cells, but are less effective against cancer cells. This research was carried out by combining concentrations of sea minerals with natural ingredients that have anti-cancer potential, one of which is α-mangostin. This study aims to determine the IC50 of the combination of α-mangostin, marine mineral concentrate, the combination of α-mangostin & marine mineral concentrate when compared cisplatin and evaluate the activity of α-mangostin, KML and the combination of α-mangostin and KML compared with ciplatin against the DU 145 cancer cell line and HEK 293. The method used is cytotoxicity testing using the WST-8 method. The results of the test materials were α-Mangostin 16.89 ppm, the combination of α-Mangostin-KML with a concentration of 12.5 ppm, namely 1,732 ppm, the combination of α-Mangostin-KML with a concentration of 25 ppm, namely 4,930 ppm, the combination of α-Mangostin-KML with concentration of 50 ppm 5,194 ppm, and cisplatin 4,649 ppm. The results of data analysis show significant differences for all samples. Conclusion α-Mangostin helps KML increase the cytotoxic effect on DU 145 cancer cells and sea mineral concentrate helps reduce the cytotoxic effect of α-Mangostin on normal HEK-293 cells.
Determination of specific and non-specific standardization parameters for ethanol extract of purple leaves (Graptophyllum pictum (L) Griff ) Tampang, Rivani; Alaydrus, Syafika; Dewi, Niluh Puspita; Tandi, Joni
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8812

Abstract

this study aims to determine the standardization of specific parameters (organoleptic and chemical content) and non-specific parameters (ash content, water content, drying loss, heavy metal contamination, Yeast Mold Number (AKK), microbial contamination / Total Plate Count (ALT)). The results showed that the specific parameters of the organoleptic properties of 96% ethanol extract of purple leaves (Grapthophyllum pictum (L) Griff) were black, shaped like a paste, a distinctive purple leaf odor and a bitter taste. The results of phytochemical screening of 96% purple leaf ethanol extract contained alkaloids, flavonoids, and tannins. However, the saponin test was negative for saponins. Non-specific parameters of 96% ethanol extract of cherry leaves were water content of 5.96%, total ash content of 16.86%, drying loss of 17.26%, heavy metals As and Cd were not detected, the presence of metals in Pb was 0.12 mg / kg, microbial contamination (Alt) and yeast mold numbers (Akk) were not found colonies. Based on these results, it can be concluded that the standardization test of specific and non-specific parameters, the ethanol extract of purple leaves has met the quality standards of simple drugs.
MACROSCOPIC AND MICROSCOPIC GASTROPROTECTIVE ACTIVITY OF MUCOADHESIVE GRANULE FORMULATIONS OF CLOVE LEAF ETHANOL EXTRACT Harliwong, Dhitania Ivana; Wulandari, Ayu; Dewi, Niluh Puspita; Muthmainnah, Sririzqi; Tandi, Joni; Intan, Putu
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8949

Abstract

Gastric ulcers can be triggered by excessive HCl secretion, and the regenerative capacity of mucosal cells can be weakened by high alcohol levels and anti-inflammatory drugs, including NSAIDs. Gastrin functions to stimulate the secretion of gastric juice, particularly HCl and pepsinogen This study aims to evaluate the macroscopic and microscopic gastroprotective activity of clove leaf ethanol extract mucoadhesive granule formulations. The study used 25 rats divided into five groups: normal control, negative control, positive control, clove leaf ethanol extract group, and mucoadhesive granule formulation of clove leaf ethanol extract group. All groups except the normal control were administered acetylsalicylic acid. Treatments were conducted over 9 days, with surgical examination and observations performed macroscopically and microscopically on day 10. Macroscopic assessments revealed ulcer damage improvement in the positive control, extract, and mucoadhesive granule groups, all scored at 1. Microscopic assessments also indicated a significant difference between the negative control and the positive control, extract, and mucoadhesive granule groups, showing better gastric repair, scored at 0.5. Therefore, it can be concluded that the administration of the mucoadhesive granule formulation of clove leaf ethanol extract exhibits gastroprotective activity comparable to that of the clove leaf ethanol extract.
Suspension of Sonchus arvensis L Leaves Ethanolic Extract Affects Blood Creatinine and Urea Levels in Streptozotocin-Induced Wistar Male Rats Dewi, Niluh Puspita; Alaydrus, Syafika; Lestari, Widya Ayu; Magfirah, Magfirah; Utami, Indah Kurnia; Polontalo, Nani Astria; Tuldjanah, Muthmainah
Sciences of Pharmacy Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0301173

