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Journal : Chimica et Natura Acta

Identification of Secondary Metabolites in Ethyl Acetate Extract of Ki Encok Plant Roots (Plumbago zeylanica Linn) and In Silico Cytotoxicity Activity Purwoko, Mitayani; Mundijo, Trisnawati; Astri, Yesi; Rohani, Siti
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.50815

Abstract

The Ki Encok plant (Plumbago zeylanica Linn) has been extensively studied and is known to have cytotoxic activity. However, no research has yet investigated the compound content of the ethyl acetate extract from that plant. This study aims to identify the secondary metabolite content in the ethyl acetate extract of Plumbago zeylanica L. roots and to determine the potential of these secondary metabolites to bind with the Caspase-3 protein in silico. The ethyl acetate extract of Plumbago zeylanica roots was tested for its phytochemical properties and examined using GC-MS. The compounds found were then searched for their structures in Pubchem, tested in silico using the CB-Dock2 software, and evaluated for drug-likeness with SwissADME. Qualitative phytochemical tests indicate the presence of alkaloid and tannin compounds. The GC-MS test showed the presence of Plumbagin, Gamma sitosterol, and 4-ethoxybenzaldehyde. In the in silico test, docking between Gamma sitosterol, Plumbagin, and 4-ethoxybenzaldehyde with the target protein Caspase-3 has free binding energies of -8.5, -7.0, and -6.1. The Gamma sitosterol-Caspase-3 complex shows the best free-binding energy among the three ligands. Further in vitro or in vivo studies are needed to assess whether the interaction between Gamma sitosterol and Caspase-3 is inhibition or activation.
Co-Authors -, Hasmeinah Adhi Permana Aditya Warman Aditya, Muhammad Akbar Aflah, Anisatul Ahmad Ghiffari Akrom, Muhamad Afif Al Alifah, Haura Zatty Amalda, Dea Anggina, Dientyah Nur Anggraini, Wieke Antonia, As Syifa Anzani, Tsabitah Zahra Dwi Asyik, Hadi Aziza, Nurita Azzahra, Rashieka Adawiya Chairani, Liza Dewi Yuniasih Dian Wahyuningsih Eka Sri Yusmartini Eko Ariyanto Eriko Erenkwot Fachrozi, Muhammad Fuad Arifin fatimah Fatimah Ferzieza Dizayang Fitrianti, Yuni Franscisco, Jimmi Gani, Rima January Putri Ridwan Ghea Lingga Septiareni Gialini, Windy Ulfa Gunawan, Ernes Putra Hartina, Nabila Hasmeinah - Hasmeinah Bambang Hastuti, Riliani Heriyanto, Mochammad Junaidy Herlangga, Arya Indawaty, Septiani Nadra Indriani, M. A. Yenny Iqsa, Abil Jamaiyah, Miranda Lucille Anisa Suardin M. Mansyur Romi Meddy Setiawan Meilina Wardhani Miranda, Mira Muhamad Ayus Astoni Muhammad Aditya Alfarizki Muhammad Nazir Muhammad Perdana Airlangga, Muhammad Perdana Mundijo, Trisnawati Mutia Mutmainnah Nafatilana, Dinda Ningsih, Ena Aprita Nofitasari, Camelia Novitasari, Erlina Krisdianita Nurjanah, Rizki Anisa Oktariza, Rury Tiara Pamudji, Raden Pandhita, Gea Permana, Adhi Prakoso, Denny Anggoro Pranata, Muhammad Ari Putra, Chendra Perdana Ramayanti, Indri Ratih Pratiwi Ressy Irma Juwita Reza Reza Rizki, Putri Nersi Rodhiaty, Fera Yunita Ronnia, Ronnia Rudiyanto, Waluyo Sabrina, Siti Safitri, Oktarina Salsabilla, Rizky Salsabilla, Salsabilla Salsyah, Alya Saraswati, Nia Ayu Sheilla Yonaka Lindri Silvana, Rista Sinta, Adliah Zahira Padya Siti Rohani Sriningsih, Solikah Stiawan, Ridho Suciandari, Altiara Risky Suciandari, Altiara Risky Sukarno, Rizky Triutami Sulistiani, Taris Ade SULISTIYANI SULISTIYANI Syadra Bardiman Tubarad, Gladys Dwiani Tinovella Utami, Dhiya Luthfiyyah Wakilla, Putri Wijaya, Otchi Putri Yanuarita Tursinawati, Yanuarita Yesi Astri