Abstract

The study focused on analyzing the secondary metabolites present in the ethanol extract of Sonchus arvensis L. leaves (SALEE) and their impact on creatinine and urea levels when administered in suspension form at different doses. Phytochemical screening of SALEE identified alkaloids, flavonoids, phenols, saponins, and tannins. In the experiment, twenty-five white male rats were divided into five groups: a healthy control group (Group I), a negative control group (Group II), and three test groups (Groups III, IV, and V) receiving SALEE at doses of 200, 300, and 400 mg/kg BW, respectively. After inducing diabetes with streptozotocin and a 21-day follow-up period, creatinine and urea levels were assessed. The results demonstrated that SALEE administration significantly reduced creatinine levels and increased urea levels. Notably, the 200 mg/kg BW dose of SALEE exhibited a consistent and long-term effect. It was observed that blood urea levels fluctuated even in healthy and negative control groups during the 21-day observation period. In the group receiving the highest dose of SALEE (400 mg/kg BW), blood urea levels increased significantly on days 14 and 21, indicating a potential increase in the rats' appetite rather than renal function failure. Overall, the findings suggest that SALEE has promising potential to regulate creatinine and urea levels in the blood of individuals with diabetes, highlighting its potential for therapeutic and supplemental use.
SOSIALISASI DAN EDUKASI DAGUSIBU OBAT DENGAN BENAR PADA MASYARAKAT KELURAHAN TATURA UTARA, PALU SELATAN Dewi, Niluh Puspita; Wirawan, Wayan; Rakanita, Yasinta; Polontalo, Nani Astria; Insani, Fadillah
Jurnal Abdi Insani Vol 12 No 10 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i10.2873

Abstract

Various health problems, particularly those related to drugs, persist in the community. This can be caused by a lack of public understanding of the proper use and handling of drugs. The DAGUSIBU program is one method for proper drug management. The goal of DAGUSIBU outreach is to increase public understanding of drugs and how to manage and monitor their proper use. The methods used include public education through counseling and practical training. The effectiveness of the outreach was tested using pre- and post-tests, as well as a community satisfaction questionnaire. The results showed an increase in public knowledge and understanding after the DAGUSIBU outreach and education activities. Overall, the average increase in knowledge and understanding of DAGUSIBU among participants was 84%. This can help the government provide better health services. By improving participants' understanding of proper drug management, this outreach is expected to enable them to utilize the knowledge they gain within their families and communities.
Effect of Purple Leaf (Graptophyllum pictum (L.) Griff) Emulsion on the Histological Parameters of Streptozotocin-Induced Diabetic Rats Dewi, Niluh Puspita; Dewik, Komang; Alaydrus, Syafika; Kasim, Athia Kurnia; Polontalo, Nani Astria; Wirawan, Wayan; Andini, Dian; Irma, Irma; Fatu, Imelda Synthia
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.14172

Abstract

Damage to vital organs such as the liver, kidneys, and pancreas is a common complication of diabetes mellitus, characterized by chronic hyperglycemia due to pancreatic cell dysfunction. Graptophyllum pictum (purple leaf) is a potential herbal therapy containing bioactive compounds with antioxidant and organ-protective effects. This study aimed to evaluate the effect of purple leaf emulsion on blood glucose levels and the histopathological features of diabetic rats induced by streptozotocin. Rats were divided into six groups: normal control, negative control, positive control (glibenclamide), and three doses of purple leaf emulsion (100, 200, and 300 mg/kg BW). After 28 days of treatment, the emulsion significantly reduced blood glucose levels and improved the histological structures of the liver, kidneys, and pancreas. The 200 mg/kg BW dose was most effective for pancreatic protection, while 300 mg/kg BW provided optimal hepatoprotective and renoprotective effects. These findings highlight the potential of purple leaf as a natural antidiabetic and organ-protective agent.
Co-Authors Agustina, Giska Putri Alaydrus, Syafika Andini, Dian Arfiah, Arfiah Astria, Nani Ayu Wulandari Darmayanti Darmayanti Darmayanti David Pakaya Dewik, Komang Dipayana, I Made Fatu, Imelda Synthia Gabriella Bamba Ratih Lintin Halik, Nur Handayani, Tien Wahyu Harliwong, Dhitania Ivana Insani, Fadillah Intan, Putu Irma Irma Joni Tandi, Joni Kasim, Athia Kurnia Lakiu, Debora Rislianti Lestari, Widya Ayu Liska, Iluh Magfira Magfirah, Magfirah Maria Kanan Mariyani Marsella, Mimi Meike Rachmawati Muthmainnah, Sririzqi Nadila, Nadila Nur Azizah Ocvinta, Sisca Pamudji, Gunawan Pasaribu, Meilinda Handayani Polontalo, Nani Astria R, Yana Novika Rakanita, Yasinta Recky Patala Rianto Rianto Rusliyana, Rusliyana Solehah, Puput Octaviani Suarsana, I Made Agus Surat, Megawati R. Syafika Alaydrus Tampang, Rivani Tamunu, Jeine Sweet Natasya Tarusu, Fikhta Agnesya Toding, Ficanata A. Tuldjanah, Muthmainah Utami, Indah Kurnia Viani Anggi Wardani, Yunira Wawang Anwarudin Widiastuti, Aris Wirawan, Resky Chandra wirawan, Wayan Yanuarty, Rezky Yuli Fitriana Yuliet Yuliet